PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32168763-6 2020 The irreversible inhibitor of TG2 NC9 not only decreased reactive oxygen species production 28-fold, but decreased the concentration of MCP-1, IL-1beta and TNF-alpha 8-, 15- and 61-fold, respectively in the combined ATRA + ATO-treated wild-type NB4 cell culture. Tretinoin 216-220 interleukin 1 alpha Homo sapiens 143-151 32630207-5 2020 Here, we showed that ATRA prolongs the expression of IL-6 and IL-1beta following a 2-, 6-, 12-, and 24-h LPS (100ng/mL) activation in human monocyte-derived macrophages. Tretinoin 21-25 interleukin 1 alpha Homo sapiens 62-70 14515147-1 2003 In the retinoic acid-differentiated neuroblastoma SH-SY5Y cells, IL-1 induced binding activity of NFkappaB and up-regulated the expression and activity of MnSOD. Tretinoin 7-20 interleukin 1 alpha Homo sapiens 65-69 31434807-7 2019 We found that retinoic acid-related orphan receptor alpha (RORalpha) was increased by inflammatory mediators, such as IL-1beta, and bound to ANGPTL4 promoter in MSCs. Tretinoin 14-27 interleukin 1 alpha Homo sapiens 118-126 29200759-7 2017 In cultured keratinocytes, the RA combination significantly decreased cell viability, but increased cytotoxicity and extracellular interleukin 1 alpha release with corresponding doses of HQ. Tretinoin 31-33 interleukin 1 alpha Homo sapiens 131-150 25642823-0 2015 IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Tretinoin 80-93 interleukin 1 alpha Homo sapiens 0-4 21566987-5 1994 Further experiments indicated that interleukin 1 (IL-1), one of the mediators of LPS activity, also synergized with t-RA to stimulate G-CSF secretion. Tretinoin 116-120 interleukin 1 alpha Homo sapiens 35-54 10102285-0 1999 Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid. Tretinoin 142-155 interleukin 1 alpha Homo sapiens 43-61 7763262-1 1995 We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7. Tretinoin 140-153 interleukin 1 alpha Homo sapiens 66-85 7763262-1 1995 We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7. Tretinoin 140-153 interleukin 1 alpha Homo sapiens 87-97 7763262-1 1995 We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7. Tretinoin 155-159 interleukin 1 alpha Homo sapiens 66-85 7763262-1 1995 We have studied the relationship between interleukin-8 (IL-8) and interleukin-1 alpha (IL-1 alpha) release after stimulation with all-trans retinoic acid (ATRA) and tumor necrosis factor-alpha (TNF-alpha) in the human epithelial ovarian cancer cell line HOC-7. Tretinoin 155-159 interleukin 1 alpha Homo sapiens 87-97 7763262-2 1995 Both IL-1 alpha and IL-8 protein release were enhanced by treatment with ATRA and TNF-alpha after 48 h exposure. Tretinoin 73-77 interleukin 1 alpha Homo sapiens 5-15 7763262-3 1995 Blocking of IL-1 alpha activity in HOC-7 cells with either IL-1 receptor antagonist (IL-1ra) or a neutralizing antibody directed against IL-1 alpha resulted in a dose-dependent decrease of IL-8 release by ATRA, TNF-alpha and IL-1 alpha treated HOC-7 cells. Tretinoin 205-209 interleukin 1 alpha Homo sapiens 12-22 7763262-3 1995 Blocking of IL-1 alpha activity in HOC-7 cells with either IL-1 receptor antagonist (IL-1ra) or a neutralizing antibody directed against IL-1 alpha resulted in a dose-dependent decrease of IL-8 release by ATRA, TNF-alpha and IL-1 alpha treated HOC-7 cells. Tretinoin 205-209 interleukin 1 alpha Homo sapiens 137-147 7763262-3 1995 Blocking of IL-1 alpha activity in HOC-7 cells with either IL-1 receptor antagonist (IL-1ra) or a neutralizing antibody directed against IL-1 alpha resulted in a dose-dependent decrease of IL-8 release by ATRA, TNF-alpha and IL-1 alpha treated HOC-7 cells. Tretinoin 205-209 interleukin 1 alpha Homo sapiens 137-147 8083217-0 1994 Induction of human interleukin-1 gene expression by retinoic acid and its regulation at processing of precursor transcripts. Tretinoin 52-65 interleukin 1 alpha Homo sapiens 19-32 8083217-1 1994 Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA. Tretinoin 0-13 interleukin 1 alpha Homo sapiens 123-142 8083217-1 1994 Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA. Tretinoin 0-13 interleukin 1 alpha Homo sapiens 144-154 8083217-1 1994 Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA. Tretinoin 15-17 interleukin 1 alpha Homo sapiens 123-142 8083217-1 1994 Retinoic acid (RA), we show, induces in peripheral blood mononuclear cells a transient wave of newly transcribed, unstable interleukin-1 alpha (IL-1 alpha) and IL-1 beta mRNA. Tretinoin 15-17 interleukin 1 alpha Homo sapiens 144-154 8020193-0 1994 Retinoic acid effects on endothelial cell function: interaction with interleukin 1. Tretinoin 0-13 interleukin 1 alpha Homo sapiens 69-82 8020193-3 1994 To explore alternate hypotheses, we examined the interaction of retinoic acid and IL-1 on endothelial cell (EC) function and found that RA directly affects and modifies the effects of IL-1 on EC proliferation, prostacyclin production, and plasminogen activator inhibitor capacity (PAI-1). Tretinoin 136-138 interleukin 1 alpha Homo sapiens 82-86 8020193-3 1994 To explore alternate hypotheses, we examined the interaction of retinoic acid and IL-1 on endothelial cell (EC) function and found that RA directly affects and modifies the effects of IL-1 on EC proliferation, prostacyclin production, and plasminogen activator inhibitor capacity (PAI-1). Tretinoin 136-138 interleukin 1 alpha Homo sapiens 184-188 8020193-6 1994 With respect to EC prostacyclin production, although retinoic acid alone had no effect, cis and trans-retinoic acid and retinol all induced a dose-dependent increase in IL-1-mediated prostacyclin production, which was most marked at higher concentrations (20 U/ml) of IL-1. Tretinoin 53-66 interleukin 1 alpha Homo sapiens 169-173 8020193-8 1994 With respect to plasminogen activator inhibitor capacity, both IL-1 and retinoic acid stimulated EC PAI-1 synthesis, but the individual effects were additive, with RA augmenting the known IL-1 effects on EC PAI-1 production. Tretinoin 164-166 interleukin 1 alpha Homo sapiens 188-192 8020193-9 1994 The interaction between RA and IL-1 on the endothelium, described in this study, may play a role in the fashion through which retinoic acid alters the expression of synovitis in certain types of experimental inflammatory arthritis. Tretinoin 126-139 interleukin 1 alpha Homo sapiens 31-35 8982293-3 1996 After 5 d exposure to ATRA 10(-6) M APL-treated samples showed a significant reduction of IL-6 (p = 0.008) and GM-CSF (p = 0.03) and a significant increase of IL-1 alpha (p = 0.01) production, if compared to untreated APL samples. Tretinoin 22-26 interleukin 1 alpha Homo sapiens 159-169 8753812-0 1996 Production of granulocyte colony-stimulating factor by THP-1 cells in response to retinoic acid and phorbol ester is mediated through the autocrine production of interleukin-1. Tretinoin 82-95 interleukin 1 alpha Homo sapiens 162-175 8301142-0 1994 Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts. Tretinoin 0-13 interleukin 1 alpha Homo sapiens 28-32 1717193-1 1991 All trans-retinoic acid (ATRA) and related compounds, at concentrations ranging from 10(-8) to 10(-6) M, augmented the proliferation of human synovial fibroblasts (HSN) stimulated by human interleukin-1 alpha or -beta (IL-1 alpha, IL-beta) and both the acidic and basic forms of fibroblast growth factor (FGFa, FGFb). Tretinoin 4-23 interleukin 1 alpha Homo sapiens 189-217 8489769-0 1993 Effects of retinoic acid on interleukin-1 alpha and -1 beta expression by normal human keratinocytes cultured in defined medium. Tretinoin 11-24 interleukin 1 alpha Homo sapiens 28-59 8489769-2 1993 We investigated the effects of retinoic acid (RA) treatments on IL-1 alpha and -beta protein and mRNA expression of normal human keratinocytes cultured in low-calcium defined medium with or without hydrocortisone. Tretinoin 46-48 interleukin 1 alpha Homo sapiens 64-84 8489769-5 1993 Release of both IL-1 alpha and -beta in culture supernatants was detectable only after RA treatment and in the absence of hydrocortisone. Tretinoin 87-89 interleukin 1 alpha Homo sapiens 16-26 1717193-1 1991 All trans-retinoic acid (ATRA) and related compounds, at concentrations ranging from 10(-8) to 10(-6) M, augmented the proliferation of human synovial fibroblasts (HSN) stimulated by human interleukin-1 alpha or -beta (IL-1 alpha, IL-beta) and both