PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9186002-8 1997 ATRA treatment of NB4 cells sensitized them to IFN action as seen by increased IFN-gamma activation site DNA-binding activity or by efficient formation of IFN-alpha-specific ISGF3 complex and subsequent oligoadenylate synthetase and MxB gene expression. Tretinoin 0-4 interferon gamma Homo sapiens 79-88 7578267-0 1995 Cooperative effects of interferon-gamma on the induction of NADPH oxidase by retinoic acid or 1,25(OH)2-vitamin D3 in monocytic U937 cells. Tretinoin 77-90 interferon gamma Homo sapiens 23-39 8975882-1 1996 Interferon-gamma (IFN-gamma), vitamin D3 (VD), and retinoic acid (RA) induce differentiation of human monoblastic leukemia U937 cells to macrophage-like cells with potential superoxide anion-generating activity upon further stimulation. Tretinoin 66-68 interferon gamma Homo sapiens 0-16 8975882-1 1996 Interferon-gamma (IFN-gamma), vitamin D3 (VD), and retinoic acid (RA) induce differentiation of human monoblastic leukemia U937 cells to macrophage-like cells with potential superoxide anion-generating activity upon further stimulation. Tretinoin 66-68 interferon gamma Homo sapiens 18-27 8900159-0 1996 Retinoic acid-induced transcriptional modulation of the human interferon-gamma promoter. Tretinoin 0-13 interferon gamma Homo sapiens 62-78 8900159-2 1996 In particular, IFN-gamma gene expression is significantly affected by vitamin A and/or its derivatives (e.g. retinoic acid (RA)). Tretinoin 109-122 interferon gamma Homo sapiens 15-24 8900159-2 1996 In particular, IFN-gamma gene expression is significantly affected by vitamin A and/or its derivatives (e.g. retinoic acid (RA)). Tretinoin 124-126 interferon gamma Homo sapiens 15-24 8900159-3 1996 Here, we analyze the effect of retinoic acid on IFN-gamma transcription. Tretinoin 31-44 interferon gamma Homo sapiens 48-57 8900159-4 1996 Transient transfection assays in the human T lymphoblastoid cell line Jurkat demonstrated that the activation of the IFN-gamma promoter was significantly down-regulated in the presence of RA. Tretinoin 188-190 interferon gamma Homo sapiens 117-126 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 79-92 interferon gamma Homo sapiens 26-42 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 79-92 interferon gamma Homo sapiens 44-53 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 79-92 interferon gamma Homo sapiens 99-108 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 94-96 interferon gamma Homo sapiens 26-42 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 94-96 interferon gamma Homo sapiens 44-53 8615638-2 1996 Recently we reported that interferon-gamma (IFN-gamma) modulates the action of retinoic acid (RA): IFN-gamma increased expression of retinoic acid receptor-gamma (RAR-gamma) and suppressed the increase of retinoic acid binding protein type II (CRABP-II) expression. Tretinoin 94-96 interferon gamma Homo sapiens 99-108 8090031-8 1994 On treatment with various biomodulators, only all-trans retinoic acid significantly upregulated MSE message and protein levels but could not induce new MSE expression in several leukemia cell lines; lipopolysaccharide and interferon-gamma increased MSE expression in normal monocytes. Tretinoin 56-69 interferon gamma Homo sapiens 222-238 7763006-4 1995 Analysis of cellular inducible pathways demonstrated that RA augmented levels of gene expression: (i) induced by IFN-alpha such as 2"-5"-oligoadenylate synthetase, mRNA 561 and mRNA 6-16; (ii) induced by IFN-gamma such as 2A and P56; and (iii) induced by both IFN-alpha and IFN-gamma such as mRNA 1-8. Tretinoin 58-60 interferon gamma Homo sapiens 204-213 7763006-4 1995 Analysis of cellular inducible pathways demonstrated that RA augmented levels of gene expression: (i) induced by IFN-alpha such as 2"-5"-oligoadenylate synthetase, mRNA 