PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33997692-4 2021 We show that in NB4 (APL/AML-M3) cells, ATRA activates canonical myeloid lineage factors-including SPI1, CEBPE, and STAT1-to direct near-normal differentiation toward mature granulocytes. Tretinoin 40-44 CCAAT enhancer binding protein epsilon Homo sapiens 105-110 33901013-8 2021 Finally, simultaneous knockdown of C/EBPalpha and C/EBPbeta reduces ATRA-induced upregulation of C/EBPepsilon and dramatically impaired NEAT1 activation and APL cell differentiation. Tretinoin 68-72 CCAAT enhancer binding protein epsilon Homo sapiens 97-109 27101150-0 2016 RAF-1/MEK/ERK pathway regulates ATRA-induced differentiation in acute promyelocytic leukemia cells through C/EBPbeta, C/EBPepsilon and PU.1. Tretinoin 32-36 CCAAT enhancer binding protein epsilon Homo sapiens 118-130 29966306-7 2018 Expression of CEBPB induced by ATRA is accompanied by upregulated expression of CEBPE with similar kinetics. Tretinoin 31-35 CCAAT enhancer binding protein epsilon Homo sapiens 80-85 27605212-0 2017 Activation of G0S2 is coordinated by recruitment of PML/RARalpha and C/EBPepsilon to its promoter during ATRA-induced APL differentiation. Tretinoin 105-109 CCAAT enhancer binding protein epsilon Homo sapiens 69-81 27101150-5 2016 ATRA-enhanced protein levels of C/EBPbeta, C/EBPepsilon and PU.1, which were required for differentiation in APL cells, were suppressed by the specific inhibitor of MEK. Tretinoin 0-4 CCAAT enhancer binding protein epsilon Homo sapiens 43-55 27101150-7 2016 Taken together, our study suggested that RAF-1/MEK/ERK cascade was involved in ATRA-induced differentiation in APL cells through enhancing the protein level of C/EBPbeta, C/EBPepsilon and PU.1. Tretinoin 79-83 CCAAT enhancer binding protein epsilon Homo sapiens 171-183 23528261-2 2013 In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPepsilon gene expression induced by ATRA. Tretinoin 145-149 CCAAT enhancer binding protein epsilon Homo sapiens 105-117 24800886-9 2014 Combined treatment with belinostat and RA dose dependently accelerated and reinforced granulocytic differentiation, accompanied by changes in the expression of CD11b, C/EBPalpha (CCAAT/enhancer binding protein-alpha), and C/EBPepsilon. Tretinoin 39-41 CCAAT enhancer binding protein epsilon Homo sapiens 222-234 24769646-3 2014 Treatment with ATRA induced significant myeloid differentiation accompanied by upregulation of RARalpha, C/EBPalpha, C/EBPe and PU.1 in MLL-AF9-positive but not in MLL-AF4/5q31-positive cells. Tretinoin 15-19 CCAAT enhancer binding protein epsilon Homo sapiens 117-123 19507250-5 2009 Notably, RAD001 (10 nM) significantly augmented ATRA-induced expression of CCAAT/enhancer-binding protein epsilon (C/EBPepsilon) and p27(kip1) and downregulated levels of c-Myc in these cells. Tretinoin 48-52 CCAAT enhancer binding protein epsilon Homo sapiens 75-113 20661648-0 2010 C/EBPepsilon participates in all-trans retinoic acid induction of PI3Kgamma in U937 cells via an intronic matrix attachment region sequence. Tretinoin 39-52 CCAAT enhancer binding protein epsilon Homo sapiens 0-12 20661648-1 2010 ATRA (all-trans retinoic acid) regulates gene expression by binding as a ligand to its specific receptors like C/EBPepsilon which is directly induced. Tretinoin 0-4 CCAAT enhancer binding protein epsilon Homo sapiens 111-123 20661648-1 2010 ATRA (all-trans retinoic acid) regulates gene expression by binding as a ligand to its specific receptors like C/EBPepsilon which is directly induced. Tretinoin 6-29 CCAAT enhancer binding protein