PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33268713-2 2020 We previously reported that the combined therapy of oral immune therapy (OIT) and kakkonto downregulates the mRNA expression of Cyp26b1, a major retinoic acid (RA)-degrading enzyme, in the colon of food allergy mice and thereby ameliorates allergic symptoms. Tretinoin 145-158 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 128-135 33105029-3 2020 In adult rodents, inhibition of Cyp26a1 and Cyp26b1 increases atRA concentrations and signaling. Tretinoin 62-66 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 44-51 33105029-11 2020 Postnatal knockout of Cyp26b1 resulted in increased atRA concentrations in the skin while the postnatal knockout of both Cyp26a1 and Cyp26b1 resulted in increased atRA concentrations in the liver, serum, skin, spleen, and intestines. Tretinoin 52-56 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 22-29 33105029-11 2020 Postnatal knockout of Cyp26b1 resulted in increased atRA concentrations in the skin while the postnatal knockout of both Cyp26a1 and Cyp26b1 resulted in increased atRA concentrations in the liver, serum, skin, spleen, and intestines. Tretinoin 163-167 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 133-140 31896743-2 2020 We found that formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid (RA). Tretinoin 135-148 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 80-100 31896743-2 2020 We found that formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid (RA). Tretinoin 135-148 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 102-109 31896743-2 2020 We found that formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid (RA). Tretinoin 150-152 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 80-100 31896743-2 2020 We found that formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid (RA). Tretinoin 150-152 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 102-109 34599305-5 2021 Furthermore, retinoic acid signalling is largely confined to the prospective PFC by CYP26B1, a retinoic-acid-catabolizing enzyme, which is upregulated in the prospective motor cortex. Tretinoin 13-26 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 84-91 35364055-10 2022 We show that loss of Cyp26b1 results in upregulation of retinoic acid (RA) target genes, supporting the observation that Cyp26b1 has RA-dependent roles. Tretinoin 56-69 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 21-28 35364055-10 2022 We show that loss of Cyp26b1 results in upregulation of retinoic acid (RA) target genes, supporting the observation that Cyp26b1 has RA-dependent roles. Tretinoin 56-69 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 121-128 35364055-10 2022 We show that loss of Cyp26b1 results in upregulation of retinoic acid (RA) target genes, supporting the observation that Cyp26b1 has RA-dependent roles. Tretinoin 71-73 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 21-28 35364055-10 2022 We show that loss of Cyp26b1 results in upregulation of retinoic acid (RA) target genes, supporting the observation that Cyp26b1 has RA-dependent roles. Tretinoin 71-73 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 121-128 35364055-10 2022 We show that loss of Cyp26b1 results in upregulation of retinoic acid (RA) target genes, supporting the observation that Cyp26b1 has RA-dependent roles. Tretinoin 133-135 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 121-128 33721419-8 2021 Indeed, retinoic acid levels were reduced owing to increased degradation following the elevation of Cyp26b1 in Sox30-null testes. Tretinoin 8-21 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 100-107 32385093-3 2020 Here we analyze male and female mice and show that HBCs also are activated with increasing age as well as non-cell-autonomously by increased expression of the retinoic acid-degrading enzyme CYP26B1. Tretinoin 159-172 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 190-197 32385093-5 2020 Odor/air stimulates CYP26B1 expression in olfactory sensory neurons mainly located in the dorsomedial OE, which is spatially inverse to ventrolateral constitutive expression of the retinoic acid-synthesizing enzyme (RALDH1) in supporting cells. Tretinoin 181-194 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 20-27 33268713-2 2020 We previously reported that the combined therapy of oral immune therapy (OIT) and kakkonto downregulates the mRNA expression of Cyp26b1, a major retinoic acid (RA)-degrading enzyme, in the colon of food allergy mice and thereby ameliorates allergic symptoms. Tretinoin 160-162 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 128-135 31561560-3 2019 In fetal testes, the RA-degrading enzyme CYP26B1 prevents meiosis initiation. Tretinoin 21-23 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 41-48 31749343-4 2019 Moreover, we found that mRNA