PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21173077-2 2011 We have shown that retinoic acid (RA), which is known to play a necessary role in early events in pregnancy, can combine with transcriptional activators of VEGF (e.g. TPA, TGF-beta, IL-1beta) to rapidly induce VEGF secretion from human endometrial stromal cells through a translational mechanism of action. Tretinoin 19-32 interleukin 1 beta Homo sapiens 182-190 21237205-4 2011 Furthermore, when stimulated with flagellin, ATRA-induced THP-1 cells expressed multiple cytokines, including TNF-alpha, IL-1beta, and IL-12p40, and several co-stimulatory molecules, such as CD40, CD80, CD86, and MHC class I and II. Tretinoin 45-49 interleukin 1 beta Homo sapiens 121-129 21173077-2 2011 We have shown that retinoic acid (RA), which is known to play a necessary role in early events in pregnancy, can combine with transcriptional activators of VEGF (e.g. TPA, TGF-beta, IL-1beta) to rapidly induce VEGF secretion from human endometrial stromal cells through a translational mechanism of action. Tretinoin 34-36 interleukin 1 beta Homo sapiens 182-190 16920192-0 2007 Retinoic acid-induced CD38 antigen promotes leukemia cells attachment and interferon-gamma/interleukin-1beta-dependent apoptosis of endothelial cells: implications in the etiology of retinoic acid syndrome. Tretinoin 0-13 interleukin 1 beta Homo sapiens 91-108 18291094-0 2008 Interleukin-1beta mediates LPS-induced inhibition of apoptosis in retinoic acid-differentiated HL-60 cells. Tretinoin 66-79 interleukin 1 beta Homo sapiens 0-17 16920192-4 2007 In the present study, we found that RA treatment induces the expression of interferon-gamma (IFN-gamma) and interleukin-1beta (IL-1beta) in peripheral blast cells from APL patients. Tretinoin 36-38 interleukin 1 beta Homo sapiens 108-125 16920192-4 2007 In the present study, we found that RA treatment induces the expression of interferon-gamma (IFN-gamma) and interleukin-1beta (IL-1beta) in peripheral blast cells from APL patients. Tretinoin 36-38 interleukin 1 beta Homo sapiens 127-135 16804330-3 2006 In all-trans-retinoic acid (atRA)-treated human aortic smooth muscle cells (AOSMC), significant increases in IL-1beta levels were observed, compared with untreated cells. Tretinoin 3-26 interleukin 1 beta Homo sapiens 109-117 16804330-3 2006 In all-trans-retinoic acid (atRA)-treated human aortic smooth muscle cells (AOSMC), significant increases in IL-1beta levels were observed, compared with untreated cells. Tretinoin 28-32 interleukin 1 beta Homo sapiens 109-117 16804330-5 2006 The results show that atRA-treated AOSMC express both the precursor (33 kDa) and the active form (17 kDa) of the IL-1beta protein. Tretinoin 22-26 interleukin 1 beta Homo sapiens 113-121 16804330-6 2006 atRA-treated carotid lesions showed significantly elevated IL-1beta mRNA levels (2.9 +/- 2.33) compared with untreated lesions (2.0 +/- 1.77; p < 0.05). Tretinoin 0-4 interleukin 1 beta Homo sapiens 59-67 21190613-0 2005 [Experimental study of effects of retinoic acid on IL-1beta and IFN-gamma induced C3 and factor B secretion in lung cancer cell line]. Tretinoin 34-47 interleukin 1 beta Homo sapiens 51-59 21190613-2 2005 The aim of this study is to investigate the regulated effects of retinoic acid (RA) on IL-1beta and IFN-gamma induced C3 and factor B secretion in human lung cancer cell line A549. Tretinoin 65-78 interleukin 1 beta Homo sapiens 87-95 21190613-2 2005 The aim of this study is to investigate the regulated effects of retinoic acid (RA) on IL-1beta and IFN-gamma induced C3 and factor B secretion in human lung cancer cell line A549. Tretinoin 80-82 interleukin 1 beta Homo sapiens 87-95 21190613-6 2005 