PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10092805-6	1999	Dephosphorylation of 4E-BP1 was also observed when U-937 cells were induced to differentiate into monocytes/macrophages following treatment with retinoic acid or DMSO.	Tretinoin	145-158	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	21-27	
20724538-7	2010	Overexpression of OLFM4 in HL-60 cells inhibited constitutive and ATRA-induced phosphorylation of the eukaryote initiation factor 4E-binding protein 1 (4E-BP1), whereas down-regulation of OLFM4 protein in acute myeloid leukemia-193 cells increased 4E-BP1 phosphorylation, suggesting that OLFM4 is a potent upstream inhibitor of 4E-BP1 phosphorylation/deactivation.	Tretinoin	66-70	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	130-150	
20724538-7	2010	Overexpression of OLFM4 in HL-60 cells inhibited constitutive and ATRA-induced phosphorylation of the eukaryote initiation factor 4E-binding protein 1 (4E-BP1), whereas down-regulation of OLFM4 protein in acute myeloid leukemia-193 cells increased 4E-BP1 phosphorylation, suggesting that OLFM4 is a potent upstream inhibitor of 4E-BP1 phosphorylation/deactivation.	Tretinoin	66-70	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	152-158	
20724538-7	2010	Overexpression of OLFM4 in HL-60 cells inhibited constitutive and ATRA-induced phosphorylation of the eukaryote initiation factor 4E-binding protein 1 (4E-BP1), whereas down-regulation of OLFM4 protein in acute myeloid leukemia-193 cells increased 4E-BP1 phosphorylation, suggesting that OLFM4 is a potent upstream inhibitor of 4E-BP1 phosphorylation/deactivation.	Tretinoin	66-70	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	248-254	
20724538-7	2010	Overexpression of OLFM4 in HL-60 cells inhibited constitutive and ATRA-induced phosphorylation of the eukaryote initiation factor 4E-binding protein 1 (4E-BP1), whereas down-regulation of OLFM4 protein in acute myeloid leukemia-193 cells increased 4E-BP1 phosphorylation, suggesting that OLFM4 is a potent upstream inhibitor of 4E-BP1 phosphorylation/deactivation.	Tretinoin	66-70	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	248-254	
18280804-3	2008	We now demonstrate that treatment of acute promyelocytic leukemia (APL)-derived NB4 cells with ATRA results in dissociation of the translational repressor 4E-BP1 from the eukaryotic initiation factor eIF4E, and subsequent formation of eIF4G-eIF4E complexes.	Tretinoin	95-99	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	155-161	
18280804-4	2008	We also show that siRNA-mediated inhibition of 4E-BP1 expression enhances ATRA-dependent upregulation of p21(Waf1/Cip1), a protein that plays a key role in the induction of retinoid-dependent responses.	Tretinoin	74-78	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	47-53	
18280804-6	2008	Moreover, generation of ATRA- or cis-retinoic acid (cis-RA)-antiproliferative responses is enhanced in 4E-BP1 knockout cells.	Tretinoin	24-28	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	103-109	
11069026-4	2000	In contrast, following treatment of HL-60 cells with retinoic acid (RA) which results in a granulocytic differentiation of these cells, 4E-BP1 protein expression is decreased whereas 4E-BP2 protein expression is strongly increased.	Tretinoin	53-66	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	136-142	
11069026-4	2000	In contrast, following treatment of HL-60 cells with retinoic acid (RA) which results in a granulocytic differentiation of these cells, 4E-BP1 protein expression is decreased whereas 4E-BP2 protein expression is strongly increased.	Tretinoin	68-70	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	136-142	
11069026-6	2000	RA treatment resulted in a decrease in 4E-BP1 protein and mRNA expression and concomitant increase in 4E-BP2 protein expression, in NB4 cells, but not in NB4-R1 and NB4-R2 cells.	Tretinoin	0-2	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	39-45	
10092805-7	1999	In contrast, treatment of HL-60 cells with retinoic acid or DMSO, which results in a granulocytic differentiation of these cells, decreases 4E-BP1 amount without affecting its phosphorylation and strongly increases 4E-BP2 amount.	Tretinoin	43-56	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	140-146