PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2484657-7 1989 Treatment of P19 cells with retinoic acid resulted in a decrease in the expression of Thy-1 antigen which preceded changes in morphology of the cells. Tretinoin 28-41 interleukin 23, alpha subunit p19 Mus musculus 13-16 2674852-2 1989 P19 cells are induced to differentiate into neurons, astrocytes and fibroblast-like cells following exposure to retinoic acid (RA). Tretinoin 112-125 interleukin 23, alpha subunit p19 Mus musculus 0-3 2674852-2 1989 P19 cells are induced to differentiate into neurons, astrocytes and fibroblast-like cells following exposure to retinoic acid (RA). Tretinoin 127-129 interleukin 23, alpha subunit p19 Mus musculus 0-3 2674852-6 1989 Nuclear run-on transcription assays showed that int-1 expression in RA-treated P19 cells was induced at the transcriptional level. Tretinoin 68-70 interleukin 23, alpha subunit p19 Mus musculus 79-82 2458954-4 1988 In contrast, P19 cells showed increased levels of both mRNAs both mRNAs when induced to differentiate along the neural pathway by retinoic acid, whereas differentiation along the muscle pathway by dimethyl sulfoxide resulted in decreased levels of c-abl expression. Tretinoin 130-143 interleukin 23, alpha subunit p19 Mus musculus 13-16 3078960-1 1988 Mouse embryonal carcinoma (EC) cells of the P19 line can be induced to differentiate into neurons, astrocytes and fibroblasts by exposure to retinoic acid (RA), whereas treatment of the EC cells with dimethyl sulfoxide (DMSO) leads to differentiation into mesodermal tissues, including cardiac and skeletal muscle. Tretinoin 141-154 interleukin 23, alpha subunit p19 Mus musculus 44-47 3078960-1 1988 Mouse embryonal carcinoma (EC) cells of the P19 line can be induced to differentiate into neurons, astrocytes and fibroblasts by exposure to retinoic acid (RA), whereas treatment of the EC cells with dimethyl sulfoxide (DMSO) leads to differentiation into mesodermal tissues, including cardiac and skeletal muscle. Tretinoin 156-158 interleukin 23, alpha subunit p19 Mus musculus 44-47 32209473-5 2020 Administration of RA in DC-specific CD137-/- mice represses IL-23-producing CD11b+CD103- DCs and TH17 cells, indicating that RA is a major inhibitory effector molecule against intestinal CD11b+CD103- DCs. Tretinoin 18-20 interleukin 23, alpha subunit p19 Mus musculus 60-65 2997185-0 1985 An increase in prolyl-4-hydroxylase activity occurs during the retinoic acid-induced differentiation of mouse teratocarcinoma stem cell lines F9 and P19. Tretinoin 63-76 interleukin 23, alpha subunit p19 Mus musculus 149-152 2997185-1 1985 Monolayer cultures of F9 teratocarcinoma stem cells and P19 stem cells differentiate into endoderm, and fibroblast-like cells, respectively, when treated with retinoic acid. Tretinoin 159-172 interleukin 23, alpha subunit p19 Mus musculus 56-59 3595420-2 1987 The aggregates of P19, a mouse EC cell line, undergo differentiation and rapidly lose its colony-forming ability in culture with retinoic acid (RA) or DMSO. Tretinoin 129-142 interleukin 23, alpha subunit p19 Mus musculus 18-21 3595420-2 1987 The aggregates of P19, a mouse EC cell line, undergo differentiation and rapidly lose its colony-forming ability in culture with retinoic acid (RA) or DMSO. Tretinoin 144-146 interleukin 23, alpha subunit p19 Mus musculus 18-21 24583076-1 2014 BACKGROUND: P19 mouse embryonic carcinoma cells are conventionally induced to differentiate into neural cells by suspension culture in the presence of retinoic acid to form cell aggregates, followed by adhesion culture in a poly-l-lysine-coated dish. Tretinoin 151-164 interleukin 23, alpha subunit p19 Mus musculus 12-15 31081818-2 2019 In the presence of retinoic acid (RA), the suspension cultured P19 cell line is induced to differentiate into neurons. Tretinoin 19-32 interleukin 23, alpha subunit p19 Mus musculus 63-66 31081818-2 2019 In the presence