PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2405249-0	1990	Rapid and transient decrease of N-myc expression in retinoic acid-induced differentiation of OTF9 teratocarcinoma stem cells.	Tretinoin	52-65	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	32-37	
2405249-2	1990	Previous studies have shown that N-myc expression significantly decreases when the stem cells are subjected to long-term induction for differentiation by retinoic acid (RA).	Tretinoin	154-167	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	33-38	
2405249-2	1990	Previous studies have shown that N-myc expression significantly decreases when the stem cells are subjected to long-term induction for differentiation by retinoic acid (RA).	Tretinoin	169-171	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	33-38	
2405249-3	1990	We found that in a stem cell line, OTF9, a steep yet transient decrease of N-myc expression takes place much earlier, immediately after induction by RA.	Tretinoin	149-151	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	75-80	
2405249-6	1990	Therefore, transient decrease of N-myc expression may be the consequence of RA-induced differentiation, even though it occurs very early in the process.	Tretinoin	76-78	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	33-38	
3060804-4	1988	Following retinoic acid addition, N-myc expression declines but then returns to initial levels as the cells undergo endodermal differentiation.	Tretinoin	10-23	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	34-39	
35490242-6	2022	RESULTS: We found that MYCN-specific inhibition by BGA002 in combination with RA (BGA002-RA) act synergistically and overcame resistance in NB cell lines.	Tretinoin	78-80	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	23-27	
35490242-10	2022	CONCLUSION: Taken together, MYCN modulation mediates the therapeutic efficacy of RA and the development of RA resistance in MNA-NB.	Tretinoin	81-83	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	28-32	
35490242-10	2022	CONCLUSION: Taken together, MYCN modulation mediates the therapeutic efficacy of RA and the development of RA resistance in MNA-NB.	Tretinoin	107-109	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	28-32	
3021829-4	1986	In several tumor cells, including human promyelocytic leukemia, human and murine neuroblastoma, and murine teratocarcinoma, retinoic acid induces terminal differentiation, accompanied by suppression of the expression of either the c-myc or the N-myc gene.	Tretinoin	124-137	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	244-249	
3700483-4	1986	The level of N-myc mRNA decreased by 85% when PCC7 EC cells were induced by retinoic acid and cAMP treatment to form nerve-like cells.	Tretinoin	76-89	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	13-18	
3916193-4	1985	The ability of retinoic acid to induce differentiation in several types of human and murine tumor cells also is associated with the ability of retinoic acid to suppress the expression of either the c-myc oncogene, or the related N-myc gene.	Tretinoin	15-28	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	229-234	
3916193-4	1985	The ability of retinoic acid to induce differentiation in several types of human and murine tumor cells also is associated with the ability of retinoic acid to suppress the expression of either the c-myc oncogene, or the related N-myc gene.	Tretinoin	143-156	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	229-234