PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22449228-12 2012 Our results suggest that CRBP-1 plays a role in ventricular remodeling after MI allegedly through its RA binding activity. Tretinoin 102-104 retinol binding protein 1 Homo sapiens 25-31 22945948-9 2012 RBP1, important in retinoic acid metabolism, was found to be hypermethylated in 76 of 79 IDH1 MUT, 3 of 3 IDH2 MUT, and 0 of 116 IDH1/IDH2 WT tumors. Tretinoin 19-32 retinol binding protein 1 Homo sapiens 0-4 22945948-14 2012 Because RBP1 is involved in retinoic acid synthesis, our results suggest that dysregulation of retinoic acid metabolism may contribute to glioma formation along the IDH1/IDH2-mutant pathway. Tretinoin 28-41 retinol binding protein 1 Homo sapiens 8-12 22945948-14 2012 Because RBP1 is involved in retinoic acid synthesis, our results suggest that dysregulation of retinoic acid metabolism may contribute to glioma formation along the IDH1/IDH2-mutant pathway. Tretinoin 95-108 retinol binding protein 1 Homo sapiens 8-12 21621639-10 2012 The ratio apo-CRBP1/holo-CRBP1 participates by influencing retinol flux into and out of storage as retinyl esters, thereby modulating substrate to support atRA biosynthesis. Tretinoin 155-159 retinol binding protein 1 Homo sapiens 14-19 21621639-10 2012 The ratio apo-CRBP1/holo-CRBP1 participates by influencing retinol flux into and out of storage as retinyl esters, thereby modulating substrate to support atRA biosynthesis. Tretinoin 155-159 retinol binding protein 1 Homo sapiens 25-30 21382444-1 2011 BACKGROUND: Cellular retinol binding-protein I (CRBPI) and cellular retinol binding-protein II (CRBPII) serve as intracellular retinoid chaperones that bind retinol and retinal with high affinity and facilitate substrate delivery to select enzymes that catalyze retinoic acid (RA) and retinyl ester biosynthesis. Tretinoin 277-279 retinol binding protein 1 Homo sapiens 12-46 21782811-5 2011 Moreover, we show that this initial step of atRA synthesis occurs predominantly in a membrane-bound cellular compartment, which prevents inhibition by the cytosolic cellular retinol-binding protein (RBP1). Tretinoin 44-48 retinol binding protein 1 Homo sapiens 199-203 21382444-1 2011 BACKGROUND: Cellular retinol binding-protein I (CRBPI) and cellular retinol binding-protein II (CRBPII) serve as intracellular retinoid chaperones that bind retinol and retinal with high affinity and facilitate substrate delivery to select enzymes that catalyze retinoic acid (RA) and retinyl ester biosynthesis. Tretinoin 277-279 retinol binding protein 1 Homo sapiens 48-53 19250215-2 2009 In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC). Tretinoin 195-218 retinol binding protein 1 Homo sapiens 139-143 21514413-6 2011 Aberrantly expressed RA signaling molecules included i) the retinol-binding protein CRBP1, which facilitates cellular retinoid uptake; ii) ALDH1A1, capable of activating RA precursors; iii) the RA-degrading enzyme CYP26B1; and iv) the RA-binding protein FABP5, which can inhibit RA-induced differentiation. Tretinoin 21-23 retinol binding protein 1 Homo sapiens 84-89 19216755-7 2009 CRBP-1 is a key regulator of All-trans retinoic acid (ATRA) through ATRA metabolism and nuclear localization. Tretinoin 29-52 retinol binding protein 1 Homo sapiens 0-6 19216755-7 2009 CRBP-1 is a key regulator of All-trans retinoic acid (ATRA) through ATRA metabolism and nuclear localization. Tretinoin 54-58 retinol binding protein 1 Homo sapiens 0-6 19216755-7 2009 CRBP-1 is a key regulator of All-trans retinoic acid (ATRA) through ATRA metabolism and nuclear localization. Tretinoin 68-72 retinol binding protein 1 Homo sapiens 0-6 19216755-16 2009 CONCLUSION: Collectively our data provides evidence that Chmp1A mediates the growth inhibitory activity of ATRA in human pancreatic cancer cells via regulation of CRBP-1. Tretinoin 107-111 retinol binding protein 1 Homo sapiens 163-169 21382444-1 2011 BACKGROUND: Cellular retinol binding-protein I (CRBPI) and cellular retinol binding-protein II (CRBPII) serve as intracellular retinoid chaperones that bind retinol and retinal with high affinity and facilitate