PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15587392-10 2004 Both ATRA and/or sodium butyrate stimulated p21 expression at the mRNA levels. Tretinoin 5-9 H3 histone pseudogene 16 Homo sapiens 44-47 15254726-5 2004 Expression of p53, p21 and bax was increased, and bcl-2 was decreased in melanoma cells after exposure to atRA at different concentrations for various periods of time. Tretinoin 106-110 H3 histone pseudogene 16 Homo sapiens 19-22 15254726-8 2004 These data indicate that p53, p21, bax and bcl-2 proteins were involved in atRA-induced apoptosis in melanoma cells. Tretinoin 75-79 H3 histone pseudogene 16 Homo sapiens 30-33 10706449-7 1999 The ATRA-mediated increase in p21 preceded the change in RB phosphorylation and G1 arrest and was not reversed by the addition of exogenous IL-6. Tretinoin 4-8 H3 histone pseudogene 16 Homo sapiens 30-33 12027902-0 2002 Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid. Tretinoin 134-157 H3 histone pseudogene 16 Homo sapiens 20-23 11753676-4 2001 However, RA sensitive CA-OV3 cells expressed higher levels of p53, p27, p21, and p16 compared to RA resistant SK-OV3 cells. Tretinoin 9-11 H3 histone pseudogene 16 Homo sapiens 72-75 10929428-15 2000 Although RA at the concentration of 10(-6) mmol/l caused lower p21 expression, Ni(RA)2.3H2O did not affect p21 expression in EJ cells. Tretinoin 9-11 H3 histone pseudogene 16 Homo sapiens 63-66 10706449-8 1999 The levels of CDK2 activity were inhibited approximately 60% in ATRA-treated cells, suggesting that the increased p21 levels were sufficient to inhibit CDK activity and cause RB hypophosphorylation. Tretinoin 64-68 H3 histone pseudogene 16 Homo sapiens 114-117 21843507-0 2011 All-trans retinoic acid induces cellular senescence by up-regulating levels of p16 and p21 via promoter hypomethylation. Tretinoin 10-23 H3 histone pseudogene 16 Homo sapiens 87-90 32124141-2 2020 The results show that all-trans retinoic acid enhances the effect of Fra-1 on inhibiting cervical cancer proliferation and the glucose consumption, its effect on the loss of mitochondrial membrane potential, on the decreasing of lactic acid as well as ATP, and also influences the expression of MDM2/P53/P21 and LDHA. Tretinoin 32-45 H3 histone pseudogene 16 Homo sapiens 304-307 28911263-9 2017 In the presence of RA, we observed a decrease of OCT4 expression, associated with a loss of clonogenic and proliferation capacities, cell cycle arrest, and upregulation of p21, in HL60, NB4, KASUMI, and Me-1 cell lines. Tretinoin 19-21 H3 histone pseudogene 16 Homo sapiens 172-175 25564054-4 2014 RESULTS: Western blot showed that the overexpression of RIG-G protein significantly upregulated p21 protein level in the NB4 cells, and the level of p21 protein largely increased along with the induction of endogenous RIG-G protein during the differentiation of NB4 cells treated by all-trans retinoic acid (ATRA). Tretinoin 293-306 H3 histone pseudogene 16 Homo sapiens 149-152 25564054-4 2014 RESULTS: Western blot showed that the overexpression of RIG-G protein significantly upregulated p21 protein level in the NB4 cells, and the level of p21 protein largely increased along with the induction of endogenous RIG-G protein during the differentiation of NB4 cells treated by all-trans retinoic acid (ATRA). Tretinoin 308-312 H3 histone pseudogene 16 Homo sapiens 149-152 24646031-3 2014 In many cases, downregulation of CDK activity by ATRA and vitamin D3 is a result of elevated p21- and p27-bound CDKs. Tretinoin 49-53 H3 histone pseudogene 16 Homo sapiens 93-96 24635079-8 2014 ATRA also induced G1 cell-cycle arrest, inhibited the expression of cyclin D1/cyclin-dependent kinase (CDK)4 and cyclinE/CDK2, and increased the