CONCLUSIONS: RA can up-regulate C3 and factor B secretion induced by IL-1beta and IFN-gamma in human lung cancer cell A549. Tretinoin 13-15 interleukin 1 beta Homo sapiens 69-77 15304040-5 2004 ATRA treatment was associated with a significant decrease in TF gene expression in bone marrow cells during the first 30 days of treatment, whereas IL-1 beta gene expression, which decreased in the cells of six patients treated with either chemotherapy or ATRA, actually increased in the remaining six patients treated with either chemotherapy or ATRA. Tretinoin 256-260 interleukin 1 beta Homo sapiens 148-157 15830921-1 2005 UNLABELLED: All-trans-retinoic acid (tRA) modulates in human mesangial cells (MC) antioxidant defenses, the expression of interleukin-1beta-induced vascular cell-adhesion molecule-1 (VCAM-1), cyclooxygenase-2 (COX-2), and the retinoic acid-receptor-beta (RAR-beta). Tretinoin 12-35 interleukin 1 beta Homo sapiens 122-139 15830921-1 2005 UNLABELLED: All-trans-retinoic acid (tRA) modulates in human mesangial cells (MC) antioxidant defenses, the expression of interleukin-1beta-induced vascular cell-adhesion molecule-1 (VCAM-1), cyclooxygenase-2 (COX-2), and the retinoic acid-receptor-beta (RAR-beta). Tretinoin 37-40 interleukin 1 beta Homo sapiens 122-139 15304040-5 2004 ATRA treatment was associated with a significant decrease in TF gene expression in bone marrow cells during the first 30 days of treatment, whereas IL-1 beta gene expression, which decreased in the cells of six patients treated with either chemotherapy or ATRA, actually increased in the remaining six patients treated with either chemotherapy or ATRA. Tretinoin 256-260 interleukin 1 beta Homo sapiens 148-157 14646600-4 2003 Effect of the ATRA treatment was demonstrated by the concomitant induction of cd14 and il1beta genes in four patients. Tretinoin 14-18 interleukin 1 beta Homo sapiens 87-94 8639429-3 1996 To explore this we used a functional assay to study the effect of ATRA treatment on the adhesion of blast cells to cultured human endothelial cells (EC), endothelial cell matrix (ECM), and interleukin 1beta-activated EC (IL1 + EC). Tretinoin 66-70 interleukin 1 beta Homo sapiens 189-206 10414449-5 1999 Our results have shown that ATRA induces an increased expression of IL-8, IL-1beta, TNF-alpha and ICAM-1 in APL cells, which can be amplified by the addition of G-CSF. Tretinoin 28-32 interleukin 1 beta Homo sapiens 74-82 8753812-4 1996 The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production. Tretinoin 44-46 interleukin 1 beta Homo sapiens 123-141 8753812-4 1996 The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production. Tretinoin 44-46 interleukin 1 beta Homo sapiens 143-152 8753812-4 1996 The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production. Tretinoin 44-46 interleukin 1 beta Homo sapiens 178-187 8753812-5 1996 It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway. Tretinoin 162-164 interleukin 1 beta Homo sapiens 37-41 8753812-6 1996 Finally, we demonstrated that RA can also enhance IL-1-induced G-CSF production in primary monocytes of human peripheral blood. Tretinoin 30-32 interleukin 1 beta Homo sapiens 50-54 8702454-5 1996 Serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), and IL-1 beta normalized within 7 days after the first administration of tretinoin, transiently increased at the time of radiotherapy, increased again after withdrawal of the tretinoin, and decreased again after its reintroduction. Tretinoin 152-161 interleukin 1 beta Homo sapiens 83-92 8702454-7 1996 This study documents in vivo the ability of all-trans-retinoic acid to down-regulate the release of IL-6, IL-1 beta, and TNF alpha, and illustrates its potential