PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1323347-0	1992	Stimulation of tissue plasminogen activator production by retinoic acid: synergistic effect on protein kinase C-mediated activation.	Tretinoin	58-71	chromosome 20 open reading frame 181	Homo sapiens	15-43	
1323347-1	1992	Trans retinoic acid (t-RA) stimulated the production of tissue plasminogen activator (tPA) in HeLa-S3 and human umbilical vein endothelial cells (huvecs) in a dose-dependent manner with maximal release (four to five times control) at 40 nmol/L and 40 mumol/L, respectively.	Tretinoin	0-19	chromosome 20 open reading frame 181	Homo sapiens	56-84	
1323347-1	1992	Trans retinoic acid (t-RA) stimulated the production of tissue plasminogen activator (tPA) in HeLa-S3 and human umbilical vein endothelial cells (huvecs) in a dose-dependent manner with maximal release (four to five times control) at 40 nmol/L and 40 mumol/L, respectively.	Tretinoin	0-19	chromosome 20 open reading frame 181	Homo sapiens	86-89	
1323347-1	1992	Trans retinoic acid (t-RA) stimulated the production of tissue plasminogen activator (tPA) in HeLa-S3 and human umbilical vein endothelial cells (huvecs) in a dose-dependent manner with maximal release (four to five times control) at 40 nmol/L and 40 mumol/L, respectively.	Tretinoin	21-25	chromosome 20 open reading frame 181	Homo sapiens	56-84	
1323347-1	1992	Trans retinoic acid (t-RA) stimulated the production of tissue plasminogen activator (tPA) in HeLa-S3 and human umbilical vein endothelial cells (huvecs) in a dose-dependent manner with maximal release (four to five times control) at 40 nmol/L and 40 mumol/L, respectively.	Tretinoin	21-25	chromosome 20 open reading frame 181	Homo sapiens	86-89	
1323347-2	1992	In endothelial cells, the stimulation of tPA production by phorbol 12-myristate 13-acetate (PMA) was potentiated 1.9-fold by 10 mumol/L t-RA, or 1.8 times the additive effect.	Tretinoin	136-140	chromosome 20 open reading frame 181	Homo sapiens	41-44	
1323347-3	1992	In HeLa cells, total tPA secretion with 10 nmol/L PMA was increased from 43 ng/mL to 96 ng/mL by 40 nmol/L t-RA, which was two times the additive effect.	Tretinoin	107-111	chromosome 20 open reading frame 181	Homo sapiens	21-24	
1323347-4	1992	Higher concentrations of t-RA (400 nmol/L) depressed tPA secretion by itself and also suppressed PMA-induced tPA production by 50%.	Tretinoin	25-29	chromosome 20 open reading frame 181	Homo sapiens	53-56	
1323347-4	1992	Higher concentrations of t-RA (400 nmol/L) depressed tPA secretion by itself and also suppressed PMA-induced tPA production by 50%.	Tretinoin	25-29	chromosome 20 open reading frame 181	Homo sapiens	109-112	
1323347-6	1992	t-RA (40 nmol/L) and 10 micrograms/mL histamine or 10 U/mL thrombin combined to induce tPA production 3.4 and 1.3 times the additive effect in HeLa cells.	Tretinoin	0-4	chromosome 20 open reading frame 181	Homo sapiens	87-90	
1323347-8	1992	Nor did 10 nmol/L PMA and 40 nmol/L t-RA together affect cAMP levels, suggesting that t-RA-mediated potentiation of PMA-induced tPA production occurred via a mechanism that was independent of cAMP levels.	Tretinoin	86-90	chromosome 20 open reading frame 181	Homo sapiens	128-131	
1323347-11	1992	These studies suggest that the mechanism mediating t-RA stimulation of tPA production interacts with the PKC pathway, resulting in synergism.	Tretinoin	51-55	chromosome 20 open reading frame 181	Homo sapiens	71-74	
2172788-0	1990	Transcription factor Sp1 is important for retinoic acid-induced expression of the tissue plasminogen activator gene during F9 teratocarcinoma cell differentiation.	Tretinoin	42-55	chromosome 20 open reading frame 181	Homo sapiens	82-110	
2172788-1	1990	The induced differentiation of F9 cells by retinoic acid (RA) and cyclic AMP (cAMP) activated transcription of the tissue plasminogen activator (t-PA) gene.	Tretinoin	43-56	chromosome 20 open reading frame 181	Homo sapiens	115-143	
2172788-1	1990	The induced differentiation of F9 cells by retinoic acid (RA) and cyclic AMP (cAMP) activated transcription of the tissue plasminogen activator (t-PA) gene.	Tretinoin	43-56	chromosome 20 open reading frame 181	Homo sapiens	145-149	
2172788-1	1990	The induced differentiation of F9 cells by retinoic acid (RA) and cyclic AMP (cAMP) activated transcription of the tissue plasminogen activator (t-PA) gene.	Tretinoin	58-60	chromosome 20 open reading frame 181	Homo sapiens	115-143	
2172788-1	1990	The induced differentiation of F9 cells by retinoic acid (RA) and cyclic AMP (cAMP) activated transcription of the tissue plasminogen activator (t-PA) gene.	Tretinoin	58-60	chromosome 20 open reading frame 181	Homo sapiens	145-149	
1698671-3	1990	Retinoic acid induced primitive endoderm differentiation of F9 cells and simultaneously activated tissue plasminogen activator synthesis.	Tretinoin	0-13	chromosome 20 open reading frame 181	Homo sapiens	98-126