PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9751509-11 1998 Similar to ATRA, 9-cis-RA transiently induced the messenger RNA expression of the nuclear RA receptor RAR beta, suggesting a role for this receptor in the effects of retinoids on the differentiation and proliferation of A spermatogonia. Tretinoin 11-15 retinoic acid receptor, beta Mus musculus 102-110 10100049-11 1998 These findings indicate that the induction of RAR beta mRNA in the fetal palate correlates well with the tissue concentration of all-trans RA after RA treatment, and RAR beta may be one of the most influential candidate molecules for RA-induced teratogenesis. Tretinoin 139-141 retinoic acid receptor, beta Mus musculus 46-54 9458794-0 1998 Retinoic acid and dexamethasone affect RAR-beta and surfactant protein C mRNA in the MLE lung cell line. Tretinoin 0-13 retinoic acid receptor, beta Mus musculus 39-47 9458794-7 1998 Despite Dex, RA increased both RAR-beta and SP-C mRNA. Tretinoin 13-15 retinoic acid receptor, beta Mus musculus 31-39 9075714-3 1997 Only the expression of RAR beta messenger RNA was transiently induced within 24 h after ATRA injection. Tretinoin 88-92 retinoic acid receptor, beta Mus musculus 23-31 9390004-8 1997 It was concluded that RA had a suppressive effect on CRABP-I gene expression in embryos and P19 cells and the effect could be mediated through RAR beta, RAR gamma or RXR alpha. Tretinoin 22-24 retinoic acid receptor, beta Mus musculus 143-151 9075714-4 1997 ATRA-induced RAR beta expression was also found in purified Sertoli cells, suggesting that these cells mediate at least part of the effect of retinoids on germ cells. Tretinoin 0-4 retinoic acid receptor, beta Mus musculus 13-21 9387266-6 1996 Retinoic acid significantly inhibited monolayer growth of the breast carcinoma cells expressing RAR beta, while it had no effect on the growth of the control cells. Tretinoin 0-13 retinoic acid receptor, beta Mus musculus 96-104 9015314-2 1997 There are three types of nuclear receptors for all-trans retinoic acid in mammals, RAR alpha, RAR beta, and RAR gamma, which transduce the retinoic acid signal by inducing or repressing the transcription of target genes (Leid, M., P. Kastner, and P. Chambon. Tretinoin 57-70 retinoic acid receptor, beta Mus musculus 94-102 8960371-7 1996 RAR beta 2 promoter activation by calcitriol was blocked by inhibitors of protein kinase C indicating that calcitriol elicits its effect via protein kinase C. Therefore, calcitriol induces differentiation of F9 mouse embryonal carcinoma cells at least in part by a pathway different from the classical one operative with retinoic acids. Tretinoin 321-335 retinoic acid receptor, beta Mus musculus 0-8 7615548-6 1995 After 48 h of treatment with retinoic acid, Complex I is replaced by a faster migrating Complex II, which can be supershifted by anti-RAR beta and anti-RXR alpha antibodies. Tretinoin 29-42 retinoic acid receptor, beta Mus musculus 134-142 21544324-10 1996 Treatment with retinoic acid increased RAR-alpha level in C4I, HT-3, and CaSki; RAR-beta in HT-3; and RAR-gamma in HT-3 and C4I cells. Tretinoin 15-28 retinoic acid receptor, beta Mus musculus 80-88 8563020-18 1995 Exogenous RA can activate a more widespread response resulting in ectopic transgene and RAR beta expression in the thoracic and sacral cord. Tretinoin 10-12 retinoic acid receptor, beta Mus musculus 88-96 8619960-2 1995 Since one of the RA receptors--RAR-beta 2, is specifically induced in the limb bud cells upon treatment of embryos with teratogenic doses of RA, we investigated if this receptor played a role in teratogenesis by regulating the process of chondrogenesis. Tretinoin 17-19 retinoic acid receptor, beta Mus musculus 31-39 8619960-6 1995 Our results further strengthen the argument that RA-dependent elevation in RAR-beta 2 levels plays a unique role in RA-induced teratogenesis. Tretinoin 49-51 retinoic acid receptor, beta Mus musculus 75-83 7556459-3 1995 Northern blot hybridization revealed that RA induced the expression of RAR-beta mRNA, there being little or no detectable expression in untreated MEPM cells. Tretinoin 42-44 retinoic acid receptor, beta Mus musculus 71-79 7720576-0 1995 Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma. Tretinoin 100-113 retinoic acid receptor, beta Mus musculus 140-148 8528505-11 1995 Inhibition of endogenous CRABP expression renders MEPM cells less responsive to RA with respect to induction of TGF-beta 3, RAR-beta, and tenascin gene expression. Tretinoin 26-28 retinoic acid receptor, beta Mus musculus 124-132 7720576-1 1995 A role for all-trans-retinoic acid in spinal neurulation is suggested by: (1) the reciprocal domains of expression of the retinoic acid receptors RAR-beta and RAR-gamma