expression of the cyclin-dependent kinase inhibitors p21 and p27. Tretinoin 0-4 H3 histone pseudogene 16 Homo sapiens 198-201 22766505-6 2012 The protein levels of cyclin-dependent kinase inhibitors, p21 and p27(Kip), which inhibit cell proliferation by blocking cell cycle progression at G1/S phase, increased after RA treatment. Tretinoin 175-177 H3 histone pseudogene 16 Homo sapiens 58-61 10460485-5 1999 Retinoic acid (RA) treatment will drive these cells to differentiation toward the neuronal lineage and cause an increase in expression of the cyclin-dependent kinase inhibitor p21 protein, which leads to an inhibition in cellular proliferation. Tretinoin 0-13 H3 histone pseudogene 16 Homo sapiens 176-179 10460485-5 1999 Retinoic acid (RA) treatment will drive these cells to differentiation toward the neuronal lineage and cause an increase in expression of the cyclin-dependent kinase inhibitor p21 protein, which leads to an inhibition in cellular proliferation. Tretinoin 15-17 H3 histone pseudogene 16 Homo sapiens 176-179 9260897-3 1997 RA did not induce p16 and p27 expression, but obviously reduced p21 level in MCF-7 cells. Tretinoin 0-2 H3 histone pseudogene 16 Homo sapiens 64-67 7576949-0 1995 Effect of retinoic acid on p21ras and regulators of its activity in neuroblastoma. Tretinoin 10-23 H3 histone pseudogene 16 Homo sapiens 27-30 7576949-3 1995 Therefore, the aim of the present study was to examine the role of p21ras and regulators of its activity in the differentiation of neuroblastoma cells induced by retinoic acid (RA). Tretinoin 162-175 H3 histone pseudogene 16 Homo sapiens 67-70 7576949-3 1995 Therefore, the aim of the present study was to examine the role of p21ras and regulators of its activity in the differentiation of neuroblastoma cells induced by retinoic acid (RA). Tretinoin 177-179 H3 histone pseudogene 16 Homo sapiens 67-70 33241756-6 2021 In addition, we found that HOTAIR promoted ATRA-induced differentiation via the regulation of the cell cycle regulator p21 via miR-17-5p. Tretinoin 43-47 H3 histone pseudogene 16 Homo sapiens 119-122 32124141-7 2020 CONCLUSION: The overall results of the study strongly suggest that all-trans retinoic acid enhances the effect of Fra-1 on inhibiting cervical cancer proliferation and metabolism in vitro, and also influences the expression of MDM2/P53/P21 and LDHA. Tretinoin 77-90 H3 histone pseudogene 16 Homo sapiens 236-239 21803488-0 2011 All-trans retinoic acid induces cellular senescence via upregulation of p16, p21, and p27. Tretinoin 10-23 H3 histone pseudogene 16 Homo sapiens 77-80 21803488-3 2011 ATRA also upregulated levels of p16, p21, and p27 which lead to activation of Rb and subsequent inactivation of E2F1. Tretinoin 0-4 H3 histone pseudogene 16 Homo sapiens 37-40 21843507-1 2011 All-trans retinoic acid (ATRA) induces cellular senescence via up-regulation of p16 and p21; however, the action mechanism of ATRA is unknown. Tretinoin 0-23 H3 histone pseudogene 16 Homo sapiens 88-91 21843507-1 2011 All-trans retinoic acid (ATRA) induces cellular senescence via up-regulation of p16 and p21; however, the action mechanism of ATRA is unknown. Tretinoin 25-29 H3 histone pseudogene 16 Homo sapiens 88-91 21843507-2 2011 Here, we show that ATRA induces promoter hypomethylation of p16 and p21 via down-regulation of DNA methyltransferases 1, 3a, and 3b to facilitate binding of Ets1/2 to the p16 promoter and p53 to the p21 promoter, resulting in up-regulation of their expression and subsequent induction of cellular senescence in HepG2 cells. Tretinoin 19-23 H3 histone pseudogene 16 Homo sapiens 68-71 21843507-2 2011 Here, we show that ATRA induces promoter hypomethylation of p16 and p21 via down-regulation of DNA