epsilon Homo sapiens 111-123 20661648-3 2010 Here, we show that C/EBPepsilon and PI3Kgamma are induced in U937 cells by ATRA both in levels of mRNA and protein. Tretinoin 75-79 CCAAT enhancer binding protein epsilon Homo sapiens 19-31 20200558-6 2010 Co-treatment with a pharmacologic inhibitor of PRKCD and RA resulted in the induction of an RA responsive reporter construct, as well as the endogenous RA target genes, CEBPE, CYP26A1 and RIG-I. Tretinoin 57-59 CCAAT enhancer binding protein epsilon Homo sapiens 169-174 19507250-5 2009 Notably, RAD001 (10 nM) significantly augmented ATRA-induced expression of CCAAT/enhancer-binding protein epsilon (C/EBPepsilon) and p27(kip1) and downregulated levels of c-Myc in these cells. Tretinoin 48-52 CCAAT enhancer binding protein epsilon Homo sapiens 115-127 18776924-4 2008 Retinoic acid (RA) induced monocytic differentiation in the myelomonocytic cell lines with MLL-fusion genes, THP-1, MOLM-14 and HF-6 cells, accompanied by monocytic differentiation with the upregulation of C/EBPalpha and C/EBPepsilon. Tretinoin 0-13 CCAAT enhancer binding protein epsilon Homo sapiens 221-233 18776924-4 2008 Retinoic acid (RA) induced monocytic differentiation in the myelomonocytic cell lines with MLL-fusion genes, THP-1, MOLM-14 and HF-6 cells, accompanied by monocytic differentiation with the upregulation of C/EBPalpha and C/EBPepsilon. Tretinoin 15-17 CCAAT enhancer binding protein epsilon Homo sapiens 221-233 11071654-6 2000 Moreover, indinavir enhanced the ability of ATRA to induce expression of the myeloid differentiation-related transcription factor C/EBPepsilon messenger RNA in NB4 cells by 9.5-fold. Tretinoin 44-48 CCAAT enhancer binding protein epsilon Homo sapiens 130-142 16918696-6 2006 We demonstrate that ATRA-induced upregulation of Stat2, ICSBP/IRF8 and C/EBPepsilon, key transcription factors linked to myelomonocytic differentiation, is selectively impaired in cells expressing mutant Stat1. Tretinoin 20-24 CCAAT enhancer binding protein epsilon Homo sapiens 71-83 16918696-8 2006 Taken together, our data suggest that ATRA-induced regulation of Stat2, ICSBP and C/EBPepsilon is dependent on active Stat1, and that a failure to correctly regulate these transcription factors is associated with the inhibition of monocytic differentiation. Tretinoin 38-42 CCAAT enhancer binding protein epsilon Homo sapiens 82-94 15770638-2 2006 Microarray analysis by ATRA treatment for 48 hr in peripheral blood mononuclear cells (in vivo) and in cultured bone marrow mononuclear cells (in vitro) from a patient with APL revealed upregulation of CD11b, CD11c, CCAAT enhancer binding protein epsilon, Rb1, Mad, and tumor necrosis factor-related genes; and downregulation of hTERT, c-Myc, WT1, bcl-2, and eukaryotic translation elongation factor 1alpha2. Tretinoin 23-27 CCAAT enhancer binding protein epsilon Homo sapiens 216-254 17483073-5 2007 Both U937 and NB4 cells treated with 10-7 M all-trans retinoic acid (ATRA) for 6 days displayed increased levels of BPI protein and accompanying up-regulated C/EBP epsilon expression. Tretinoin 44-67 CCAAT enhancer binding protein epsilon Homo sapiens 158-171 17483073-5 2007 Both U937 and NB4 cells treated with 10-7 M all-trans retinoic acid (ATRA) for 6 days displayed increased levels of BPI protein and accompanying up-regulated C/EBP epsilon expression. Tretinoin 69-73 CCAAT enhancer binding protein epsilon Homo sapiens 158-171 16684888-0 2006 All-trans retinoic acid-induced expression of bactericidal/permeability-increasing protein (BPI) in human myeloid cells correlates to binding