in the region of the closed neural tube and open posterior neuropore, respectively, and (2) the preventive effect of maternally administered retinoic acid (5 mg/kg) on spinal neural tube defects in curly tail (ct/ct) mice. Tretinoin 15-34 retinoic acid receptor, beta Mus musculus 146-154 7720576-1 1995 A role for all-trans-retinoic acid in spinal neurulation is suggested by: (1) the reciprocal domains of expression of the retinoic acid receptors RAR-beta and RAR-gamma in the region of the closed neural tube and open posterior neuropore, respectively, and (2) the preventive effect of maternally administered retinoic acid (5 mg/kg) on spinal neural tube defects in curly tail (ct/ct) mice. Tretinoin 21-34 retinoic acid receptor, beta Mus musculus 146-154 7935490-4 1994 Loss of both T3R alpha alleles resulted in an increase in basal and RA-induced expression of the endogenous RA-responsive genes, RAR beta and alkaline phosphatase, which demonstrates that T3R alpha has an inhibitory effect on the RA response. Tretinoin 68-70 retinoic acid receptor, beta Mus musculus 129-137 8688195-1 1995 The three retinoic acid receptors (RAR alpha, RAR beta and RAR gamma) are known to modulate the transcription of target genes through interaction of the individual receptors with their naturally occurring ligand, retinoic acid (RA). Tretinoin 10-23 retinoic acid receptor, beta Mus musculus 46-54 7958449-6 1994 This RA effect is particularly interesting since under conditions of RA excess, RAR beta 2 promoter activity and transcript accumulation are induced in regions of developing embryos in which malformations subsequently appear, such as the craniofacial region, the hindbrain, and the limbs. Tretinoin 5-7 retinoic acid receptor, beta Mus musculus 80-88 7958449-6 1994 This RA effect is particularly interesting since under conditions of RA excess, RAR beta 2 promoter activity and transcript accumulation are induced in regions of developing embryos in which malformations subsequently appear, such as the craniofacial region, the hindbrain, and the limbs. Tretinoin 69-71 retinoic acid receptor, beta Mus musculus 80-88 7935490-4 1994 Loss of both T3R alpha alleles resulted in an increase in basal and RA-induced expression of the endogenous RA-responsive genes, RAR beta and alkaline phosphatase, which demonstrates that T3R alpha has an inhibitory effect on the RA response. Tretinoin 108-110 retinoic acid receptor, beta Mus musculus 129-137 8264603-4 1994 DBD- was transfected into P19 murine embryonal carcinoma (EC) cells, in which reporters containing the RA-responsive elements (RAREs) were activated by RA through the activity of endogenous RXR-RA receptor (RAR) heterodimers. Tretinoin 103-105 retinoic acid receptor, beta Mus musculus 127-130 8011555-0 1994 RAR beta isoforms: distinct transcriptional control by retinoic acid and specific spatial patterns of promoter activity during mouse embryonic development. Tretinoin 55-68 retinoic acid receptor, beta Mus musculus 0-8 8011555-3 1994 It has been previously shown that the RA modulation of RAR beta 2/beta 4 transcripts is achieved at the level of transcriptional initiation via a RA response element (RARE) present in the P2 RAR beta 2/beta 4 promoter. Tretinoin 38-40 retinoic acid receptor, beta Mus musculus 55-63 8011555-3 1994 It has been previously shown that the RA modulation of RAR beta 2/beta 4 transcripts is achieved at the level of transcriptional initiation via a RA response element (RARE) present in the P2 RAR beta 2/beta 4 promoter. Tretinoin 38-40 retinoic acid receptor, beta Mus musculus 191-199 8011555-3 1994 It has been previously shown that the RA modulation of RAR beta 2/beta 4 transcripts is achieved at the level of transcriptional initiation via a RA response element (RARE) present in the P2 RAR beta 2/beta 4 promoter. Tretinoin 55-57 retinoic acid receptor, beta Mus musculus 191-199 8011555-4 1994 In contrast, the mechanism by which RA up-regulates RAR beta 1/beta 3 transcripts has not yet been elucidated. Tretinoin 36-38 retinoic acid receptor, beta Mus musculus 52-60 8011556-1 1994 We have previously shown that oral treatment of pregnant mice with all-trans retinoic acid (RA) at doses which cause 100% fetal dysmorphogenesis results in a rapid elevation in the mRNA of one specific isoform of the RA receptor-beta, RAR-beta 2, in susceptible embryonic regions. Tretinoin 71-90 retinoic acid receptor, beta Mus musculus 235-243 8011556-1 1994 We have previously shown that oral treatment of pregnant mice with all-trans retinoic acid (RA) at doses which cause 100% fetal dysmorphogenesis results in a rapid elevation in the mRNA of one specific isoform of the RA receptor-beta, RAR-beta 2, in susceptible embryonic regions. Tretinoin 92-94 retinoic