PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9831819-6 1999 RA treatment of FCS-stimulated RPE cells shifted the peak of ornithine decarboxylase (ODC) activity from 16 to 4 h. S-adenosylmethionine decarboxylase (SAMDC) activity and spermidine/spermine N1-acetyltransferase (SAT) activity of RA-treated RPE cells were significantly greater until 8 and 16 h after incubation, respectively. Tretinoin 0-2 spermidine/spermine N1-acetyltransferase 1 Bos taurus 172-212 9831819-6 1999 RA treatment of FCS-stimulated RPE cells shifted the peak of ornithine decarboxylase (ODC) activity from 16 to 4 h. S-adenosylmethionine decarboxylase (SAMDC) activity and spermidine/spermine N1-acetyltransferase (SAT) activity of RA-treated RPE cells were significantly greater until 8 and 16 h after incubation, respectively. Tretinoin 0-2 spermidine/spermine N1-acetyltransferase 1 Bos taurus 214-217 9831819-7 1999 The putrescine content was significantly increased in RA-treated RPE cells up until 24 h, while spermidine, spermine and N1-acetylspermidine contents were significantly increased until 16 h. Our findings suggest that RA treatment increases the intracellular polyamine concentration of RPE cells via activation of ODC, SAMDC and SAT and that this results in the promotion of RPE cell growth until the cells reach full confluency. Tretinoin 217-219 spermidine/spermine N1-acetyltransferase 1 Bos taurus 328-331