as a therapeutic agent in conditions associated with chronic overproduction of proinflammatory cytokines. Tretinoin 44-67 interleukin 1 beta Homo sapiens 106-115 8702428-0 1996 Retinoic acid regulates differentially the expression of IL-1 beta and IL-1 receptor antagonist (IL-1ra) in PMA-activated human monocytes. Tretinoin 0-13 interleukin 1 beta Homo sapiens 57-66 8702428-3 1996 In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes. Tretinoin 41-43 interleukin 1 beta Homo sapiens 61-70 8702428-4 1996 RA enhanced gene expression and production of IL-1 beta in PMA-activated monocytes. Tretinoin 0-2 interleukin 1 beta Homo sapiens 46-55 12385002-0 2002 Retinoic acid induces expression of the interleukin-1beta gene in cultured normal human mammary epithelial cells and in human breast carcinoma lines. Tretinoin 0-13 interleukin 1 beta Homo sapiens 40-57 11376874-8 2001 Retinoic acid elicited synergistic effects on the CNP secretion rate from HL-60 cells when administered with lipopolysaccharide, interferon-gamma, interleukin-1beta, tumor necrosis factor-alpha, or phorbol ester. Tretinoin 0-13 interleukin 1 beta Homo sapiens 147-193 9783809-0 1998 Retinoic acid differentially regulates interleukin-1beta and interleukin-1 receptor antagonist production by human alveolar macrophages. Tretinoin 0-13 interleukin 1 beta Homo sapiens 39-56 9783809-4 1998 In the present study, we examined the effect of RA on IL-1beta and IL-1ra production by human alveolar macrophages in order to clarify the mechanism in pulmonary infiltration of neutrophils, since IL-1 has been shown to initiate neutrophil recruitment into the lung through up-regulated expression of adhesion molecules on vascular endothelium. Tretinoin 48-50 interleukin 1 beta Homo sapiens 54-62 9783809-4 1998 In the present study, we examined the effect of RA on IL-1beta and IL-1ra production by human alveolar macrophages in order to clarify the mechanism in pulmonary infiltration of neutrophils, since IL-1 has been shown to initiate neutrophil recruitment into the lung through up-regulated expression of adhesion molecules on vascular endothelium. Tretinoin 48-50 interleukin 1 beta Homo sapiens 54-58 9783809-5 1998 RA enhanced IL-1beta and inhibited IL-1ra production by 4beta phorbol 12beta-myristate-13alpha acetate (PMA)- and lipopolysaccharide (LPS)-stimulated human alveolar macrophages. Tretinoin 0-2 interleukin 1 beta Homo sapiens 12-20 8639429-3 1996 To explore this we used a functional assay to study the effect of ATRA treatment on the adhesion of blast cells to cultured human endothelial cells (EC), endothelial cell matrix (ECM), and interleukin 1beta-activated EC (IL1 + EC). Tretinoin 66-70 interleukin 1 beta Homo sapiens 221-224 8869967-0 1996 The antiproliferative effect of trans-retinoic acid is associated with selective induction of interleukin-1 beta, a cytokine that directly inhibits growth of lung cancer cells. Tretinoin 32-51 interleukin 1 beta Homo sapiens 94-112 8555483-10 1996 These data indicate that ATRA increases the promyelocyte-induced EC TF, partly through increased IL-1 beta production. Tretinoin 25-29 interleukin 1 beta Homo sapiens 97-106 8869967-7 1996 Growth inhibition similar to that following RA treatment could be reproduced by exposing cells to exogeneous IL-1 beta alone. Tretinoin 44-46 interleukin 1 beta Homo sapiens 109-118 1646841-0 1991 Retinoic acid enhances IL-1 beta expression in myeloid leukemia cells and in human monocytes. Tretinoin 0-13 interleukin 1 beta Homo sapiens 23-32 21552804-2 1995 We report that all-trans retinoic acid (tRA) synergizes with LPS to enhance the production of granulocyte colony-stimulating factor (G-CSF) in