PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7529599-0	1994	Regulation of vitronectin receptor expression by retinoic acid on human melanoma cells.	Tretinoin	49-62	vitronectin	Homo sapiens	14-25	
12653733-0	2003	Early vitronectin receptor downregulation in a melanoma cell line during all-trans retinoic acid-induced apoptosis.	Tretinoin	83-96	vitronectin	Homo sapiens	6-17	
12653733-8	2003	At this time point, decrease in the F-actin polymerization as well as inhibition of cell adhesive ability to vitronectin (Vn) was exerted by ATRA treatment.	Tretinoin	141-145	vitronectin	Homo sapiens	109-120	
12653733-8	2003	At this time point, decrease in the F-actin polymerization as well as inhibition of cell adhesive ability to vitronectin (Vn) was exerted by ATRA treatment.	Tretinoin	141-145	vitronectin	Homo sapiens	122-124	
12653733-10	2003	Functionally, the treatment of melanoma cells with 10 micromol L-1 ATRA for 48 h causes an inhibition of directional cell migration towards Vn-coated filters.	Tretinoin	67-71	vitronectin	Homo sapiens	140-142	
10525374-6	1999	The binding of SiHa cells to ECM proteins (fibronectin, vitronectin, laminin, collagen IV) was drastically reduced when cells were treated with ATRA at 10 microM for 96 h in culture.	Tretinoin	144-148	vitronectin	Homo sapiens	56-67	
10525374-7	1999	Interestingly, when ATRA-treated (10 microM, 96 h) SiHa cells were allowed to grow for 15 days in ATRA-free complete medium the binding of SiHa cells to fibronectin and vitronectin was inhibited, even after 15 days of drug withdrawal, whereas cell adhesion to laminin and collagen IV returned to normal within 3-7 days.	Tretinoin	20-24	vitronectin	Homo sapiens	169-180	
10525374-7	1999	Interestingly, when ATRA-treated (10 microM, 96 h) SiHa cells were allowed to grow for 15 days in ATRA-free complete medium the binding of SiHa cells to fibronectin and vitronectin was inhibited, even after 15 days of drug withdrawal, whereas cell adhesion to laminin and collagen IV returned to normal within 3-7 days.	Tretinoin	98-102	vitronectin	Homo sapiens	169-180	
9137089-0	1997	Vitronectin expression in differentiating neuroblastic tumors: integrin alpha v beta 5 mediates vitronectin-dependent adhesion of retinoic-acid-differentiated neuroblastoma cells.	Tretinoin	130-143	vitronectin	Homo sapiens	96-107	
9137089-8	1997	These data suggest that the synthesis of vitronectin and the ability of integrin alpha v beta 5 to mediate vitronectin adhesion on retinoic-acid-differentiated neuroblastoma cells may promote differentiation of neuroblastoma cells in vivo.	Tretinoin	131-144	vitronectin	Homo sapiens	107-118	
7529599-6	1994	Although the mechanism by which retinoic acid regulates the expression of vitronectin receptor in MeWo cells needs further examination, this system may represent a good model for understanding the role of this receptor in melanoma progression, as well the molecular basis for retinoic acid therapy in these tumors.	Tretinoin	32-45	vitronectin	Homo sapiens	74-85	
7529599-6	1994	Although the mechanism by which retinoic acid regulates the expression of vitronectin receptor in MeWo cells needs further examination, this system may represent a good model for understanding the role of this receptor in melanoma progression, as well the molecular basis for retinoic acid therapy in these tumors.	Tretinoin	276-289	vitronectin	Homo sapiens	74-85	
19162023-3	2009	Combined treatment of retinoic acid, sonic hedgehog, and noggin in the presence of VN allows hESCs to differentiate into O4-positive oligodendrocytes.	Tretinoin	22-35	vitronectin	Homo sapiens	83-85