561 and mRNA 6-16; (ii) induced by IFN-gamma such as 2A and P56; and (iii) induced by both IFN-alpha and IFN-gamma such as mRNA 1-8. Tretinoin 58-60 interferon gamma Homo sapiens 274-283 7763006-6 1995 Co-treatment of NB-4 cells by IFN-gamma plus RA induced a sub-set of IFN-induced genes which were not induced by either IFN-gamma or RA alone. Tretinoin 45-47 interferon gamma Homo sapiens 120-129 7533818-0 1995 Retinoic acid inhibits basal and interferon-gamma-induced expression of intercellular adhesion molecule 1 in monocytic cells. Tretinoin 0-13 interferon gamma Homo sapiens 33-49 7533818-5 1995 In contrast, suppression of IFN-gamma-induced ICAM-1 expression by RA was only partly reversible by indomethacin, suggesting that inhibition of IFN-gamma stimulation was not completely due to cyclooxygenase induction. Tretinoin 67-69 interferon gamma Homo sapiens 28-37 7533818-8 1995 RA also blocked ICAM-1 induction by IFN-gamma in isolated human blood monocytes. Tretinoin 0-2 interferon gamma Homo sapiens 36-45 7904998-5 1994 The action of IFN-gamma on the expression of squamous cell-specific genes is antagonized by retinoic acid and transforming growth factor beta 1. Tretinoin 92-105 interferon gamma Homo sapiens 14-23 7987085-4 1994 Combination of retinoic acid with interferon-gamma increased the down-regulation of specific binding sites of interferon-gamma. Tretinoin 15-28 interferon gamma Homo sapiens 34-50 7987085-4 1994 Combination of retinoic acid with interferon-gamma increased the down-regulation of specific binding sites of interferon-gamma. Tretinoin 15-28 interferon gamma Homo sapiens 110-126 8274426-6 1993 Comparing all-trans- with 9-cis-RA, the latter was more effective in inhibiting tumor cell growth and in inducing synergism with interferon-gamma. Tretinoin 26-34 interferon gamma Homo sapiens 129-145 2172660-0 1990 Difference in effects of interferon-alpha and interferon-gamma on the induction of differentiation of retinoic acid-treated acute myeloid leukemia cells in primary culture. Tretinoin 102-115 interferon gamma Homo sapiens 46-62 1648223-5 1991 However, the v-myc-associated block of phorbol 12-myristate 13-acetate-, 1 alpha,25-dihydroxycholecalciferol-, and retinoic acid-induced differentiation retinoic acid-induced differentiation can be overcome by adding interferon gamma as a costimulatory factor. Tretinoin 115-128 interferon gamma Homo sapiens 217-233 1648223-5 1991 However, the v-myc-associated block of phorbol 12-myristate 13-acetate-, 1 alpha,25-dihydroxycholecalciferol-, and retinoic acid-induced differentiation retinoic acid-induced differentiation can be overcome by adding interferon gamma as a costimulatory factor. Tretinoin 153-166 interferon gamma Homo sapiens 217-233 1673449-6 1991 Reversal of IFN-gamma"s ability to influence neuroblastoma cell growth as well as potentiate the anti-tumor effects of RA was obtained in the presence of an antibody against the IFN-gamma receptor, implying receptor-mediated physiological events. Tretinoin 119-121 interferon gamma Homo sapiens 12-21 1673449-6 1991 Reversal of IFN-gamma"s ability to influence neuroblastoma cell growth as well as potentiate the anti-tumor effects of RA was obtained in the presence of an antibody against the IFN-gamma receptor, implying receptor-mediated physiological events. Tretinoin 119-121 interferon gamma Homo sapiens 178-187 2176907-5 1990 In differentiated HL-60 and U 937 cells, the oxidative metabolism increases in parallel with Cyt b specific contents, both being enhanced by the addition of IFN gamma to the RA treatment. Tretinoin 174-176 interferon gamma Homo sapiens 157-166 2172660-3 1990 In particular, interferon-alpha enhanced granulocytic differentiation and interferon-gamma induced mono-macrophage differentiation of promyelocytic leukemic cells in the presence of RA. Tretinoin 182-184 