substrate delivery to select enzymes that catalyze retinoic acid (RA) and retinyl ester biosynthesis. Tretinoin 262-275 retinol binding protein 1 Homo sapiens 12-46 21382444-1 2011 BACKGROUND: Cellular retinol binding-protein I (CRBPI) and cellular retinol binding-protein II (CRBPII) serve as intracellular retinoid chaperones that bind retinol and retinal with high affinity and facilitate substrate delivery to select enzymes that catalyze retinoic acid (RA) and retinyl ester biosynthesis. Tretinoin 262-275 retinol binding protein 1 Homo sapiens 48-53 21042705-3 2010 As CRBP1 regulates intracellular retinoic acid (vitamin A) homeostasis, which is involved in morphogenesis, and cellular proliferation and differentiation, the loss of CRBP1 could cause tumorigenesis in BC. Tretinoin 33-46 retinol binding protein 1 Homo sapiens 3-8 20506167-6 2010 Because CRBP1 plays a dual role in the retina-retinal recycling and generation of retinoic acid-we evaluated both possibilities. Tretinoin 82-95 retinol binding protein 1 Homo sapiens 8-13 20506167-9 2010 The localization of CRBP1 within Muller cells and the RPE and its demonstrated role in modulating the proper folding of nascent outer segment membranes through retinoic acid further elucidates the role of these cells in directly influencing photoreceptor physiology. Tretinoin 160-173 retinol binding protein 1 Homo sapiens 20-25 20501978-9 2010 We propose other candidates such as STRA6, LRAT, CRBP1, CRBP2 and CRABP1 are directly implicated in retinoic acid metabolism. Tretinoin 100-113 retinol binding protein 1 Homo sapiens 49-54 19250215-2 2009 In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC). Tretinoin 195-218 retinol binding protein 1 Homo sapiens 150-154 19250215-2 2009 In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC). Tretinoin 185-189 retinol binding protein 1 Homo sapiens 139-143 19250215-2 2009 In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC). Tretinoin 185-189 retinol binding protein 1 Homo sapiens 150-154 19250215-3 2009 Since both XDH and CRBP are required for the biosynthesis of t-RA, we have inspected their bioavailability in both estrogen-responsive and nonresponsive human mammary epithelial cancer cells. Tretinoin 61-65 retinol binding protein 1 Homo sapiens 19-23 16134180-1 2005 BACKGROUND: Hypermethylation of CpG islands has been associated with silencing of various tumor suppressor genes, and the retinoid acid receptor beta (RARbeta), cellular retinol-binding protein 1 (CRBP1), and tazarotene-induced gene 1 (TIG1) genes have been associated with retinoic acid signaling. Tretinoin 274-287 retinol binding protein 1 Homo sapiens 197-202 18569334-6 2008 is capable to oxidize all-trans-retinol bound to CRBP (holo-CRBP) to all-trans-retinaldehyde and then to all-trans-retinoic acid. Tretinoin 105-128 retinol binding protein 1 Homo sapiens 49-53 18569334-6 2008 is capable to oxidize all-trans-retinol bound to CRBP (holo-CRBP) to all-trans-retinaldehyde and then to all-trans-retinoic acid. Tretinoin 105-128 retinol binding protein 1 Homo sapiens 60-64 18343808-5 2008 RA and retinol also regulate expression of ADH1, cellular retinol binding protein 1 and cellular RA binding protein 2 in fibroid and myometrial cells. Tretinoin 0-2 retinol binding protein 1 Homo sapiens 49-83 17079450-2 2006 Here, we show for the first time that RA, via the RA receptor alpha (RARalpha), epigenetically regulates in a concerted fashion the transcription of two RA-responsive genes, the RA receptor beta2 (RARbeta2) and the cellular retinol-binding protein 1 (CRBP1). Tretinoin 38-40 retinol binding protein 1 Homo sapiens 215-249 17079450-2 2006 Here, we show for the first time that RA, via the RA receptor alpha (RARalpha), epigenetically regulates in a concerted fashion the transcription of two RA-responsive genes, the RA receptor beta2 (RARbeta2) and the cellular retinol-binding protein 1 (CRBP1). Tretinoin 38-40 retinol binding protein 1 Homo sapiens 251-256 17079450-3 2006 Specifically, an impaired RA signal through RARalpha in human breast epithelial cells triggers a repressive epigenetic domino effect, involving first