expression of retinoic acid-specific hydroxylase CYP26b1 was dose-dependently up-regulated by atRal exposure in RPE cells, indicating that atRA inactivation may be also initiated in atRal-accumulated RPE cells. Tretinoin 43-56 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 78-85 31755607-2 2020 CYP26B1 degrades retinoic acid in the testis during prenatal development preventing meiosis initiation. Tretinoin 17-30 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 0-7 31561560-11 2019 Collectively, our data reveal that CYP26B1 has other activities apart from metabolizing RA in fetal gonads and suggest a role of endogenous RA in amplifying Stra8, rather than being the initial inducer of Stra8. Tretinoin 88-90 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 35-42 31561560-11 2019 Collectively, our data reveal that CYP26B1 has other activities apart from metabolizing RA in fetal gonads and suggest a role of endogenous RA in amplifying Stra8, rather than being the initial inducer of Stra8. Tretinoin 140-142 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 35-42 27488031-2 2016 We have identified retinoic acid (RA) and the RA-degrading enzyme CYP26B1 as regulators of ovarian follicle development and showed that RA and a CYP26 inhibitor stimulated ovarian granulosa cell proliferation. Tretinoin 46-48 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 66-73 28446509-0 2017 Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling. Tretinoin 43-47 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 74-81 28446509-10 2017 The increased atRA concentrations in serum without a change in liver suggest that CYP26B1 in extrahepatic sites plays a key role in regulating systemic atRA exposure. Tretinoin 14-18 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 82-89 28446509-10 2017 The increased atRA concentrations in serum without a change in liver suggest that CYP26B1 in extrahepatic sites plays a key role in regulating systemic atRA exposure. Tretinoin 152-156 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 82-89 28111553-3 2016 Robust expression of RA-degrading enzymes Cyp26b1 and Cyp26c1 in developing murine teeth suggested RA excess would reduce tooth hard tissue mineralization, adversely affecting enamel. Tretinoin 21-23 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 42-49 28111553-3 2016 Robust expression of RA-degrading enzymes Cyp26b1 and Cyp26c1 in developing murine teeth suggested RA excess would reduce tooth hard tissue mineralization, adversely affecting enamel. Tretinoin 99-101 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 42-49 30868103-3 2019 Here we show that the retinoic acid (RA)-degrading enzyme CYP26B1 (cytochrome P450 family 26, subfamily B, member 1) is transiently expressed in the mouse frontal cortex during postnatal development, and that medial ganglionic eminence (MGE)-derived interneurons, particularly in parvalbumin (PV)-expressing neurons, are the main cell type that has active RA signaling during this period. Tretinoin 22-35 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 58-65 30868103-3 2019 Here we show that the retinoic acid (RA)-degrading enzyme CYP26B1 (cytochrome P450 family 26, subfamily B, member 1) is transiently expressed in the mouse frontal cortex during postnatal development, and that medial ganglionic eminence (MGE)-derived interneurons, particularly in parvalbumin (PV)-expressing neurons, are the main cell type that has active RA signaling during this period. Tretinoin 37-39 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 58-65 30868103-3 2019 Here we show that the retinoic acid (RA)-degrading enzyme CYP26B1 (cytochrome P450 family 26, subfamily B, member 1) is transiently expressed in the mouse frontal cortex during postnatal development, and that medial ganglionic eminence (MGE)-derived interneurons, particularly in parvalbumin (PV)-expressing neurons, are the main cell type that has active RA signaling during this period. Tretinoin 356-358 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 58-65 30868103-4 2019 We found that frontal cortex-specific Cyp26b1 knock-out mice had an increased density of PV-expressing, but not somatostatin-expressing, interneurons in medial PFC, indicating a novel role of RA signaling in controlling PV neuron development. Tretinoin 192-194 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 38-45 30067986-2 2018 Here, we investigated whether removal of the signaling molecule retinoic acid (RA) by the degradative enzyme CYP26B1 is necessary for proper development of somatic cells of the testes. Tretinoin 64-77 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 109-116 29044428-3 2017 In developing mouse testes, cytochrome P450 family 26, subfamily b, polypeptide 1 (CYP26B1) produced by the Sertoli cells degrades retinoic acid, preventing Stimulated by Retinoic Acid Gene 8 (Stra8), expression