interferon gamma Homo sapiens 74-90 2826339-1 1987 The combination of retinoic acid or tumor necrosis factor alpha (TNF-alpha) with interferon gamma (IFN-gamma) resulted in a synergistic amplification of the anti-proliferative effect of IFN-gamma on cultured breast cancer cells. Tretinoin 19-32 interferon gamma Homo sapiens 81-108 34723044-5 2021 T cells and T cell-derived IFN-gamma are crucial for increasing inflammatory macrophage levels in IR and RA treated tumors. Tretinoin 105-107 interferon gamma Homo sapiens 27-36 2492900-1 1989 Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). Tretinoin 0-13 interferon gamma Homo sapiens 125-141 2492900-1 1989 Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). Tretinoin 0-13 interferon gamma Homo sapiens 143-152 2826339-1 1987 The combination of retinoic acid or tumor necrosis factor alpha (TNF-alpha) with interferon gamma (IFN-gamma) resulted in a synergistic amplification of the anti-proliferative effect of IFN-gamma on cultured breast cancer cells. Tretinoin 19-32 interferon gamma Homo sapiens 99-108 2826339-5 1987 On the other hand, only TNF-alpha and not retinoic acid was able to increase the IFN-gamma induced expression of HLA-DR on the cell surface. Tretinoin 42-55 interferon gamma Homo sapiens 81-90 2826339-7 1987 The combinations of retinoic acid with IFN-gamma increased the down-regulation of specific binding sites for 125I-IFN-gamma. Tretinoin 20-33 interferon gamma Homo sapiens 39-48 2826339-7 1987 The combinations of retinoic acid with IFN-gamma increased the down-regulation of specific binding sites for 125I-IFN-gamma. Tretinoin 20-33 interferon gamma Homo sapiens 114-123 2826339-9 1987 Data obtained in this study demonstrate a different pattern of action between retinoic acid and TNF-alpha regarding their synergism in combination with IFN-gamma. Tretinoin 78-91 interferon gamma Homo sapiens 152-161 3088310-3 1986 Differentiation of the RA-resistant variant could be induced by immune interferon (IFN-gamma) and a T-lymphocyte-derived lymphokine of a differentiation-inducing activity (DIA), alone or in combination with 10 nM RA. Tretinoin 23-25 interferon gamma Homo sapiens 83-92 3026615-5 1987 Also, IFN-gamma neither induced differentiation of NTERA-2 cl.D1 cells, which are pluripotent human stem cells, nor influenced their differentiation induced by retinoic acid. Tretinoin 160-173 interferon gamma Homo sapiens 6-15 32469071-0 2021 Retinoic Acid Is Elevated in the Mucosa of Patients With Active Ulcerative Colitis and Displays a Proinflammatory Role by Augmenting IL-17 and IFNgamma Production. Tretinoin 0-13 interferon gamma Homo sapiens 143-151 2411582-2 1985 At least an additive differentiation-inducing effect was found between IFN-gamma and 1-100 nM retinoic acid (RA). Tretinoin 94-107 interferon gamma Homo sapiens 71-86 2411582-2 1985 At least an additive differentiation-inducing effect was found between IFN-gamma and 1-100 nM retinoic acid (RA). Tretinoin 109-111 interferon gamma Homo sapiens 71-86 6181013-1 1982 Retinoic acid (RA) suppressed the production of interferon (IFN) alpha and IFN gamma of human peripheral blood leukocytes in response to stimulation with lectin mitogens, bacterial products, synthetic polynucleotides, viruses, and tumor cell lines in vitro. Tretinoin 0-13 interferon gamma Homo sapiens 75-84 6181013-1 1982 Retinoic acid (RA) suppressed the production of interferon (IFN) alpha and IFN gamma of human peripheral blood leukocytes in response to stimulation with lectin mitogens, bacterial products, synthetic polynucleotides, viruses, and tumor cell lines in vitro. Tretinoin 15-17 interferon gamma Homo sapiens 75-84 32469071-2 2021 Our previous research highlighted that in the face of inflammatory conditions, RA plays a contrary role where it aggravates intestinal inflammation by promoting interferon (IFN) gamma