PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7639703-0 1995 Identification and characterization of a functional retinoic acid/thyroid hormone-response element upstream of the human insulin gene enhancer. Tretinoin 52-65 insulin Homo sapiens 121-128 11277867-8 2001 The transduced hepatocytes were shown to secrete immunoreactive proinsulin/insulin, which were stimulated by the concentrations of retinoic acid, dexamethasone and dbcAMP in the culture medium. Tretinoin 131-144 insulin Homo sapiens 64-74 11277867-8 2001 The transduced hepatocytes were shown to secrete immunoreactive proinsulin/insulin, which were stimulated by the concentrations of retinoic acid, dexamethasone and dbcAMP in the culture medium. Tretinoin 131-144 insulin Homo sapiens 67-74 9458362-0 1998 Retinoic acid suppresses insulin-induced cell growth and cyclin D1 gene expression in human breast cancer cells. Tretinoin 0-13 insulin Homo sapiens 25-32 9458362-1 1998 We examined the effects of all-trans retinoic acid (RA) on the insulin-induced cell growth, cell cycle progression and cyclin D1 gene expression in breast cancer cells. Tretinoin 37-50 insulin Homo sapiens 63-70 9458362-1 1998 We examined the effects of all-trans retinoic acid (RA) on the insulin-induced cell growth, cell cycle progression and cyclin D1 gene expression in breast cancer cells. Tretinoin 52-54 insulin Homo sapiens 63-70 9458362-2 1998 RA exerted a dose-dependent growth inhibition on insulin-induced proliferation in T47D and MCF-7 hormone-dependent cell lines, whereas MDA-MB231 hormone-independent cells were not affected. Tretinoin 0-2 insulin Homo sapiens 49-56 9458362-3 1998 The RA antagonism of insulin growth effect was associated with an inhibition of cell cycle progression and a suppression of insulin-induced cyclin D1 mRNA. Tretinoin 4-6 insulin Homo sapiens 21-28 9458362-4 1998 The effect of RA on cyclin D1 mRNA was dose-dependent and was observed within 5 h of treatment when insulin response was maximal. Tretinoin 14-16 insulin Homo sapiens 100-107 10427161-3 1999 Insulin, tri-iodothyronine (T(3)) and norepinephrine, the main regulators of brown adipose tissue function, upregulated GAPDH mRNA levels, whereas retinoic acid inhibited them. Tretinoin 147-160 insulin Homo sapiens 0-7 7559803-0 1995 Insulin-like growth factors modulate the growth inhibitory effects of retinoic acid on MCF-7 breast cancer cells. Tretinoin 70-83 insulin Homo sapiens 0-7 7559803-11 1995 These results indicate that RA action on MCF-7 cells is biphasic in the presence of IGF-I or insulin with 10(-9) - 10(-7) M RA enhancing cell proliferation and > or = 10(-6) M RA causing growth inhibition. Tretinoin 28-30 insulin Homo sapiens 93-100 7559803-11 1995 These results indicate that RA action on MCF-7 cells is biphasic in the presence of IGF-I or insulin with 10(-9) - 10(-7) M RA enhancing cell proliferation and > or = 10(-6) M RA causing growth inhibition. Tretinoin 124-126 insulin Homo sapiens 93-100 7559803-11 1995 These results indicate that RA action on MCF-7 cells is biphasic in the presence of IGF-I or insulin with 10(-9) - 10(-7) M RA enhancing cell proliferation and > or = 10(-6) M RA causing growth inhibition. Tretinoin 124-126 insulin Homo sapiens 93-100 7639703-11 1995 In human islets of Langerhans, retinoic acid was shown to stimulate insulin mRNA levels. Tretinoin 31-44 insulin Homo sapiens 68-75 7758830-3 1995 At the myoblast stage, treatment with 1 microM retinoic acid for 24 h increased both 1 h and 8 h insulin stimulated uptake of 2-deoxyglucose by more than twofold. Tretinoin 47-60 insulin Homo sapiens 97-104 7758830-4 1995 A dose and time dependent effect of retinoic acid on 8 h insulin stimulated 2-deoxyglucose uptake was observed at both the myoblast and myocyte stage. Tretinoin 36-49 insulin Homo sapiens 57-64 7758830-6 1995 In myoblast cells, retinoic acid increased the content of GLUT4 mRNA in a dose and time dependent manner, an effect that was partially attenuated by insulin. Tretinoin 19-32 insulin Homo sapiens 149-156 34945773-1 2021 BACKGROUND: Recent reports indicate the potential role of the stimulated by retinoic acid 6 (STRA6) protein in developing insulin