of retinoic acid (RA), the suspension cultured P19 cell line is induced to differentiate into neurons. Tretinoin 34-36 interleukin 23, alpha subunit p19 Mus musculus 63-66 30030768-2 2018 Most protocols developed so far for directing neural differentiation of P19 cells depend on the use of culture medium supplemented with retinoic acid (RA) and serum, which has an undefined composition. Tretinoin 136-149 interleukin 23, alpha subunit p19 Mus musculus 72-75 30030768-2 2018 Most protocols developed so far for directing neural differentiation of P19 cells depend on the use of culture medium supplemented with retinoic acid (RA) and serum, which has an undefined composition. Tretinoin 151-153 interleukin 23, alpha subunit p19 Mus musculus 72-75 30030768-4 2018 In this study, we achieved neural differentiation of P19 cells in a serum- and RA-free culture medium by employing the knockout serum replacement (KSR) supplement. Tretinoin 79-81 interleukin 23, alpha subunit p19 Mus musculus 53-56 27306567-0 2017 Retinoic Acid Signaling in P19 Stem Cell Differentiation. Tretinoin 0-13 interleukin 23, alpha subunit p19 Mus musculus 27-30 27306567-5 2017 P19 ES cells can differentiate to endodermal-like, mesodermal-like, and neuronal-like phenotypes in response to specific morphogens including RA and dimethyl sulfoxide (DMSO). Tretinoin 142-144 interleukin 23, alpha subunit p19 Mus musculus 0-3 27306567-6 2017 At low concentrations, RA directs P19 ES cells to differentiate into cells displaying an endodermal phenotype, whereas at higher concentrations it induces differentiation to neuroectoderm. Tretinoin 23-25 interleukin 23, alpha subunit p19 Mus musculus 34-37 27306567-10 2017 In addition to summarizing the reports on gene/protein targets of RA in stem cells, the signaling pathways driven by some of the specific class of proteins in the presence or absence of RA in P19 ES cell differentiation, especially to an endodermal phenotype, are the focus of this review. Tretinoin 186-188 interleukin 23, alpha subunit p19 Mus musculus 192-195 27089940-4 2016 We found that RA had a dramatic suppressive effect on IL-17A and IL-17F production by gammadelta T cells stimulated with IL-1beta and IL-23. Tretinoin 14-16 interleukin 23, alpha subunit p19 Mus musculus 134-139 23011767-5 2012 We later showed that ATA significantly enhanced the attachment of the retinoic acid differentiated P19 mouse embryonal carcinoma (P19) neurons, with an optimal concentration around 30 mug/mL. Tretinoin 70-83 interleukin 23, alpha subunit p19 Mus musculus 99-102 23011767-5 2012 We later showed that ATA significantly enhanced the attachment of the retinoic acid differentiated P19 mouse embryonal carcinoma (P19) neurons, with an optimal concentration around 30 mug/mL. Tretinoin 70-83 interleukin 23, alpha subunit p19 Mus musculus 130-133 21672091-0 2011 Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells. Tretinoin 48-61 interleukin 23, alpha subunit p19 Mus musculus 126-129 22973984-2 2012 P19 mouse embryonal carcinoma cells can differentiate into neurons when cultured in aggregates and induced with RA (retinoic acid). Tretinoin 112-114 interleukin 23, alpha subunit p19 Mus musculus 0-3 22973984-2 2012 P19 mouse embryonal carcinoma cells can differentiate into neurons when cultured in aggregates and induced with RA (retinoic acid). Tretinoin 116-129 interleukin 23, alpha subunit p19 Mus musculus 0-3 22973984-5 2012 P27KIP1 was up-regulated during the differentiation process of both P19/ADAM23KD cells without RA induction, and P19 cells with RA induction. Tretinoin 128-130 interleukin 23, alpha subunit p19 Mus musculus 113-116 22973984-7 2012 The findings indicate that ADAM23 suppresses neuronal differentiation through its disintegrin domain, and Adam23 KD up-regulates P27KIP1 in P19/ADAM23KD cells, one reason that P19/ADAM23KD cells can differentiate into neurons without RA induction. Tretinoin 234-236 