PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27374082-9 2016 However, further depletion of Cdh1 in APL significantly reduced viability of leukemia cells upon ATRA-induced differentiation. Tretinoin 97-101 cadherin 1 Homo sapiens 30-34 33069641-11 2021 Effects of HDACi, DXM and ATRA were seen on the expression of Connexins and E-Cadherin in both the cell lines. Tretinoin 26-30 cadherin 1 Homo sapiens 76-86 29344218-14 2017 ATRA treatment decreased the expression of phosphorylated (p-)beta-catenin, p-GSK-3beta, vimentin, and fibronectin, and increased the expression of NIS and E-cadherin, compared with the control. Tretinoin 0-4 cadherin 1 Homo sapiens 156-166 31899223-9 2020 At the same time, All-trans retinoic acid (ATRA), which has the properties of pro-differentiation and inhibition of invasion and metastasis, upregulated the expression of PD-L1 and E-cadherin. Tretinoin 18-41 cadherin 1 Homo sapiens 181-191 31899223-9 2020 At the same time, All-trans retinoic acid (ATRA), which has the properties of pro-differentiation and inhibition of invasion and metastasis, upregulated the expression of PD-L1 and E-cadherin. Tretinoin 43-47 cadherin 1 Homo sapiens 181-191 30622531-10 2018 In MoDCs generated in the presence of retinoic acid, which express increased CD103, intracellular CD103 significantly redistributed toward the E-cadherin-coated glass surface. Tretinoin 38-51 cadherin 1 Homo sapiens 143-153 26660958-11 2016 Taken together, ATRA can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. Tretinoin 16-20 cadherin 1 Homo sapiens 77-87 23428742-7 2013 Microarray and q PCR analysis showed RA treatment did inhibit the motility of human RPE cells by inhibition of metalloproteinases (MMP) 1, 2, 9, fibronectin-1, transforming growth factor beta, thrombospondin-1, tenascin C, most collagen, integrin, laminin molecules and along enhancing E-cadherin and MMP3 genes expression. Tretinoin 37-39 cadherin 1 Homo sapiens 286-296 26902198-4 2016 Additionally, ATRA effectively upregulated the protein level of NIS, and reversed EMT phenotype in alcohol treated cells, with absence in epithelial expression of E-cadherin and cytokeratin 18, as well as abnormal expression of Vimentin, urinary plasminogen activator (uPA), uPAR and Fibronectin.Compared with alcohol-treated group, both in vitro proliferation and invasion potential of ATRA treated cells markedly decreased (all P<0.05), and iodine uptake in vitro increased about 3.5-folds (P=0.007). Tretinoin 14-18 cadherin 1 Homo sapiens 163-173 21842375-7 2012 Zebularine alone or in sequential combination with RA decreased expression of DNMT1, caused fast and time-dependent expression of pan-cadherin and partial demethylation of E-cadherin but not tumor suppressor p15. Tretinoin 51-53 cadherin 1 Homo sapiens 172-182 22910408-0 2012 All-trans retinoic acid activates E-cadherin expression via promoter hypomethylation in the human colon carcinoma HCT116 cells. Tretinoin 10-23 cadherin 1 Homo sapiens 34-44 19636436-9 2009 However, expression of E-cadherin, RAR, and CRABP increased upon ATRA treatment. Tretinoin 65-69 cadherin 1 Homo sapiens 23-33 21455565-4 2011 Induction of E-cadherin expression by all-trans retinoic acid (ATRA) was also blocked in both cell lines expressing icb-1 siRNA. Tretinoin 63-67 cadherin 1 Homo sapiens 13-23 20197308-10 2010 We confirmed a role for RA in reversal of TGF-beta1-induced changes associated with epithelial-mesenchymal transition, including expression changes in Snail, E-cadherin, vimetin, and redistribution of beta-catenin. Tretinoin 24-26 cadherin 1 Homo sapiens 158-168 19918205-5 2010 Cdh1 was upregulated, whereas Id2 (one downstream substrate of Cdh1-APC) was downregulated when primary neural stem cells were induced to differentiate into neurons by all-trans retinoic acid. Tretinoin 178-191 cadherin 1 Homo sapiens 63-67 21455565-4 2011 Induction of E-cadherin expression by all-trans retinoic acid (ATRA) was also blocked in both cell lines expressing icb-1 siRNA. Tretinoin 38-61 cadherin 1 Homo sapiens 13-23 19115248-2 2009 The combined action of tamoxifen/all-trans retinoic acid was advantageous in MCF-7 cells, reducing cell proliferation, Bcl-2 and c-Myc protein levels and increasing E-Cadherin protein levels and Gap junctional Intercellular Communication. Tretinoin 43-56 cadherin 1 Homo sapiens 165-175 19115248-5 2009 The co-incubation of bradykinin-MCF-7 cells with tamoxifen/all-trans retinoic