PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33451981-7 2021 The expression of CD1d on CLL cells is upregulated by all-trans retinoic acid, and sensitizes the malignant cells to bispecific VHH-induced lysis. Tretinoin 64-77 CD1d molecule Homo sapiens 18-22 1534272-9 1992 An RA-resistant clone, designated HL-60/R3, constitutively expressed larger amounts of alpha-actinin, vinculin, lipocortin I, and lipocortin II than parental HL-60 cells. Tretinoin 3-5 CD1d molecule Homo sapiens 34-42 1534272-10 1992 Treatment of HL-60/R3 with RA resulted in decreases in the amounts of these actin-binding proteins. Tretinoin 27-29 CD1d molecule Homo sapiens 13-21 33128583-7 2021 Although CD1d expression was low on glioblastoma stem-like cells, retinoic acid, which is the most common differentiating agent, upregulated CD1d expression in these cells and induced iNKT cell-mediated cytotoxicity. Tretinoin 66-79 CD1d molecule Homo sapiens 141-145 22585464-2 2012 Although RA promotes natural killer T (NKT) cell activation in vitro by increasing CD1d expression on antigen-presenting cells (APCs), the direct effects of RA on NKT-cell responses in vivo are not known. Tretinoin 9-11 CD1d molecule Homo sapiens 83-87 19651460-0 2010 Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness. Tretinoin 48-61 CD1d molecule Homo sapiens 19-23 19651460-4 2010 We also show that retinoic acid (RA) and the beta-glucocerebrosidase inhibitor conduritol-B-epoxide (CBE) lead to upregulation of CD1d expression by THP-1 cells, which correlated with an increase in mRNA expression. Tretinoin 18-31 CD1d molecule Homo sapiens 130-134 19651460-4 2010 We also show that retinoic acid (RA) and the beta-glucocerebrosidase inhibitor conduritol-B-epoxide (CBE) lead to upregulation of CD1d expression by THP-1 cells, which correlated with an increase in mRNA expression. Tretinoin 33-35 CD1d molecule Homo sapiens 130-134 16982809-0 2006 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. Tretinoin 49-62 CD1d molecule Homo sapiens 19-23 16982809-7 2006 The retinoic acid-induced elevated expression of CD1d is coupled to enhanced iNKT cell activation. Tretinoin 4-17 CD1d molecule Homo sapiens 49-53 30300581-5 2018 CD1D transcriptional de-repression by all-trans retinoic acid results in further enhanced cytotoxicity of CAR19-iNKT cells against CD19+ chronic lymphocytic leukemia cells. Tretinoin 48-61 CD1d molecule Homo sapiens 0-4 28780376-0 2017 Retinoic acid induction of CD1d expression primes chronic lymphocytic leukemia B cells for killing by CD8+ invariant natural killer T cells. Tretinoin 0-13 CD1d molecule Homo sapiens 27-31 25248321-0 2015 All-trans-retinoic acid and CD38 ligation differentially regulate CD1d expression and alpha-galactosylceramide-induced immune responses. Tretinoin 0-23 CD1d molecule Homo sapiens 66-70 25248321-5 2015 Whereas a physiological concentration (20 nM) of RA alone rapidly and markedly increased CD1d protein in THP-1 cells, there was a marked synergy between RA and ligation of CD38 with antibody to CD38. Tretinoin 49-51 CD1d molecule Homo sapiens 89-93 23816303-2 2013 Previously, we showed that all-trans-retinoic acid (RA) increases the expression of CD1d and the magnitude of CD1d-mediated antibody production in vivo. Tretinoin 27-50 CD1d molecule Homo sapiens 84-88 23816303-2 2013 Previously, we showed that all-trans-retinoic acid (RA) increases the expression of CD1d and the magnitude of CD1d-mediated antibody production in vivo. Tretinoin 27-50 CD1d molecule Homo sapiens 110-114 23816303-2 2013 Previously, we showed that all-trans-retinoic acid (RA) increases the expression of CD1d and the magnitude of CD1d-mediated antibody production in vivo. Tretinoin 52-54 CD1d molecule Homo sapiens 84-88 23816303-2 2013 Previously, we showed that all-trans-retinoic acid (RA) increases the expression of CD1d and the magnitude of CD1d-mediated antibody production in vivo. Tretinoin 52-54 CD1d molecule Homo sapiens 110-114 18552205-9 2008 CD1d expression was also induced by ATRA in HL-60 cells and ligation with anti-CD1d antibody-induced apoptosis. Tretinoin 36-40 CD1d molecule Homo sapiens 0-4 17392484-3 2007 Here we show that all-trans-retinoic acid (RA), the active metabolite of vitamin A, rapidly (1 hr after treatment) increases CD1d mRNA in human and rodent monocytic cells at a physiologic dose (10 nM). Tretinoin 18-41 CD1d molecule Homo sapiens 125-129 17392484-3 2007 Here we show that all-trans-retinoic acid (RA), the active metabolite of vitamin A, rapidly (1 hr after treatment) increases CD1d mRNA in human and rodent monocytic cells at a physiologic dose (10 nM). Tretinoin 43-45 CD1d molecule Homo sapiens 125-129 17392484-6 2007 A putative RA-response element was identified in the distal 5" flanking region of the CD1d gene, which binds nuclear retinoid receptors and was responsive to RA in both gel mobility shift assay and transient transfection assay in THP-1 cells. Tretinoin 11-13 CD1d molecule Homo sapiens 86-90 17392484-6 2007 A putative RA-response element was identified in the distal 5" flanking region of the CD1d gene, which binds nuclear retinoid receptors and was responsive to RA in both gel mobility shift assay and transient transfection assay in THP-1 cells. Tretinoin 158-160 CD1d molecule Homo sapiens 86-90 17392484-9 2007 These studies together provide evidence for a previously unknown mechanism of CD1d gene expression regulation by RA and suggest that RA is a significant modulator of NKT cell activation. Tretinoin 113-115 CD1d molecule Homo sapiens 78-82 17392484-9 2007 These studies together provide evidence for a previously unknown mechanism of CD1d gene expression regulation by RA and suggest that RA is a significant modulator of NKT cell activation. Tretinoin 133-135 CD1d molecule Homo sapiens 78-82