interleukin 23, alpha subunit p19 Mus musculus 140-143 22973984-7 2012 The findings indicate that ADAM23 suppresses neuronal differentiation through its disintegrin domain, and Adam23 KD up-regulates P27KIP1 in P19/ADAM23KD cells, one reason that P19/ADAM23KD cells can differentiate into neurons without RA induction. Tretinoin 234-236 interleukin 23, alpha subunit p19 Mus musculus 176-179 21672091-9 2011 These results suggest that Sp1 plays a critical role in RA-induced CADM1 expression through possible interaction with RARalpha in the neural differentiation of P19. Tretinoin 56-58 interleukin 23, alpha subunit p19 Mus musculus 160-163 21362455-6 2011 Overexpressed p53 induces marked DUOXA1 expression in P19 cells and intensifies neuronal differentiation in the presence of retinoic acid, which suggests that p53 and DUOXA1 possess a neural differentiation potential. Tretinoin 124-137 interleukin 23, alpha subunit p19 Mus musculus 54-57 19814781-4 2009 Thus, the purpose of this study is to examine the molecular mechanisms by which RA enhances skeletal myogenesis and interacts with Wnt and BMP4 signalling during P19 or mouse embryonic stem (ES) cell differentiation. Tretinoin 80-82 interleukin 23, alpha subunit p19 Mus musculus 162-165 19814781-5 2009 RESULTS: Treatment of P19 or mouse ES cells with low levels of RA led to an enhancement of skeletal myogenesis by upregulating the expression of the mesodermal marker, Wnt3a, the skeletal muscle progenitor factors Pax3 and Meox1, and the myogenic regulatory factors (MRFs) MyoD and myogenin. Tretinoin 63-65 interleukin 23, alpha subunit p19 Mus musculus 22-25 19275242-2 2009 P19 mouse embryonic carcinoma cells can differentiate into neural cells by the addition of retinoic acid (RA) or by overexpression of the Wnt1 gene, with both processes dependent on cell aggregation. Tretinoin 91-104 interleukin 23, alpha subunit p19 Mus musculus 0-3 19244314-5 2009 These molecules regulate Cdc42 and p38MAPK activities, which increase in a Cdo-dependent manner during neuronal differentiation of C17.2 cells and retinoic acid-treated P19 cells. Tretinoin 147-160 interleukin 23, alpha subunit p19 Mus musculus 169-172 19275242-2 2009 P19 mouse embryonic carcinoma cells can differentiate into neural cells by the addition of retinoic acid (RA) or by overexpression of the Wnt1 gene, with both processes dependent on cell aggregation. Tretinoin 106-108 interleukin 23, alpha subunit p19 Mus musculus 0-3 19275242-9 2009 Silencing of NDRG1 reduced the size of cell aggregates and the expression of N-cadherin, and it also impaired the RA-induced P19 cell neural differentiation. Tretinoin 114-116 interleukin 23, alpha subunit p19 Mus musculus 125-128 17622165-0 2007 A differential phosphoproteomic analysis of retinoic acid-treated P19 cells. Tretinoin 44-57 interleukin 23, alpha subunit p19 Mus musculus 66-69 18987612-3 2008 For this reason, the modification of retinoic acid (RA) induced neuronal differentiation of mouse embryonal carcinoma cells P19 by selected ROS scavengers and flavoprotein inhibitor was evaluated. Tretinoin 37-50 interleukin 23, alpha subunit p19 Mus musculus 124-127 18987612-3 2008 For this reason, the modification of retinoic acid (RA) induced neuronal differentiation of mouse embryonal carcinoma cells P19 by selected ROS scavengers and flavoprotein inhibitor was evaluated. Tretinoin 52-54 interleukin 23, alpha subunit p19 Mus musculus 124-127 16889372-2 2006 When treated with retinoic acid, P19 cells can be differentiated along a neural cell lineage in culture. Tretinoin 18-31 interleukin 23, alpha subunit p19 Mus musculus 33-36 14511111-4 2003 After retinoic acid (RA) treatment and in the absence of doxycycline, neuronal progenitor cells in the p19 clone were found to extend their processes towards the neighboring colony to form network-like connections, as revealed by neuron-specific microtubule-associated protein 2 staining