and inhibiting meiosis. Tretinoin 131-144 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 83-90 27488031-2 2016 We have identified retinoic acid (RA) and the RA-degrading enzyme CYP26B1 as regulators of ovarian follicle development and showed that RA and a CYP26 inhibitor stimulated ovarian granulosa cell proliferation. Tretinoin 46-48 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 66-73 26892828-1 2016 Substantial evidence exists that during fetal ovarian development in mammals, retinoic acid (RA) induces germ cells to express the pre-meiotic marker Stra8 and enter meiosis, and that these effects are prevented in the fetal testis by the RA-degrading P450 enzyme CYP26B1. Tretinoin 78-91 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 264-271 27214556-8 2016 Finally, spleen growth was impaired in mice lacking either cytochrome P450 26B1 (Cyp26b1), which results in excess RA, or retinol dehydrogenase 10 (Rdh10), which results in RA deficiency. Tretinoin 115-117 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 59-79 27214556-8 2016 Finally, spleen growth was impaired in mice lacking either cytochrome P450 26B1 (Cyp26b1), which results in excess RA, or retinol dehydrogenase 10 (Rdh10), which results in RA deficiency. Tretinoin 115-117 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 81-88 26892828-1 2016 Substantial evidence exists that during fetal ovarian development in mammals, retinoic acid (RA) induces germ cells to express the pre-meiotic marker Stra8 and enter meiosis, and that these effects are prevented in the fetal testis by the RA-degrading P450 enzyme CYP26B1. Tretinoin 93-95 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 264-271 23991089-0 2013 The retinoic acid-metabolizing enzyme Cyp26b1 regulates CD4 T cell differentiation and function. Tretinoin 4-17 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 38-45 26083127-7 2015 Mechanistically, ActA-dependent SMAD3 signaling modulated the expression of members of the retinoic acid (RA) system, including the RA degradation CYP26B1 enzyme and the RA receptors. Tretinoin 91-104 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 147-154 26040672-4 2015 One previous study alluded to a requirement for one of the RA degrading enzymes, CYP26B1, in Sertoli cells but no data exist to determine whether germ cells possess the ability to degrade RA. Tretinoin 59-61 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 81-88 24618783-7 2014 T3 had opposing influences on retinoic acid synthesizing enzymes, increasing the expression of Aldh1a1, and decreasing Aldh1a3, while increasing the retinoic acid degrading enzyme Cyp26b1. Tretinoin 149-162 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 180-187 24361262-3 2014 Here we identify a novel function for CYP26B1, an enzyme known to play a role in tissue morphogenesis by fine-tuning retinoic acid (RA) concentration, in regulating lymphangiogenesis. Tretinoin 117-130 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 38-45 24361262-3 2014 Here we identify a novel function for CYP26B1, an enzyme known to play a role in tissue morphogenesis by fine-tuning retinoic acid (RA) concentration, in regulating lymphangiogenesis. Tretinoin 132-134 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 38-45 24361262-4 2014 Cyp26b1-null mice, in which RA levels are elevated, exhibited an increased number of lymphatic endothelial progenitor cells in the cardinal veins, together with hyperplastic, blood filled lymph sacs and hyperplastic dermal lymphatic vessels. Tretinoin 28-30 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 0-7 24361262-6 2014 Our data suggest that RA clearance by CYP26B1 in the vicinity of lymphatic endothelial progenitor cells is important for determining the position and size of the progenitor pool specified. Tretinoin 22-24 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 38-45 24797530-5 2015 We show that expression of BACE1 and the all-trans retinoic acid (RA)-degrading enzyme Cyp26B1 form DM-VL counter gradients in the olfactory epithelium. Tretinoin 51-64 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 87-94 24797530-5 2015 We show that expression of BACE1 and the all-trans retinoic acid (RA)-degrading enzyme Cyp26B1 form DM-VL counter gradients in the olfactory epithelium. Tretinoin 66-68 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 87-94 25305491-4 2014 We found localized RA activities in the diaphyseal portion of the growth plate cartilage were associated with the specific expression of Cyp26b1 in the epiphyseal portion in juvenile mice. Tretinoin 19-21 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 137-144 22972661-0 2012 The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Tretinoin 29-42 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 57-64 23638129-5 2013 ATRA and the RARgamma agonist further increased retinoid