the acidic and basic forms of fibroblast growth factor (FGFa, FGFb). Tretinoin 4-23 interleukin 1 alpha Homo sapiens 219-229 1717193-1 1991 All trans-retinoic acid (ATRA) and related compounds, at concentrations ranging from 10(-8) to 10(-6) M, augmented the proliferation of human synovial fibroblasts (HSN) stimulated by human interleukin-1 alpha or -beta (IL-1 alpha, IL-beta) and both the acidic and basic forms of fibroblast growth factor (FGFa, FGFb). Tretinoin 25-29 interleukin 1 alpha Homo sapiens 189-217 1717193-1 1991 All trans-retinoic acid (ATRA) and related compounds, at concentrations ranging from 10(-8) to 10(-6) M, augmented the proliferation of human synovial fibroblasts (HSN) stimulated by human interleukin-1 alpha or -beta (IL-1 alpha, IL-beta) and both the acidic and basic forms of fibroblast growth factor (FGFa, FGFb). Tretinoin 25-29 interleukin 1 alpha Homo sapiens 219-229 2470302-1 1988 Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid. Tretinoin 183-196 interleukin 1 alpha Homo sapiens 55-65 2178224-5 1990 In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun. Tretinoin 128-141 interleukin 1 alpha Homo sapiens 26-30 2178224-5 1990 In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun. Tretinoin 128-141 interleukin 1 alpha Homo sapiens 151-155 35436742-0 2022 All-trans retinoic acid inhibits the osteogenesis of periodontal ligament stem cells by promoting IL-1beta production via NF-kappaB signaling. Tretinoin 0-23 interleukin 1 alpha Homo sapiens 98-106 35436742-12 2022 Levels of interleukin-1beta (IL-1beta) were increased at varied time points after ATRA treatment. Tretinoin 82-86 interleukin 1 alpha Homo sapiens 29-37 35436742-13 2022 The inhibitive influence of ATRA on the osteogenesis of PDLSCs was partially reversed after neutralizing IL-1beta. Tretinoin 28-32 interleukin 1 alpha Homo sapiens 105-113 35436742-15 2022 Taken together, our results demonstrate that ATRA disrupts the osteogenesis and mineralizationof PDLSCs by promoting IL-1beta expression via activating NF-kappaB signaling and NLRP3 inflammasome, which may offer a new method for improving the ATRA-induced disruption of osteoblast differentiation. Tretinoin 45-49 interleukin 1 alpha Homo sapiens 117-125 35436742-15 2022 Taken together, our results demonstrate that ATRA disrupts the osteogenesis and mineralizationof PDLSCs by promoting IL-1beta expression via activating NF-kappaB signaling and NLRP3 inflammasome, which may offer a new method for improving the ATRA-induced disruption of osteoblast differentiation. Tretinoin 243-247 interleukin 1 alpha Homo sapiens 117-125 35173714-6 2022 However, ATRA attenuated TGEV-induced inflammatory response by inhibiting the release of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8 and TNF-alpha. Tretinoin 9-13 interleukin 1 alpha Homo sapiens 127-135 3142527-3 1988 Recombinant IL-1 (10-100 U/ml) could stimulate cartilage resorption, although the maximum degree of tissue breakdown rarely reached the levels obtained when cartilage was treated with crude mononuclear-cell conditioned medium or all-trans retinoic acid (1 microM) over a similar time course. Tretinoin 239-252 interleukin 1 alpha Homo sapiens 12-16 2206968-0 1990 Effect of topical retinoic acid on the interleukin 1 alpha and beta immunoreactive pool in normal human epidermis. Tretinoin 18-31 interleukin 1 alpha Homo sapiens 39-58 35278669-5 2022 In addition, we observed that ATRA could induce KCs to produce IL-1beta through retinoic acid receptor (RAR) in vitro. Tretinoin 30-34 interleukin 1 alpha Homo sapiens 63-71 2465548-8 1989 Although constitutive levels of IL-1 biological activity and protein are significant in these cultures, IL-1 levels increase when either PMA or retinoic acid alone are added to cultures. Tretinoin 144-157 interleukin 1 alpha Homo sapiens 104-108 2465548-9 1989 IL-1 does not increase when PMA and retinoic acid are added simultaneously to cultures; nor is it induced when extracellular Ca2+ concentrations are raised to 2 mM. Tretinoin 36-49 interleukin 1 alpha Homo sapiens 0-4 2470302-1 1988 Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid. Tretinoin 183-196 interleukin 1 alpha Homo sapiens 140-150