and laser scanning confocal microscopy. Tretinoin 6-19 interleukin 23, alpha subunit p19 Mus musculus 103-106 16477621-2 2006 This study was undertaken to investigate the expression of CB1 and CB2 cannabinoid receptors in neurons that develop from retinoic acid (RA)-primed mouse P19 embryonal carcinoma cells. Tretinoin 122-135 interleukin 23, alpha subunit p19 Mus musculus 154-157 16477621-2 2006 This study was undertaken to investigate the expression of CB1 and CB2 cannabinoid receptors in neurons that develop from retinoic acid (RA)-primed mouse P19 embryonal carcinoma cells. Tretinoin 137-139 interleukin 23, alpha subunit p19 Mus musculus 154-157 16477621-3 2006 Both undifferentiated P19 cells and RA-treated P19 neurons were positive, by using reverse transcription-polymerase chain reaction (RT-PCR), for CB1 (but not CB2) mRNA. Tretinoin 36-38 interleukin 23, alpha subunit p19 Mus musculus 47-50 16142318-1 2005 The P19 mouse embryonal carcinoma cell line was used as a model for a study of apoptosis accompanying differentiation induced by all-trans retinoic acid (ATRA). Tretinoin 129-152 interleukin 23, alpha subunit p19 Mus musculus 4-7 16142318-1 2005 The P19 mouse embryonal carcinoma cell line was used as a model for a study of apoptosis accompanying differentiation induced by all-trans retinoic acid (ATRA). Tretinoin 154-158 interleukin 23, alpha subunit p19 Mus musculus 4-7 15762294-0 2004 DNA rearrangement activity during retinoic acid-induced neural differentiation of P19 mouse embryonal carcinoma cells. Tretinoin 34-47 interleukin 23, alpha subunit p19 Mus musculus 82-85 14511111-4 2003 After retinoic acid (RA) treatment and in the absence of doxycycline, neuronal progenitor cells in the p19 clone were found to extend their processes towards the neighboring colony to form network-like connections, as revealed by neuron-specific microtubule-associated protein 2 staining and laser scanning confocal microscopy. Tretinoin 21-23 interleukin 23, alpha subunit p19 Mus musculus 103-106 10929206-1 2000 Exposure of aggregated murine P19 embryonal carcinoma cells to dimethylsulfoxide (DMSO) induces mesoderm and both embryonic cardiac and skeletal muscle differentiation, while retinoic acid (RA) is an inducer of neuroectodermal differentiation. Tretinoin 175-188 interleukin 23, alpha subunit p19 Mus musculus 30-33 11092879-7 2001 It is proposed that in an RA-induced P19 differentiation model, RA elevates Ik-1 expression, which recruits histone deacetylase to intron 1 of the KOR gene and silences KOR gene promoters. Tretinoin 26-28 interleukin 23, alpha subunit p19 Mus musculus 37-40 10807954-0 2000 Characterization of the mouse nuclear orphan receptor TR2-11 gene promoter and its potential role in retinoic acid-induced P19 apoptosis. Tretinoin 101-114 interleukin 23, alpha subunit p19 Mus musculus 123-126 10807954-7 2000 In P19 cells, both the endogenous TR2-11 gene and the reporters driven by this promoter were induced by RA in a protein synthesis-independent manner, and overexpression of TR2-11 protein resulted in cellular apoptosis in the absence of RA. Tretinoin 104-106 interleukin 23, alpha subunit p19 Mus musculus 3-6 10929206-1 2000 Exposure of aggregated murine P19 embryonal carcinoma cells to dimethylsulfoxide (DMSO) induces mesoderm and both embryonic cardiac and skeletal muscle differentiation, while retinoic acid (RA) is an inducer of neuroectodermal differentiation. Tretinoin 190-192 interleukin 23, alpha subunit p19 Mus musculus 30-33 10929206-2 2000 P19 cells constitutively express the retinoic acid receptor alpha (RAR alpha) and RAR gamma mRNAs while RAR beta expression is induced by RA through a consensus RA-response element in the RAR beta promoter. Tretinoin 67-69 interleukin 23, alpha subunit p19 Mus musculus 0-3 10929206-2 2000 P19 cells constitutively express the retinoic acid receptor alpha (RAR alpha) and RAR gamma mRNAs while RAR beta expression