resistance. Tretinoin 76-89 insulin Homo sapiens 122-129 8393790-4 1993 In this work, we study the modulation by adrenergic stimuli, cAMP effectors and retinoic acid on the induction produced by insulin and 3,5,3"-triiodothyronine on malic-enzyme-gene expression. Tretinoin 80-93 insulin Homo sapiens 123-130 34419449-17 2021 We conclude that Rdh10/RA affects whole body energy use and insulin resistance partially through sexual dimorphic effects on skeletal muscle gene expression, structure, and mitochondria activity. Tretinoin 23-25 insulin Homo sapiens 60-67 3030555-5 1987 Data presented here are consistent with literature reports that RA modifies cell surface glycoproteins, including those that act as cell surface receptors for epidermal growth factor and insulin. Tretinoin 64-66 insulin Homo sapiens 187-194 2640155-1 1989 The initial cell association and metabolic conversion of retinoic acid (RA) by HL-60 cells in serum-free, transferrin/insulin-supplemented, RPMI 1640 medium was greater than or equal to 10-fold greater than in RPMI 1640 medium containing 10% fetal bovine serum (FBS). Tretinoin 57-70 insulin Homo sapiens 118-125 2640155-1 1989 The initial cell association and metabolic conversion of retinoic acid (RA) by HL-60 cells in serum-free, transferrin/insulin-supplemented, RPMI 1640 medium was greater than or equal to 10-fold greater than in RPMI 1640 medium containing 10% fetal bovine serum (FBS). Tretinoin 72-74 insulin Homo sapiens 118-125 35458115-0 2022 Retinoic Acid: Sexually Dimorphic, Anti-Insulin and Concentration-Dependent Effects on Energy. Tretinoin 0-13 insulin Homo sapiens 40-47 2984029-4 1985 Their actions on insulin receptors were the opposite, however; 1 alpha,25-dihydroxyvitamin D3 increased the binding of the hormone, while RA plus db-cAMP decreased the binding. Tretinoin 138-140 insulin Homo sapiens 17-24 33616807-5 2021 We aimed at studying the influence of STZ treatment on insulin signaling in SH-SY5Y cells differentiated by retinoic acid (RA). Tretinoin 108-121 insulin Homo sapiens 55-62 7004463-2 1980 Dimethyl sulfoxide (DMSO) and retinoic acid myeloid induced differentiation in HHL 60 cells was accompanied by a marked decrease of insulin receptors. Tretinoin 30-43 insulin Homo sapiens 132-139 33616807-5 2021 We aimed at studying the influence of STZ treatment on insulin signaling in SH-SY5Y cells differentiated by retinoic acid (RA). Tretinoin 123-125 insulin Homo sapiens 55-62 33165749-0 2021 Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). Tretinoin 112-135 insulin Homo sapiens 77-84 33165749-0 2021 Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). Tretinoin 137-141 insulin Homo sapiens 77-84 33165749-1 2021 All-trans retinoic acid (ATRA) promotes the development and the function of insulin producing cells and induces partial differentiation of pancreatic tumor cells. Tretinoin 0-23 insulin Homo sapiens 76-83 33165749-1 2021 All-trans retinoic acid (ATRA) promotes the development and the function of insulin producing cells and induces partial differentiation of pancreatic tumor cells. Tretinoin 25-29 insulin Homo sapiens 76-83 33165749-6 2021 Using pancreatic ductal adenocarcinoma (PDAC)-derived cells, we also revealed that the ATRA induced up-modulation of Vav1 is essential for the retinoid-induced trans-differentiation of neoplastic cells into insulin producing cells. Tretinoin 87-91 insulin Homo sapiens 207-214 33165749-7 2021 The results of this study identify Vav1 as crucial molecule in ATRA induced maturation of insulin producing cells and suggest this protein as a marker for new strategies ended to restore functional beta-cells. Tretinoin 63-67 insulin Homo sapiens 90-97 28920418-9 2018 CONCLUSION: Retinoic acid was found to produce smaller preadipocytes which have been assumed to have insulin sensitization and hence retinoic acid could be used as a potential agent to sensitize tissues to insulin in combination with TZD"s to treat diabetic conditions in humans and animals in future. Tretinoin 12-25 insulin Homo sapiens 101-108 32467243-5 2020 In addition, the inhibition of the RA pathway in hESC-derived pancreatic progenitors downstream of NEUROG3 induction impairs