acid receptor, beta Mus musculus 235-243 8067288-14 1994 Recent data suggest a role for the RAR-beta in mediating the effect of retinoic acid on PKC induction. Tretinoin 71-84 retinoic acid receptor, beta Mus musculus 35-43 8067288-17 1994 When B16 cells were transfected with and overexpressed RAR-beta, they also expressed more PKC-alpha mRNA and protein, and the induction of PKC by retinoic acid was not blocked by protein synthesis inhibitors. Tretinoin 146-159 retinoic acid receptor, beta Mus musculus 55-63 8264603-10 1994 By genomic footprinting, we show that RA treatment induces in vivo occupancy of the RARE in the endogenous RAR beta gene in control P19 cells but that this occupancy is not observed with the DBD- cells. Tretinoin 38-40 retinoic acid receptor, beta Mus musculus 107-115 8384988-5 1993 Furthermore, while AtT-20 and F9 cells both expressed multiple RAR beta isoforms, including RAR beta 2, which was profoundly induced by RA in F9 cells, none of these was highly regulated by RA in AtT-20 cells. Tretinoin 63-65 retinoic acid receptor, beta Mus musculus 92-100 8384988-5 1993 Furthermore, while AtT-20 and F9 cells both expressed multiple RAR beta isoforms, including RAR beta 2, which was profoundly induced by RA in F9 cells, none of these was highly regulated by RA in AtT-20 cells. Tretinoin 92-94 retinoic acid receptor, beta Mus musculus 63-71 8388240-1 1993 Induction of the retinoic acid receptor beta 2 (RAR beta 2) gene by retinoic acid (RA) is mediated by a RA response element (RARE), which represents a high affinity binding site for RAR/RXR heterodimers acting at this site as RA-inducible transcription activators. Tretinoin 48-50 retinoic acid receptor, beta Mus musculus 17-44 8388240-1 1993 Induction of the retinoic acid receptor beta 2 (RAR beta 2) gene by retinoic acid (RA) is mediated by a RA response element (RARE), which represents a high affinity binding site for RAR/RXR heterodimers acting at this site as RA-inducible transcription activators. Tretinoin 83-85 retinoic acid receptor, beta Mus musculus 17-44 8388240-1 1993 Induction of the retinoic acid receptor beta 2 (RAR beta 2) gene by retinoic acid (RA) is mediated by a RA response element (RARE), which represents a high affinity binding site for RAR/RXR heterodimers acting at this site as RA-inducible transcription activators. Tretinoin 83-85 retinoic acid receptor, beta Mus musculus 17-44 8099268-7 1993 Retinoic acid skin treatment brings about RAR beta expression in the dermis, leading to the formation of glomerular glands. Tretinoin 0-13 retinoic acid receptor, beta Mus musculus 42-50 1332684-9 1992 Gel-retardation analysis demonstrated that RAR-gamma 1 specifically bound the RA response element of the mouse RAR-beta gene. Tretinoin 43-45 retinoic acid receptor, beta Mus musculus 111-119 8251184-1 1993 Nuclear retinoic acid receptors RAR alpha, RAR beta and RAR gamma are transcription factors that bind all-trans retinoic acid as their ligand and mediate its action by activating particular set of genes that contain retinoic acid responsive elements in their promoter-enhancers. Tretinoin 8-21 retinoic acid receptor, beta Mus musculus 43-51 8251184-1 1993 Nuclear retinoic acid receptors RAR alpha, RAR beta and RAR gamma are transcription factors that bind all-trans retinoic acid as their ligand and mediate its action by activating particular set of genes that contain retinoic acid responsive elements in their promoter-enhancers. Tretinoin 112-125 retinoic acid receptor, beta Mus musculus 43-51 1334737-1 1992 Many of the biological effects of retinoic acid are mediated by its nuclear receptors (RAR-alpha, RAR-beta, and RAR-gamma), and each of these three receptors exist in multiple isoforms. Tretinoin 34-47 retinoic acid receptor, beta Mus musculus 98-106 1333403-6 1992 Interestingly, the expression of the three genes, RAR-beta, CRABP II and CRBP I, is induced by retinoic acid, which suggests a link between the synthesis of RA from retinol and the control of expression of subsets of RA-responsive genes. Tretinoin 95-108 retinoic acid receptor, beta Mus musculus 50-58 1668276-0 1991 Developmental analysis of the retinoic acid-inducible RAR-beta 2 promoter in transgenic animals. Tretinoin 30-43 retinoic acid receptor, beta Mus musculus 54-62 1658797-2 1991 This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-beta 2 promoter. Tretinoin 25-38 retinoic acid receptor, beta Mus musculus 118-126 1668276-2 1991 There are three known types of nuclear receptors for RA in mammals, RAR-alpha, RAR-beta and RAR-gamma, which transduce the RA signal by inducing or repressing the transcription of target genes. Tretinoin 53-55 retinoic acid receptor, beta Mus musculus 79-87 1668276-6 1991 Analysis of the lacZ expression