RARbeta2 and second CRBP1. Tretinoin 26-28 retinol binding protein 1 Homo sapiens 170-175 17079450-4 2006 The phenotype acquired by breast epithelial cells clearly implies that the resistance to RA-mediated growth inhibition precedes the acquisition of morphological epithelial transformation, thus supporting the occurrence of sequential transcriptional silencing of first RARbeta2 and second CRBP1. Tretinoin 89-91 retinol binding protein 1 Homo sapiens 288-293 16959971-5 2006 Furthermore, the expression of COX-2, Cx-43, CRABPI, the transcription factor c-Jun and the retinoic acid receptor RARbeta altered in response to different concentrations of ATRA, suggesting that the differential expression of cellular retinoid-binding proteins may lead to different levels of retinoic acid being delivered to its nuclear targets, leading to the differential expression of specific target genes within the myometrium during pregnancy. Tretinoin 174-178 retinol binding protein 1 Homo sapiens 45-51 15152096-5 2004 Retinoic acid bound equally well to wild type and P85V-CRABP I, confirming the functional integrity of this mutation. Tretinoin 0-13 retinol binding protein 1 Homo sapiens 55-62 16128742-2 2005 Retinoic acid receptor-beta (RAR-beta), cellular retinol-binding protein 1 (CRBP1), and tazarotene-induced gene 1 (TIG1) have been linked to retinoic acid signaling. Tretinoin 141-154 retinol binding protein 1 Homo sapiens 40-74 16128742-2 2005 Retinoic acid receptor-beta (RAR-beta), cellular retinol-binding protein 1 (CRBP1), and tazarotene-induced gene 1 (TIG1) have been linked to retinoic acid signaling. Tretinoin 141-154 retinol binding protein 1 Homo sapiens 76-81 12956703-2 2003 We suggest that the transcriptional activator retinoic acid (RA), takes part in gene regulation after peripheral nerve injury and that RA signalling is activated via the cellular retinoic acid binding protein (CRABP)-II and cellular retinol binding protein (CRBP)-I. Tretinoin 46-59 retinol binding protein 1 Homo sapiens 258-265 15113415-7 2004 In some cells CRBP reexpression was potentiated by co-treatment with retinoic acid, an inducer of CRBP, and trichostatin A, a histone deacetylase inhibitor. Tretinoin 69-82 retinol binding protein 1 Homo sapiens 14-18 15113415-7 2004 In some cells CRBP reexpression was potentiated by co-treatment with retinoic acid, an inducer of CRBP, and trichostatin A, a histone deacetylase inhibitor. Tretinoin 69-82 retinol binding protein 1 Homo sapiens 98-102 12956703-2 2003 We suggest that the transcriptional activator retinoic acid (RA), takes part in gene regulation after peripheral nerve injury and that RA signalling is activated via the cellular retinoic acid binding protein (CRABP)-II and cellular retinol binding protein (CRBP)-I. Tretinoin 61-63 retinol binding protein 1 Homo sapiens 258-265 12956703-2 2003 We suggest that the transcriptional activator retinoic acid (RA), takes part in gene regulation after peripheral nerve injury and that RA signalling is activated via the cellular retinoic acid binding protein (CRABP)-II and cellular retinol binding protein (CRBP)-I. Tretinoin 135-137 retinol binding protein 1 Homo sapiens 258-265 12956703-6 2003 Sciatic nerve crush as well as transection resulted in a more than 10-fold up-regulation of CRBP-I, which is thought to facilitate the synthesis of RA. Tretinoin 148-150 retinol binding protein 1 Homo sapiens 92-98 12485405-4 2003 PCR analysis of total mRNA from RA-treated cells showed a biphasic early induction of CRBP-I, CRABP-II, and RARgamma2 genes. Tretinoin 32-34 retinol binding protein 1 Homo sapiens 86-92 12485405-8 2003 These data suggest that the RA-specific induction of CRBP-I and CRABP-II could be an early event in the process leading to neuronal differentiation of NT2 cells. Tretinoin 28-30 retinol binding protein 1 Homo sapiens 53-59 11704871-4 2001 Ectopic CRBP-mediated inhibition of anchorage-independent cell survival and colony formation in the absence of significantly altered responses to either retinol or retinoic acid was also documented in T47D human breast cancer cells. Tretinoin 164-177 retinol binding protein 1 Homo