is induced by RA through a consensus RA-response element in the RAR beta promoter. Tretinoin 82-84 interleukin 23, alpha subunit p19 Mus musculus 0-3 10929206-3 2000 In the present study we show that the RAR beta transcript is strongly expressed in both P19 cells and in a RA-nonresponsive derivative of P19 cells, called RAC65, during DMSO-induced mesoderm and muscle differentiation. Tretinoin 38-40 interleukin 23, alpha subunit p19 Mus musculus 88-91 10929206-3 2000 In the present study we show that the RAR beta transcript is strongly expressed in both P19 cells and in a RA-nonresponsive derivative of P19 cells, called RAC65, during DMSO-induced mesoderm and muscle differentiation. Tretinoin 38-40 interleukin 23, alpha subunit p19 Mus musculus 138-141 10929206-8 2000 RA treatment of P19 cells stably transfected with the RA-responsive element from the RAR beta gene showed that RAR beta 2 mRNA expression during DMSO differentiation was associated with increased sensitivity to RA. Tretinoin 0-2 interleukin 23, alpha subunit p19 Mus musculus 16-19 10715587-11 2000 In this study, P19 cells were driven to the neuronal pathway with retinoic acid. Tretinoin 66-79 interleukin 23, alpha subunit p19 Mus musculus 15-18 10798446-7 2000 The expression of ZAN75 was transiently increased at both the mRNA and the protein levels when P19 cells were treated with retinoic acid to induce neuronal differentiation. Tretinoin 123-136 interleukin 23, alpha subunit p19 Mus musculus 95-98 10320792-6 1999 During the differentiation of mouse carcinoma cells P19 to neuron-like cells by retinoic acid, Bdm1 mRNA was up-regulated almost parallel to neurofilament mRNA. Tretinoin 80-93 interleukin 23, alpha subunit p19 Mus musculus 52-55 10712606-5 2000 We searched for a suitable cell line expressing the MT-3 gene to be used for determination of MT-3 promoter tissue specificity, and showed that MT-3 expression is activated during neuroectodermal differentiation of P19 cells induced by retinoic acid to levels similar to those found in whole brain. Tretinoin 236-249 interleukin 23, alpha subunit p19 Mus musculus 215-218 10929206-8 2000 RA treatment of P19 cells stably transfected with the RA-responsive element from the RAR beta gene showed that RAR beta 2 mRNA expression during DMSO differentiation was associated with increased sensitivity to RA. Tretinoin 54-56 interleukin 23, alpha subunit p19 Mus musculus 16-19 10929206-8 2000 RA treatment of P19 cells stably transfected with the RA-responsive element from the RAR beta gene showed that RAR beta 2 mRNA expression during DMSO differentiation was associated with increased sensitivity to RA. Tretinoin 54-56 interleukin 23, alpha subunit p19 Mus musculus 16-19 10426553-1 1999 P19 embryonal carcinoma cells are pluripotential and able to differentiate into a variety of cell types, including neurons, glia and fibroblast-like cells, upon retinoic acid treatment and cellular aggregation. Tretinoin 161-174 interleukin 23, alpha subunit p19 Mus musculus 0-3 10079512-6 1999 We used the mouse P19 embryonal carcinoma cell line, which differentiates into neurons and astrocytes upon retinoic acid (RA) induction. Tretinoin 107-120 interleukin 23, alpha subunit p19 Mus musculus 18-21 11367680-5 1998 However, immunostaining data showed that beta-catenin was translocalized into nuclei after retinoic acid induced P19 cell aggregates were trypsinized and cultured in serum free N2 medium for 2 and 4 d. In this period, transcription of En-2, a downstream target gene of Wnt signal, increased evidently. Tretinoin 91-104 interleukin 23, alpha subunit p19 Mus musculus 113-116 9331505-1 1997 Serum-free culture conditions for retinoic acid-induced neural differentiation of mouse P19 embryonal carcinoma cells were determined for future ex vivo retroviral gene transfer and brain transplantation studies. Tretinoin 34-47 interleukin 23, alpha subunit p19 Mus musculus 88-91 9425271-9 