pattern in embryos from mothers treated with teratogenic doses of RA, indicated that mRAR-beta 2 promoter is selectively induced in a manner suggesting that overexpression of the mRAR-beta 2 isoform is involved in RA-generated malformations. Tretinoin 98-100 retinoic acid receptor, beta Mus musculus 117-126 1668276-6 1991 Analysis of the lacZ expression pattern in embryos from mothers treated with teratogenic doses of RA, indicated that mRAR-beta 2 promoter is selectively induced in a manner suggesting that overexpression of the mRAR-beta 2 isoform is involved in RA-generated malformations. Tretinoin 98-100 retinoic acid receptor, beta Mus musculus 211-220 1849102-0 1991 Retinoic acid-induced glandular metaplasia in mouse skin is linked to the dermal expression of retinoic acid receptor beta mRNA. Tretinoin 0-13 retinoic acid receptor, beta Mus musculus 95-122 1661245-5 1991 Response elements for retinoic acid have so far been identified for the rat growth hormone and phosphoenolpyruvate carboxykinase, the mouse complement H and laminin B1, the human and mouse retinoic acid receptor beta, the human osteocalcin, and the human alcohol dehydrogenase genes. Tretinoin 22-35 retinoic acid receptor, beta Mus musculus 189-216 1851295-4 1991 Our results show that RA treatment causes a strong enhancement in c-jun promoter activity, an effect probably mediated by the RA-receptor beta (RAR beta). Tretinoin 22-24 retinoic acid receptor, beta Mus musculus 144-152 1650576-7 1991 These results clearly show that RAR alpha and RAR gamma 1 can transactivate the RAR beta gene; that RAR beta can stimulate its own expression and that resistance to RA in RAC65 cells is probably due to the altered RAR alpha transcript present in these cells. Tretinoin 32-34 retinoic acid receptor, beta Mus musculus 80-88 1649387-3 1991 Transcription of RAR beta is rapidly upregulated through a retinoic acid-responsive element (here referred to as the beta RARE) in its promoter. Tretinoin 59-72 retinoic acid receptor, beta Mus musculus 17-25 2172028-4 1990 Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. Tretinoin 48-67 retinoic acid receptor, beta Mus musculus 95-103 2178220-6 1990 RAR beta mRNA, which was undetectable in untreated cells, was detected after 24 h of treatment with a RA concentration as low as 10(-9) M, and its level increased with up to 10(-6) M RA. Tretinoin 102-104 retinoic acid receptor, beta Mus musculus 0-8 2178220-9 1990 Several retinoids and related synthetic compounds, including 13-cis RA, TTNPB, Ch55, Am80, and the trifluoromethyl nonyloxyphenyl analog of RA, also induced RAR beta mRNA, whereas a 24-h treatment with 10(-6) M retinol, TTNP (a decarboxylated analog of TTNPB), or the phenyl analog of RA failed to induce RAR beta mRNA. Tretinoin 68-70 retinoic acid receptor, beta Mus musculus 157-165 2178220-11 1990 However, S91-C154, a RA-resistant mutant subclone derived from S91-C2 cells, showed mRNA levels of RAR alpha and RAR gamma and induction of RAR beta by RA similar to those detected in the sensitive S91-C2 cells. Tretinoin 21-23 retinoic acid receptor, beta Mus musculus 140-148 34599305-6 2021 Genetic deletions in mice revealed that retinoic acid signalling through the retinoic acid receptors RXRG and RARB, as well as CYP26B1-dependent catabolism, are involved in proper molecular patterning of prefrontal and motor areas, development of PFC-mediodorsal thalamus connectivity, intra-PFC dendritic spinogenesis and expression of the layer 4 marker RORB. Tretinoin 40-53 retinoic acid receptor, beta Mus musculus 110-114 2553481-3 1989 RA induced a rapid accumulation of RAR alpha within 2 h and this was followed by an increase in the RAR beta mRNA. Tretinoin 0-2 retinoic acid receptor, beta Mus musculus 100-108 34001245-15 2021 During the reversal process of ATRA, the expression of retinoic acid receptor beta (RARbeta) was elevated. Tretinoin 31-35 retinoic acid receptor, beta Mus musculus 55-82 28154153-6 2017 Intriguingly, RA signaling defects caused by in vitro inhibition of GCN5 can be rescued through RA-dependent mechanisms that require RARbeta. Tretinoin 14-16 retinoic acid receptor, beta Mus musculus 133-140 31732869-2 2020 RA signaling is mediated by nuclear retinoic acid receptors, alpha, beta, and gamma (RARalpha, RARbeta, and RARgamma). Tretinoin 0-2 retinoic acid receptor, beta Mus musculus 95-102 31732869-2 2020 RA signaling is mediated by nuclear retinoic acid receptors, alpha, beta, and gamma (RARalpha, RARbeta, and RARgamma). Tretinoin 36-49 retinoic acid receptor, beta Mus musculus 95-102 29388081-16 2018 Also, retinoic acid transcriptional signaling was shown to be amplified as evidenced by specific increased Rarbeta and decreased Erbb4 mRNA expression in AS mice versus Ctrl