sapiens 8-12 12034496-1 2002 Members of the cellular retinoic acid (CRABP) and retinol binding (CRBP) proteins family are involved in the metabolic pathways of retinoic acid (RA) and retinal respectively. Tretinoin 24-37 retinol binding protein 1 Homo sapiens 67-71 12034496-1 2002 Members of the cellular retinoic acid (CRABP) and retinol binding (CRBP) proteins family are involved in the metabolic pathways of retinoic acid (RA) and retinal respectively. Tretinoin 131-144 retinol binding protein 1 Homo sapiens 67-71 12153175-2 2002 Intracellular retinoid signaling induced by endogenous or exogenous RA is regulated by retinoid binding proteins such as CRBPI, CRABPI and CRABPII and there are data suggesting that the expression of these proteins can influence the sensitivity to the growth inhibitory effects of ATRA. Tretinoin 68-70 retinol binding protein 1 Homo sapiens 121-126 12153175-2 2002 Intracellular retinoid signaling induced by endogenous or exogenous RA is regulated by retinoid binding proteins such as CRBPI, CRABPI and CRABPII and there are data suggesting that the expression of these proteins can influence the sensitivity to the growth inhibitory effects of ATRA. Tretinoin 68-70 retinol binding protein 1 Homo sapiens 128-134 12153175-2 2002 Intracellular retinoid signaling induced by endogenous or exogenous RA is regulated by retinoid binding proteins such as CRBPI, CRABPI and CRABPII and there are data suggesting that the expression of these proteins can influence the sensitivity to the growth inhibitory effects of ATRA. Tretinoin 281-285 retinol binding protein 1 Homo sapiens 121-126 12153175-3 2002 In this study, we investigated the basal and ATRA-induced expression of CRBPI and CRABPI and II in leukemic cell lines and in cells from patients with acute myeloid leukemia (AML). Tretinoin 45-49 retinol binding protein 1 Homo sapiens 72-77 12153175-3 2002 In this study, we investigated the basal and ATRA-induced expression of CRBPI and CRABPI and II in leukemic cell lines and in cells from patients with acute myeloid leukemia (AML). Tretinoin 45-49 retinol binding protein 1 Homo sapiens 82-88 11879576-6 2002 We hypothesize that the loss of CRBP1 and RBP expression disrupts retinol metabolism and retinoic acid production, which may facilitate the occurrence of genetic damage leading to the malignant transformation of the ovarian surface epithelium, the cells from which ovarian cancer arises. Tretinoin 89-102 retinol binding protein 1 Homo sapiens 32-37 10460195-3 1999 Thus, high expression of human CRBP(I) [hCRBP(I)] in transgenic mice might be expected to increase the production of retinoic acid in tissues, thereby inducing a phenotype resembling vitamin A toxicity. Tretinoin 117-130 retinol binding protein 1 Homo sapiens 31-38 10460195-3 1999 Thus, high expression of human CRBP(I) [hCRBP(I)] in transgenic mice might be expected to increase the production of retinoic acid in tissues, thereby inducing a phenotype resembling vitamin A toxicity. Tretinoin 117-130 retinol binding protein 1 Homo sapiens 40-48 8841765-3 1996 The retinol-binding proteins CRBP I and CRBP II appear to play an essential role in retinyl ester hydrolysis and formation and in retinoic acid formation. Tretinoin 130-143 retinol binding protein 1 Homo sapiens 29-35 10506831-6 1999 Similarly, CRBP and/or other retinoid-binding proteins function in the synthesis of retinal esters, the reduction of retinal generated from intestinal beta-carotene metabolism, and retinoic acid metabolism. Tretinoin 181-194 retinol binding protein 1 Homo sapiens 11-15 10209249-2 1999 Immunohistochemistry was used to localise the cellular retinoid binding-proteins for retinol (CRBP I) and retinoic acid (CRABP I) in the embryonic and adult olfactory system. Tretinoin 106-119 retinol binding protein 1 Homo sapiens 121-128 10026291-1 1999 Microsomal enzymes that catalyze the first step in the biosynthesis of retinoic acid from retinal, retinol dehydrogenases (RDHs), access retinol bound to cellular retinol-binding protein (CRBP). Tretinoin 71-84 retinol binding protein 1 Homo sapiens 154-186 10026291-1 1999 Microsomal enzymes that