insulin expression. Tretinoin 35-37 insulin Homo sapiens 125-132 28920418-9 2018 CONCLUSION: Retinoic acid was found to produce smaller preadipocytes which have been assumed to have insulin sensitization and hence retinoic acid could be used as a potential agent to sensitize tissues to insulin in combination with TZD"s to treat diabetic conditions in humans and animals in future. Tretinoin 12-25 insulin Homo sapiens 206-213 28920418-9 2018 CONCLUSION: Retinoic acid was found to produce smaller preadipocytes which have been assumed to have insulin sensitization and hence retinoic acid could be used as a potential agent to sensitize tissues to insulin in combination with TZD"s to treat diabetic conditions in humans and animals in future. Tretinoin 133-146 insulin Homo sapiens 206-213 25627686-0 2015 Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1. Tretinoin 65-78 insulin Homo sapiens 0-7 28651670-0 2017 Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance. Tretinoin 25-38 insulin Homo sapiens 79-86 26863424-4 2016 RESULTS: At baseline, higher RA levels were inversely associated with the presence of MetS (odds ratio 0.61; 95% confidence interval [CI] 0.44-0.74, P < .001) after adjustment for age, gender, body mass index, the homeostasis model assessment index for insulin resistance (HOMA-IR), and other confounding factors. Tretinoin 29-31 insulin Homo sapiens 256-263 25627686-9 2015 Thus, energy status via insulin and FoxO1 regulate Rdh expression and atRA biosynthesis. Tretinoin 70-74 insulin Homo sapiens 24-31 25627686-10 2015 These results reveal mechanisms for regulating atRA biosynthesis and the opposing effects of atRA and insulin on gluconeogenesis, and also suggest an interaction between atRA and insulin signaling related diseases, such as type II diabetes and cancer. Tretinoin 47-51 insulin Homo sapiens 179-186 25627686-10 2015 These results reveal mechanisms for regulating atRA biosynthesis and the opposing effects of atRA and insulin on gluconeogenesis, and also suggest an interaction between atRA and insulin signaling related diseases, such as type II diabetes and cancer. Tretinoin 93-97 insulin Homo sapiens 179-186 25627686-10 2015 These results reveal mechanisms for regulating atRA biosynthesis and the opposing effects of atRA and insulin on gluconeogenesis, and also suggest an interaction between atRA and insulin signaling related diseases, such as type II diabetes and cancer. Tretinoin 93-97 insulin Homo sapiens 179-186 27335827-11 2013 I discuss the roles of RA production in the development of insulin resistance in hepatocytes and proposes a mechanism by which RA production may contribute to hepatic insulin resistance. Tretinoin 23-25 insulin Homo sapiens 59-66 24456325-2 2014 In the present study, we have investigated the neuroprotective effects of insulin on H2O2-induced toxicity of retinoic acid (RA)-differentiated SH-SY5Y cells. Tretinoin 110-123 insulin Homo sapiens 74-81 21669299-2 2012 Treatment with retinoic acid, in particular, has been shown to reduce body fat and improve insulin sensitivity in lean and obese rodents by enhancing fat mobilization and energy utilization systemically, in tissues including brown and white adipose tissues, skeletal muscle and the liver. Tretinoin 15-28 insulin Homo sapiens 91-98 20197308-0 2010 Proinsulin C-peptide antagonizes the profibrotic effects of TGF-beta1 via up-regulation of retinoic acid and HGF-related signaling pathways. Tretinoin 91-104 insulin Homo sapiens 0-10 20197308-0 2010 Proinsulin C-peptide antagonizes the profibrotic effects of TGF-beta1 via up-regulation of retinoic acid and HGF-related signaling pathways. Tretinoin 91-104 insulin Homo sapiens 11-20 17726077-2 2007 Moreover, protein C inhibitor (PCI), which specifically binds retinoic acid, was found to be increased in myocardial infarction survivors who are also insulin resistant. Tretinoin 62-75 insulin Homo sapiens 151-158 12930299-5 2003 Interestingly, insulin-like growth factor-II (IGF-II, 50 ng/ml) was able to significantly (67.3%; P < 0.05) reduce RA effects, whereas IGF-I (50 ng/ml) and insulin (75 ng/ml) were without effect. Tretinoin 118-120 insulin Homo sapiens 15-22