PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27546728-2	2016	Retinoic acid (RA) signalling initiates germ cell meiosis by activating Stra8 (stimulated by RA gene 8).	Tretinoin	0-13	stimulated by retinoic acid 8	Gallus gallus	72-77	
22733143-2	2013	Previous studies showed that retinoic acid (RA) as the vitamin A metabolite is crucial for controlling Stra8 (Stimulated by retinoic acid gene 8) expression in the gonad and to initiate meiosis; however, the mechanism by which retinoid-signaling acts has remained unclear.	Tretinoin	29-42	stimulated by retinoic acid 8	Gallus gallus	103-108	
22733143-2	2013	Previous studies showed that retinoic acid (RA) as the vitamin A metabolite is crucial for controlling Stra8 (Stimulated by retinoic acid gene 8) expression in the gonad and to initiate meiosis; however, the mechanism by which retinoid-signaling acts has remained unclear.	Tretinoin	29-42	stimulated by retinoic acid 8	Gallus gallus	110-144	
22733143-2	2013	Previous studies showed that retinoic acid (RA) as the vitamin A metabolite is crucial for controlling Stra8 (Stimulated by retinoic acid gene 8) expression in the gonad and to initiate meiosis; however, the mechanism by which retinoid-signaling acts has remained unclear.	Tretinoin	44-46	stimulated by retinoic acid 8	Gallus gallus	103-108	
22733143-2	2013	Previous studies showed that retinoic acid (RA) as the vitamin A metabolite is crucial for controlling Stra8 (Stimulated by retinoic acid gene 8) expression in the gonad and to initiate meiosis; however, the mechanism by which retinoid-signaling acts has remained unclear.	Tretinoin	44-46	stimulated by retinoic acid 8	Gallus gallus	110-144	
18799012-10	2008	In particular, the retinoic acid-synthesising enzyme, RALDH2, is expressed in the left ovarian cortex at the time of STRA8 up-regulation, prior to meiosis.	Tretinoin	19-32	stimulated by retinoic acid 8	Gallus gallus	117-122	
31596288-7	2019	Luciferase report showed RA binding to RARalpha regulated stimulated by RA 8 (Stra8) promoter activity during SSC formation, while mutations in RAR binding sites inhibited the Stra8 expression and SSC formation.	Tretinoin	25-27	stimulated by retinoic acid 8	Gallus gallus	58-76	
31596288-7	2019	Luciferase report showed RA binding to RARalpha regulated stimulated by RA 8 (Stra8) promoter activity during SSC formation, while mutations in RAR binding sites inhibited the Stra8 expression and SSC formation.	Tretinoin	25-27	stimulated by retinoic acid 8	Gallus gallus	78-83	
27546728-2	2016	Retinoic acid (RA) signalling initiates germ cell meiosis by activating Stra8 (stimulated by RA gene 8).	Tretinoin	0-13	stimulated by retinoic acid 8	Gallus gallus	79-102	
27026484-7	2016	Expression analysis of specific genes after 7days of RA treatment, as examined by RT-PCR, proved positive for some germ cell markers such as CVH, STRA8, PLZF and some genes involved in spermatogonial stem cell maintenance like BCL6b and c-KIT.	Tretinoin	53-55	stimulated by retinoic acid 8	Gallus gallus	146-151	
26811260-6	2016	Retinoic acid significantly upregulated Piwil1 and Stra8 mRNA expression as well as Piwil1 levels in chicken PGCs.	Tretinoin	0-13	stimulated by retinoic acid 8	Gallus gallus	51-56