PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28978663-2 2017 In this study, we aimed at further understanding DAPK2 function and regulation during arsenic trioxide (ATO) cytotoxic or all-trans retinoic acid (ATRA) differentiation therapy in APL cells. Tretinoin 132-145 death associated protein kinase 2 Homo sapiens 49-54 28978663-2 2017 In this study, we aimed at further understanding DAPK2 function and regulation during arsenic trioxide (ATO) cytotoxic or all-trans retinoic acid (ATRA) differentiation therapy in APL cells. Tretinoin 147-151 death associated protein kinase 2 Homo sapiens 49-54 28978663-6 2017 In contrast, the p73-DAPK2 pathway is essential for ATRA-induced autophagy that is mediated by an interaction of DAPK2 with the key autophagy-related protein (ATG)5. Tretinoin 52-56 death associated protein kinase 2 Homo sapiens 21-26 28978663-6 2017 In contrast, the p73-DAPK2 pathway is essential for ATRA-induced autophagy that is mediated by an interaction of DAPK2 with the key autophagy-related protein (ATG)5. Tretinoin 52-56 death associated protein kinase 2 Homo sapiens 113-118 28978663-7 2017 Lastly, we show that DAPK2 binds and stabilizes the p73 protein; thus, we propose a novel mechanism by which ATO- or ATRA-induced therapy responses initiate a positive p73-DAPK2 feedback loop. Tretinoin 117-121 death associated protein kinase 2 Homo sapiens 21-26 28978663-7 2017 Lastly, we show that DAPK2 binds and stabilizes the p73 protein; thus, we propose a novel mechanism by which ATO- or ATRA-induced therapy responses initiate a positive p73-DAPK2 feedback loop. Tretinoin 117-121 death associated protein kinase 2 Homo sapiens 172-177 24038216-3 2014 DAPK2 levels were restored in APL patients undergoing ATRA therapy. Tretinoin 54-58 death associated protein kinase 2 Homo sapiens 0-5 20096012-0 2010 Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2. Tretinoin 102-115 death associated protein kinase 2 Homo sapiens 155-188 20096012-6 2010 Moreover, combined ATRA and EGCG treatment resulted in cooperative DAPK2 induction and potentiated differentiation. Tretinoin 19-23 death associated protein kinase 2 Homo sapiens 67-72 17347302-5 2007 In addition, all-trans retinoic acid (ATRA)-induced neutrophil differentiation of two leukemic cell lines, NB4 and U937, revealed significantly higher DAPK2 mRNA expression paralleled by protein induction. Tretinoin 13-36 death associated protein kinase 2 Homo sapiens 151-156 17347302-5 2007 In addition, all-trans retinoic acid (ATRA)-induced neutrophil differentiation of two leukemic cell lines, NB4 and U937, revealed significantly higher DAPK2 mRNA expression paralleled by protein induction. Tretinoin 38-42 death associated protein kinase 2 Homo sapiens 151-156 17347302-8 2007 Lentiviral vector-mediated expression of DAPK2 in NB4 cells enhanced, whereas small interfering RNA-mediated DAPK2 knockdown reduced ATRA-induced granulocytic differentiation, as evidenced by morphology and neutrophil stage-specific maturation genes, such as CD11b, G-CSF receptor, C/EBPepsilon, and lactoferrin. Tretinoin 133-137 death associated protein kinase 2 Homo sapiens 109-114