catalyze the first step in the biosynthesis of retinoic acid from retinal, retinol dehydrogenases (RDHs), access retinol bound to cellular retinol-binding protein (CRBP). Tretinoin 71-84 retinol binding protein 1 Homo sapiens 188-192 8964570-7 1996 Within the cell, two cellular retinoic acid-binding proteins (CRABP-I and -II) and a ROL-binding protein (CRBP-I) regulate the levels of free RA and ROL. Tretinoin 30-43 retinol binding protein 1 Homo sapiens 62-77 8789718-9 1996 Displacement of 1,8-ANS from CRBP by all-trans-retinal and all-trans-retinoic acid yielded Ki values of 1.7 and 5.3 microM, respectively. Tretinoin 59-82 retinol binding protein 1 Homo sapiens 29-33 7626500-6 1995 Considerable data favor a model pathway of RA biosynthesis and metabolism consisting of enzymes that recognize CRBP (apo and holo) and holo-CRABP as substrates and/or affecters of activity. Tretinoin 43-45 retinol binding protein 1 Homo sapiens 111-115 7556191-7 1995 Exposure of HUVEC to 1 microM retinoic acid or the retinobenzoic acid, Ch55, led to the induction of the two RAR-beta mRNAs, RXR-alpha mRNA and CRBP-I mRNA, whereas the expression of the other receptor and CRABP-I transcripts did not change appreciably. Tretinoin 30-43 retinol binding protein 1 Homo sapiens 144-150 7615982-1 1995 We examined the regulation of cellular retinol-binding protein (CRBP) mRNA and protein expression in human skin in vivo by all-trans retinoic acid and all-trans retinol. Tretinoin 133-146 retinol binding protein 1 Homo sapiens 64-68 7615982-2 1995 Treatment of human skin for 24 h with all-trans retinoic acid (0.1%) or all-trans retinol (1.6%) induced CRBP mRNA 5.5-fold (p < 0.01, n = 10) and 5.7-fold (p < 0.01, n = 5), respectively, compared with skin treated with vehicle or sodium lauryl sulfate (used as an irritant control). Tretinoin 48-61 retinol binding protein 1 Homo sapiens 105-109 7615982-3 1995 In vitro translation of poly A+ RNA from all-trans retinoic acid, all-trans retinol, sodium lauryl sulfate, and vehicle-treated human skin demonstrated that the observed increased CRBP mRNA in all-trans retinoic acid- and all-trans retinol-treated skin was able to direct increased (2.3-2.9-fold) CRBP protein synthesis. Tretinoin 51-64 retinol binding protein 1 Homo sapiens 180-184 7615982-4 1995 Riboprobe in situ hybridization revealed that CRBP mRNA was uniformly elevated throughout the epidermis and in dermal cells after all-trans retinoic acid treatment of human skin. Tretinoin 140-153 retinol binding protein 1 Homo sapiens 46-50 7615982-5 1995 Western analysis revealed that CRBP protein was elevated 3.2-fold (p < 0.01, n = 6) and 3.0-fold (p < 0.01, n = 6) after all-trans retinoic acid treatment of human skin in vivo for 24 and 96 h, respectively, compared with vehicle- and sodium lauryl sulfate-treated skin. Tretinoin 137-150 retinol binding protein 1 Homo sapiens 31-35 7615982-6 1995 In addition, functional CRBP levels measured by [3H]all-trans retinol binding were elevated 1.9-fold (p < 0.01, n = 6) and 3.5-fold (p < 0.01, n = 6) at 24 and 94 h, respectively, after all-trans retinoic acid treatment, compared with vehicle- or sodium lauryl sulfate-treated skin. Tretinoin 202-215 retinol binding protein 1 Homo sapiens 24-28 7615982-8 1995 Monoclonal antibodies to nuclear retinoid receptors demonstrated that predominantly retinoic acid receptor-alpha/retinoid X receptor-alpha heterodimers bound to the CRBP retinoic acid response element. Tretinoin 84-97 retinol binding protein 1 Homo sapiens 165-169 7615982-9 1995 These data demonstrate that CRBP expression in human skin in vivo is regulated by exogenous all-trans retinoic acid and all-trans retinol. Tretinoin 102-115 retinol binding protein 1 Homo sapiens 28-32 7626500-11 1995 Retinal generated in microsomes from holo-CRBP by RDH supports cytosolic RA synthesis by an NAD-dependent retinal dehydrogenase (RalDH). Tretinoin 73-75 retinol binding protein 1 Homo sapiens 42-46 8385449-5 1993 In this article I propose that the amount of RA reaching the nucleus in different embryonic tissues is modulated by a mechanism involving three cytoplasmic binding proteins