acid reduced cell proliferation, ERK1/2 activity, as well as Bcl-2, c-Myc, and bradykinin receptor-2 levels, without altering the enhanced E-cadherin levels induced by tamoxifen/all-trans retinoic acid. Tretinoin 69-82 cadherin 1 Homo sapiens 217-227 19636436-14 2009 This study is focused on the effect of ATRA on MMP, MMP-integrin-E-cadherin interrelationship, and also the effect of the drug on different signaling molecules which may involve in the progression of malignant tumor development. Tretinoin 39-43 cadherin 1 Homo sapiens 65-75 18212744-0 2008 Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation. Tretinoin 0-13 cadherin 1 Homo sapiens 48-52 18212744-4 2008 We found that retinoic acid induced the nuclear accumulation of Cdh1 that paralleled Skp2 destabilization and p27 accumulation. Tretinoin 14-27 cadherin 1 Homo sapiens 64-68 18212744-8 2008 Thus, retinoic acid downregulates Rae1, hence facilitating APC(Cdh1)-mediated Skp2 degradation leading to the arrest of cell cycle progression and neuroblastoma differentiation. Tretinoin 6-19 cadherin 1 Homo sapiens 63-67 18212744-5 2008 The mRNA and protein abundance of Rae1-a nuclear export factor that limits APC(Cdh1) activity in mitosis-decreased upon retinoic acid-induced inhibition of neuroblastoma cell proliferation. Tretinoin 120-133 cadherin 1 Homo sapiens 79-83 18212744-6 2008 Furthermore, either Rae1 overexpression or Cdh1 inhibition promoted Skp2 accumulation, p27 destabilization and prevented retinoic acid-induced cell cycle arrest and differentiation. Tretinoin 121-134 cadherin 1 Homo sapiens 43-47 15500294-3 2004 Results showed that retinoic acid treatment increases the amount of beta-catenin bound to E-cadherin by decreasing its tyrosine-phosphorylation level. Tretinoin 20-33 cadherin 1 Homo sapiens 90-100 14988021-10 2004 Moreover, E-cadherin, a major cell adhesion molecule of wild-type P19, was strongly induced by Sox6, resulting in cellular aggregation without RA. Tretinoin 143-145 cadherin 1 Homo sapiens 10-20 11054636-14 2000 Immunofluorescence, however, revealed enhanced organisation of E-cadherin along the cell membrane by RA treatment. Tretinoin 101-103 cadherin 1 Homo sapiens 63-73 12761879-8 2003 Blockage of the RA + Tx-induced GJIC with 18-beta-glycyrrhetinic acid (beta-Gly) prevented in 34% the inhibition of MCF-7 proliferation and the E-cadherin increment in 30% at 96 h of culture. Tretinoin 16-18 cadherin 1 Homo sapiens 144-154 10928048-7 2000 Furthermore, immunohistochemical analysis showed that the differentiation-inducing agent, all-trans retinoic acid, can up-regulate E-cadherin expression in esophageal SCC cells in vitro. Tretinoin 100-113 cadherin 1 Homo sapiens 131-141 9414661-0 1997 All-trans-retinoic acid-dependent inhibition of E-cadherin-based cell adhesion with concomitant dephosphorylation of beta-catenin in metastatic human renal carcinoma cells. Tretinoin 0-23 cadherin 1 Homo sapiens 48-58 9414661-5 1997 The clustering induced by ATRA was virtually blocked in the presence of anti-E cadherin antibody. Tretinoin 26-30 cadherin 1 Homo sapiens 77-87 9414661-6 1997 E-Cadherin and beta-catenin were each localized mainly at the cell-cell adherent junctions of colonizing cell populations that had been treated with ATRA. Tretinoin 149-153 cadherin 1 Homo sapiens 0-10 8880870-11 1996 At least in vitro, insulin-like growth factor-I, retinoic acid, tangeretin and tamoxifen were shown to upregulate the functions of the E-cadherin/catenin complex including inhibition of invasion. Tretinoin 49-62 cadherin 1 Homo sapiens 135-145 8519658-0 1995 Activation of the E-cadherin/catenin complex in human MCF-7 breast cancer cells by all-trans-retinoic acid. Tretinoin 83-106 cadherin 1 Homo sapiens 18-28 8519658-3 1995 We did a series of experiments to determine whether the anti-invasive effect of RA also implicated the invasion-suppressor E-cadherin/catenin complex. Tretinoin 80-82 cadherin 1 Homo sapiens 123-133 8519658-9 1995 RA up-regulates the function of the invasion-suppressor complex E-cadherin/catenin. Tretinoin 0-2 cadherin 1 Homo sapiens 64-74 8062253-6 1994 Both 9cRA and all-trans-retinoic acid induce the expression of the adhesion molecule, E-cadherin, in the SK-BR-3 cell line. Tretinoin 14-37 cadherin 1 Homo sapiens 86-96 9613452-7 1998 Treating SUIT-2 cells with retinoic acid also induced the upregulation of E-cadherin expression. Tretinoin 27-40 cadherin 1 Homo sapiens 74-84