mice hippocampi. Tretinoin 6-19 retinoic acid receptor, beta Mus musculus 107-114 29777906-7 2018 Both ATRA and lipo-ATRA treated groups showed detectable RAR-beta expression with relatively lesser density than the normal group. Tretinoin 5-9 retinoic acid receptor, beta Mus musculus 57-65 29777906-14 2018 These results revealed that the lipo-ATRA treatment has efficiently delivered ATRA into target site than free ATRA and in-turn it might have induced the expression of RAR-beta gene or prevented loss of RAR-beta gene in cancer animals. Tretinoin 37-41 retinoic acid receptor, beta Mus musculus 167-175 29777906-14 2018 These results revealed that the lipo-ATRA treatment has efficiently delivered ATRA into target site than free ATRA and in-turn it might have induced the expression of RAR-beta gene or prevented loss of RAR-beta gene in cancer animals. Tretinoin 37-41 retinoic acid receptor, beta Mus musculus 202-210 29777906-14 2018 These results revealed that the lipo-ATRA treatment has efficiently delivered ATRA into target site than free ATRA and in-turn it might have induced the expression of RAR-beta gene or prevented loss of RAR-beta gene in cancer animals. Tretinoin 78-82 retinoic acid receptor, beta Mus musculus 167-175 29921692-7 2018 However, the response of APL with RARB translocation to retinoids was attenuated compared with that of PML-RARA, an observation in line with the clinical resistance of RARB-positive APL to ATRA. Tretinoin 189-193 retinoic acid receptor, beta Mus musculus 34-38 29848550-0 2018 Combinatorial knockout of RARalpha, RARbeta, and RARgamma completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells. Tretinoin 108-121 retinoic acid receptor, beta Mus musculus 36-43 28715585-5 2017 Results: AM induction by atRA was confirmed via quantification of retinoic acid receptor beta (RARbeta), a well-established retinoic acid-induced gene. Tretinoin 25-29 retinoic acid receptor, beta Mus musculus 66-93 28715585-5 2017 Results: AM induction by atRA was confirmed via quantification of retinoic acid receptor beta (RARbeta), a well-established retinoic acid-induced gene. Tretinoin 25-29 retinoic acid receptor, beta Mus musculus 95-102 28715585-5 2017 Results: AM induction by atRA was confirmed via quantification of retinoic acid receptor beta (RARbeta), a well-established retinoic acid-induced gene. Tretinoin 66-79 retinoic acid receptor, beta Mus musculus 95-102 28154153-6 2017 Intriguingly, RA signaling defects caused by in vitro inhibition of GCN5 can be rescued through RA-dependent mechanisms that require RARbeta. Tretinoin 96-98 retinoic acid receptor, beta Mus musculus 133-140 27684594-4 2016 Most established reporter systems, both transgenic mice and cell lines, make use of the highly potent RA response element (RARE) upstream of the RAR-beta gene to drive RA-inducible expression of reporter genes, such as beta-galactosidase or luciferase. Tretinoin 102-104 retinoic acid receptor, beta Mus musculus 145-153 27684594-4 2016 Most established reporter systems, both transgenic mice and cell lines, make use of the highly potent RA response element (RARE) upstream of the RAR-beta gene to drive RA-inducible expression of reporter genes, such as beta-galactosidase or luciferase. Tretinoin 123-125 retinoic acid receptor, beta Mus musculus 145-153 25087568-4 2014 DNA binding data revealed that RA receptors retinoic acid receptor beta (RARbeta) and retinoid x receptor alpha (RXRalpha) bound to cell cycle genes Cdk1, Cdk2, Cyclin B, Cyclin E, and Cdc25a in mice with and without RA treatment. Tretinoin 31-33 retinoic acid receptor, beta Mus musculus 73-80 25087568-5 2014 In addition, RA treatment induced novel binding of RARbeta/RXRalpha to Cdk1, Cdk2, Cyclin D, and Cdk6 genes. Tretinoin 13-15 retinoic acid receptor, beta Mus musculus 51-58 25087568-8 2014 RA signaling was implicated in normal liver regeneration as the mRNA levels of RARbeta, Aldh1a2, Crabp1, and Crbp1 were all induced 1.5 days after PH during the active phase of hepatocyte proliferation. Tretinoin 0-2 retinoic acid receptor, beta Mus musculus 79-86 25087568-9 2014 RA treatment prior to PH resulted in early up-regulation of RARbeta, Aldh1a2, Crabp1, and Crbp1, which was accompanied by an early induction of cell cycle genes. Tretinoin 0-2 retinoic acid receptor, beta Mus musculus 60-67 25053430-6 2014 The co-regulator RERE, the loss of which results in ectopic Fgf8 expression and somite defects, was recruited near the RARb RARE by RA, but was released from the Fgf8 RARE by RA. Tretinoin 124-126 retinoic acid receptor, beta Mus musculus 119-123 21278145-9 2011 LRAT deficiency decreased diethylnitrosamine-induced injury and tumour load and increased the expression of the retinoic acid responsive genes