and interleukin (IL)-17 differentiation in vitro. Tretinoin 79-81 interferon gamma Homo sapiens 161-183 32469071-6 2021 Moreover, the raised RA levels in patients with active disease showed a positive correlation with proinflammatory cytokines (IL-17, IFNgamma) and a negative correlation with IL-10. Tretinoin 21-23 interferon gamma Homo sapiens 132-140 31406210-4 2019 Stimulation of myeloid blasts" maturation by all-trans retinoic acid (ATRA) or 1alpha,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-gamma. Tretinoin 45-68 interferon gamma Homo sapiens 194-203 33196459-7 2020 In retinoic acid-differentiated ATXN3/Q75-GFP SH-SY5Y cells inflamed with IFN-gamma-primed HMC3 conditioned medium, treatment with the tested compounds mitigated the increased caspase 1 activity and lactate dehydrogenase release, reduced polyQ aggregation and ROS and/or promoted neurite outgrowth. Tretinoin 3-16 interferon gamma Homo sapiens 74-83 31634391-6 2020 The effect of ATRA on IFN-gamma-mediated inhibition of DRA function, expression, and promoter activity were elucidated. Tretinoin 14-18 interferon gamma Homo sapiens 22-31 31634391-8 2020 RESULTS: All-trans retinoic acid (10 muM, 24 h) abrogated IFN-gamma (30 ng/mL, 24 h)-induced decrease in DRA function, expression, and promoter activity in Caco-2 cells. Tretinoin 9-32 interferon gamma Homo sapiens 58-67 31634391-9 2020 All-trans retinoic acid altered IFN-gamma signaling via blocking IFN-gamma-induced tyrosine phosphorylation of STAT-1. Tretinoin 0-23 interferon gamma Homo sapiens 32-41 31634391-9 2020 All-trans retinoic acid altered IFN-gamma signaling via blocking IFN-gamma-induced tyrosine phosphorylation of STAT-1. Tretinoin 0-23 interferon gamma Homo sapiens 65-74 31406210-4 2019 Stimulation of myeloid blasts" maturation by all-trans retinoic acid (ATRA) or 1alpha,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-gamma. Tretinoin 70-74 interferon gamma Homo sapiens 194-203 25959810-8 2015 RESULTS: Retinoic acid acted synergistically with IL-2 and other activating cytokines to induce expression of the gut-homing integrin alpha4beta7 in ILCs, as well as production of IL-5 and IL-13 in ILC2 cells, and IFN-gamma in ILC1 and ILC3 cells. Tretinoin 9-22 interferon gamma Homo sapiens 214-223 26980802-4 2016 We report a novel role of retinoic acid in an inflammatory setup, where retinoic acid-primed dendritic cells (retinoic acid-monocyte-derived dendritic cells) up-regulated CCR9(+)T cells, which were observed to express high levels of IFN-gamma in the presence of Th1/Th17 conditions. Tretinoin 26-39 interferon gamma Homo sapiens 233-242 26980802-4 2016 We report a novel role of retinoic acid in an inflammatory setup, where retinoic acid-primed dendritic cells (retinoic acid-monocyte-derived dendritic cells) up-regulated CCR9(+)T cells, which were observed to express high levels of IFN-gamma in the presence of Th1/Th17 conditions. Tretinoin 72-85 interferon gamma Homo sapiens 233-242 26980802-4 2016 We report a novel role of retinoic acid in an inflammatory setup, where retinoic acid-primed dendritic cells (retinoic acid-monocyte-derived dendritic cells) up-regulated CCR9(+)T cells, which were observed to express high levels of IFN-gamma in the presence of Th1/Th17 conditions. Tretinoin 72-85 interferon gamma Homo sapiens 233-242 26980802-7 2016 Experiments with naive CD4(+) T cells, activated in the presence of Th1/Th17 conditions and absence of DCs, indicated that retinoic acid inhibited IFN-gamma and IL-17 expression on T cells. Tretinoin 123-136 interferon gamma Homo sapiens 147-156 25343668-7 2015 Our results demonstrated a novel function of RA in modulating the IFN-gamma expression by activated NKT cells. Tretinoin 45-47 interferon gamma Homo sapiens 66-75 25592248-6 2015 Lastly, we observed that IFN-gamma and IL-17 production by ex vivo re-stimulated