PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11274148-3	2001	Clustered retinoic acid-responsive element and TTF-1 binding sites were identified in the enhancer region of the SP-B gene and were required for retinoic acid stimulation of the human SP-B (hSP-B) promoter.	Tretinoin	10-23	surfactant protein B	Homo sapiens	113-117	
11788590-5	2002	Interleukin 6 and interleukin 11, known to activate STAT3 synergistically, stimulated the SP-B promoter activity with retinoic acid, which is at least partially mediated through interactions between STAT3 and retinoid nuclear receptor enhanceosome proteins in pulmonary epithelial cells.	Tretinoin	118-131	surfactant protein B	Homo sapiens	90-94	
11274148-3	2001	Clustered retinoic acid-responsive element and TTF-1 binding sites were identified in the enhancer region of the SP-B gene and were required for retinoic acid stimulation of the human SP-B (hSP-B) promoter.	Tretinoin	145-158	surfactant protein B	Homo sapiens	184-188	
11274148-3	2001	Clustered retinoic acid-responsive element and TTF-1 binding sites were identified in the enhancer region of the SP-B gene and were required for retinoic acid stimulation of the human SP-B (hSP-B) promoter.	Tretinoin	145-158	surfactant protein B	Homo sapiens	190-195	
11274148-9	2001	RAR DBD greatly enhanced TTF-1 homeodomain DNA binding activity to a hSP-B enhancer oligonucleotide, in which retinoic acid-responsive element and TTF-1 DNA binding sites overlap.	Tretinoin	110-123	surfactant protein B	Homo sapiens	69-74	
11274148-10	2001	Chromatin immunoprecipitation assay demonstrated that retinoic acid treatment of H441 cells greatly stimulated both RAR and TTF-1 DNA binding to the hSP-B enhancer region in H441 cells.	Tretinoin	54-67	surfactant protein B	Homo sapiens	149-154	
11274148-3	2001	Clustered retinoic acid-responsive element and TTF-1 binding sites were identified in the enhancer region of the SP-B gene and were required for retinoic acid stimulation of the human SP-B (hSP-B) promoter.	Tretinoin	10-23	surfactant protein B	Homo sapiens	184-188	
11274148-3	2001	Clustered retinoic acid-responsive element and TTF-1 binding sites were identified in the enhancer region of the SP-B gene and were required for retinoic acid stimulation of the human SP-B (hSP-B) promoter.	Tretinoin	10-23	surfactant protein B	Homo sapiens	190-195	
11274148-3	2001	Clustered retinoic acid-responsive element and TTF-1 binding sites were identified in the enhancer region of the SP-B gene and were required for retinoic acid stimulation of the human SP-B (hSP-B) promoter.	Tretinoin	145-158	surfactant protein B	Homo sapiens	113-117	
10617585-3	2000	Previous studies supported the role of retinoic acids (RA) and their receptors (RARs) in SP-B gene transcription.	Tretinoin	55-57	surfactant protein B	Homo sapiens	89-93	
10617585-0	2000	Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.	Tretinoin	0-13	surfactant protein B	Homo sapiens	39-59	
10617585-8	2000	Importantly, RA stimulation of the hSP-B promoter depends on tissue-specific thyroid transcription factor (TTF-1) DNA-binding sites.	Tretinoin	13-15	surfactant protein B	Homo sapiens	35-40	
10617585-3	2000	Previous studies supported the role of retinoic acids (RA) and their receptors (RARs) in SP-B gene transcription.	Tretinoin	39-53	surfactant protein B	Homo sapiens	89-93	
10070102-7	1999	The mutant retained DNA binding activity in the presence of retinoid X receptor-gamma to an RA response element in the hSP-B promoter.	Tretinoin	92-94	surfactant protein B	Homo sapiens	119-124	
9128293-2	1997	We have previously shown that SP-B mRNA is increased whereas SP-A and SP-C mRNA are decreased by all-trans-retinoic acid (RA) in a dose-dependent manner in human fetal lung explants.	Tretinoin	122-124	surfactant protein B	Homo sapiens	30-34	
9700083-3	1998	In the present work, the mechanism by which retinoic acid (RA) regulates surfactant protein (SP) B expression was assessed in vitro.	Tretinoin	44-57	surfactant protein B	Homo sapiens	73-98	
9700083-3	1998	In the present work, the mechanism by which retinoic acid (RA) regulates surfactant protein (SP) B expression was assessed in vitro.	Tretinoin	59-61	surfactant protein B	Homo sapiens	73-98	
9700083-7	1998	An RA responsive element mediating RA stimulation of the human SP-B promoter was identified.	Tretinoin	3-5	surfactant protein B	Homo sapiens	63-67	
9700083-7	1998	An RA responsive element mediating RA stimulation of the human SP-B promoter was identified.	Tretinoin	35-37	surfactant protein B	Homo sapiens	63-67	
9575874-2	1998	We characterized the effects of cortisol and all trans-retinoic acid (RA) on SP-A and SP-B gene expression in H441 cells, a human pulmonary adenocarcinoma cell line.	Tretinoin	49-68	surfactant protein B	Homo sapiens	86-90	
9575874-2	1998	We characterized the effects of cortisol and all trans-retinoic acid (RA) on SP-A and SP-B gene expression in H441 cells, a human pulmonary adenocarcinoma cell line.	Tretinoin	70-72	surfactant protein B	Homo sapiens	86-90	
9575874-5	1998	RA alone and the combination of cortisol and RA both significantly increased SP-B mRNA levels.	Tretinoin	0-2	surfactant protein B	Homo sapiens	77-81	
9575874-10	1998	We conclude that RA has no effect on SP-A gene expression and increases SP-B mRNA levels by an effect on SP-B mRNA stability and not on the rate of SP-B gene transcription.	Tretinoin	17-19	surfactant protein B	Homo sapiens	72-76	
9575874-10	1998	We conclude that RA has no effect on SP-A gene expression and increases SP-B mRNA levels by an effect on SP-B mRNA stability and not on the rate of SP-B gene transcription.	Tretinoin	17-19	surfactant protein B	Homo sapiens	105-109	
9575874-10	1998	We conclude that RA has no effect on SP-A gene expression and increases SP-B mRNA levels by an effect on SP-B mRNA stability and not on the rate of SP-B gene transcription.	Tretinoin	17-19	surfactant protein B	Homo sapiens	105-109	
7742011-4	1995	We found that retinoic acid interferes, in a dose-dependent fashion, with the expression of epithelial genes that are found in distal segments of the fetal lung (surfactant-associated proteins SP-A, SP-B, and SP-C).	Tretinoin	14-27	surfactant protein B	Homo sapiens	199-203	
8404646-11	1993	In contrast, retinoic acid increased SP-B mRNA levels in a concentration-dependent manner (ANOVA, P < 0.03).	Tretinoin	13-26	surfactant protein B	Homo sapiens	37-41