1997 These results show that RA but not DMSO induces the expression of GM3, GD3, GT1b and GQ1b synthases, and particularly GD3 synthase mRNA, in the ganglioside biosynthetic pathway during the neural differentiation of embryonic carcinoma P19 cells. Tretinoin 24-26 interleukin 23, alpha subunit p19 Mus musculus 234-237 9305907-0 1997 Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid. Tretinoin 100-113 interleukin 23, alpha subunit p19 Mus musculus 49-52 9305907-2 1997 At low concentrations, retinoic acid stimulates P19 embryonal cells to differentiate to cells displaying an endodermal phenotype, whereas at higher concentrations it stimulates differentiation to neuroectoderm. Tretinoin 23-36 interleukin 23, alpha subunit p19 Mus musculus 48-51 9261178-11 1997 Furthermore, we demonstrated, using mouse P19 embryonal carcinoma cells, that this 371-base pair sequence is likely to be sufficient to confer the transcriptional activation of the ERK2 promoter during the retinoic acid-induced differentiation of P19 cells. Tretinoin 206-219 interleukin 23, alpha subunit p19 Mus musculus 42-45 9261178-11 1997 Furthermore, we demonstrated, using mouse P19 embryonal carcinoma cells, that this 371-base pair sequence is likely to be sufficient to confer the transcriptional activation of the ERK2 promoter during the retinoic acid-induced differentiation of P19 cells. Tretinoin 206-219 interleukin 23, alpha subunit p19 Mus musculus 247-250 9207922-1 1997 Apoptotic cell death was observed during aggregate culture of the mouse embryonal carcinoma cell line P19 exposed to all-trans retinoic acid (tRA). Tretinoin 127-140 interleukin 23, alpha subunit p19 Mus musculus 102-105 9207922-1 1997 Apoptotic cell death was observed during aggregate culture of the mouse embryonal carcinoma cell line P19 exposed to all-trans retinoic acid (tRA). Tretinoin 142-145 interleukin 23, alpha subunit p19 Mus musculus 102-105 8660922-1 1996 A 2.8-kb cDNA encoding a new transcription factor (AP-2.2) has been cloned from mouse P19 embryonal carcinoma cells, in which the corresponding mRNA begins to accumulate 30 min after retinoic acid (RA) addition. Tretinoin 183-196 interleukin 23, alpha subunit p19 Mus musculus 86-89 9051263-1 1997 The mouse EC cell line P19, differentiating in vitro into neural cell types under the influence of retinoic acid, represents a well established model system for neurogenesis. Tretinoin 99-112 interleukin 23, alpha subunit p19 Mus musculus 23-26 8824230-1 1996 Mouse P19 embryonal carcinoma cells in aggregation culture in the presence of 10(-6) M retinoic acid followed by monolayer culture differentiate into nerve and glial cells. Tretinoin 87-100 interleukin 23, alpha subunit p19 Mus musculus 6-9 9305908-1 1997 Retinoic acid induces P19 mouse embryonal carcinoma cells to differentiate to endoderm and increases expression of the heterotrimeric G-protein subunits Galpha12 and Galpha13. Tretinoin 0-13 interleukin 23, alpha subunit p19 Mus musculus 22-25 8660922-1 1996 A 2.8-kb cDNA encoding a new transcription factor (AP-2.2) has been cloned from mouse P19 embryonal carcinoma cells, in which the corresponding mRNA begins to accumulate 30 min after retinoic acid (RA) addition. Tretinoin 198-200 interleukin 23, alpha subunit p19 Mus musculus 86-89 8710207-1 1996 P19 embryonal carcinoma cells differentiate into neuroectodermal derivates upon aggregation and treatment with retinoic acid (RA). Tretinoin 111-124 interleukin 23, alpha subunit p19 Mus musculus 0-3 8710207-1 1996 P19 embryonal carcinoma cells differentiate into neuroectodermal derivates upon aggregation and treatment with retinoic acid (RA). Tretinoin 126-128 interleukin 23, alpha subunit p19 Mus musculus 0-3 8710207-2 1996 Such RA-induced P19 cells, concomitant with neuronal differentiation, produce the neuropeptide head activator (HA) and release HA into the culture medium. Tretinoin 5-7 interleukin 23, alpha