dLNs cells is greatly increased during rejection, which it turns depends on RA synthesis, as shown in experiments using a specific RALDH inhibitor. Tretinoin 157-159 interferon gamma Homo sapiens 25-34 25343668-0 2015 Retinoic acid modulates interferon-gamma production by hepatic natural killer T cells via phosphatase 2A and the extracellular signal-regulated kinase pathway. Tretinoin 0-13 interferon gamma Homo sapiens 24-40 23129057-4 2013 The decrease in JNK-1 activity was followed by a marked decrease in the expression of interleukin (IL)-2 and a weak increase in interferon (IFN)-gamma in Jurkat cells treated with ATRA in a dose-dependent manner, suggesting a correlation between the expression of JNK-1 and the activity of the Tax protein. Tretinoin 216-220 interferon gamma Homo sapiens 152-174 26124839-8 2015 ATRA-pretreated MSCs significantly decreased not only the vital pathogenic cytokine in AS, tumor necrosis factor-alpha (TNF-alpha), but also AS-boosting factors interleukin-17 (IL-17A) and interferon-gamma (IFN-gamma). Tretinoin 0-4 interferon gamma Homo sapiens 189-205 26124839-8 2015 ATRA-pretreated MSCs significantly decreased not only the vital pathogenic cytokine in AS, tumor necrosis factor-alpha (TNF-alpha), but also AS-boosting factors interleukin-17 (IL-17A) and interferon-gamma (IFN-gamma). Tretinoin 0-4 interferon gamma Homo sapiens 207-216 23701916-0 2013 Increased production of IFN-gamma by natural killer cells triggered with bone marrow-derived dendritic cells cultured in the presence of retinoic acid. Tretinoin 137-150 interferon gamma Homo sapiens 24-33 23457382-8 2013 ATRA significantly increased intracellular IFN-gamma in cases but not in controls. Tretinoin 0-4 interferon gamma Homo sapiens 43-52 22585464-5 2012 In correlation with cytokine levels in serum, RA regulated the production of IFN-gamma and IL-4 but not TNF-alpha by NKT cells without influencing the NKT-cell activation status. Tretinoin 46-48 interferon gamma Homo sapiens 77-86 22585464-6 2012 However, RA did not alleviate alpha-GalCer-induced liver injury, even though it reduced IFN-gamma and IL-4 but not TNF-alpha levels in serum. Tretinoin 9-11 interferon gamma Homo sapiens 88-97 22969967-11 2012 IFN-gamma in combination with ATRA not only strengthens the induction differentiation effect of ATRA on NB4 cells, but also can partially induce the maturation of NB4-R1 cells with ATRA resistance. Tretinoin 96-100 interferon gamma Homo sapiens 0-9 22969967-0 2012 Interferon-gamma enhances promyelocytic leukemia protein expression in acute promyelocytic cells and cooperates with all-trans-retinoic acid to induce maturation of NB4 and NB4-R1 cells. Tretinoin 117-140 interferon gamma Homo sapiens 0-16 22969967-11 2012 IFN-gamma in combination with ATRA not only strengthens the induction differentiation effect of ATRA on NB4 cells, but also can partially induce the maturation of NB4-R1 cells with ATRA resistance. Tretinoin 96-100 interferon gamma Homo sapiens 0-9 22969967-10 2012 Together, IFN-gamma augments the proliferation inhibition effect of ATRA on NB4 and NB4-R1 cells through enhancing the expression of PML protein. Tretinoin 68-72 interferon gamma Homo sapiens 10-19 19784600-3 2009 The Taqman Array results show that (1) stimulation with the liver-X-receptor and retinoid-X-receptor ligands T0901317 and 9-cis retinoic acid induces several genes of lipid metabolism, (2) lipopolysaccharide (LPS) and interferon-g (Ifn-g) strongly repress lipid-related genes, and (3) coincubation with docosahexaenoic acid dampens the repressing effect of LPS. Tretinoin 128-141 interferon gamma Homo sapiens 218-230 19784600-3 2009 The Taqman Array results show that (1) stimulation with the liver-X-receptor and retinoid-X-receptor ligands T0901317 and 9-cis retinoic acid induces several genes of lipid metabolism, (2) lipopolysaccharide (LPS) and interferon-g (Ifn-g) strongly repress lipid-related genes, and (3) coincubation with docosahexaenoic acid dampens the repressing effect of LPS. Tretinoin 128-141 interferon gamma Homo sapiens 232-237 17616812-8 2007 Combination of ATRA and IFN-gamma showed more efficacy than IFN-gamma alone in causing apoptosis that occurred due to increases in Bax:Bcl-2 ratio, mitochondrial release of cytochrome c, and caspase-3 activity. Tretinoin 15-19 interferon gamma Homo sapiens 60-69 18416830-1 2008 BACKGROUND: We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Tretinoin 47-70 interferon gamma Homo sapiens 170-179 18416830-1 2008 BACKGROUND: We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 from accessory cells. Tretinoin 72-76 interferon gamma Homo sapiens 170-179 17676389-5 2007 Our recent study demonstrated that combination of the chemotherapeutic agent all-trans retinoic acid (ATRA) and the immunotherapeutic agent interferon-gamma (IFN-gamma) could concurrently induce differentiation, apoptotic death, and immune components in two different human glioblastoma cell lines. Tretinoin 87-100 interferon gamma Homo sapiens 158-167 17938259-4 2007 We and others have previously reported that IFN-gamma synergistically potentiates retinoic acid (RA)-induced sympathetic differentiation and growth inhibition in neuroblastoma cells. Tretinoin 82-95 interferon gamma Homo sapiens 44-53 17938259-4 2007 We and others have previously reported that IFN-gamma synergistically potentiates retinoic acid (RA)-induced sympathetic differentiation and growth inhibition in neuroblastoma cells. Tretinoin 97-99 interferon gamma Homo sapiens 44-53 16947022-7 2007 Interestingly, both T98G and U87MG cells showed more increase in apoptosis with expression of the HLA class II components for an effective immune response following treatment with ATRA plus IFN-gamma than with IFN-gamma alone. Tretinoin 180-184 interferon gamma Homo sapiens 210-219 16920192-4 2007 In the present study, we found that RA treatment induces the expression of interferon-gamma (IFN-gamma) and interleukin-1beta (IL-1beta) in peripheral blast cells from APL patients. Tretinoin 36-38 interferon gamma Homo sapiens 75-91 16920192-4 2007 In the present study, we found that RA treatment induces the expression of interferon-gamma (IFN-gamma) and interleukin-1beta (IL-1beta) in peripheral blast cells from APL patients. Tretinoin 36-38 interferon gamma Homo sapiens 93-102 16920192-0 2007 Retinoic acid-induced CD38 antigen promotes leukemia cells attachment and interferon-gamma/interleukin-1beta-dependent apoptosis of endothelial cells: implications in the etiology of retinoic acid syndrome. Tretinoin 0-13 interferon gamma Homo sapiens 74-90 17107666-6 2007 Our results demonstrated that ATRA suppressed NF-kappaB activity and prevented IkappaBalpha degradation in a dose-dependent way, inhibited IFN-gamma production and gene expression of granzyme B and NKp46. Tretinoin 30-34 interferon gamma Homo sapiens 139-148 17343783-0 2007 [Experimental study of IFN-alpha and IFN-gamma on reversing ATRA-resistance in MR2 cell line]. Tretinoin 60-64 interferon gamma Homo sapiens 37-46 17343783-1 2007 AIM: To explore the possibility and the possible mechanism of reversing ATRA-resistance in MR2 cells by using IFN-alpha and IFN-gamma in combination with all-trans retinoic acid (ATRA). Tretinoin 72-76 interferon gamma Homo sapiens 124-133 17343783-5 2007 The effects were more obviously in both IFN-alpha+ATRA group and IFN-gamma+ATRA group. Tretinoin 75-79 interferon gamma Homo sapiens 65-74 16085646-9 2005 In addition, atRA pretreatment affected the transcriptional functions of IFNgamma-induced IRF-1, increasing its nuclear localization and DNA binding activity as well as the transcript levels of IRF-1 target genes. Tretinoin 13-17 interferon gamma Homo sapiens 