PMA-treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA. Tretinoin 25-38 interleukin 1 beta Homo sapiens 216-234 21552804-2 1995 We report that all-trans retinoic acid (tRA) synergizes with LPS to enhance the production of granulocyte colony-stimulating factor (G-CSF) in PMA-treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA. Tretinoin 25-38 interleukin 1 beta Homo sapiens 236-245 21552804-2 1995 We report that all-trans retinoic acid (tRA) synergizes with LPS to enhance the production of granulocyte colony-stimulating factor (G-CSF) in PMA-treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA. Tretinoin 40-43 interleukin 1 beta Homo sapiens 216-234 21552804-2 1995 We report that all-trans retinoic acid (tRA) synergizes with LPS to enhance the production of granulocyte colony-stimulating factor (G-CSF) in PMA-treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA. Tretinoin 40-43 interleukin 1 beta Homo sapiens 236-245 7523800-0 1994 Modulation of IL-8, IL-1 beta, and G-CSF secretion by all-trans retinoic acid in acute promyelocytic leukemia. Tretinoin 64-77 interleukin 1 beta Homo sapiens 20-29 7523800-9 1994 Interestingly, the increase of IL-1 beta and G-CSF production in the presence of ATRA was highly correlated to an increase in APL cell count in vitro and in vivo hyperleukocytosis, resulting in fatal outcome. Tretinoin 81-85 interleukin 1 beta Homo sapiens 31-40 8360592-4 1993 RA differentially modulated the expression of interleukin-1 beta (IL-1 beta), IL-6, and IL-8 mRNAs depending on the inducing stimulus. Tretinoin 0-2 interleukin 1 beta Homo sapiens 46-64 8360592-4 1993 RA differentially modulated the expression of interleukin-1 beta (IL-1 beta), IL-6, and IL-8 mRNAs depending on the inducing stimulus. Tretinoin 0-2 interleukin 1 beta Homo sapiens 66-75 8360592-7 1993 IL-1-induced de novo synthesis of IL-6 protein and secretion of biologically active IL-6 were also inhibited by RA. Tretinoin 112-114 interleukin 1 beta Homo sapiens 0-4 8360592-8 1993 The inhibition pattern of RA was different from that of dexamethasone, which inhibited both IL-1 and LPS effects. Tretinoin 26-28 interleukin 1 beta Homo sapiens 92-96 8344702-0 1993 Effect of retinoic acid and vitamin D on the expression of interleukin-1 beta, tumour necrosis factor-alpha and interleukin-6 in the human monocytic cell line U937. Tretinoin 10-23 interleukin 1 beta Homo sapiens 59-77 8489769-3 1993 Radioimmunoassay showed that after stimulation by RA, the IL-1 beta intracellular level is predominantly increased, with no significant modification of IL-1 alpha expression. Tretinoin 50-52 interleukin 1 beta Homo sapiens 58-67 8489769-4 1993 The addition of hydrocortisone in the culture medium resulted in a decrease in RA-induced IL-1 beta overexpression, without notable modifications in untreated cultures. Tretinoin 79-81 interleukin 1 beta Homo sapiens 90-99 8489769-6 1993 The overexpression of IL-1 beta in control and RA-treated cultures mainly concerned the 52- and 31- to 36-kD biologically inactive precursor forms. Tretinoin 47-49 interleukin 1 beta Homo sapiens 22-31 8489769-8 1993 These findings indicate that in cultured keratinocytes intracellular IL-1 beta is preferentially increased by RA but in its immature forms. Tretinoin 110-112 interleukin 1 beta Homo sapiens 69-78 1717193-4 1991 The mechanism by which ATRA enhances IL-1-induced HSN proliferation does not appear mediated by changes in the affinity or number of IL-1 receptors expressed by HSN; however, treatment with dexamethasone (DEX, 10(-6)M) resulted in a twofold increase in IL-1 receptor number. Tretinoin 23-27 interleukin 1 beta Homo sapiens 37-41 1717193-5 1991 ATRA inhibited both IL-1 beta- and TNF alpha-induced