PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30008902-3 2018 Research into CCR9 and CCL25 has revealed their associated upstream and downstream signaling pathways; CCR9 is regulated by several immunological factors, including NOTCH, interleukin 2, interleukin 4 and retinoic acid. Tretinoin 205-218 C-C motif chemokine receptor 9 Homo sapiens 103-107 29766641-6 2019 To induce tissue-specific migration, addition of retinoic acid (RA) during Treg expansion induced expression of the gut-homing receptors alpha4beta7-integrin and CCR9. Tretinoin 49-62 C-C motif chemokine receptor 9 Homo sapiens 162-166 29766641-6 2019 To induce tissue-specific migration, addition of retinoic acid (RA) during Treg expansion induced expression of the gut-homing receptors alpha4beta7-integrin and CCR9. Tretinoin 64-66 C-C motif chemokine receptor 9 Homo sapiens 162-166 25027601-2 2015 RA primes dendritic cells (DCs) to express CD103 and produce RA themselves, which induces the gut-homing receptors alpha4beta7 and CCR9 on T cells and amplifies transforming growth factor (TGF)-beta-mediated development of Foxp3(+) regulatory T (Treg) cells. Tretinoin 0-2 C-C motif chemokine receptor 9 Homo sapiens 131-135 29801999-1 2018 All-trans retinoic acid (ATRA) up-regulates, in laboratory animals, the expression of the gut homing markers alpha4beta7 integrin and CCR9 on lymphocytes, increasing their gut tropism. Tretinoin 0-23 C-C motif chemokine receptor 9 Homo sapiens 134-138 29801999-1 2018 All-trans retinoic acid (ATRA) up-regulates, in laboratory animals, the expression of the gut homing markers alpha4beta7 integrin and CCR9 on lymphocytes, increasing their gut tropism. Tretinoin 25-29 C-C motif chemokine receptor 9 Homo sapiens 134-138 29801999-3 2018 The coordinated increase of alpha4beta7 and CCR9 by ATRA was seen in 57% (12/21) of volunteers and only when given together with an oral Vivotif vaccine. Tretinoin 52-56 C-C motif chemokine receptor 9 Homo sapiens 44-48 28321213-5 2017 Upon retinoic acid (RA) exposure, CD161+ T cells were more enriched for CCR9+ and integrin alpha4+beta7+ cells than CD161- T cells. Tretinoin 5-18 C-C motif chemokine receptor 9 Homo sapiens 72-76 28321213-5 2017 Upon retinoic acid (RA) exposure, CD161+ T cells were more enriched for CCR9+ and integrin alpha4+beta7+ cells than CD161- T cells. Tretinoin 20-22 C-C motif chemokine receptor 9 Homo sapiens 72-76 26980802-1 2016 All-trans-retinoic acid plays a central role in mucosal immunity, where it promotes its synthesis by up-regulating CD103 expression on dendritic cells, induces gut tropic (alpha4beta7(+) and CCR9(+)) T cells, and inhibits Th1/Th17 differentiation. Tretinoin 0-23 C-C motif chemokine receptor 9 Homo sapiens 191-195 26980802-4 2016 We report a novel role of retinoic acid in an inflammatory setup, where retinoic acid-primed dendritic cells (retinoic acid-monocyte-derived dendritic cells) up-regulated CCR9(+)T cells, which were observed to express high levels of IFN-gamma in the presence of Th1/Th17 conditions. Tretinoin 26-39 C-C motif chemokine receptor 9 Homo sapiens 171-175 26980802-4 2016 We report a novel role of retinoic acid in an inflammatory setup, where retinoic acid-primed dendritic cells (retinoic acid-monocyte-derived dendritic cells) up-regulated CCR9(+)T cells, which were observed to express high levels of IFN-gamma in the presence of Th1/Th17 conditions. Tretinoin 72-85 C-C motif chemokine receptor 9 Homo sapiens 171-175 26980802-4 2016 We report a novel role of retinoic acid in an inflammatory setup, where retinoic acid-primed dendritic cells (retinoic acid-monocyte-derived dendritic cells) up-regulated CCR9(+)T cells, which were observed to express high levels of IFN-gamma in the presence of Th1/Th17 conditions. Tretinoin 72-85 C-C motif chemokine receptor 9 Homo sapiens 171-175 25027601-4 2015 We report a novel role of RA in immune regulation by showing that RA-conditioned human DCs did not substantially enhance Foxp3 but induced alpha4beta7(+) CCR9(+) T cells expressing high levels of interleukin (IL)-10, which were functional suppressive Treg cells. Tretinoin 26-28 C-C motif chemokine receptor 9 Homo sapiens 154-158 25227295-3 2014 The vitamin A (VA) metabolite all-trans retinoic acid (RA) signaling via RA nuclear receptors plays a key role in immune homeostasis in the small bowel, and recent work indicates that RA is required for establishing immune tolerance to dietary antigens in the upper intestinal tract by inducing alpha4beta7(+)CCR9(+) gut-tropic TREG. Tretinoin 40-53 C-C motif chemokine receptor 9 Homo sapiens 309-313 24237035-3 2014 All-trans retinoic acid (ATRA) up-regulates expression of alpha4beta7 integrin and CCR9 on lymphocytes in laboratory animals, increasing their gut tropism. Tretinoin 0-23 C-C motif chemokine receptor 9 Homo sapiens 83-87 24237035-3 2014 All-trans retinoic acid (ATRA) up-regulates expression of alpha4beta7 integrin