73-81 16872382-5 2006 In addition, all-trans-retinoic acid-treated dendritic cells could drive T cells towards T-helper cell type 2 responses with decreased secretion of interleukin-12, interferon-gamma, and increased production of interleukin-10 and interleukin-4. Tretinoin 13-36 interferon gamma Homo sapiens 164-180 16292516-0 2006 All-trans-retinoic acid suppresses interferon-gamma and tumor necrosis factor-alpha; a possible therapeutic agent for rheumatoid arthritis. Tretinoin 0-23 interferon gamma Homo sapiens 35-83 16292516-7 2006 In contrast, ATRA suppressed the production of IFN-gamma and TNF-alpha significantly. Tretinoin 13-17 interferon gamma Homo sapiens 47-56 16292516-9 2006 CONCLUSIONS: ATRA was demonstrated to affect the cytokine production of IFN-gamma and TNF-alpha. Tretinoin 13-17 interferon gamma Homo sapiens 72-81 16085646-3 2005 In this study, we have used the human lung epithelial cell line A549 to examine the effect of atRA on IFNgamma-induced expression of IFN regulatory factor-1 (IRF-1), an important transcription factor involved in cell growth and apoptosis, differentiation, and antiviral and antibacterial immune responses. Tretinoin 94-98 interferon gamma Homo sapiens 102-110 16085646-4 2005 At least 4 h of pretreatment with atRA followed by suboptimal concentrations of IFNgamma induced a faster, higher, and more stable expression of IRF-1 than IFNgamma alone. Tretinoin 34-38 interferon gamma Homo sapiens 156-164 21190613-0 2005 [Experimental study of effects of retinoic acid on IL-1beta and IFN-gamma induced C3 and factor B secretion in lung cancer cell line]. Tretinoin 34-47 interferon gamma Homo sapiens 64-73 16007204-6 2005 Interestingly, while the upregulation of STAT-1 by IFNgamma is partially inhibited by RA, IFNgamma is shown to repress RA-driven TGFbeta-2 induction, pointing to the involvement of alternative mechanism(s) in IFNgamma-RA synergism. Tretinoin 86-88 interferon gamma Homo sapiens 51-59 21190613-2 2005 The aim of this study is to investigate the regulated effects of retinoic acid (RA) on IL-1beta and IFN-gamma induced C3 and factor B secretion in human lung cancer cell line A549. Tretinoin 65-78 interferon gamma Homo sapiens 100-109 21190613-2 2005 The aim of this study is to investigate the regulated effects of retinoic acid (RA) on IL-1beta and IFN-gamma induced C3 and factor B secretion in human lung cancer cell line A549. Tretinoin 80-82 interferon gamma Homo sapiens 100-109 21190613-6 2005 CONCLUSIONS: RA can up-regulate C3 and factor B secretion induced by IL-1beta and IFN-gamma in human lung cancer cell A549. Tretinoin 13-15 interferon gamma Homo sapiens 82-91 15189689-14 2004 Expression of mRNA for IL-12p35, IL-12p40, IFN-gamma in the cells that had been incubated with RA declined, but IL-10, IL-4 increased significantly. Tretinoin 95-97 interferon gamma Homo sapiens 43-52 12383199-2 2002 While RA (10(-8) m) alone did not alter STAT-1 activation or expression in THP-1 cells, RA enhanced or prolonged STAT-1 activation (tyrosine 701 phosphorylation) and gene expression (mRNA and protein) induced by either IFN-beta or IFN-gamma. Tretinoin 88-90 interferon gamma Homo sapiens 231-240 12569559-8 2003 Retinoic acid-treated hepatoma cells induced IFN gamma production from cocultured NK cells and rendered themselves more susceptible to NK cells. Tretinoin 0-13 interferon gamma Homo sapiens 45-54 11668484-0 2001 Interferon-gamma cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells. Tretinoin 33-46 interferon gamma Homo sapiens 0-16 12191570-1 2002 When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. Tretinoin 93-106 interferon gamma Homo sapiens 136-145 12191570-1 2002 When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. Tretinoin 108-112 interferon gamma Homo sapiens 136-145 11376874-8 2001 Retinoic acid elicited synergistic effects