target gene expression (Rbp1, Crabp2, Krt4, Cyp26a1, Cyp26b1) and the chemokines Ccl17 and Ccl22. Tretinoin 0-4 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 110-117 23385081-5 2013 Conversely, activated microglia showed increased protein expression of RA-degrading cytochromes CYP26A1, CYP26B1, CYP3A4 and CYP2C. Tretinoin 71-73 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 105-112 23007396-3 2012 In the present study, we demonstrate that specific levels of RA, regulated by Cyp26b1, one of the RA-degrading enzymes, are required for hair follicle (hf) morphogenesis. Tretinoin 61-63 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 78-85 23007396-3 2012 In the present study, we demonstrate that specific levels of RA, regulated by Cyp26b1, one of the RA-degrading enzymes, are required for hair follicle (hf) morphogenesis. Tretinoin 98-100 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 78-85 23007396-4 2012 Mice with embryonic ablation of Cyp26b1 (Cyp26b1(-/-)) have excessive endogenous RA, resulting in arrest of hf growth at the hair germ stage. Tretinoin 81-83 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 32-39 23007396-4 2012 Mice with embryonic ablation of Cyp26b1 (Cyp26b1(-/-)) have excessive endogenous RA, resulting in arrest of hf growth at the hair germ stage. Tretinoin 81-83 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 41-48 23007396-7 2012 Conditional deficiency of Cyp26b1 in the dermis (En1Cre;Cyp26b1f/-) results in decreased hair follicle density and specific effect on hair type, indicating that RA levels also influence regulators of hair bending. Tretinoin 161-163 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 26-33 23007396-9 2012 To elucidate target gene pathways of RA, we performed microarray and RNA-Seq profiling of genes differentially expressed in Cyp26b1(-/-) skin and En1Cre;Cyp26b1f/- tissues. Tretinoin 37-39 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 124-131 23007396-9 2012 To elucidate target gene pathways of RA, we performed microarray and RNA-Seq profiling of genes differentially expressed in Cyp26b1(-/-) skin and En1Cre;Cyp26b1f/- tissues. Tretinoin 37-39 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 153-160 22972661-2 2012 In the present study, we deleted Cyp26b1, one of the RA-degrading enzymes, to further study the effects of excess RA in the normal developing palate and to understand how endogenous levels of RA are regulated. Tretinoin 53-55 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 33-40 22972661-10 2012 The regulation of RA signaling through CYP26B1 is also necessary for the development of tongue musculature and for tongue depression. Tretinoin 18-20 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 39-46 22127979-5 2012 We found dynamic patterns of gene expression for the RA-synthesizing enzyme, Raldh2, and for the RA-catabolizing enzyme, Cyp26b1, during GT development. Tretinoin 97-99 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 121-128 22214285-7 2012 We further demonstrate that the differential RA response was mediated by the RA-degrading enzyme cytochrome P450 oxidase b1 Cyp26b1. Tretinoin 45-47 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 124-131 22214285-7 2012 We further demonstrate that the differential RA response was mediated by the RA-degrading enzyme cytochrome P450 oxidase b1 Cyp26b1. Tretinoin 77-79 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 124-131 22214285-8 2012 Lumbar cells express high levels of Cyp26b1 and low levels of the RA-synthesizing enzyme retinaldehyde dehydrogenase Raldh2, resulting in limited activation of the RA signaling pathway in these cells. Tretinoin 164-166 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 36-43 22214285-9 2012 In contrast, low Cyp26b1 expression in cervical spinal cord progenitor cells allows RA signaling to be readily activated upon RA treatment. Tretinoin 84-86 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 17-24 22214285-9 2012 In contrast, low Cyp26b1 expression in cervical spinal cord progenitor cells allows RA signaling to be readily activated upon RA treatment. Tretinoin 126-128 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 17-24 22127979-7 2012 Excessive RA signaling in Cyp26b1(-/-) mutants leads to abnormal extents of cell proliferation and differentiation during GT development, and also upregulates expression of growth factor signalings. Tretinoin 10-12 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 26-33 22009938-7 2012 Finally, we showed that CNG channel activity regulated expression of the retinoic acid-degrading enzyme Cyp26B1. Tretinoin 73-86 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 104-111 21249211-0 2011 Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-beta. Tretinoin 18-31 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 0-7 21757499-1 2011 Sex determination