PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23710639-5	2013	Under the all-trans-retinoic acid (RA)-induced differentiation condition, spheroids extended neurites and further up-regulated the expression of synaptophysin, NSE, CAMs, and ECM proteins.	Tretinoin	10-33	enolase 2	Homo sapiens	160-163	
35204719-9	2022	ATRA or UDP-4 treatment significantly upregulated ENO2 and NF1 expression, indicating neuronal differentiation.	Tretinoin	0-4	enolase 2	Homo sapiens	50-54	
27771902-4	2017	We found that RA treatment for 7 days reduced the cell number and proliferative capacity and induced the expression of adult catecholaminergic/neuronal markers such as tyrosine hydroxylase (TH), beta-III tubulin, and enolase-2.	Tretinoin	14-16	enolase 2	Homo sapiens	217-226	
27771902-9	2017	Importantly, Trolox  co-treatment inhibited the appearance of morphological characteristics such as neurite extension and branching, and decreased the expression of TH, beta-III tubulin, and enolase-2 after a seven-day differentiation with RA, indicating that RS production is a necessary step in this process.	Tretinoin	240-242	enolase 2	Homo sapiens	191-200	
14743441-5	2004	RA-treated CD133+ cells expressed mRNA transcripts for neuron-specific markers neurofilament proteins (NF-L, -M, -H) and synaptophysin as determined by RT-PCR, structural proteins characteristic of neurons including tubulin beta III and neuron specific enolase (NSE) by Western blot, and neuron-specific markers NeuN and microtubule-associated protein-2 (MAP2) by immunocytochemistry.	Tretinoin	0-2	enolase 2	Homo sapiens	237-260	
14743441-5	2004	RA-treated CD133+ cells expressed mRNA transcripts for neuron-specific markers neurofilament proteins (NF-L, -M, -H) and synaptophysin as determined by RT-PCR, structural proteins characteristic of neurons including tubulin beta III and neuron specific enolase (NSE) by Western blot, and neuron-specific markers NeuN and microtubule-associated protein-2 (MAP2) by immunocytochemistry.	Tretinoin	0-2	enolase 2	Homo sapiens	262-265	
29380316-4	2018	In the described method, the SH-SY5Y neuroblastoma cell line is differentiated to neuronal cell which expresses NSE, neuronal marker, and dopamine transporter (DAT) by treatment with all-trans-retinoic acid.	Tretinoin	186-206	enolase 2	Homo sapiens	112-115	
23710639-5	2013	Under the all-trans-retinoic acid (RA)-induced differentiation condition, spheroids extended neurites and further up-regulated the expression of synaptophysin, NSE, CAMs, and ECM proteins.	Tretinoin	35-37	enolase 2	Homo sapiens	160-163	
23318218-5	2013	mRNA and protein levels of the neural-markers Nestin, NSE, MAP-2, Tau and Tuj1 were stronger in neural-like cells derived from all-trans retinoic acid-pretreated mesenchymal stem cells than in those not pre-induction.	Tretinoin	137-150	enolase 2	Homo sapiens	54-57	
23597229-6	2013	Cells treated with 10 muM trans-retinoic acid (RA) for 72 hrs exhibited marked changes in morphology to include neurite extensions; presence of P/Q, N and T-type voltage-gated Ca2+ channels; and expression of neuron specific enolase (NSE), synaptosomal-associated protein 25 (SNAP-25), nicotinic acetylcholine receptor alpha7 (nAChR-alpha7) and other neuronal markers.	Tretinoin	26-45	enolase 2	Homo sapiens	209-232	
23597229-6	2013	Cells treated with 10 muM trans-retinoic acid (RA) for 72 hrs exhibited marked changes in morphology to include neurite extensions; presence of P/Q, N and T-type voltage-gated Ca2+ channels; and expression of neuron specific enolase (NSE), synaptosomal-associated protein 25 (SNAP-25), nicotinic acetylcholine receptor alpha7 (nAChR-alpha7) and other neuronal markers.	Tretinoin	26-45	enolase 2	Homo sapiens	234-237	
23597229-6	2013	Cells treated with 10 muM trans-retinoic acid (RA) for 72 hrs exhibited marked changes in morphology to include neurite extensions; presence of P/Q, N and T-type voltage-gated Ca2+ channels; and expression of neuron specific enolase (NSE), synaptosomal-associated protein 25 (SNAP-25), nicotinic acetylcholine receptor alpha7 (nAChR-alpha7) and other neuronal markers.	Tretinoin	47-49	enolase 2	Homo sapiens	209-232	
23597229-6	2013	Cells treated with 10 muM trans-retinoic acid (RA) for 72 hrs exhibited marked changes in morphology to include neurite extensions; presence of P/Q, N and T-type voltage-gated Ca2+ channels; and expression of neuron specific enolase (NSE), synaptosomal-associated protein 25 (SNAP-25), nicotinic acetylcholine receptor alpha7 (nAChR-alpha7) and other neuronal markers.	Tretinoin	47-49	enolase 2	Homo sapiens	234-237	
19035249-15	2008	After the ATRA treatment, cells were stained strongly positive, strongly positive and moderately positive by NSE, vimentin and GFAP antibodies, respectively.	Tretinoin	10-14	enolase 2	Homo sapiens	109-112