methyltransferases 1, 3a, and 3b to facilitate binding of Ets1/2 to the p16 promoter and p53 to the p21 promoter, resulting in up-regulation of their expression and subsequent induction of cellular senescence in HepG2 cells. Tretinoin 19-23 H3 histone pseudogene 16 Homo sapiens 199-202 21325480-0 2011 Hepatitis B virus X protein overcomes all-trans retinoic acid-induced cellular senescence by downregulating levels of p16 and p21 via DNA methylation. Tretinoin 48-61 H3 histone pseudogene 16 Homo sapiens 126-129 21325480-4 2011 In addition, HBx suppressed ATRA-mediated induction of p16 and p21 in HepG2 cells via promoter hypermethylation, resulting in inactivation of retinoblastoma protein. Tretinoin 28-32 H3 histone pseudogene 16 Homo sapiens 63-66 21325480-5 2011 Furthermore, the ability of HBx to overcome ATRA-induced cellular senescence almost completely disappeared when the levels of p16 and p21 in the HBx-expressing cells became similar to those in the control cells by complementation in the former by exogenous expression, knockdown of their expression in the latter using specific small interfering RNA or treatment with a DNA methylation inhibitor, 5-Aza-2"-deoxycytidine. Tretinoin 44-48 H3 histone pseudogene 16 Homo sapiens 134-137 18539384-3 2008 In addition, LMP1 abolished the potentials of retinoic acid (RA) to down-regulate Cdk2 and Cdk4 and to up-regulate p16, p21, and p27, resulting in activation of E2F1 in the presence of RA. Tretinoin 46-59 H3 histone pseudogene 16 Homo sapiens 120-123 22087283-9 2011 The combination of bortezomib and ATRA triggered increased differentiation through the activation of proteins, including RARalpha, RARbeta, RARgamma, p-JNK and p21, compared with ATRA treatment alone. Tretinoin 34-38 H3 histone pseudogene 16 Homo sapiens 160-163 19828754-3 2010 In addition, HBx abolished the potential of retinoic acid (RA) to downregulate levels of G(1)-checkpoint regulators including p16, p21 and p27, resulting in activation of E2F1 in the presence of RA. Tretinoin 44-57 H3 histone pseudogene 16 Homo sapiens 131-134 19828754-3 2010 In addition, HBx abolished the potential of retinoic acid (RA) to downregulate levels of G(1)-checkpoint regulators including p16, p21 and p27, resulting in activation of E2F1 in the presence of RA. Tretinoin 59-61 H3 histone pseudogene 16 Homo sapiens 131-134 19428697-2 2009 This study demonstrates that retinoic acid (RA) improves SKPs exit from self-proliferation to neural differentiation through up-regulating of NeuroD and cell-cycle regulatory protein p21, meanwhile RA also induces p75 neurotrophin receptor (p75NTR) up-regulation and apoptosis of SKPs. Tretinoin 29-42 H3 histone pseudogene 16 Homo sapiens 183-186 19428697-2 2009 This study demonstrates that retinoic acid (RA) improves SKPs exit from self-proliferation to neural differentiation through up-regulating of NeuroD and cell-cycle regulatory protein p21, meanwhile RA also induces p75 neurotrophin receptor (p75NTR) up-regulation and apoptosis of SKPs. Tretinoin 44-46 H3 histone pseudogene 16 Homo sapiens 183-186 19723072-5 2009 Chromatin immunoprecipitation analysis has revealed phenyl butyrate and its combinations with RA and vitamin B3 cause histone H4 acetylation in the p21 promoter regions corresponding to p53 and/or Sp1 sites. Tretinoin 94-96 H3 histone pseudogene 16 Homo sapiens 148-151 19557639-0 2009 Function of retinoid acid receptor alpha and p21 in all-trans-retinoic acid-induced acute T-lymphoblastic leukemia apoptosis. Tretinoin 62-75 H3 histone pseudogene 16 Homo sapiens 45-48 19557639-7 2009 Consequently, it has been shown that, in RA-treated Molt3 cells, upregulation of p21 due to RA accompanies caspase 3/PARP activation which