in fetal germ cells depends on a balance between exposure to retinoic acid (RA) and the degradation of RA achieved by the testis-specific expression of the catabolic cytochrome P450 enzyme, CYP26B1. Tretinoin 121-123 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 208-215 21224842-1 2011 Sex-specific initiation of meiosis in the fetal ovary has been suggested to require retinoic acid (RA) for induction of Stra8, with expression of the RA-degrading enzyme Cyp26b1 in fetal testis delaying meiosis until postnatal development. Tretinoin 150-152 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 170-177 21224842-4 2011 Ketoconazole inhibition of Cyp26b1 in Raldh2(-/-) testis allows RA-independent induction of Stra8, but only when the mesonephros remains attached, pointing to a non-RA signal from the mesonephros that induces Stra8 in the adjacent gonad. Tretinoin 64-66 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 27-34 21807937-1 2011 Cyp26b1, a retinoic acid (RA)-metabolising enzyme, is expressed in the developing limb bud, and Cyp26b1(-/-) mice present with severe limb defects. Tretinoin 11-24 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 0-7 21807937-1 2011 Cyp26b1, a retinoic acid (RA)-metabolising enzyme, is expressed in the developing limb bud, and Cyp26b1(-/-) mice present with severe limb defects. Tretinoin 26-28 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 0-7 21807937-5 2011 We systematically examined the role of endogenous RA signalling in chondrogenesis and found that Cyp26b1(-/-) cells and limb mesenchymal cells treated with a CYP inhibitor, are maintained in a pre-chondrogenic state, exhibit reduced chondroblast differentiation and have modestly accelerated chondrocyte hypertrophy. Tretinoin 50-52 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 97-104 21471156-0 2011 SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Tretinoin 73-86 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 56-63 21471156-5 2011 In particular, retinoic acid (RA) target genes were upregulated proximally, while the expression of the RA-inactivating Cyp26b1 enzyme was downregulated distally, pointing to increased RA activity in Shh-deficient mouse limb buds. Tretinoin 104-106 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 120-127 21471156-5 2011 In particular, retinoic acid (RA) target genes were upregulated proximally, while the expression of the RA-inactivating Cyp26b1 enzyme was downregulated distally, pointing to increased RA activity in Shh-deficient mouse limb buds. Tretinoin 104-106 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 120-127 21471156-7 2011 During initiation of limb bud outgrowth, the activation of Cyp26b1 expression creates a distal "RA-free" domain, as indicated by complementary downregulation of a transcriptional sensor of RA activity. Tretinoin 96-98 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 59-66 21471156-7 2011 During initiation of limb bud outgrowth, the activation of Cyp26b1 expression creates a distal "RA-free" domain, as indicated by complementary downregulation of a transcriptional sensor of RA activity. Tretinoin 189-191 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 59-66 21471156-11 2011 In summary, SHH promotes distal progression of limb development by enhancing CYP26B1-mediated RA clearance as part of a signalling network linking the SHH/GREM1/AER-FGF feedback loop to the newly identified AER-FGF/CYP26B1/RA module. Tretinoin 94-96 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 77-84 21471156-11 2011 In summary, SHH promotes distal progression of limb development by enhancing CYP26B1-mediated RA clearance as part of a signalling network linking the SHH/GREM1/AER-FGF feedback loop to the newly identified AER-FGF/CYP26B1/RA module. Tretinoin 94-96 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 215-222 21249211-8 2011 Accordingly, physiological levels of RA (1-10 nM) could induce Cyp26b1 expression in naive T cells upon activation in vitro, but could not do so in the presence of TGF-beta. Tretinoin 37-39 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 63-70 21249211-9 2011 Overexpression of Cyp26b1 significantly suppressed the RA effect to induce expression of the gut-homing receptor CCR9 on T cells. Tretinoin 55-57 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 18-25 21249211-11 2011 CONCLUSIONS/SIGNIFICANCE: Our data demonstrate a role for CYP26B1 in regulating RA-dependent signals in activated T cells but not during TGF-beta-dependent differentiation to Foxp3+ regulatory T cells. Tretinoin 80-82 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 58-65 21084447-4 2011 The gene most strongly inhibited by activin was Cyp26b1, which encodes a P450 cytochrome enzyme that degrades retinoic acid (RA). Tretinoin 110-123 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 48-55 21084447-4 2011 