subunit p19 Mus musculus 16-19 8603926-1 1996 We report here that all trans-retinoic acid (RA), a classical morphogen, induces apoptosis during the neural differentiation of the embryonic stem cell line P19. Tretinoin 24-43 interleukin 23, alpha subunit p19 Mus musculus 157-160 8593698-5 1996 Under chemical induction of high concentrations of retinoic acid (1 micromol/L), P19 cells showed optimum differentiation into SMCs. Tretinoin 51-64 interleukin 23, alpha subunit p19 Mus musculus 81-84 8603926-1 1996 We report here that all trans-retinoic acid (RA), a classical morphogen, induces apoptosis during the neural differentiation of the embryonic stem cell line P19. Tretinoin 45-47 interleukin 23, alpha subunit p19 Mus musculus 157-160 8558234-3 1996 Within 2-3 weeks after induction by retinoic acid, subsets of P19 and ES cells formed excitatory synapses, mediated by glutamate receptors, or inhibitory synapses, mediated by receptors for GABA or glycine. Tretinoin 36-49 interleukin 23, alpha subunit p19 Mus musculus 62-65 8185572-1 1994 The pluripotent mouse embryonal carcinoma cell line P19 provides an excellent model system to study the mechanisms by which retinoic acid (RA) exerts its biological effects. Tretinoin 124-137 interleukin 23, alpha subunit p19 Mus musculus 52-55 7476016-0 1995 Cloning of a retinoic acid-induced gene, GT1, in the embryonal carcinoma cell line P19: neuron-specific expression in the mouse brain. Tretinoin 13-26 interleukin 23, alpha subunit p19 Mus musculus 83-86 7476016-1 1995 Mouse P19 embryonal carcinoma cells can be reproducibly differentiated into neurons and glial cells upon treatment with high concentrations of retinoic acid (RA). Tretinoin 143-156 interleukin 23, alpha subunit p19 Mus musculus 6-9 7476016-1 1995 Mouse P19 embryonal carcinoma cells can be reproducibly differentiated into neurons and glial cells upon treatment with high concentrations of retinoic acid (RA). Tretinoin 158-160 interleukin 23, alpha subunit p19 Mus musculus 6-9 8185572-1 1994 The pluripotent mouse embryonal carcinoma cell line P19 provides an excellent model system to study the mechanisms by which retinoic acid (RA) exerts its biological effects. Tretinoin 139-141 interleukin 23, alpha subunit p19 Mus musculus 52-55 8185572-2 1994 When aggregated and exposed to low concentrations of RA, P19 cells differentiate into neuron- and glial-like cells. Tretinoin 53-55 interleukin 23, alpha subunit p19 Mus musculus 57-60 8388815-4 1993 In this paper we demonstrate that met/HGF/SFR mRNA, protein, and its ligand are expressed at a low level in undifferentiated P19 cells and that their expression is increased as P19 cells are induced to differentiate into neuroectodermal derivatives following treatment with retinoic acid (RA) and into mesodermal derivatives following treatment with dimethyl sulfoxide (DMSO). Tretinoin 274-287 interleukin 23, alpha subunit p19 Mus musculus 177-180 1282809-3 1992 Undifferentiated P19 cells are completely devoid of lamins A and C. We show that undifferentiated P19 cells contain low, but detectable steady-state levels of RNAs for lamins A and C that begin to increase by 24 h of retinoic acid-induced differentiation. Tretinoin 217-230 interleukin 23, alpha subunit p19 Mus musculus 98-101 1467987-0 1992 Chronological expression of microtubule-associated proteins (MAPs) in EC cell P19 after neuronal induction by retinoic acid. Tretinoin 110-123 interleukin 23, alpha subunit p19 Mus musculus 78-81 1467987-1 1992 Pluripotent murine embryonal carcinoma (EC) P19 cells are induced at a high rate into neural cells using retinoic acid and serum-free medium. Tretinoin 105-118 interleukin 23, alpha subunit p19 Mus musculus 44-47 1360646-2 1992 We found that the mouse embryonal carcinoma cell line P19 expresses Hox-2.5 during differentiation by the treatment with retinoic acid (RA). Tretinoin 121-134 interleukin 23, alpha subunit p19 Mus musculus 54-57