PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27008339-11 2016 We demonstrate here that ATRA is absorbed by PDMS in a time-dependent manner and results in the concomitant reduced expression of CD38 on the cell surface of CB-derived CD34(+) cells. Tretinoin 25-29 CD34 molecule Homo sapiens 169-173 27685949-7 2018 Supplementing the differentiation medium with combinations of fibroblast growth factor-2, transforming growth factor-beta3 and retinoic acid maintained viability, restored expression of CD34, aldehyde dehydrogenase 3A1 and keratocan, and facilitated production of abundant extracellular matrix as shown by immunofluorescent staining for collagen-I and lumican, alongside quantitative assays for collagen and glycosaminoglycan production. Tretinoin 127-140 CD34 molecule Homo sapiens 186-190 28946811-13 2017 Pretreatment with all-trans retinoic acid (ATRA) was found to partially restore the capacity of MSCs in both ITP patients and healthy controls in inducing CD34+-derived regDCs. Tretinoin 18-41 CD34 molecule Homo sapiens 155-159 28946811-13 2017 Pretreatment with all-trans retinoic acid (ATRA) was found to partially restore the capacity of MSCs in both ITP patients and healthy controls in inducing CD34+-derived regDCs. Tretinoin 43-47 CD34 molecule Homo sapiens 155-159 11734301-13 2002 However, P-gp/MDR1 expression augmented by ATRA, which was observed in monocytic AML, was recognized as a functional molecule of mature monocyte/macrophage, because CD34 expression decreased and CD13 expression increased by ATRA. Tretinoin 43-47 CD34 molecule Homo sapiens 165-169 27431256-0 2016 Highly Efficient Neural Differentiation of CD34-Positive Hair-Follicle-Associated Pluripotent Stem Cells Induced by Retinoic Acid and Serum-Free Medium. Tretinoin 116-129 CD34 molecule Homo sapiens 43-47 25239423-8 2014 The best interpretative approach to ATRA-treated APL (CD34- or HLA-DR-) showed 100% sensitivity but limited specificity (73%). Tretinoin 36-40 CD34 molecule Homo sapiens 54-58 21423769-2 2011 We report that from all inductive signals tested, retinoic acid (RA) and platelet derived growth factor (PDGF(BB)) are the most effective agents in guiding the differentiation of CD34(+) cells into smooth muscle progenitor cells (SMPCs) characterized by the expression of SMC genes and proteins, secretion of SMC-related cytokines, contraction in response to depolarization agents and vasoactive peptides and expression of SMC-related genes in a 3D environment. Tretinoin 50-63 CD34 molecule Homo sapiens 179-183 21423769-2 2011 We report that from all inductive signals tested, retinoic acid (RA) and platelet derived growth factor (PDGF(BB)) are the most effective agents in guiding the differentiation of CD34(+) cells into smooth muscle progenitor cells (SMPCs) characterized by the expression of SMC genes and proteins, secretion of SMC-related cytokines, contraction in response to depolarization agents and vasoactive peptides and expression of SMC-related genes in a 3D environment. Tretinoin 65-67 CD34 molecule Homo sapiens 179-183 20565948-0 2010 Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients. Tretinoin 16-29 CD34 molecule Homo sapiens 55-59 20565948-8 2010 CONCLUSIONS: The altered gene expression profile of CD34+ cells in CAD patients was related to activation/differentiation by a retinoic acid-induced differentiation program. Tretinoin 127-140 CD34 molecule Homo sapiens 52-56 20565948-9 2010 These results suggest that circulating CD34+ cells in CAD patients are programmed by retinoic acid, leading to a reduced capacity to migrate to ischemic tissues. Tretinoin 85-98 CD34 molecule Homo sapiens 39-43 17259349-3 2007 Expression of PDCD4 was markedly up-regulated during all-trans retinoic acid (ATRA)-induced granulocytic differentiation in NB4 and HL60 AML cell lines and in primary human promyelocytic