PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21611753-6	2012	Our study also implies that RA induced to express Wnt antagonist Dickkopf-1 (Dkk-1) for neural differentiation.	Tretinoin	28-30	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	65-75	
21611753-6	2012	Our study also implies that RA induced to express Wnt antagonist Dickkopf-1 (Dkk-1) for neural differentiation.	Tretinoin	28-30	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	77-82	
20484817-5	2010	We demonstrated that activation of Wnt signaling required for lung formation was dependent on local repression of its antagonist, Dickkopf homolog 1 (Dkk1), by endogenous RA.	Tretinoin	171-173	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	130-148	
20484817-5	2010	We demonstrated that activation of Wnt signaling required for lung formation was dependent on local repression of its antagonist, Dickkopf homolog 1 (Dkk1), by endogenous RA.	Tretinoin	171-173	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	150-154	
19858186-4	2010	This stimulation was accompanied by increased gene expression of Wnt proteins and receptors and was inhibited by co-treatment with Dickkopf-related protein-1, an extracellular inhibitor of Wnt/beta-catenin signaling, suggesting that RA modulates Wnt signaling at Wnt cell surface receptor level.	Tretinoin	233-235	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	131-157	
17064353-0	2007	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	Tretinoin	152-165	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	32-42	
17064353-2	2007	A 4-day treatment with retinoic acid (RA), which promoted neural differentiation of EBs, substantially increased the expression of the Wnt antagonist Dkk-1, and induced the synthesis of the Wnt/Dkk-1 co-receptor LRP6.	Tretinoin	23-36	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	150-155	
17064353-2	2007	A 4-day treatment with retinoic acid (RA), which promoted neural differentiation of EBs, substantially increased the expression of the Wnt antagonist Dkk-1, and induced the synthesis of the Wnt/Dkk-1 co-receptor LRP6.	Tretinoin	23-36	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	194-199	
17064353-2	2007	A 4-day treatment with retinoic acid (RA), which promoted neural differentiation of EBs, substantially increased the expression of the Wnt antagonist Dkk-1, and induced the synthesis of the Wnt/Dkk-1 co-receptor LRP6.	Tretinoin	38-40	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	150-155	
17064353-2	2007	A 4-day treatment with retinoic acid (RA), which promoted neural differentiation of EBs, substantially increased the expression of the Wnt antagonist Dkk-1, and induced the synthesis of the Wnt/Dkk-1 co-receptor LRP6.	Tretinoin	38-40	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	194-199	
17064353-3	2007	Recombinant Dkk-1 applied to EBs behaved like RA in inducing the expression of the neural markers nestin and distal-less homeobox gene (Dlx-2).	Tretinoin	46-48	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	12-17	
17064353-5	2007	Remarkably, the antisense- or small interfering RNA-induced knockdown of Dkk-1 largely reduced the expression of Dlx-2, and the neuronal marker beta-III tubulin in EBs exposed to RA.	Tretinoin	179-181	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	73-78	
28177772-7	2017	Dkk1, encoding a WNT antagonist, was examined and results showed that its expression increased in F9 cells treated with retinoic acid (RA) or overexpressing Wnt6.	Tretinoin	120-133	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	0-4	
31479736-12	2019	In contrast, RA increased the expression of the WNT inhibitors Dkk1 at day 21 and Dkk2 at days 14 and 21 (p < 0.01).	Tretinoin	13-15	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	63-67