PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21325480-2	2011	Here, it was shown that HBx overcomes cellular senescence provoked by all-trans retinoic acid (ATRA) in HepG2 cells, as demonstrated by the impaired induction of irreversible G(1) arrest and senescence-associated beta-galactosidase activity by ATRA in the presence of HBx.	Tretinoin	80-93	X protein	Hepatitis B virus	24-27	
21325480-2	2011	Here, it was shown that HBx overcomes cellular senescence provoked by all-trans retinoic acid (ATRA) in HepG2 cells, as demonstrated by the impaired induction of irreversible G(1) arrest and senescence-associated beta-galactosidase activity by ATRA in the presence of HBx.	Tretinoin	95-99	X protein	Hepatitis B virus	24-27	
21325480-2	2011	Here, it was shown that HBx overcomes cellular senescence provoked by all-trans retinoic acid (ATRA) in HepG2 cells, as demonstrated by the impaired induction of irreversible G(1) arrest and senescence-associated beta-galactosidase activity by ATRA in the presence of HBx.	Tretinoin	244-248	X protein	Hepatitis B virus	24-27	
21325480-4	2011	In addition, HBx suppressed ATRA-mediated induction of p16 and p21 in HepG2 cells via promoter hypermethylation, resulting in inactivation of retinoblastoma protein.	Tretinoin	28-32	X protein	Hepatitis B virus	13-16	
21325480-5	2011	Furthermore, the ability of HBx to overcome ATRA-induced cellular senescence almost completely disappeared when the levels of p16 and p21 in the HBx-expressing cells became similar to those in the control cells by complementation in the former by exogenous expression, knockdown of their expression in the latter using specific small interfering RNA or treatment with a DNA methylation inhibitor, 5-Aza-2"-deoxycytidine.	Tretinoin	44-48	X protein	Hepatitis B virus	28-31	
19828754-3	2010	In addition, HBx abolished the potential of retinoic acid (RA) to downregulate levels of G(1)-checkpoint regulators including p16, p21 and p27, resulting in activation of E2F1 in the presence of RA.	Tretinoin	44-57	X protein	Hepatitis B virus	13-16	
19828754-3	2010	In addition, HBx abolished the potential of retinoic acid (RA) to downregulate levels of G(1)-checkpoint regulators including p16, p21 and p27, resulting in activation of E2F1 in the presence of RA.	Tretinoin	59-61	X protein	Hepatitis B virus	13-16	
19828754-3	2010	In addition, HBx abolished the potential of retinoic acid (RA) to downregulate levels of G(1)-checkpoint regulators including p16, p21 and p27, resulting in activation of E2F1 in the presence of RA.	Tretinoin	195-197	X protein	Hepatitis B virus	13-16	
31706164-1	2020	Hepatitis B virus (HBV) X protein (HBx) has been reported to counteract the innate immune responses through interfering with the pattern recognition receptors signaling activated by retinoic acid-inducible gene-I (RIG-I)-mitochondrial antiviral signaling protein (MAVS).	Tretinoin	182-195	X protein	Hepatitis B virus	35-38	
29068287-2	2017	In this study, we found that the oncogenic hepatitis B virus (HBV) X protein (HBx) of HBV, derived from both overexpression and 1.2-mer replicon systems, suppresses ATRA-induced apoptosis in p53-positive human hepatocytes.	Tretinoin	165-169	X protein	Hepatitis B virus	78-81	
29068287-3	2017	For this effect, HBx upregulated both protein and enzyme activity levels of DNA methyltransferase 1, 3a and 3b, in the presence of ATRA and thereby inhibited p14 expression via promoter hypermethylation, resulting in inactivation of the p14-mouse double minute 2 pathway and subsequent downregulation of p53 levels.	Tretinoin	131-135	X protein	Hepatitis B virus	17-20	
29068287-4	2017	As a result, HBx was able to impair the potential of ATRA to activate apoptosis-related molecules, including Bax, p53-upregulated modulator of apoptosis, caspase-9, caspase-3 and poly (ADP-ribose) polymerase.	Tretinoin	53-57	X protein	Hepatitis B virus	13-16	
29068287-5	2017	In conclusion, the present study provides a new oncogenic action mechanism of HBx, namely by suppressing the anticancer potential of ATRA to induce p53-dependent apoptosis in HBV-infected hepatocytes.	Tretinoin	133-137	X protein	Hepatitis B virus	78-81	
24227948-4	2013	Many genes involved in hepatic retinoid physiology, including CRBP-I, were altered and the tissue levels of retinol and all-trans retinoic acid (ATRA) were elevated in the liver of HBx Tg mice compared to those of wild type (WT) control mice.	Tretinoin	130-143	X protein	Hepatitis B virus	181-184	
24227948-4	2013	Many genes involved in hepatic retinoid physiology, including CRBP-I, were altered and the tissue levels of retinol and all-trans retinoic acid (ATRA) were elevated in the liver of HBx Tg mice compared to those of wild type (WT) control mice.	Tretinoin	145-149	X protein	Hepatitis B virus	181-184