PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10931510-3	2000	The way in which RA modulates secondary neurulation is unclear but probably involves RA-regulated downstream genes such midkine (MK), which encodes a growth factor implicated in tail bud mesenchymal-neuroepithelial conversion.	Tretinoin	17-19	midkine (neurite growth-promoting factor 2)	Gallus gallus	120-127	
10931510-3	2000	The way in which RA modulates secondary neurulation is unclear but probably involves RA-regulated downstream genes such midkine (MK), which encodes a growth factor implicated in tail bud mesenchymal-neuroepithelial conversion.	Tretinoin	17-19	midkine (neurite growth-promoting factor 2)	Gallus gallus	129-131	
10931510-3	2000	The way in which RA modulates secondary neurulation is unclear but probably involves RA-regulated downstream genes such midkine (MK), which encodes a growth factor implicated in tail bud mesenchymal-neuroepithelial conversion.	Tretinoin	85-87	midkine (neurite growth-promoting factor 2)	Gallus gallus	120-127	
10931510-3	2000	The way in which RA modulates secondary neurulation is unclear but probably involves RA-regulated downstream genes such midkine (MK), which encodes a growth factor implicated in tail bud mesenchymal-neuroepithelial conversion.	Tretinoin	85-87	midkine (neurite growth-promoting factor 2)	Gallus gallus	129-131	
10931510-7	2000	Competitive RT-PCR was used to examine the effects of excess RA and RA deficiency due to citral on the expression of MK mRNA.	Tretinoin	61-63	midkine (neurite growth-promoting factor 2)	Gallus gallus	117-119	
10931510-11	2000	Competitive RT-PCR showed that excess RA decreased MK expression by 60%.	Tretinoin	38-40	midkine (neurite growth-promoting factor 2)	Gallus gallus	51-53	
10931510-14	2000	While excess RA decreased MK expression, RA deficiency had minimal effects.	Tretinoin	13-15	midkine (neurite growth-promoting factor 2)	Gallus gallus	26-28	
8292531-0	1993	Localization of RIHB (retinoic acid-induced heparin-binding factor) transcript and protein during early chicken embryogenesis and in the developing wing.	Tretinoin	22-35	midkine (neurite growth-promoting factor 2)	Gallus gallus	16-20	
9633525-1	1998	The heparin-binding growth-associated molecule HB-GAM (also named pleiotrophin) and the retinoic acid-induced heparin-binding protein RIHB (chicken midkine) are developmentally regulated proteins forming a new family of heparin-binding molecules with putative functions during cell growth and differentiation.	Tretinoin	88-101	midkine (neurite growth-promoting factor 2)	Gallus gallus	134-138	
8741221-0	1996	Retinoic acid-induced heparin binding (RIHB, chicken midkine) factor expression by cultured chondrocytes is strongly enhanced by ascorbic acid.	Tretinoin	0-13	midkine (neurite growth-promoting factor 2)	Gallus gallus	39-43	
7925417-8	1994	Analysis of the promoter activity suggests an indirect regulation of transcription by retinoic acid and demonstrates a high degree of complexity of the regulation of the RIHB gene.	Tretinoin	86-99	midkine (neurite growth-promoting factor 2)	Gallus gallus	170-174	
1822401-3	1991	Its synthesis and that of the RIHB mRNA are induced by retinoic acid in chicken myoblasts cell culture.	Tretinoin	55-68	midkine (neurite growth-promoting factor 2)	Gallus gallus	30-34	
8344391-0	1993	Retinoic acid-induced heparin-binding factor (RIHB) mRNA and protein are strongly induced in chick embryo chondrocytes treated with retinoic acid.	Tretinoin	132-145	midkine (neurite growth-promoting factor 2)	Gallus gallus	0-44	
8344391-0	1993	Retinoic acid-induced heparin-binding factor (RIHB) mRNA and protein are strongly induced in chick embryo chondrocytes treated with retinoic acid.	Tretinoin	132-145	midkine (neurite growth-promoting factor 2)	Gallus gallus	46-50	
8344391-2	1993	We have examined the induction of RIHB by retinoic acid in chondrocytes isolated from the sterna of Day 15 chick embryos and the effects of exogenous RIHB on these cells.	Tretinoin	42-55	midkine (neurite growth-promoting factor 2)	Gallus gallus	34-38	
8344391-3	1993	There is an induction of RIHB mRNA in chondrocytes which is dose dependent, with maximal levels of expression observed with concentrations of retinoic acid in the 10(-6) M range.	Tretinoin	142-155	midkine (neurite growth-promoting factor 2)	Gallus gallus	25-29	
2018506-0	1991	Molecular cloning of RI-HB, a heparin binding protein regulated by retinoic acid.	Tretinoin	67-80	midkine (neurite growth-promoting factor 2)	Gallus gallus	21-26	
2018506-1	1991	RI-HB is an extracellular heparin binding protein regulated by retinoic acid and essentially expressed during embryogenesis.	Tretinoin	63-76	midkine (neurite growth-promoting factor 2)	Gallus gallus	0-5	
2018506-5	1991	Northern blot analysis indicates that RI-HB mRNA is strongly expressed during early chicken embryogenesis and that it is induced by retinoic acid treatment of chicken fibroblasts and myotubes in culture.	Tretinoin	132-145	midkine (neurite growth-promoting factor 2)	Gallus gallus	38-43