The gene most strongly inhibited by activin was Cyp26b1, which encodes a P450 cytochrome enzyme that degrades retinoic acid (RA). Tretinoin 125-127 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 48-55 19838304-3 2009 In mice, retinoic acid (RA) signaling has been implicated in controlling entry into meiosis in germ cells, as meiosis in male embryonic germ cells is blocked by the activity of a RA-catabolizing enzyme, CYP26B1. Tretinoin 9-22 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 203-210 20650878-7 2010 The RA-degrading enzyme, CYP26B1, was found to have germ cell localization and nonuniform distribution between tubules via immunohistochemistry. Tretinoin 4-6 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 25-32 20043900-2 2010 Exogenous RA produces a teratogenic effect on limb morphology; similarly, changes in the endogenous distribution of RA following genetic ablation of the RA-metabolizing enzyme, CYP26B1, result in phocomelia accompanied by changes in expression of proximo-distal (P-D) patterning genes, increased cell death, and delayed chondrocyte maturation. Tretinoin 116-118 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 177-184 20043900-2 2010 Exogenous RA produces a teratogenic effect on limb morphology; similarly, changes in the endogenous distribution of RA following genetic ablation of the RA-metabolizing enzyme, CYP26B1, result in phocomelia accompanied by changes in expression of proximo-distal (P-D) patterning genes, increased cell death, and delayed chondrocyte maturation. Tretinoin 116-118 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 177-184 20043900-5 2010 This model reveals two genetically separable effects of RA in the limb: an apoptotic effect mediated by RARgamma in the presence of ectopic RA, and a P-D patterning defect which is uncovered following the loss of both CYP26B1 and RARgamma. Tretinoin 56-58 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 218-225 20009537-3 2010 Meiotic suppression in embryonic male germ cells is believed to result from sex-specific differences in CYP26B1-catalyzed RA metabolism in the developing gonads. Tretinoin 122-124 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 104-111 20043900-0 2010 Analysis of Cyp26b1/Rarg compound-null mice reveals two genetically separable effects of retinoic acid on limb outgrowth. Tretinoin 89-102 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 12-19 20034106-2 2010 Here, we report that the RA-generating enzyme retinaldehyde dehydrogenase-2 (Raldh2) is expressed in the interdigital mesenchyme whereas Cyp26b1, controlling RA degradation, is expressed in digits, limiting autopodal RA action to the interdigital zones. Tretinoin 158-160 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 137-144 20034106-2 2010 Here, we report that the RA-generating enzyme retinaldehyde dehydrogenase-2 (Raldh2) is expressed in the interdigital mesenchyme whereas Cyp26b1, controlling RA degradation, is expressed in digits, limiting autopodal RA action to the interdigital zones. Tretinoin 158-160 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 137-144 15161092-8 2004 These results reveal specific tissue- and cellular expression patterns of RA synthesizing and catabolizing enzymes in the pre-natal inner ear, and suggest that a precise control of RA concentrations in various cell types of the inner ear is achieved by the balance between RALDHs and CYP26B1 activities. Tretinoin 74-76 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 284-291 18816858-3 2008 RA-degrading enzymes (Cyp26a1 and Cyp26b1) were expressed at early stages of normal tongue development, but exogenous RA perturbed their expression in the fetal tongue. Tretinoin 0-2 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 34-41 18256537-2 2008 Retinoic acid (RA) is degraded by Cyp26b1 in the embryonic testis but not in the ovary where it initiates the mitosis/meiosis transition. Tretinoin 0-13 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 34-41 18256537-2 2008 Retinoic acid (RA) is degraded by Cyp26b1 in the embryonic testis but not in the ovary where it initiates the mitosis/meiosis transition. Tretinoin 15-17 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 34-41 19556237-9 2009 Furthermore, cadmium inhibited the expression of Cyp26a1 and Cyp26b1, which are involved in retinoic acid degradation. Tretinoin 92-105 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 61-68 19235731-1 2009 Cyp26b1 encodes a cytochrome-P450 enzyme that catabolizes retinoic acid (RA), a vitamin A derived signaling molecule. Tretinoin 58-71 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 0-7 19235731-1 2009 Cyp26b1 encodes a cytochrome-P450 enzyme that catabolizes retinoic acid (RA), a vitamin A derived signaling molecule. Tretinoin 73-75 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 0-7 18478160-0 2008 Expression