precedes the occurrence of apoptosis. Tretinoin 41-43 H3 histone pseudogene 16 Homo sapiens 81-84 19557639-7 2009 Consequently, it has been shown that, in RA-treated Molt3 cells, upregulation of p21 due to RA accompanies caspase 3/PARP activation which precedes the occurrence of apoptosis. Tretinoin 92-94 H3 histone pseudogene 16 Homo sapiens 81-84 18539384-3 2008 In addition, LMP1 abolished the potentials of retinoic acid (RA) to down-regulate Cdk2 and Cdk4 and to up-regulate p16, p21, and p27, resulting in activation of E2F1 in the presence of RA. Tretinoin 61-63 H3 histone pseudogene 16 Homo sapiens 120-123 17185354-11 2007 LCA and ATRA caused a synergistic increase in RA signalling as shown by increased p21 (p<0.01). Tretinoin 8-12 H3 histone pseudogene 16 Homo sapiens 82-85 17376583-4 2008 Treatment with ATRA alone also induced cell cycle arrest and moderate increase in p21 expression but joint treatment of ATRA and TSA/VPA did not further enhance cell cycle arrest as compared with TSA/VPA treatment alone. Tretinoin 15-19 H3 histone pseudogene 16 Homo sapiens 82-85 17185354-11 2007 LCA and ATRA caused a synergistic increase in RA signalling as shown by increased p21 (p<0.01). Tretinoin 10-12 H3 histone pseudogene 16 Homo sapiens 82-85 17449938-8 2007 Our results suggest that minoxidil plus ATRA would additively enhance hair growth by mediating dual functions: 1) the prolongation of cell survival by activating the Erk and Akt signaling pathways, and 2) the prevention of apoptosis of DPCs and epithelial cells by increasing the ratio of Bcl-2/Bax and downregulating the expressions of P53 and P21. Tretinoin 40-44 H3 histone pseudogene 16 Homo sapiens 345-348 17449938-7 2007 In addition, minoxidil plus ATRA elevated phosphorylated Erk, phosphorylated Akt and the ratio of Bcl-2/Bax, but decreased the expressions of P53 and P21 more effectively than by minoxidil alone. Tretinoin 28-32 H3 histone pseudogene 16 Homo sapiens 150-153 16740359-5 2007 We concluded that PML and all-trans-retinoic acid cause cell death by different pathways: PML activates ERK1/2, p38 MAPK, and p21; arrests the cell cycle; and later causes cell death; and all-trans-retinoic acid activates proteasome function, caspase cleavage, and apoptosis. Tretinoin 26-49 H3 histone pseudogene 16 Homo sapiens 126-129 16765349-1 2006 Cip/Kip family protein p21, a cyclin-dependent kinase (CDK) inhibitor, is directly transactivated by retinoic acid receptor alpha (RARalpha) upon retinoic acid (RA):RARalpha binding. Tretinoin 101-114 H3 histone pseudogene 16 Homo sapiens 23-26 16752155-3 2007 RA treatment resulted in an increase of p21, p27 and p53 protein levels and G1 arrest in UM cells, which correlated with significant down-modulation of surface Her2/neu proto-oncogene expression. Tretinoin 0-2 H3 histone pseudogene 16 Homo sapiens 40-43 16765349-1 2006 Cip/Kip family protein p21, a cyclin-dependent kinase (CDK) inhibitor, is directly transactivated by retinoic acid receptor alpha (RARalpha) upon retinoic acid (RA):RARalpha binding. Tretinoin 131-133 H3 histone pseudogene 16 Homo sapiens 23-26 16765349-2 2006 Yet the role of p21 upregulation by RA in lymphoma cells remains unknown. Tretinoin 36-38 H3 histone pseudogene 16 Homo sapiens 16-19 16765349-4 2006 Upregulated p21 by RA accompanies caspase-3 activation and precedes the occurrence of apoptosis. Tretinoin 19-21 H3 histone pseudogene 16 Homo sapiens 12-15 16765349-7 2006 Data presented here suggest a novel RA-signaling, by which RA-induced p21 induction and complex formation with cyclin E/CDK2 diverts CDK2 function from normally driving proliferation to alternatively promoting apoptosis. Tretinoin 36-38 H3 histone pseudogene 16 Homo sapiens 70-73