Cyp26a1, RARb and p21, suggesting that the lower tumour load of LRAT-deficient mice was a result of increased retinoid signalling and subsequent p21-mediated inhibition of proliferation. Tretinoin 112-125 retinoic acid receptor, beta Mus musculus 152-156 24833708-3 2014 The current study examines the hepatic binding profile of two RA receptor isoforms, RARA (RARalpha) and RARB (RARbeta), in response to RA treatment in mouse livers. Tretinoin 62-64 retinoic acid receptor, beta Mus musculus 104-108 24833708-3 2014 The current study examines the hepatic binding profile of two RA receptor isoforms, RARA (RARalpha) and RARB (RARbeta), in response to RA treatment in mouse livers. Tretinoin 62-64 retinoic acid receptor, beta Mus musculus 110-117 24833708-7 2014 RA treatment generated 18,821 novel RARB bindings but only 14,798 of RARA bindings, compared with the control group. Tretinoin 0-2 retinoic acid receptor, beta Mus musculus 36-40 24410928-8 2014 Our results show that the upregulating effect of atRA on TGF-beta1 was mediated by RARalpha, and the enhancing effect of atRA on IL-10 expression was mediated via RARbeta. Tretinoin 121-125 retinoic acid receptor, beta Mus musculus 163-170 24570662-11 2014 Interestingly, RA treatment induces a modulation of RA receptors RARalpha and RARbeta expression in middle-aged mice, a finding which has been correlated with the amplitude of intrahippocampal CORT levels after novelty-induced stress. Tretinoin 15-17 retinoic acid receptor, beta Mus musculus 78-85 23150428-7 2013 The increase in Cyp26a1 and Rarbeta mRNA during pregnancy indicates increased retinoic acid signaling in the liver during pregnancy. Tretinoin 78-91 retinoic acid receptor, beta Mus musculus 28-35 23150428-8 2013 A putative retinoic acid response element was identified within the Cyp2d40 promoter and the mRNA of Cyp2d40 correlated (P < 0.05) with Cyp26a1 and Rarbeta. Tretinoin 11-24 retinoic acid receptor, beta Mus musculus 151-158 24310731-5 2014 AtRA and retinol affected GM-CSF and IL-16 expression mainly through RA receptor beta (RARbeta). Tretinoin 0-4 retinoic acid receptor, beta Mus musculus 87-94 23105114-6 2012 The switch in RA signaling is accomplished by a transient up-regulation of RARbeta concomitantly with a transient increase in the CRABP-II/FABP5 ratio at early stages of differentiation. Tretinoin 14-16 retinoic acid receptor, beta Mus musculus 75-82 22270475-3 2012 Our results show that the expression of mouse liver, bone, and kidney ALP (mL/B/K-ALP) induced by ATRA in C3H10T 1/2 cells was related to the retinoic acid nuclear receptors, RARalpha and RARbeta, which are not involved in the MAPK pathway. Tretinoin 98-102 retinoic acid receptor, beta Mus musculus 188-195 20231276-5 2010 Retinoid receptors (RARgamma, RXRalpha), coactivators (pCIP (NCOA3, SRC3)), and p300 and RNA polymerase II are recruited only to the RARbeta(2) RA response element (RARE) in Balb/c3T3, whereas these proteins are recruited to RAREs of all three genes by RA in F9 cells. Tretinoin 20-22 retinoic acid receptor, beta Mus musculus 133-140 16207763-2 2005 In POM, the effects of the paracrine RA signal are mediated by the nuclear RA receptors heterodimers RXRalpha/RARbeta and RXRalpha/RARgamma. Tretinoin 37-39 retinoic acid receptor, beta Mus musculus 110-117 16813970-6 2006 Proteins involved in mediating the cellular responses to RA include the cellular retinoic acid binding proteins CRABP-I and CRABP-II and the nuclear retinoic acid receptors RAR-alpha, RAR-beta, and RAR-gamma. Tretinoin 57-59 retinoic acid receptor, beta Mus musculus 184-192 16427040-8 2006 Similar analysis of wild type foregut shows that endogenous RAR alpha activity is required to maintain overall RA signaling, and to refine the RAR beta effects in the lung field. Tretinoin 60-62 retinoic acid receptor, beta Mus musculus 143-151 19029830-2 2008 RA exerts its biological functions primarily through binding to and activating nuclear RA receptors (RARs, which include the RAR alpha, beta and gamma isotypes RARA, RARB and RARC). Tretinoin 0-2 retinoic acid receptor, beta Mus musculus 166-170 18443282-8 2008 Importantly, during striatal neurogenesis, endogenous levels of retinoic acid were spatiotemporally regulated such that transduction of high levels of retinoic acid through RARbeta selectively expanded the population of late-born striosomal progenitors, which evolved into a highly elaborate compartment in the rostral striatum. Tretinoin 64-77 retinoic acid receptor, beta Mus musculus 173-180 18443282-8 2008 Importantly, during striatal neurogenesis, endogenous levels of retinoic acid were spatiotemporally regulated such that transduction of high levels of retinoic acid through RARbeta selectively expanded the population of