PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18212744-1	2008	In neuroblastoma cells, retinoic acid induces cell cycle arrest and differentiation through degradation of the F-box protein, Skp2, and stabilization of cyclin-dependent kinase inhibitor, p27.	Tretinoin	24-37	S-phase kinase associated protein 2	Homo sapiens	126-130	
19035179-6	2008	Western blot displayed that ATRA could decrease the expression of cyclin A, up-regulate the expression of p21 and p27, and down-regulate the expression of p27 related proteins Skp2.	Tretinoin	28-32	S-phase kinase associated protein 2	Homo sapiens	176-180	
18212744-8	2008	Thus, retinoic acid downregulates Rae1, hence facilitating APC(Cdh1)-mediated Skp2 degradation leading to the arrest of cell cycle progression and neuroblastoma differentiation.	Tretinoin	6-19	S-phase kinase associated protein 2	Homo sapiens	78-82	
18212744-2	2008	However, the mechanism responsible for retinoic acid-mediated Skp2 destabilization is unknown.	Tretinoin	39-52	S-phase kinase associated protein 2	Homo sapiens	62-66	
18212744-4	2008	We found that retinoic acid induced the nuclear accumulation of Cdh1 that paralleled Skp2 destabilization and p27 accumulation.	Tretinoin	14-27	S-phase kinase associated protein 2	Homo sapiens	85-89	
12700651-0	2003	Retinoic acid decreases targeting of p27 for degradation via an N-myc-dependent decrease in p27 phosphorylation and an N-myc-independent decrease in Skp2.	Tretinoin	0-13	S-phase kinase associated protein 2	Homo sapiens	149-153	
15735731-0	2005	Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins.	Tretinoin	0-13	S-phase kinase associated protein 2	Homo sapiens	138-145	
15735731-3	2005	Furthermore, we demonstrate that RA downregulates the expression of the p45Skp2 and Cks1 proteins, two essential components of the SCF(Skp2) ubiquitin ligase complex that target p27Kip1 for degradation.	Tretinoin	33-35	S-phase kinase associated protein 2	Homo sapiens	72-79	
15735731-3	2005	Furthermore, we demonstrate that RA downregulates the expression of the p45Skp2 and Cks1 proteins, two essential components of the SCF(Skp2) ubiquitin ligase complex that target p27Kip1 for degradation.	Tretinoin	33-35	S-phase kinase associated protein 2	Homo sapiens	75-79	
15735731-5	2005	Moreover, overexpression of p45Skp2 in DG75 cells prevents p27Kip1 protein accumulation and promotes resistance to the antiproliferative effects of RA.	Tretinoin	148-150	S-phase kinase associated protein 2	Homo sapiens	28-35	
15735731-9	2005	These results indicate that downregulation of p45Skp2 is a key element underlying RA-induced p27Kip1 stabilization in B cells, resulting in an impaired targeting of the protein to the ubiquitin-proteasome pathway and probably contributing to the nuclear accumulation of p27Kip1.	Tretinoin	82-84	S-phase kinase associated protein 2	Homo sapiens	46-53	
12700651-10	2003	However, RA also decreases Skp2 levels thus impairing the ability of p27 to be ubiquitinated.	Tretinoin	9-11	S-phase kinase associated protein 2	Homo sapiens	27-31	
34921867-6	2022	KEY FINDINGS: We report that the progression of APL and the attenuation of APL sensitivity to ATRA are positively associated with Skp2.	Tretinoin	94-98	S-phase kinase associated protein 2	Homo sapiens	130-134	
34921867-8	2022	Coupled with ATRA or GSK3beta inhibitor treatment, genetic or pharmacological inhibition of Skp2 strikingly induces JunB expression by accelerating the degradation of PML-RARalpha, which contributes to the eradication of APL.	Tretinoin	13-17	S-phase kinase associated protein 2	Homo sapiens	92-96	
11595732-0	2001	Retinoic acid-mediated growth arrest requires ubiquitylation and degradation of the F-box protein Skp2.	Tretinoin	0-13	S-phase kinase associated protein 2	Homo sapiens	98-102	
11595732-5	2001	Furthermore, we demonstrate that ATRA promotes the ubiquitylation of Skp2, an F-box protein that targets p27 for degradation.	Tretinoin	33-37	S-phase kinase associated protein 2	Homo sapiens	69-73	
11595732-8	2001	We found that the mechanism of ATRA-induced ubiquitylation of cyclin D1 and Skp2 is independent of CUL-1 expression and that ATRA can rescue cyclin D1 degradation in the uterine cell line SK-UT-1, where D-type cyclins are stabilized due to a specific defect in proteolysis.	Tretinoin	31-35	S-phase kinase associated protein 2	Homo sapiens	76-80	
11595732-9	2001	These data suggest that ATRA induces a novel pathway of ubiquitylation and that the degradation of the F-box protein Skp2 is the mechanism underlying p27 accumulation and cyclin E-cdk2 inactivation following ATRA treatment.	Tretinoin	24-28	S-phase kinase associated protein 2	Homo sapiens	117-121	
11595732-9	2001	These data suggest that ATRA induces a novel pathway of ubiquitylation and that the degradation of the F-box protein Skp2 is the mechanism underlying p27 accumulation and cyclin E-cdk2 inactivation following ATRA treatment.	Tretinoin	208-212	S-phase kinase associated protein 2	Homo sapiens	117-121