and CCR9 on lymphocytes in laboratory animals, increasing their gut tropism. Tretinoin 25-29 C-C motif chemokine receptor 9 Homo sapiens 83-87 25227295-3 2014 The vitamin A (VA) metabolite all-trans retinoic acid (RA) signaling via RA nuclear receptors plays a key role in immune homeostasis in the small bowel, and recent work indicates that RA is required for establishing immune tolerance to dietary antigens in the upper intestinal tract by inducing alpha4beta7(+)CCR9(+) gut-tropic TREG. Tretinoin 55-57 C-C motif chemokine receptor 9 Homo sapiens 309-313 21444662-1 2011 The production of retinoic acid (RA) by dendritic cells (DCs) is critical for the induction of gut-tropic immune responses by driving the expression of intestinal-specific homing receptors, such as alpha4beta7 and CCR9, upon T and B cell activation. Tretinoin 18-31 C-C motif chemokine receptor 9 Homo sapiens 214-218 23607934-5 2013 Retinoic acid (RA) induced gut-homing markers (beta7 and CCR9) and a regulatory phenotype and function [decreased human leucocyte antigen D-related (HLA-DR) and increased ILT3 and fluorescein isothiocyanate (FITC-dextran uptake) in MoDC]. Tretinoin 15-17 C-C motif chemokine receptor 9 Homo sapiens 57-61 23607934-5 2013 Retinoic acid (RA) induced gut-homing markers (beta7 and CCR9) and a regulatory phenotype and function [decreased human leucocyte antigen D-related (HLA-DR) and increased ILT3 and fluorescein isothiocyanate (FITC-dextran uptake) in MoDC]. Tretinoin 0-13 C-C motif chemokine receptor 9 Homo sapiens 57-61 23529927-3 2013 The administration of exogenous RA significantly increased expression of the gut-homing molecules, CCR9 and alpha4beta7, on donor T cells in mesenteric lymph nodes, and augmented the accumulation of proinflammatory CD4(+) and CD8(+) T cells within the gut mucosa, leading to a selective exacerbation of colonic GVHD and increased overall mortality. Tretinoin 32-34 C-C motif chemokine receptor 9 Homo sapiens 99-103 21444662-1 2011 The production of retinoic acid (RA) by dendritic cells (DCs) is critical for the induction of gut-tropic immune responses by driving the expression of intestinal-specific homing receptors, such as alpha4beta7 and CCR9, upon T and B cell activation. Tretinoin 33-35 C-C motif chemokine receptor 9 Homo sapiens 214-218 19841174-2 2009 Expression of gut-homing molecules alpha(4)beta(7) and CCR9 is induced by retinoic acid, a vitamin A metabolite produced by retinal dehydrogenases, which are specifically expressed in dendritic cells as well as stromal cells in mucosa-draining lymph nodes. Tretinoin 74-87 C-C motif chemokine receptor 9 Homo sapiens 55-59 20400707-6 2010 The Th17 cells, induced in the presence or absence of RA, differentially expressed the trafficking receptors CCR9 and alpha4beta7. Tretinoin 54-56 C-C motif chemokine receptor 9 Homo sapiens 109-113 15928487-8 2005 Gut dendritic cells and retinoic acid induce the expression of alpha4beta7 and CCR9 on T cells for their homing to the gut. Tretinoin 24-37 C-C motif chemokine receptor 9 Homo sapiens 79-83 34088744-4 2021 Mechanistically, intestinal cDC1-derived PD-L1, TGFbeta, and retinoic acid contributed to the generation of gut-tropic CCR9+CD103+FoxP3+CD8+ Tregs Last, CD103-deficient CD8+ T cells lacked tolerogenic activity in vivo, indicating a role for CD103 in FoxP3+CD8+ Treg function. Tretinoin 61-74 C-C motif chemokine receptor 9 Homo sapiens 119-123 15485630-2 2004 Here, we show that the vitamin A (retinol) metabolite, retinoic acid, enhances the expression of alpha4beta7 and CCR9 on T cells upon activation and imprints them with the gut tropism. Tretinoin 55-68 C-C motif chemokine receptor 9 Homo sapiens 113-117 35154092-8 2022 Here we show that select novel rexinoids act as ATRA mimics, as they cause increased CCR9 and alpha4beta7 expression and enhanced migration to the CCR9 ligand, CCL25 in vitro, even in the absence of ATRA. Tretinoin 48-52 C-C motif chemokine receptor 9 Homo sapiens 85-89 35154092-2 2022 All-trans-retinoic acid (ATRA) promotes T cell migration to mucosal surfaces by inducing transcription of the mucosal-homing receptors CCR9 and alpha4beta7 via binding to retinoic acid receptors (RARs), which heterodimerize with retinoid X receptors (RXRs) to function. Tretinoin 0-23 C-C motif chemokine receptor 9 Homo sapiens 135-139 35154092-2 2022 All-trans-retinoic acid (ATRA) promotes T cell migration to mucosal surfaces by inducing transcription of the mucosal-homing receptors CCR9 and alpha4beta7 via binding to retinoic acid receptors (RARs), which heterodimerize with retinoid X receptors (RXRs) to function. Tretinoin 25-29 C-C motif chemokine receptor 9 Homo sapiens 135-139 35154092-9 2022 Conversely, other rexinoids act synergistically with ATRA, as culturing cells with suboptimal doses of both compounds resulted in CCR9 expression and migration to CCL25. Tretinoin 53-57 C-C motif chemokine receptor 9 Homo sapiens 130-134