for retinol (CRBP I) and retinoic acid (CRABP I and II). Tretinoin 45-47 retinol binding protein 1 Homo sapiens 186-192 8387121-3 1993 CRBP (I) functions in cellular uptake of retinol from the plasma, solubilizes and renders retinol nontoxic in the aqueous system, and presents retinol to the appropriate enzymes to biosynthesize retinoic acid (an active form of retinoids) or retinyl esters (a storage form). Tretinoin 195-208 retinol binding protein 1 Homo sapiens 0-4 8387121-5 1993 CRBP (III) is recognized as one of oncofetal proteins and binds both retinol and retinoic acid, the function of which still remains unclear. Tretinoin 81-94 retinol binding protein 1 Homo sapiens 0-4 8381481-0 1993 Biosynthesis and metabolism of retinoic acid: roles of CRBP and CRABP in retinoic acid: roles of CRBP and CRABP in retinoic acid homeostasis. Tretinoin 31-44 retinol binding protein 1 Homo sapiens 55-59 8381481-5 1993 A cytosolic retinal dehydrogenase has been purified that produces retinoic acid from retinal generated by microsomes in the presence of CRBP and from the complex CRBP-retinal itself. Tretinoin 66-79 retinol binding protein 1 Homo sapiens 136-140 8381481-5 1993 A cytosolic retinal dehydrogenase has been purified that produces retinoic acid from retinal generated by microsomes in the presence of CRBP and from the complex CRBP-retinal itself. Tretinoin 66-79 retinol binding protein 1 Homo sapiens 162-166 8381481-6 1993 Thus, CRBP(type I) seems to channel retinoids through the reactions of retinoic acid synthesis via a series of protein-protein interactions. Tretinoin 71-84 retinol binding protein 1 Homo sapiens 6-10 8385449-5 1993 In this article I propose that the amount of RA reaching the nucleus in different embryonic tissues is modulated by a mechanism involving three cytoplasmic binding proteins for retinol (CRBP I) and retinoic acid (CRABP I and II). Tretinoin 45-47 retinol binding protein 1 Homo sapiens 213-227 8385449-5 1993 In this article I propose that the amount of RA reaching the nucleus in different embryonic tissues is modulated by a mechanism involving three cytoplasmic binding proteins for retinol (CRBP I) and retinoic acid (CRABP I and II). Tretinoin 198-211 retinol binding protein 1 Homo sapiens 213-227 1768424-2 1991 Tritiated analogues of retinol (ROL) and retinoic acid corresponding to substituted benzo[b]thiophene (CD-270) alcohol and carboxylic acid, respectively, were used for the binding studies of the cellular retinoic acid-(CRABP-) and retinol-(CRBP-) binding proteins in human epidermal cells and serum retinol-binding protein (RBP). Tretinoin 41-54 retinol binding protein 1 Homo sapiens 240-244 1542003-5 1992 The ability of pure hCRBP(II) to bind all-trans-retinol, retinal and retinoic acid was examined by competitive binding assay and compared with the binding specificity of pure human cellular retinol-binding protein (hCRBP). Tretinoin 69-82 retinol binding protein 1 Homo sapiens 20-25 1768424-2 1991 Tritiated analogues of retinol (ROL) and retinoic acid corresponding to substituted benzo[b]thiophene (CD-270) alcohol and carboxylic acid, respectively, were used for the binding studies of the cellular retinoic acid-(CRABP-) and retinol-(CRBP-) binding proteins in human epidermal cells and serum retinol-binding protein (RBP). Tretinoin 204-217 retinol binding protein 1 Homo sapiens 240-244 2645590-4 1989 Human skin extracts incubated with either [3H]retinol or [3H]retinoic acid and analyzed by PAGE is a novel technique for the study of cellular retinol-(CRBP) and retinoic acid-(CRABP) binding proteins; it allows one to more specifically analyse these binding proteins and differentiate them from RBP. Tretinoin 61-74 retinol binding protein 1 Homo sapiens 152-156 34775955-11 2021 Furthermore, our results revealed that CRBP-1 could increase the intracellular levels of retinoic acid, which induced the activation of RARs/RXRs leading to the transcriptional expression of WIF1, a secreted antagonist of the Wnt/beta-catenin signaling pathway, by physically interacting with the region on WIF1 promoter. Tretinoin 89-102 retinol binding protein 1 Homo sapiens 