PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18957893-3 2008 Retinoic acid-elicited differentiation promoted assembly of alpha-syn aggregates after TetOff induction in 3D5 cells. Tretinoin 0-13 synuclein alpha Homo sapiens 60-69 19027885-1 2009 A tetracycline inducible transfectant cell line (3D5) capable of producing soluble and sarkosyl-insoluble assemblies of wild-type human alpha-synuclein (alpha-Syn) upon differentiation with retinoic acid was used to study the impact of alpha-Syn accumulation on protein phosphorylation and glycosylation. Tretinoin 190-203 synuclein alpha Homo sapiens 136-151 19027885-1 2009 A tetracycline inducible transfectant cell line (3D5) capable of producing soluble and sarkosyl-insoluble assemblies of wild-type human alpha-synuclein (alpha-Syn) upon differentiation with retinoic acid was used to study the impact of alpha-Syn accumulation on protein phosphorylation and glycosylation. Tretinoin 190-203 synuclein alpha Homo sapiens 153-162 10654448-1 2000 We evaluated the in vitro effect on clonogenic potential (CFU-GM) and apoptosis in myelodysplastic syndromes (MDS) progenitors of an anti-oxidant (N-acetylcysteine, NAC) and/or a differentiating (all-trans retinoic acid, ATRA) agent. Tretinoin 196-219 synuclein alpha Homo sapiens 165-168 11472875-4 2001 The levels of alpha-synuclein expression were elevated markedly in NTera2 teratocarcinoma cells following retinoic acid-induced neuronal differentiation, accompanied with an increased expression of synphilin-1, while they were unaltered in NTera2-derived differentiated neurons by exposure to TNF-alpha, IL-1beta, BDNF or GDNF. Tretinoin 106-119 synuclein alpha Homo sapiens 14-29 10654448-1 2000 We evaluated the in vitro effect on clonogenic potential (CFU-GM) and apoptosis in myelodysplastic syndromes (MDS) progenitors of an anti-oxidant (N-acetylcysteine, NAC) and/or a differentiating (all-trans retinoic acid, ATRA) agent. Tretinoin 221-225 synuclein alpha Homo sapiens 165-168 10654448-3 2000 NAC + ATRA conferred a significant advantage in terms of CFU-GM with respect to NAC and ATRA alone. Tretinoin 6-10 synuclein alpha Homo sapiens 80-83 10654448-3 2000 NAC + ATRA conferred a significant advantage in terms of CFU-GM with respect to NAC and ATRA alone. Tretinoin 88-92 synuclein alpha Homo sapiens 0-3 28190238-5 2018 Our results indicate that overexpression of wild-type or mutant A53T alpha-SYN attenuated the RA-induced upregulation of tyrosine hydroxylase and dopamine transporter as well as neurite outgrowth in SH-SY5Y cells. Tretinoin 94-96 synuclein alpha Homo sapiens 69-78 35397003-8 2022 To test the functional significance of these findings, we ectopically expressed wild-type alpha-synuclein in retinoic acid-differentiated dopaminergic SH-SY5Y cells which resulted in decreased levels of NMNAT3 protein plus a neurite pathology which could be rescued by FK866, an inhibitor of nicotinamide phosphoribosyltransferase that acts as a key enzyme in the regulation of NAD+ synthesis. Tretinoin 109-122 synuclein alpha Homo sapiens 90-105 32899900-4 2020 In retinoic acid (RA)-differentiated SH-SY5Y cells challenged with alpha-synuclein (alpha-syn) plus rotenone (Rot), glutamate significantly improved cell viability by increasing ATP levels, reducing oxidative damage and cytosolic and mitochondrial Ca2+ overload. Tretinoin 3-16 synuclein alpha Homo sapiens 67-82 32899900-4 2020 In retinoic acid (RA)-differentiated SH-SY5Y cells challenged with alpha-synuclein (alpha-syn) plus rotenone (Rot), glutamate significantly improved cell viability by increasing ATP levels, reducing oxidative damage and cytosolic and mitochondrial Ca2+ overload. Tretinoin 3-16 synuclein alpha Homo sapiens 67-76 32899900-4 2020 In retinoic acid (RA)-differentiated SH-SY5Y cells challenged with alpha-synuclein (alpha-syn) plus rotenone (Rot), glutamate significantly improved cell viability by increasing ATP levels, reducing oxidative damage and cytosolic and mitochondrial Ca2+ overload. Tretinoin 18-20 synuclein alpha Homo sapiens 67-82 32899900-4 2020 In retinoic acid (RA)-differentiated SH-SY5Y cells challenged with alpha-synuclein (alpha-syn) plus rotenone (Rot), glutamate significantly improved cell viability by increasing ATP levels, reducing oxidative damage and cytosolic and mitochondrial Ca2+ overload. Tretinoin 18-20 synuclein alpha Homo sapiens 67-76 28190238-0 2018 Alpha-Synuclein Suppresses Retinoic Acid-Induced Neuronal Differentiation by Targeting the Glycogen Synthase Kinase-3beta/beta-Catenin Signaling Pathway. Tretinoin 27-40 synuclein alpha Homo sapiens 0-15 28190238-6 2018 In addition, GSK-3beta inactivation and downstream beta-catenin stabilization were associated with RA-induced differentiation, which was attenuated by alpha-SYN. Tretinoin 99-101 synuclein alpha Homo sapiens 151-160 28190238-7 2018 Moreover, protein phosphatase 2A was positively regulated by alpha-SYN and was implicated in the alpha-SYN-mediated interference with RA signaling. Tretinoin 134-136 synuclein alpha Homo sapiens 61-70 28190238-7 2018 Moreover, protein phosphatase 2A was positively regulated by alpha-SYN and was implicated in the alpha-SYN-mediated interference with RA signaling. Tretinoin 134-136 synuclein alpha Homo sapiens 97-106 21848810-6 2011 Retinoic acid promotes differentiation and alpha-synuclein oligomer formation in neuroblastoma cells, while addition of a proteasomal inhibitor induces neurite outgrowth and toxicity to certain wild-type and truncated alpha-synuclein clones. Tretinoin 0-13 synuclein alpha Homo sapiens 43-58 24269733-2 2014 The loss of viability in retinoic acid-differentiated SH-SY5Y human neuroblastoma cells inducibly overexpressing wild-type ASYN was associated with the reduced activation of AMPK and its activator LKB1, as well as AMPK target Raptor. Tretinoin 25-38 synuclein alpha Homo sapiens 123-127