PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19960509-2 2010 In addition to confirming these findings, we further found that ATRA repressed the expression of betaine-homocysteine methyltransferase (BHMT) and cystathionine-beta-synthase (CBS), which are key enzymes that are involved in homocysteine metabolism, increased the level of intracellular homocysteine, and decreased the glutathione (GSH) level in GnT-V-AS/7721 cells. Tretinoin 64-68 betaine--homocysteine S-methyltransferase Homo sapiens 97-135 19960509-2 2010 In addition to confirming these findings, we further found that ATRA repressed the expression of betaine-homocysteine methyltransferase (BHMT) and cystathionine-beta-synthase (CBS), which are key enzymes that are involved in homocysteine metabolism, increased the level of intracellular homocysteine, and decreased the glutathione (GSH) level in GnT-V-AS/7721 cells. Tretinoin 64-68 betaine--homocysteine S-methyltransferase Homo sapiens 137-141 19960509-7 2010 These results demonstrate that ATRA intensifies ER stress and induces apoptosis in GnT-V-AS/7721 cells by disturbing homocysteine metabolism through the down-regulation of CBS and BHMT, depleting the cellular GSH and, in turn, altering the cellular redox status. Tretinoin 31-35 betaine--homocysteine S-methyltransferase Homo sapiens 180-184