late-born striosomal progenitors, which evolved into a highly elaborate compartment in the rostral striatum. Tretinoin 151-164 retinoic acid receptor, beta Mus musculus 173-180 16291826-5 2006 We further showed that atRA dose-dependently promoted mRNA expression of retinoic acid receptor beta (RAR-beta) and gamma. Tretinoin 23-27 retinoic acid receptor, beta Mus musculus 73-100 16291826-5 2006 We further showed that atRA dose-dependently promoted mRNA expression of retinoic acid receptor beta (RAR-beta) and gamma. Tretinoin 23-27 retinoic acid receptor, beta Mus musculus 102-110 16898870-13 2006 beta-Carotene-induced changes in RARbeta isoform gene expression levels were not predictive for the number of lung tumors but were indicative of intact beta-carotene metabolism and persistent sensitivity to retinoic acid in the mice. Tretinoin 207-220 retinoic acid receptor, beta Mus musculus 33-40 15634700-3 2005 We have analysed the murine retinoic acid receptor beta gene (Rarb) and show that it is induced prior to segmentation, by retinoic-acid (RA) signalling from the mesoderm. Tretinoin 122-135 retinoic acid receptor, beta Mus musculus 28-55 15634700-3 2005 We have analysed the murine retinoic acid receptor beta gene (Rarb) and show that it is induced prior to segmentation, by retinoic-acid (RA) signalling from the mesoderm. Tretinoin 122-135 retinoic acid receptor, beta Mus musculus 62-66 15634700-3 2005 We have analysed the murine retinoic acid receptor beta gene (Rarb) and show that it is induced prior to segmentation, by retinoic-acid (RA) signalling from the mesoderm. Tretinoin 137-139 retinoic acid receptor, beta Mus musculus 28-55 15634700-3 2005 We have analysed the murine retinoic acid receptor beta gene (Rarb) and show that it is induced prior to segmentation, by retinoic-acid (RA) signalling from the mesoderm. Tretinoin 137-139 retinoic acid receptor, beta Mus musculus 62-66 12834868-2 2003 Treatment with retinoic acid (RA) increases Rarb expression and reduces explant bud formation through a signaling mechanism involving RARbeta. Tretinoin 15-28 retinoic acid receptor, beta Mus musculus 134-141 12834868-2 2003 Treatment with retinoic acid (RA) increases Rarb expression and reduces explant bud formation through a signaling mechanism involving RARbeta. Tretinoin 15-28 retinoic acid receptor, beta Mus musculus 44-48 12834868-2 2003 Treatment with retinoic acid (RA) increases Rarb expression and reduces explant bud formation through a signaling mechanism involving RARbeta. Tretinoin 30-32 retinoic acid receptor, beta Mus musculus 44-48 12834868-2 2003 Treatment with retinoic acid (RA) increases Rarb expression and reduces explant bud formation through a signaling mechanism involving RARbeta. Tretinoin 30-32 retinoic acid receptor, beta Mus musculus 134-141 12000751-9 2002 The down-regulation of PKC also inhibited the binding of RAR to a retinoic acid response element and the retinoic acid induction of RAR beta expression. Tretinoin 105-118 retinoic acid receptor, beta Mus musculus 132-140 12486767-2 2002 Furthermore, retinoic acid (RA) induces RARbeta expression, a molecular event associated with neural tube closure, but treatment with RA at the appropriate gestation time causes failure of neural tube closure. Tretinoin 13-26 retinoic acid receptor, beta Mus musculus 40-47 12486767-2 2002 Furthermore, retinoic acid (RA) induces RARbeta expression, a molecular event associated with neural tube closure, but treatment with RA at the appropriate gestation time causes failure of neural tube closure. Tretinoin 28-30 retinoic acid receptor, beta Mus musculus 40-47 12668623-0 2003 Retinoic acid-induced developmental defects are mediated by RARbeta/RXR heterodimers in the pharyngeal endoderm. Tretinoin 0-13 retinoic acid receptor, beta Mus musculus 60-67 12668623-1 2003 Fusion and hypoplasia of the first two branchial arches, a defect typically observed in retinoic acid (RA) embryopathy, is generated in cultured mouse embryos upon treatment with BMS453, a synthetic compound that exhibits retinoic acid receptor beta (RARbeta) agonistic properties in transfected cells. Tretinoin 88-101 retinoic acid receptor, beta Mus musculus 222-249 12668623-1 2003 Fusion and hypoplasia of the first two branchial arches, a defect typically observed in retinoic acid (RA) embryopathy, is generated in cultured mouse embryos upon treatment with BMS453, a synthetic compound that exhibits retinoic acid receptor beta (RARbeta) agonistic properties in transfected cells. Tretinoin 103-105 retinoic acid receptor, beta Mus musculus 222-249 12668623-1 2003 Fusion and hypoplasia of the first two branchial arches, a defect typically observed in retinoic acid (RA) embryopathy, is generated in cultured mouse embryos upon