PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25802994-5	2015	We have previously shown that the early phases of neural induction of these cells by RA involve the up-regulation of SOX3 gene expression.	Tretinoin	85-87	SRY-box transcription factor 3	Homo sapiens	117-121	
25802994-6	2015	Our goal was to compare RA-induced differentiation of NT2/D1 cells in serum-containing and serum-free media, by using SOX3 protein levels as a marker of differentiation.	Tretinoin	24-26	SRY-box transcription factor 3	Homo sapiens	118-122	
25802994-8	2015	However, six days of RA treatment resulted in a marked increase in SOX3 protein levels in serum-free media compared to serum-containing media, indicating that serum might have an inhibitory effect on the expression of this neural differentiation marker.	Tretinoin	21-23	SRY-box transcription factor 3	Homo sapiens	67-71	
19799567-5	2009	By functional analysis we also showed that mutations of the PBX1/MEIS1-binding sites resulted in profound reduction of SOX3 promoter responsiveness to RA.	Tretinoin	151-153	SRY-box transcription factor 3	Homo sapiens	119-123	
21777018-3	2011	This review is focused on the retinoic acid induced regulation of SOX3 gene expression, with particular emphasis on the involvement of retinoid receptors.	Tretinoin	30-43	SRY-box transcription factor 3	Homo sapiens	66-70	
18786169-2	2008	We have previously shown that early phases of differentiation and neural induction of NT2/D1 embryonal carcinoma cells by retinoic acid (RA) involve up-regulation of the SOX3 gene expression.	Tretinoin	122-135	SRY-box transcription factor 3	Homo sapiens	170-174	
18786169-2	2008	We have previously shown that early phases of differentiation and neural induction of NT2/D1 embryonal carcinoma cells by retinoic acid (RA) involve up-regulation of the SOX3 gene expression.	Tretinoin	137-139	SRY-box transcription factor 3	Homo sapiens	170-174	
18786169-3	2008	Here, we present identification of a novel positive regulatory promoter element involved in RA-dependent activation of the SOX3 gene expression in NT2/D1 cells.	Tretinoin	92-94	SRY-box transcription factor 3	Homo sapiens	123-127	
18786169-5	2008	It is capable of independently mediating the RA effect in a heterologous promoter context and its disruption caused significant reduction of RA/RXR transactivation of the SOX3 promoter.	Tretinoin	45-47	SRY-box transcription factor 3	Homo sapiens	171-175	
18786169-6	2008	Furthermore, by using synthetic antagonists of retinoid receptors, we have shown for the first time, that RA-induced SOX3 gene expression could be significantly down-regulated by the synthetic antagonist of RXR.	Tretinoin	106-108	SRY-box transcription factor 3	Homo sapiens	117-121	
17910945-7	2007	Further, our results indicate that these elements can be recognized as modulators of retinoic acid induced activation of SOX3 expression.	Tretinoin	85-98	SRY-box transcription factor 3	Homo sapiens	121-125	
17005281-0	2006	Mapping of the RXRalpha binding elements involved in retinoic acid induced transcriptional activation of the human SOX3 gene.	Tretinoin	53-66	SRY-box transcription factor 3	Homo sapiens	115-119	
17005281-9	2006	Since it is proven that Sox3 is critical determinant of neurogenesis our data may help in providing new insight into complex regulatory networks involved in retinoic acid induced neural differentiation of NT2/D1 cells.	Tretinoin	157-170	SRY-box transcription factor 3	Homo sapiens	24-28	
12841584-6	2003	In this study it is shown for the first time that the retinoic acid-induced neuronal differentiation of NTERA2 cells is accompanied by down-regulation of SOX2 and up-regulation of SOX3 gene during early phases of induction.	Tretinoin	54-67	SRY-box transcription factor 3	Homo sapiens	180-184	
12841584-7	2003	These data suggest that the effects of retinoic acid on neural differentiation of NTERA2 EC cells might be mediated by modulation of SOX2 and SOX3 gene expression.	Tretinoin	39-52	SRY-box transcription factor 3	Homo sapiens	142-146