PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19799567-5 2009 By functional analysis we also showed that mutations of the PBX1/MEIS1-binding sites resulted in profound reduction of SOX3 promoter responsiveness to RA. Tretinoin 151-153 SRY-box transcription factor 3 Homo sapiens 119-123 17910945-7 2007 Further, our results indicate that these elements can be recognized as modulators of retinoic acid induced activation of SOX3 expression. Tretinoin 85-98 SRY-box transcription factor 3 Homo sapiens 121-125 18786169-2 2008 We have previously shown that early phases of differentiation and neural induction of NT2/D1 embryonal carcinoma cells by retinoic acid (RA) involve up-regulation of the SOX3 gene expression. Tretinoin 122-135 SRY-box transcription factor 3 Homo sapiens 170-174 18786169-2 2008 We have previously shown that early phases of differentiation and neural induction of NT2/D1 embryonal carcinoma cells by retinoic acid (RA) involve up-regulation of the SOX3 gene expression. Tretinoin 137-139 SRY-box transcription factor 3 Homo sapiens 170-174 18786169-3 2008 Here, we present identification of a novel positive regulatory promoter element involved in RA-dependent activation of the SOX3 gene expression in NT2/D1 cells. Tretinoin 92-94 SRY-box transcription factor 3 Homo sapiens 123-127 18786169-5 2008 It is capable of independently mediating the RA effect in a heterologous promoter context and its disruption caused significant reduction of RA/RXR transactivation of the SOX3 promoter. Tretinoin 45-47 SRY-box transcription factor 3 Homo sapiens 171-175 18786169-6 2008 Furthermore, by using synthetic antagonists of retinoid receptors, we have shown for the first time, that RA-induced SOX3 gene expression could be significantly down-regulated by the synthetic antagonist of RXR. Tretinoin 106-108 SRY-box transcription factor 3 Homo sapiens 117-121 17005281-0 2006 Mapping of the RXRalpha binding elements involved in retinoic acid induced transcriptional activation of the human SOX3 gene. Tretinoin 53-66 SRY-box transcription factor 3 Homo sapiens 115-119 17005281-9 2006 Since it is proven that Sox3 is critical determinant of neurogenesis our data may help in providing new insight into complex regulatory networks involved in retinoic acid induced neural differentiation of NT2/D1 cells. Tretinoin 157-170 SRY-box transcription factor 3 Homo sapiens 24-28 25802994-5 2015 We have previously shown that the early phases of neural induction of these cells by RA involve the up-regulation of SOX3 gene expression. Tretinoin 85-87 SRY-box transcription factor 3 Homo sapiens 117-121 25802994-6 2015 Our goal was to compare RA-induced differentiation of NT2/D1 cells in serum-containing and serum-free media, by using SOX3 protein levels as a marker of differentiation. Tretinoin 24-26 SRY-box transcription factor 3 Homo sapiens 118-122 25802994-8 2015 However, six days of RA treatment resulted in a marked increase in SOX3 protein levels in serum-free media compared to serum-containing media, indicating that serum might have an inhibitory effect on the expression of this neural differentiation marker. Tretinoin 21-23 SRY-box transcription factor 3 Homo sapiens 67-71 21777018-3 2011 This review is focused on the retinoic acid induced regulation of SOX3 gene expression, with particular emphasis on the involvement of retinoid receptors. Tretinoin 30-43 SRY-box transcription factor 3 Homo sapiens 66-70 12841584-6 2003 In this study it is shown for the first time that the retinoic acid-induced neuronal differentiation of NTERA2 cells is accompanied by down-regulation of SOX2 and up-regulation of SOX3 gene during early phases of induction. Tretinoin 54-67 SRY-box transcription factor 3 Homo sapiens 180-184 12841584-7 2003 These data suggest that the effects of retinoic acid on neural differentiation of NTERA2 EC cells might be mediated by modulation of SOX2 and SOX3 gene expression. Tretinoin 39-52 SRY-box transcription factor 3 Homo sapiens 142-146