of C/EBPbeta and C/EBPepsilon to the BPI promoter. Tretinoin 10-23 CCAAT enhancer binding protein epsilon Homo sapiens 159-171 16684888-9 2006 Here, we show that induction of NB4 cells with ATRA correlates to direct binding of C/EBPbeta and C/EBPepsilon to the proximal BPI promoter, as determined by electrophoretic mobility shift analysis and chromatin immunoprecipitation. Tretinoin 47-51 CCAAT enhancer binding protein epsilon Homo sapiens 98-110 15308577-11 2004 RA signaling in granulocytic differentiation involves regulated expression of CHOP and C/EBPepsilon in a coordinated fashion. Tretinoin 0-2 CCAAT enhancer binding protein epsilon Homo sapiens 87-99 15159275-10 2004 Expression of the CD11b cell surface marker and C/EBPepsilon was increased when the cells were treated for 4 days with 0.3 microm AF and a physiological concentration of all-trans retinoic acid (ATRA, 5 nm). Tretinoin 180-193 CCAAT enhancer binding protein epsilon Homo sapiens 48-60 15159275-10 2004 Expression of the CD11b cell surface marker and C/EBPepsilon was increased when the cells were treated for 4 days with 0.3 microm AF and a physiological concentration of all-trans retinoic acid (ATRA, 5 nm). Tretinoin 195-199 CCAAT enhancer binding protein epsilon Homo sapiens 48-60 14604978-9 2004 ATRA induction of NB4 cells resulted in morphologic differentiation and up-regulation of C/EBPepsilon and G-CSFR, but not in STAT3 phosphorylation. Tretinoin 0-4 CCAAT enhancer binding protein epsilon Homo sapiens 89-101 12130515-8 2002 As2O3 in combination with tRA induces gene (Bfl-1/A1 and C/EBPepsilon) expression and partial differentiation. Tretinoin 26-29 CCAAT enhancer binding protein epsilon Homo sapiens 57-69 10330422-4 1999 Reporter gene studies showed that C/EBPepsilon promoter/enhancer activity increased in a retinoid-dependent fashion via the retinoic acid response element (RARE) present in the promoter region of C/EBPepsilon. Tretinoin 124-137 CCAAT enhancer binding protein epsilon Homo sapiens 34-46 9376579-13 1997 We suspect that the C/EBP epsilon promoter/enhancer contains a retinoic acid-response element that is directly stimulated by retinoids. Tretinoin 63-76 CCAAT enhancer binding protein epsilon Homo sapiens 20-33 10330422-4 1999 Reporter gene studies showed that C/EBPepsilon promoter/enhancer activity increased in a retinoid-dependent fashion via the retinoic acid response element (RARE) present in the promoter region of C/EBPepsilon. Tretinoin 124-137 CCAAT enhancer binding protein epsilon Homo sapiens 196-208 10330422-5 1999 The RA-induced expression of C/EBPepsilon markedly increased in U937 myelomonoblasts that were induced to express promyelocytic leukemia/RARalpha (PML/RARalpha), but not in those induced to express promyelocytic leukemia zinc finger/RARalpha (PLZF/RARalpha). Tretinoin 4-6 CCAAT enhancer binding protein epsilon Homo sapiens 29-41 10330422-6 1999 In retinoid-resistant APL cell lines, C/EBPepsilon either is not induced or is induced only at very high concentrations of RA (>/=10(-6) M). Tretinoin 123-125 CCAAT enhancer binding protein epsilon Homo sapiens 38-50 9177240-7 1997 Retinoic acid treatment of HL60 promyelocytic leukemia cells for 24 hr induced C/EBPepsilon mRNA levels by 4-fold, while prolonged treatment gradually reduced mRNA expression to pretreatment levels. Tretinoin 0-13 CCAAT enhancer binding protein epsilon Homo sapiens 79-91 9376579-9 1997 ATRA also induced expression of C/EBP epsilon protein in NB4 cells, as shown by Western blotting. Tretinoin 0-4 CCAAT enhancer binding protein epsilon Homo sapiens 32-45