leukemia (AML-M3) and CD34(+) hematopoietic progenitor cells but not in differentiation-resistant NB4.R1 and HL60R cells. Tretinoin 78-82 CD34 molecule Homo sapiens 209-213 15781332-5 2005 RESULTS: All-trans retinoic acid (1 mumol/L) reduced expansion of CD34+CD38-Lin- TNC and CFUs after 2 to 5 weeks of culture. Tretinoin 9-32 CD34 molecule Homo sapiens 66-70 12769347-10 2003 The results suggest that while in normal hematopoietic cells and in PML CD34 - cells induction of CD38 antigen expression by RA results in terminal differentiation along the myeloid lineage, in early myeloblastic leukemic CD34 + cells, induction of CD38 and differentiation are not functionally related. Tretinoin 125-127 CD34 molecule Homo sapiens 72-76 12769347-10 2003 The results suggest that while in normal hematopoietic cells and in PML CD34 - cells induction of CD38 antigen expression by RA results in terminal differentiation along the myeloid lineage, in early myeloblastic leukemic CD34 + cells, induction of CD38 and differentiation are not functionally related. Tretinoin 125-127 CD34 molecule Homo sapiens 222-226 11842302-7 2002 Similarly, ATRA (10(-6) mol/L) inhibited eosinophil-basophil differentiation of cord blood CD34(+) cells in liquid culture, whereas neutrophil differentiation proceeded without impediment. Tretinoin 11-15 CD34 molecule Homo sapiens 91-95 11842302-8 2002 Most importantly, these effects of ATRA (10(-8) to 10(-6) mol/L) on CD34(+) cells were associated with a dose-dependent inhibition of IL-5Ralpha but no change in GM-CSF receptor expression, as detected with flow cytometry. Tretinoin 35-39 CD34 molecule Homo sapiens 68-72 25805962-7 2015 RESULTS: ATRA (100 nM) induced granulocytic differentiation (upregulation of CD11b and downregulation of CD34) and the effect was potentiated by addition of G-CSF, while G-CSF alone had no effect on HT93A cells. Tretinoin 9-13 CD34 molecule Homo sapiens 105-109 25294494-9 2015 Moreover, increasing RA concentration (>=10 muM) leads to increased cell death in the cells, but a lower concentration of RA (1 muM) treatment results in a decrease in CD34-expressing stem cells. Tretinoin 125-127 CD34 molecule Homo sapiens 171-175 15309027-0 2004 Pharmacological doses of all-trans retinoic acid promote G0/G1 transition and G1 arrest of normal human marrow CD34+ cells. Tretinoin 35-48 CD34 molecule Homo sapiens 111-115 12139742-1 2002 All-trans retinoic acid (ATRA) is a specific inducer of CD38 antigen on marrow CD34+ cells as well as on blast cells in acute promyelocytic and myeloblastic leukaemia. Tretinoin 0-23 CD34 molecule Homo sapiens 79-83 12139742-1 2002 All-trans retinoic acid (ATRA) is a specific inducer of CD38 antigen on marrow CD34+ cells as well as on blast cells in acute promyelocytic and myeloblastic leukaemia. Tretinoin 25-29 CD34 molecule Homo sapiens 79-83 12100164-0 2002 All-trans retinoic acid prevents apoptosis of human marrow CD34+ cells deprived of haematopoietic growth factors. Tretinoin 10-23 CD34 molecule Homo sapiens 59-63 12100164-3 2002 We studied the effects of pharmacological doses of all-transretinoic acid (ATRA) on the apoptosis of human adult marrow CD34+ progenitor cells cultured for 7 d in a serum-free medium. Tretinoin 51-73 CD34 molecule Homo sapiens 120-124 12100164-3 2002 We studied the effects of pharmacological doses of all-transretinoic acid (ATRA) on the apoptosis of human adult marrow CD34+ progenitor cells cultured for 7 d in a serum-free medium. Tretinoin 75-79 CD34 molecule Homo sapiens 120-124 12100164-7 2002 Exposure to ATRA partially prevented the decrease in viable CD34+, without a concomitant effect on the clonogenic and more immature progenitors. Tretinoin 12-16 CD34 molecule Homo sapiens 60-64 12100164-8 2002 ATRA-treated CD34+ cells displayed changes in apoptotic status compared with control cultures, particularly in