of the retinoic acid-metabolizing enzymes RALDH2 and CYP26b1 during mouse postnatal testis development. Tretinoin 18-31 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 64-71 18281459-1 2008 In mouse fetal gonads, retinoic acid (RA) induces meiosis in the female germ cells, whereas the male germ cells never enter meiosis due to Cyp26b1-mediated RA metabolism. Tretinoin 156-158 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 139-146 17584971-1 2007 Cyp26b1 encodes a retinoic acid (RA) metabolizing cytochrome P450 enzyme that is expressed in embryonic tissues undergoing morphogenesis, including the testes. Tretinoin 18-31 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 0-7 17584971-1 2007 Cyp26b1 encodes a retinoic acid (RA) metabolizing cytochrome P450 enzyme that is expressed in embryonic tissues undergoing morphogenesis, including the testes. Tretinoin 33-35 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 0-7 17584971-2 2007 We have generated transgenic mice lacking Cyp26b1 and have observed increased RA levels in embryonic testes. Tretinoin 78-80 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 42-49 17584971-8 2007 These results provide evidence that CYP26B1 maintains low levels of RA in the developing testes that blocks entry into meiosis and acts as a survival factor to prevent apoptosis of male germ cells. Tretinoin 68-70 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 36-43 16554478-5 2006 In addition, we find that nuclear retinoid signaling is required for the expression of a retinoic acid-degrading enzyme, Cyp26B1, in a small fraction of mature neurons. Tretinoin 89-102 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 121-128 15030763-2 2004 We have studied the role of RA in mouse limb development by focusing on CYP26B1, a cytochrome P450 enzyme that inactivates RA. Tretinoin 123-125 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 72-79 15030763-4 2004 The lack of CYP26B1 resulted in spreading of the RA signal toward the distal end of the developing limb and induced proximodistal patterning defects characterized by expansion of proximal identity and restriction of distal identity. Tretinoin 49-51 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 12-19 15030763-6 2004 Wild-type embryos exposed to excess RA phenocopied the limb defects of Cyp26b1(-/-) mice. Tretinoin 36-38 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 71-78 12930800-6 2003 Further regulation of RA signaling is provided by the presence of a RA sink in the form of the CYP26B1 RA catabolic enzyme expressed in deeper regions of the brain. Tretinoin 22-24 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 95-102 12930800-6 2003 Further regulation of RA signaling is provided by the presence of a RA sink in the form of the CYP26B1 RA catabolic enzyme expressed in deeper regions of the brain. Tretinoin 68-70 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 95-102 12930800-6 2003 Further regulation of RA signaling is provided by the presence of a RA sink in the form of the CYP26B1 RA catabolic enzyme expressed in deeper regions of the brain. Tretinoin 68-70 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 95-102 11744378-0 2002 Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis. Tretinoin 31-44 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 78-85 11744378-1 2002 We recently cloned the murine homologue of Cyp26B1, a novel retinoic acid (RA)-metabolizing enzyme and showed that its gene expression pattern is unique from that of Cyp26A1 during early embryogenesis. Tretinoin 60-73 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 43-50 11744378-1 2002 We recently cloned the murine homologue of Cyp26B1, a novel retinoic acid (RA)-metabolizing enzyme and showed that its gene expression pattern is unique from that of Cyp26A1 during early embryogenesis. Tretinoin 75-77 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 43-50 11744378-8 2002 In addition, Cyp26B1 was expressed at specific levels of the differentiating upper and lower thoracic spinal cord, adjacent to the cervical and lumbar regions that express the RA-synthesizing enzyme RALDH-2. Tretinoin 176-178 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 13-20 11520679-2 2001 The RA-metabolizing enzymes Cyp26A1 and Cyp26B1 are believed to play important roles in protecting certain embryonic tissues from inappropriate RA signaling. Tretinoin 144-146 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 40-47 11520679-0 2001 Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development. Tretinoin 19-32 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 63-70 11520679-2 2001 The RA-metabolizing enzymes Cyp26A1 and Cyp26B1 are believed to play important roles in protecting certain embryonic tissues from inappropriate RA signaling. Tretinoin 4-6 cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus 40-47