PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34472453-3 2021 Here, we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8 (STRA8) and MEIOSIN, which are responsive to RA and are critical for meiosis. Tretinoin 149-151 stimulated by retinoic acid 8 Homo sapiens 69-103 34472453-3 2021 Here, we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8 (STRA8) and MEIOSIN, which are responsive to RA and are critical for meiosis. Tretinoin 149-151 stimulated by retinoic acid 8 Homo sapiens 105-110 24076097-3 2014 Evidence suggests that retinoic acid (RA) induces expression of the critical pre-meiosis gene Stra8 in germ cells of the fetal ovary, pubertal testis and adult testis. Tretinoin 23-36 stimulated by retinoic acid 8 Homo sapiens 94-99 33942021-4 2021 As in mammals, stra8 expression was restricted to germ cells in the testis, transcript levels increased during the start of puberty, and decreased when blocking the production of retinoic acid. Tretinoin 179-192 stimulated by retinoic acid 8 Homo sapiens 15-20 31597660-1 2019 Retinoic acid (RA) is critical for mammalian spermatogonia differentiation, and stimulates Stra8 expression, a gene required for meiosis. Tretinoin 0-13 stimulated by retinoic acid 8 Homo sapiens 91-96 31597660-1 2019 Retinoic acid (RA) is critical for mammalian spermatogonia differentiation, and stimulates Stra8 expression, a gene required for meiosis. Tretinoin 15-17 stimulated by retinoic acid 8 Homo sapiens 91-96 29620445-6 2018 RA induction led to slender spindles and tadpole-like changes of cell morphology, and the expression of germ cell-specific markers (Oct4, Piwil2, Itgb1, SSEA-1, and Stra8) presented significant upregulation in the RA treatment group according to the polymerase chain reaction and immunofluorescence results. Tretinoin 0-2 stimulated by retinoic acid 8 Homo sapiens 165-170 27608010-8 2016 Silencing TSPO expression in gonocytes increased the stimulatory effect of RA on the expression of the differentiation marker Stra8, suggesting that TSPO exerts a repressive role on differentiation. Tretinoin 75-77 stimulated by retinoic acid 8 Homo sapiens 126-131 24576537-3 2014 In CYP26B1-null XY gonads, germ cells are exposed to a higher level of RA than in normal XY gonads and this activates Stra8 to induce meiosis while male-specific gene expression is suppressed. Tretinoin 71-73 stimulated by retinoic acid 8 Homo sapiens 118-123 24576537-10 2014 Taken together, we conclude that inhibition of RA is one of the essential factors to promote male germ cell differentiation, and that CYP26B1 suppresses two distinct genetic programs induced by RA: a Stra8-dependent meiotic pathway, and a Stra8-independent mitotic pathway. Tretinoin 194-196 stimulated by retinoic acid 8 Homo sapiens 200-205 33160998-6 2020 Furthermore, using retinoic acid (RA), we induced hPGCLCs in embryoid bodies and identified positive staining for the meiotic initiation marker STRA8. Tretinoin 19-32 stimulated by retinoic acid 8 Homo sapiens 144-149 33160998-6 2020 Furthermore, using retinoic acid (RA), we induced hPGCLCs in embryoid bodies and identified positive staining for the meiotic initiation marker STRA8. Tretinoin 34-36 stimulated by retinoic acid 8 Homo sapiens 144-149 24076097-3 2014 Evidence suggests that retinoic acid (RA) induces expression of the critical pre-meiosis gene Stra8 in germ cells of the fetal ovary, pubertal testis and adult testis. Tretinoin 38-40 stimulated by retinoic acid 8 Homo sapiens 94-99 23785470-1 2013 In mammalian germ cells, meiotic commitment requires the expression of Stimulated by retinoic acid gene 8 (Stra8), which is transcriptionally activated by retinoic acid (RA). Tretinoin 85-98 stimulated by retinoic acid 8 Homo sapiens 107-112 23785470-1 2013 In mammalian germ cells, meiotic commitment requires the expression of Stimulated by retinoic acid gene 8 (Stra8), which is transcriptionally activated by retinoic acid (RA). Tretinoin 170-172 stimulated by retinoic acid 8 Homo sapiens 71-105 23785470-1 2013 In mammalian germ cells, meiotic commitment requires the expression of Stimulated by retinoic acid gene 8 (Stra8), which is transcriptionally activated by retinoic acid (RA). Tretinoin 170-172 stimulated by retinoic acid 8 Homo sapiens 107-112 20951351-2 2010 In mammals, meiotic initiation requires retinoic acid (RA), which activates meiotic inducers, including Stra8, but how the switch to meiosis is controlled in male germ cells (spermatogonia) remains poorly understood. Tretinoin 40-53 stimulated by retinoic acid 8 Homo sapiens 104-109 21674038-8 2011 Finally, we demonstrate that RA induces a two-fold increase in STRA8 expression in cultures of human fetal testis, but is not sufficient to cause widespread meiosis-associated gene expression. Tretinoin 29-31 stimulated by retinoic acid 8 Homo sapiens 63-68 20951351-2 2010 In mammals, meiotic initiation requires retinoic acid (RA), which activates meiotic inducers, including Stra8, but how the switch to meiosis is controlled in male germ cells (spermatogonia) remains poorly understood. Tretinoin 55-57 stimulated by retinoic acid 8 Homo sapiens 104-109 19288751-5 2009 The position of retinoic acid production and CYP26b1 expression that metabolizes RA to an inactive form regulates Stra8 expression. Tretinoin 16-29 stimulated by retinoic acid 8 Homo sapiens 114-119