lower annexin V-binding. Tretinoin 0-4 CD34 molecule Homo sapiens 13-17 11279655-3 2001 Although the differentiating effects of ATRA on promyelocytes have been well established, in vitro studies have shown that less-differentiated APL blasts (CD34(+)) demonstrate a variable responsiveness to ATRA. Tretinoin 205-209 CD34 molecule Homo sapiens 155-159 11424001-10 2001 ATRA also inhibited CD34+ JCML monocytic growth and GM-CSF hypersensitivity. Tretinoin 0-4 CD34 molecule Homo sapiens 20-24 11306982-6 2001 Similarly, ATRA inhibited eosinophil/basophil differentiation of cord blood CD34+ cells, while neutrophil differentiation proceeded without impediment. Tretinoin 11-15 CD34 molecule Homo sapiens 76-80 10456672-15 1999 In conclusion, the present results suggest a potential role for the combination of RA and cytarabine in the treatment of refractory and/or relapsed AML patients with CD34+CD7- but not CD34+CD7+ blast cells. Tretinoin 83-85 CD34 molecule Homo sapiens 166-170 10803520-0 2000 All-trans-retinoic acid effects the growth, differentiation and apoptosis of normal human myeloid progenitors derived from purified CD34+ bone marrow cells. Tretinoin 0-23 CD34 molecule Homo sapiens 132-136 10803520-2 2000 In this study, we further characterized the effect of ATRA on the growth of CFU-GM stimulated by individual cytokines from multiple samples of CD34+ enriched or purified human bone marrow cells. Tretinoin 54-58 CD34 molecule Homo sapiens 143-147 10803520-6 2000 In 14 days liquid cultures of purified CD34+ cells with IL-3, ATRA increased the number of myeloid differentiated cells to 91-95%, compared to 37-70% with IL-3 alone. Tretinoin 62-66 CD34 molecule Homo sapiens 39-43 10634641-5 2000 The expression of CD34 correlated to a higher sensitivity to ATRA (P = 0.003). Tretinoin 61-65 CD34 molecule Homo sapiens 18-22 10485269-3 1999 On the other hand, 10(-12) M ATRA significantly promoted the growth of CFU-meg, in the presence either of thrombopoietin or of IL-3+ GM-CSF, and induced a reproducible stimulation of the immature CD34+DR- subset. Tretinoin 29-33 CD34 molecule Homo sapiens 196-200 10456672-0 1999 Effect of all-trans retinoic acid on chemotherapy induced apoptosis and down-regulation of Bcl-2 in human myeloid leukaemia CD34 positive cells. Tretinoin 20-33 CD34 molecule Homo sapiens 124-128 10210322-0 1999 Retinoic acid induces apoptosis of human CD34+ hematopoietic progenitor cells: involvement of retinoic acid receptors and retinoid X receptors depends on lineage commitment of the hematopoietic progenitor cells. Tretinoin 0-13 CD34 molecule Homo sapiens 41-45 10456672-4 1999 Recently, all-trans retinoic acid (RA) has been reported to enhance cytarabine-induced apoptosis and downregulate Bcl-2 in several human myeloid leukaemia CD34 negative cells. Tretinoin 10-33 CD34 molecule Homo sapiens 155-159 10456672-4 1999 Recently, all-trans retinoic acid (RA) has been reported to enhance cytarabine-induced apoptosis and downregulate Bcl-2 in several human myeloid leukaemia CD34 negative cells. Tretinoin 35-37 CD34 molecule Homo sapiens 155-159 10456672-6 1999 Thus, the efficacy of RA in enhancing cytrabine- and fludarabine-induced apoptosis and overcoming the resistance was examined in both KG1 (CD34+CD7-) and KGla (CD34+CD7+) human myeloid leukaemia cells in the present study. Tretinoin 22-24 CD34 molecule Homo sapiens 139-143 10456672-10 1999 However, RA enhanced cytarabine- or fludarabine-induced apoptosis and inhibition of proliferation in KG1 CD34+CD7- but not in KGla CD34+CD7+ myeloid leukaemia cells. Tretinoin 9-11 CD34 molecule Homo sapiens 105-109 10456672-13 1999 The addition of RA to cytarabine enhanced its induced reduction of Bcl-2 in KG1 CD34+CD7- but not in KGla CD34+CD7+ human myeloid leukaemia cells. Tretinoin 16-18 CD34 molecule Homo sapiens 80-84 10210322-9 1999 Moreover, RA