PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9659296-9 1998 However, retinoic acid (10(-6) M) stimulated both IGFBP-2 and IGFBP-6 protein and mRNA levels, but it decreased IGFBP-3 mRNA levels relative to controls. Tretinoin 9-22 insulin like growth factor binding protein 2 Bos taurus 50-57 9659296-18 1998 In addition, the differential regulation of IGFBP-2, -3 and -6 by retinoic acid (which inhibits proliferation) and IGF-I (which stimulates proliferation) suggests that these forms of IGFBP have different roles in regulating mammary epithelial cell physiology. Tretinoin 66-79 insulin like growth factor binding protein 2 Bos taurus 44-62 9659296-18 1998 In addition, the differential regulation of IGFBP-2, -3 and -6 by retinoic acid (which inhibits proliferation) and IGF-I (which stimulates proliferation) suggests that these forms of IGFBP have different roles in regulating mammary epithelial cell physiology. Tretinoin 66-79 insulin like growth factor binding protein 2 Bos taurus 44-49 8655603-10 1996 Inhibition of proliferation by RA was associated with increased levels of IGFBP-2 in conditioned media and in plasma membrane preparations. Tretinoin 31-33 insulin like growth factor binding protein 2 Bos taurus 74-81 8655603-13 1996 Thus, RA is a potent but transient inhibitor of bovine mammary epithelial cell proliferation, and this growth inhibition is correlated with increased IGFBP-2 accumulation and inhibition of IGF-I stimulated IGFBP-3 protein secretion. Tretinoin 6-8 insulin like growth factor binding protein 2 Bos taurus 150-157