treatment with BMS453, a synthetic compound that exhibits retinoic acid receptor beta (RARbeta) agonistic properties in transfected cells. Tretinoin 103-105 retinoic acid receptor, beta Mus musculus 251-258 12494454-9 2003 The ability of RA to induce RARbeta and PKCalpha expression was retained in A-fos clones, suggesting that A-fos was not interfering with RAR transcription activation functions. Tretinoin 15-17 retinoic acid receptor, beta Mus musculus 28-35 10729205-8 2000 This study shows that retinoic acid depresses alpha(2)(I) collagen gene expression but that this effect is less pronounced when the expression of this collagen is enhanced by acetaldehyde, which also decreases RARbeta message and protein. Tretinoin 22-35 retinoic acid receptor, beta Mus musculus 210-217 12054477-4 2002 Mutation of the retinoic acid response element (RARE) at -879 to -874 (site 1) enhanced promoter activity and diminished but did not eliminate the suppression by RARbeta and RXRalpha. Tretinoin 16-29 retinoic acid receptor, beta Mus musculus 162-169 12054477-7 2002 This study shows that the suppressive effect of retinoic acid on the promoter is maximal with a combination of RARbeta and RXRalpha and occurs at more than one RARE site. Tretinoin 48-61 retinoic acid receptor, beta Mus musculus 111-118 10929206-8 2000 RA treatment of P19 cells stably transfected with the RA-responsive element from the RAR beta gene showed that RAR beta 2 mRNA expression during DMSO differentiation was associated with increased sensitivity to RA. Tretinoin 0-2 retinoic acid receptor, beta Mus musculus 85-93 11821953-7 2002 Furthermore, RA blocked bile acid-induced COX-2 expression and prostaglandin E(2) production only in the RAR-beta positive cells. Tretinoin 13-15 retinoic acid receptor, beta Mus musculus 105-113 11669453-4 2001 Forskolin, but not TGF-beta1, abrogated RA-induced expression of a reporter construct containing 900 base pair (bp) of the RAR-beta gene promoter, transfected into MEPM cells, suggesting that this portion of the promoter contains the forskolin-responsive, but not the TGF-beta-responsive, element. Tretinoin 40-42 retinoic acid receptor, beta Mus musculus 123-131 11669453-5 2001 Thus, a putative TGF-beta Inhibitory Element (TIE) adjacent to the retinoic acid response element (RARE) in the RAR-beta promoter is either non-functional, or requires promoter/enhancer elements not present in the promoter construct used in these experiments. Tretinoin 67-80 retinoic acid receptor, beta Mus musculus 112-120 10929206-8 2000 RA treatment of P19 cells stably transfected with the RA-responsive element from the RAR beta gene showed that RAR beta 2 mRNA expression during DMSO differentiation was associated with increased sensitivity to RA. Tretinoin 0-2 retinoic acid receptor, beta Mus musculus 111-119 10929206-8 2000 RA treatment of P19 cells stably transfected with the RA-responsive element from the RAR beta gene showed that RAR beta 2 mRNA expression during DMSO differentiation was associated with increased sensitivity to RA. Tretinoin 54-56 retinoic acid receptor, beta Mus musculus 85-93 10929206-8 2000 RA treatment of P19 cells stably transfected with the RA-responsive element from the RAR beta gene showed that RAR beta 2 mRNA expression during DMSO differentiation was associated with increased sensitivity to RA. Tretinoin 54-56 retinoic acid receptor, beta Mus musculus 111-119 10929206-8 2000 RA treatment of P19 cells stably transfected with the RA-responsive element from the RAR beta gene showed that RAR beta 2 mRNA expression during DMSO differentiation was associated with increased sensitivity to RA. Tretinoin 54-56 retinoic acid receptor, beta Mus musculus 85-93 10929206-8 2000 RA treatment of P19 cells stably transfected with the RA-responsive element from the RAR beta gene showed that RAR beta 2 mRNA expression during DMSO differentiation was associated with increased sensitivity to RA. Tretinoin 54-56 retinoic acid receptor, beta Mus musculus 111-119 10929206-9 2000 Together these data show that RAR beta 2 is expressed spontaneously in an apparently RA-independent manner in differentiating mesoderm and mesoderm derivatives, resulting in increased sensitivity to RA in these cells. Tretinoin 85-87 retinoic acid receptor, beta Mus musculus 30-38 10529422-12 1999 These data, which indicate that retinoic acid signaling through RARalpha and/or RARbeta is essential for the specification of rhombomere identities and for the control of caudal hindbrain segmentation by restricting the expression domains of kreisler and of Krox-20, also strongly suggest that this signaling plays a crucial role in the posteriorization of the hindbrain neurectoderm. Tretinoin 32-45 retinoic acid receptor, beta Mus musculus 80-87