secretion of prostaglandin-E2 (PGE2), a potent feedback inhibitor of cytokine-stimulated HSN proliferation. Tretinoin 0-4 interleukin 1 beta Homo sapiens 20-29 1717193-6 1991 However, the synergistic effect of ATRA on IL-1- or FGF-induced proliferation did not appear related to the secretion of cyclooxygenase products since ATRA had no effect on TNF alpha-induced HSN proliferation and indomethacin was included in all HSN proliferation experiments. Tretinoin 35-39 interleukin 1 beta Homo sapiens 43-47 8589272-2 1995 Upon granulocytic differentiation with all-trans retinoic acid (ATRA) or the combination of ATRA and granulocyte-colony-stimulating factor (G-CSF), significant amounts of IL-1 beta and IL-8 mRNAs accumulated in both cell types. Tretinoin 49-62 interleukin 1 beta Homo sapiens 171-180 8589272-2 1995 Upon granulocytic differentiation with all-trans retinoic acid (ATRA) or the combination of ATRA and granulocyte-colony-stimulating factor (G-CSF), significant amounts of IL-1 beta and IL-8 mRNAs accumulated in both cell types. Tretinoin 64-68 interleukin 1 beta Homo sapiens 171-180 8083217-1 1994 Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA. Tretinoin 0-13 interleukin 1 beta Homo sapiens 160-169 8083217-1 1994 Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA. Tretinoin 15-17 interleukin 1 beta Homo sapiens 160-169 7819135-0 1994 Activation of interleukin-1 beta gene expression during retinoic acid-induced granulocytic differentiation of promyeloid leukemia cells. Tretinoin 56-69 interleukin 1 beta Homo sapiens 14-32 7521152-6 1994 Although GM-CSF, IL-3 and IL-1 significantly modulated the ATRA-induced morphological changes, they did not induce CD14 expression, a typical marker of monocytic differentiation. Tretinoin 59-63 interleukin 1 beta Homo sapiens 26-30 1365641-12 1992 In contrast, retinoic acid strongly increased phorbol myristate acetate-induced MCP-1 expression and potentiated the effects of IL-1 and LPS. Tretinoin 13-26 interleukin 1 beta Homo sapiens 128-140 1646841-1 1991 We have examined the role of retinoic acid (RA), the biologically active metabolite of vitamin A, in expression of the IL-1 beta gene in the human myeloid leukemia cell line THP-1 and in human monocytes. Tretinoin 29-42 interleukin 1 beta Homo sapiens 119-128 1646841-1 1991 We have examined the role of retinoic acid (RA), the biologically active metabolite of vitamin A, in expression of the IL-1 beta gene in the human myeloid leukemia cell line THP-1 and in human monocytes. Tretinoin 44-46 interleukin 1 beta Homo sapiens 119-128 1646841-3 1991 Physiologic RA concentrations alone were not able to induce any IL-1 beta production, but they strongly enhanced the PMA-induced IL-1 beta protein production and mRNA accumulation in both human monocytes and in THP-1 cells. Tretinoin 12-14 interleukin 1 beta Homo sapiens 129-138 1646841-5 1991 RA also slightly potentiated LPS-induced IL-1 beta expression in THP-1 cells but not in human monocytes. Tretinoin 0-2 interleukin 1 beta Homo sapiens 41-50 2206968-4 1990 Immunoblot patterns of epidermal extracts revealed both the mature form of IL-1 (17 kDa) and the precursor (36 kDa) and were identical in amounts whether the specimens were from controls or from RA- or corticosteroid-treated skin. Tretinoin 195-197 interleukin 1 beta Homo sapiens 75-79 35436742-12 2022 Levels of interleukin-1beta (IL-1beta) were increased at varied time points after ATRA treatment. Tretinoin 82-86 interleukin 1 beta Homo sapiens 10-27 1693606-6 1990 Pharmacological modulators of LPS-induced IL-1 production were identified: glucocorticoids were inhibitors whereas retinoic acid and 1.25-dihydroxy-vitamin D3 had no effects and prostaglandin