39-45 2546063-6 1989 1) Induction of CRBP occurred at lower concentrations of RA (10(-9) M) than did that of CRABP (10(-8)-10(-7) M). Tretinoin 57-59 retinol binding protein 1 Homo sapiens 16-20 2546063-7 1989 2) CRBP induction was an early response (within 3 h) to RA treatment, whereas CRABP induction occurred at a later time (12-24 h). Tretinoin 56-58 retinol binding protein 1 Homo sapiens 3-7 2546063-14 1989 Taken together, our results suggest that CRBP induction may be a direct response to RA and represent a general event in RA-induced cell differentiation, whereas CRABP induction may be an indirect response and represent a later event restricted to only certain differentiation pathways. Tretinoin 84-86 retinol binding protein 1 Homo sapiens 41-45 2825608-9 1987 Like CRBP, CRABP can deliver its ligand retinoic acid to specific binding sites within the nucleus, sites different from those for retinol. Tretinoin 40-53 retinol binding protein 1 Homo sapiens 5-9 32909215-7 2020 CRBP-1+ showed reduced proliferation and viability in basal condition and after atRA treatment when compared to empty-transfected H460 cells. Tretinoin 80-84 retinol binding protein 1 Homo sapiens 0-6 2992894-6 1985 Retinol and RA might be translocated to nuclei by their respective binding proteins [cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP)]: isolated EC nuclei have specific, independent binding sites for both holoproteins but not their ligands. Tretinoin 12-14 retinol binding protein 1 Homo sapiens 85-117 2992894-6 1985 Retinol and RA might be translocated to nuclei by their respective binding proteins [cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP)]: isolated EC nuclei have specific, independent binding sites for both holoproteins but not their ligands. Tretinoin 12-14 retinol binding protein 1 Homo sapiens 119-123 6684744-6 1983 CRBP and CRABP are assumed to be mediating factors for the retinol and retinoic acid action. Tretinoin 71-84 retinol binding protein 1 Homo sapiens 0-4 2833143-2 1987 Studies on CRBP and CRABP suggest that both retinol and retinoic acid are involved in maintaining testicular function. Tretinoin 56-69 retinol binding protein 1 Homo sapiens 11-15 32909215-10 2020 Restoration of CRBP-1 expression in H460 cells reduced proliferation and viability in both basal condition and after atRA treatment, likely by down-regulating AKT-related gene level. Tretinoin 117-121 retinol binding protein 1 Homo sapiens 15-21 27830500-4 2016 The major intracellular retinol-binding protein, CRBP1, likely enhances efficient retinoid use by providing a sink to facilitate retinol uptake from sRBP through the plasma membrane or via Stra6, delivering retinol or retinal to select enzymes that generate retinyl esters or retinoic acid, and protecting retinol/retinal from excess catabolism or opportunistic metabolism. Tretinoin 276-289 retinol binding protein 1 Homo sapiens 49-54 26807202-9 2015 At >1muM concentrations, all trans-retinoic acid and retinol reduced viability more in CRBP-1(+) than in CRBP-1(-) A549 cells. Tretinoin 32-51 retinol binding protein 1 Homo sapiens 90-99 26807202-9 2015 At >1muM concentrations, all trans-retinoic acid and retinol reduced viability more in CRBP-1(+) than in CRBP-1(-) A549 cells. Tretinoin 32-51 retinol binding protein 1 Homo sapiens 90-96 24269351-5 2014 Changes observed in the expression of factors involved in the retinoid pathway under ATRA, namely an upregulation of CRBP and CRABP2, were also reflected in GCT tissues of different histologies, providing further insight into factors involved in the differentiation of these pluripotent tumors. Tretinoin 85-89 retinol binding protein 1 Homo sapiens 117-121 29096166-6 2018 In mammals, RA is principally stored in HSC complexed to cRBP-1 and therefore cRBP-1+ HSC numbers were used as an indicator of fetal RA status. Tretinoin 12-14 retinol binding protein 1 Homo sapiens 57-63 29096166-10 2018 CONCLUSION: Fetal RA stores, reflected in the number of cRBP-1+ HSCs, influence lung growth as well as diaphragm development in human fetuses with CDH. Tretinoin 18-20 retinol binding protein 1 Homo sapiens 56-62