PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31106887-0 2019 Severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome caused by de novo mutation in the DSP gene misdiagnosed as generalized pustular psoriasis and treatment of acitretin with gabapentin. Acitretin 182-191 desmoplakin Homo sapiens 109-112 31106887-0 2019 Severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome caused by de novo mutation in the DSP gene misdiagnosed as generalized pustular psoriasis and treatment of acitretin with gabapentin. Gabapentin 197-207 desmoplakin Homo sapiens 109-112 8269032-4 1993 The stimulatory effect of RA was inhibited by a blocking monoclonal antibody directed against the binding domain of the EGF receptor. Tretinoin 26-28 epidermal growth factor Homo sapiens 120-123 8269032-7 1993 Decreased TGF alpha binding capacity is thought to be due to the ability of RA to stimulate TGF alpha, thereby resulting in EGF receptor binding and internalization. Tretinoin 76-78 epidermal growth factor Homo sapiens 124-127 8162329-9 1993 Pretreatment of cultures with retinoic acid (10(-5)-10(-7) M) significantly inhibited the induction of ODC by EGF. Tretinoin 30-43 epidermal growth factor Homo sapiens 110-113 1515368-6 1992 RA enhances the proliferative response of cultured keratinocytes to EGF, increases the number of EGFRs on the surface of some cells, and induces EGFR promoter activity in most cells. Tretinoin 0-2 epidermal growth factor Homo sapiens 68-71 8127013-3 1994 This paper describes the effects of RA on a human renal adenocarcinoma cell line (PAD) under different growth conditions, and its interactions with epidermal growth factor (EGF). Tretinoin 36-38 epidermal growth factor Homo sapiens 173-176 8127013-7 1994 RA by itself was unable to reverse contact inhibition of PAD cell growth (NS vs. control), but it synergistically enhanced the mitogenic effect of EGF on confluent monolayers (110 +/- 0.6% vs. EGF alone; P < 0.05). Tretinoin 0-2 epidermal growth factor Homo sapiens 147-150 8127013-10 1994 Thus, our data show that RA is directly mitogenic for serum starved human renal adenocarcinoma cells and that it exerts complex modulation of cell growth in the presence of EGF and serum components. Tretinoin 25-27 epidermal growth factor Homo sapiens 173-176 8402622-5 1993 ECE16-1 but not normal ectocervical epithelial cells are growth inhibited by trans-retinoic acid which attenuates the stimulatory effect of EGF on ECE16-1 cell growth. Tretinoin 77-96 epidermal growth factor Homo sapiens 140-143 8402622-6 1993 Retinoic acid reduces both EGF binding and EGF receptor protein levels in ECE16-1 cells but not in normal ectocervical cells. Tretinoin 0-13 epidermal growth factor Homo sapiens 27-30 8402622-6 1993 Retinoic acid reduces both EGF binding and EGF receptor protein levels in ECE16-1 cells but not in normal ectocervical cells. Tretinoin 0-13 epidermal growth factor Homo sapiens 43-46 1310606-4 1992 When the effect of EGF (2.5 ng/ml) was tested against the growth inhibition produced by a range of doses of RA, EGF stimulated growth and reduced the degree of inhibition produced by RA at all dose levels. Tretinoin 108-110 epidermal growth factor Homo sapiens 112-115 1310606-5 1992 Conversely, a single dose of 10(-8) M RA tested against a range of EGF concentrations reduced the dose-related EGF-induced increase in anchorage-independent growth. Tretinoin 38-40 epidermal growth factor Homo sapiens 67-70 1310606-5 1992 Conversely, a single dose of 10(-8) M RA tested against a range of EGF concentrations reduced the dose-related EGF-induced increase in anchorage-independent growth. Tretinoin 38-40 epidermal growth factor Homo sapiens 111-114 1812132-7 1991 Our results suggest that in the medial epithelial cells of the palate, retinoic acid sustains the expression of the EGF receptor and the binding of EGF at a time when the expression in control medial cells has declined, and these control cells subsequently undergo programmed cell death. Tretinoin 71-84 epidermal growth factor Homo sapiens 148-151 34569079-4 2021 It has been found that epidermal growth factor (EGF), taurine, and retinoic acid (RA) initially act in the instructive as well as lineage-restricted way in the progenitor lineage for producing neuroretinal cells or photoreceptor like cells from stem cell. Tretinoin 82-84 epidermal growth factor Homo sapiens 23-46 2226349-14 1990 In the postnatal period, thyroid and steroid hormones including retinoic acid have been shown to modulate EGF and/or EGF receptors in several tissues. Tretinoin 64-77 epidermal growth factor Homo sapiens 106-109 2226349-14 1990 In the postnatal period, thyroid and steroid hormones including retinoic acid have been shown to modulate EGF and/or EGF receptors in several tissues. Tretinoin 64-77 epidermal growth factor Homo sapiens 117-120 2164349-1 1990 The effect of retinoic acid (RA)-induced suppression of in vitro invasive ability of A549 human lung carcinoma cells on cellular binding of RA and epidermal growth factor (EGF) was investigated. Tretinoin 14-27 epidermal growth factor Homo sapiens 147-170 2164349-1 1990 The effect of retinoic acid (RA)-induced