on the CNP secretion rate from HL-60 cells when administered with lipopolysaccharide, interferon-gamma, interleukin-1beta, tumor necrosis factor-alpha, or phorbol ester. Tretinoin 0-13 interferon gamma Homo sapiens 129-145 10502453-7 1999 Retinoic acid with TNFalpha and IFN-gamma had a marked inhibitory effect (P<0.05) which was similarly reversed by increasing concentrations of IGFBP-3 antibody. Tretinoin 0-13 interferon gamma Homo sapiens 32-41 10502453-8 1999 The present data support the hypothesis that the combination of TNFalpha and IFN-gamma with retinoic acid exert their anti-proliferative effect on HSG cells by reducing the mitogenic effect of IGF-I due to a shift in IGF-I from the free to the IGFBP-3-bound form. Tretinoin 92-105 interferon gamma Homo sapiens 77-86 10334392-9 1999 The IFN-y-inducing effect of ATRA and 13-cis-retinoic acid could be abrogated by addition of anti-IL-12 antibodies, suggesting that IL-12 plays a role in the synergistic upregulation of IFN-gamma. Tretinoin 29-33 interferon gamma Homo sapiens 186-195 10319996-6 1999 We provide evidence indicating that RA-induced IRF-1 gene expression is independent of the STAT-1 activation pathway, despite the presence of the IFN-gamma activated sequence element in the gene promoter, but involves nuclear factor-kappaB activation. Tretinoin 36-38 interferon gamma Homo sapiens 146-155 9570357-4 1997 Our previous work has shown that RA works synergistically with other agents, such as interferon-gamma (IFN-gamma), to down-regulate N-myc expression and induce differentiation. Tretinoin 33-35 interferon gamma Homo sapiens 85-101 9891902-9 1998 Tretinoin very potently stimulated IL-5 release, and inhibited IFN gamma release by SEB-stimulated human PBMCs. Tretinoin 0-9 interferon gamma Homo sapiens 63-72 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Tretinoin 70-83 interferon gamma Homo sapiens 181-197 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Tretinoin 70-83 interferon gamma Homo sapiens 199-208 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Tretinoin 85-87 interferon gamma Homo sapiens 181-197 9649586-2 1998 We have tested the hypothesis that the vitamin A metabolite all-trans retinoic acid (RA) is required for the regulation of pIgR expression by the cytokines interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in HT-29 cells, a well-differentiated human epithelial cell line derived from a colonic carcinoma. Tretinoin 85-87 interferon gamma Homo sapiens 199-208 9462716-8 1998 Exposure to the combination of IFN-gamma plus retinoic acid significantly up-regulated (in an additive manner) HLA-Class-I and ICAM-1 molecules as compared with the levels obtainable after exposure to IFN-gamma alone. Tretinoin 46-59 interferon gamma Homo sapiens 201-210 9570357-4 1997 Our previous work has shown that RA works synergistically with other agents, such as interferon-gamma (IFN-gamma), to down-regulate N-myc expression and induce differentiation. Tretinoin 33-35 interferon gamma Homo sapiens 103-112 9420627-1 1997 The expression of the major histocompatibility complex (MHC) class I antigens is suppressed in early post-implantation embryonic cells as well as in embryonal carcinoma (EC) cells, but could be upregulated by treatment with interferon (IFN)-gamma or retinoic acid. Tretinoin 250-263 interferon gamma Homo sapiens 224-246 16465284-9 1997 Treatment with IFN-gamma+TNF induced GI-LI-N cells to show only a late and remarkable increase of alpha1/beta1 heterodimer; on the contrary, RA treatment caused a decrease in all integrin chains. Tretinoin 141-143 interferon gamma Homo sapiens 15-24 9444384-5 1997 The PKC antagonists (H7, sphingosine) as well as RA downregulated the IFN-gamma-induced PNA-reactive gps, whereas staurosporine and TPA upregulated their expression. Tretinoin 49-51 interferon gamma Homo sapiens 70-79