E2 and IBMX were weak inhibitors. Tretinoin 115-128 interleukin 1 beta Homo sapiens 42-46 3360803-7 1988 We also show that in human synovial fibroblast cultures human recombinant interleukin-1 beta rapidly induces high levels of MMP-3 mRNA and, conversely, that retinoic acid or dexamethasone can suppress the MMP-3 mRNA levels. Tretinoin 157-170 interleukin 1 beta Homo sapiens 74-92 30237268-7 2019 This study demonstrates that transglutaminase 2 expression induced by all-trans retinoic acid treatment reprograms inflammatory signaling networks governed by nuclear factor kappa-light-chain-enhancer of activated B-cell activation, resulting in overexpression of TNF-alpha and IL-1beta in differentiating APL cells, suggesting that atypically expressed transglutaminase 2 is a promising target for leukemia treatment. Tretinoin 80-93 interleukin 1 beta Homo sapiens 278-286 32630207-7 2020 ATRA alone induces NLRP3 expression, and enhances LPS-induced expression of NLRP3 and pro-IL-1beta via the regulation of signal transduction pathways, like NF-kappaB, p38, and ERK. Tretinoin 0-4 interleukin 1 beta Homo sapiens 86-98 31950055-4 2019 Similarly, ATRA enhanced the expression and production of TNF-alpha and IL-1beta in THP-1 cells upon flagellin challenge. Tretinoin 11-15 interleukin 1 beta Homo sapiens 72-80 31950055-8 2019 Anti-CD14 antibody treatment prior to ATRA and flagellin treatments completely abolished ATRA-enhanced TNF-alpha and IL-1beta production. Tretinoin 89-93 interleukin 1 beta Homo sapiens 117-125 30679324-0 2019 All-trans retinoic acid protects mesenchymal stem cells from immune thrombocytopenia by regulating the complement-interleukin-1beta loop. Tretinoin 10-23 interleukin 1 beta Homo sapiens 114-131 30679324-6 2019 In vitro treatment with all-trans retinoic acid increased the number and improved the function of the complement-positive bone marrow mesenchymal stem cells by upregulating DNA hypermethylation of the interleukin-1beta promoter. Tretinoin 34-47 interleukin 1 beta Homo sapiens 201-218 25725371-4 2015 Here, we demonstrate that human skin MCs display substantial susceptibility to RA by which they are instructed to increase pro-inflammatory mediators (IL-1beta, IL-8, TNF-alpha) but not histamine release. Tretinoin 79-81 interleukin 1 beta Homo sapiens 151-159 26187413-4 2015 CD127(+) ILC1 differentiated to ILC3 in the presence of interleukin-2 (IL-2), IL-23, and IL-1beta dependent on the transcription factor RORgammat, and this process was enhanced in the presence of retinoic acid. Tretinoin 196-209 interleukin 1 beta Homo sapiens 89-97 28404891-3 2017 HMGB1 and the pro-inflammatory cytokines IL-1beta and TNF-alpha were gradually released from NB4 and HL-60 cells treated with ATRA and/or ATO. Tretinoin 126-130 interleukin 1 beta Homo sapiens 41-49 25403801-7 2015 In addition, the high levels of tumor necrosis factor-alpha, interleukin-1beta, and receptor activator of nuclear factor-kappa B ligand (RANKL) expression induced by LPS were inhibited after treatment with atRA. Tretinoin 206-210 interleukin 1 beta Homo sapiens 61-78 25099355-4 2014 atRA prevents human nTregs from converting to Th1 and/or Th17 cells and sustains their Foxp3 expression and suppressive function in vitro or in vivo following encounters with IL-1 and IL-6. Tretinoin 0-4 interleukin 1 beta Homo sapiens 175-179 25099355-5 2014 Interestingly, adoptive transfer of human nTregs pretreated with atRA significantly enhanced their suppressive effects on xenograft-vs.-host diseases (xGVHDs), and atRA- but not rapamycin-pretreated nTregs sustained the functional activity against xGVHD after stimulation with IL-1/IL-6. Tretinoin 65-69 interleukin 1 beta Homo sapiens 277-281