suppression of in vitro invasive ability of A549 human lung carcinoma cells on cellular binding of RA and epidermal growth factor (EGF) was investigated. Tretinoin 14-27 epidermal growth factor Homo sapiens 172-175 2164349-1 1990 The effect of retinoic acid (RA)-induced suppression of in vitro invasive ability of A549 human lung carcinoma cells on cellular binding of RA and epidermal growth factor (EGF) was investigated. Tretinoin 29-31 epidermal growth factor Homo sapiens 147-170 2164349-1 1990 The effect of retinoic acid (RA)-induced suppression of in vitro invasive ability of A549 human lung carcinoma cells on cellular binding of RA and epidermal growth factor (EGF) was investigated. Tretinoin 29-31 epidermal growth factor Homo sapiens 172-175 1707036-4 1991 Addition of fetuin or epidermal growth factor (EGF) to incubates with serum-deprived cells increased the ability of TPA to affect growth, but addition of platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta) or retinoic acid (RA) was without effect. Tretinoin 239-252 epidermal growth factor Homo sapiens 22-45 1707036-4 1991 Addition of fetuin or epidermal growth factor (EGF) to incubates with serum-deprived cells increased the ability of TPA to affect growth, but addition of platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta) or retinoic acid (RA) was without effect. Tretinoin 239-252 epidermal growth factor Homo sapiens 47-50 1707036-4 1991 Addition of fetuin or epidermal growth factor (EGF) to incubates with serum-deprived cells increased the ability of TPA to affect growth, but addition of platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta) or retinoic acid (RA) was without effect. Tretinoin 254-256 epidermal growth factor Homo sapiens 22-45 1707036-4 1991 Addition of fetuin or epidermal growth factor (EGF) to incubates with serum-deprived cells increased the ability of TPA to affect growth, but addition of platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta) or retinoic acid (RA) was without effect. Tretinoin 254-256 epidermal growth factor Homo sapiens 47-50 2912547-8 1989 Furthermore, the autophosphorylation of either RA-treated or untreated EGF receptors occurred on similar amino acid residues. Tretinoin 47-49 epidermal growth factor Homo sapiens 71-74 2912547-9 1989 These results demonstrate that RA exhibits a heterogeneous growth-inhibitory activity against human glioma cells and suggest that the effects of RA may be mediated, at least in part, by modulation of EGF receptor phosphotyrosine kinase activity. Tretinoin 31-33 epidermal growth factor Homo sapiens 200-203 2912547-9 1989 These results demonstrate that RA exhibits a heterogeneous growth-inhibitory activity against human glioma cells and suggest that the effects of RA may be mediated, at least in part, by modulation of EGF receptor phosphotyrosine kinase activity. Tretinoin 145-147 epidermal growth factor Homo sapiens 200-203 3262523-3 1988 Retinol and each retinoid were capable of stimulating fibroblast growth alone (0-86%), while 13-cis and all-trans-retinoic acid were the most potent in potentiating the EGF promotion of fibroblast growth. Tretinoin 104-127 epidermal growth factor Homo sapiens 169-172 3262523-5 1988 While EGF and FGF stimulated fibroblast growth to the same degree (2.3-fold), only growth stimulated by EGF was potentiated by retinoic acid. Tretinoin 127-140 epidermal growth factor Homo sapiens 104-107 3262523-6 1988 Since retinoic acid might enhance the EGF stimulation of cell growth by increasing either EGF receptor number or binding affinity, the binding of 125I-labeled EGF was carried out in the presence of retinoic acid and the data were subjected to a Scatchard-type analysis. Tretinoin 6-19 epidermal growth factor Homo sapiens 38-41 3262523-6 1988 Since retinoic acid might enhance the EGF stimulation of cell growth by increasing either EGF receptor number or binding affinity, the binding of 125I-labeled EGF was carried out in the presence of retinoic acid and the data were subjected to a Scatchard-type analysis. Tretinoin 6-19 epidermal growth factor Homo sapiens 90-93 3262523-6 1988 Since retinoic acid might enhance the EGF stimulation of cell growth by increasing either EGF receptor number or binding affinity, the binding of 125I-labeled EGF was carried out in the presence of retinoic acid and the data were subjected to a Scatchard-type analysis. Tretinoin 6-19 epidermal growth factor Homo sapiens 90-93 3021829-5 1986 Many studies have indicated that retinoic acid can markedly increase the number of cellular receptors for epidermal growth factor, which is partially encoded by another oncogene, erb-B. Tretinoin 33-46 epidermal growth factor Homo sapiens 106-129 6968676-3 1980 However, when EGF was added in combination with trans-retinoic acid, cell growth was increased 159 to 214%. Tretinoin 48-67 epidermal growth factor Homo sapiens 14-17 6968676-5 1980 These results indicate that, under certain conditions, a presumed inhibitor of fibroblast growth (retinoic acid) can potentiate the mitogenic action of a hormone, namely, epidermal growth factor. Tretinoin 98-111 epidermal growth factor Homo sapiens 171-194