induced apoptosis of CD34+ cells and CD34+CD71+ cells stimulated with erythropoietin. Tretinoin 10-12 CD34 molecule Homo sapiens 34-38 10210322-2 1999 In this study we explored the effects of retinoic acid (RA) on apoptosis of human CD34+ hematopoietic progenitor cells isolated from normal bone marrow. Tretinoin 41-54 CD34 molecule Homo sapiens 82-86 10210322-9 1999 Moreover, RA induced apoptosis of CD34+ cells and CD34+CD71+ cells stimulated with erythropoietin. Tretinoin 10-12 CD34 molecule Homo sapiens 50-54 10210322-2 1999 In this study we explored the effects of retinoic acid (RA) on apoptosis of human CD34+ hematopoietic progenitor cells isolated from normal bone marrow. Tretinoin 56-58 CD34 molecule Homo sapiens 82-86 10210322-8 1999 However, we found that RA opposed anti-apoptotic effects of G-CSF and GM-CSF on CD34+ cells (G-CSF: 8% dead cells at day 6; G-CSF + RA: 20%; GM-CSF: 12%; GM-CSF + RA: 27%). Tretinoin 23-25 CD34 molecule Homo sapiens 80-84 8634418-4 1996 Erythroid colony growth was also inhibited when CD34+ progenitors were seeded at one cell per well, suggesting a direct action of RA. Tretinoin 130-132 CD34 molecule Homo sapiens 48-52 20426546-11 1999 However, ATRA inhibited colony formation, reduced the expansion of CFC and accelerated the loss of CD34 expression at doses required for the induction of CD38 expression. Tretinoin 9-13 CD34 molecule Homo sapiens 99-103 9827903-0 1998 All-trans-retinoic acid up-regulates CD38 but not c-Kit antigens on human marrow CD34+ cells without recruitment into cell cycle. Tretinoin 0-23 CD34 molecule Homo sapiens 81-85 9827903-10 1998 Contrary to steady-state cells, CD34+ cells treated with pharmacological doses of ATRA alone displayed CD38 over-expression without change in c-Kit levels and cycle status, suggesting an absence of maturation pressure. Tretinoin 82-86 CD34 molecule Homo sapiens 32-36 9207452-10 1997 Antiproliferative cytokines such as transforming growth factor-beta1 and high concentrations of all-trans-retinoic acid in cytokine-supported CD34+ cultures downmodulated telomerase activity. Tretinoin 99-119 CD34 molecule Homo sapiens 142-146 9619915-5 1998 ATRA enhanced neutrophilic maturation in liquid cultures of both normal and myelodysplastic CD34 + ve cells, as detected by conventional morphology and acquisition of CD15. Tretinoin 0-4 CD34 molecule Homo sapiens 92-96 8826891-8 1996 The down-regulation of bcl-2 expression by ATRA was particularly associated with CD34-negative AML and of the eight AML patients" cells that responded to ATRA by down-regulating bcl-2, seven were CD34 negative (P < 0.05). Tretinoin 43-47 CD34 molecule Homo sapiens 81-85 8826891-8 1996 The down-regulation of bcl-2 expression by ATRA was particularly associated with CD34-negative AML and of the eight AML patients" cells that responded to ATRA by down-regulating bcl-2, seven were CD34 negative (P < 0.05). Tretinoin 154-158 CD34 molecule Homo sapiens 196-200 8826891-9 1996 Our data suggest that the addition of ATRA to combination chemotherapy would increase the chemosensitivity of some patients with AML, particularly CD34-negative AML, due to down-regulation of bcl-2 expression. Tretinoin 38-42 CD34 molecule Homo sapiens 147-151 7511050-10 1994 Following culture with ATRA, increased CD38 protein levels were also observed in normal CD34+ bone marrow cells, but not on normal circulating granulocytes. Tretinoin 23-27 CD34 molecule Homo sapiens 88-92 7540854-0 1995 All-trans retinoic acid shows multiple effects on the survival, proliferation and differentiation of human fetal CD34+ haemopoietic progenitor cells. Tretinoin 10-23 CD34 molecule Homo sapiens 113-117 7540854-2 1995 RA, at both physiological (10(-11) and 10(-12)M) and pharmacological (10(-6) and 10(-7)M) concentrations, significantly (P < 0.01) promoted the survival of fetal CD34+ cells in liquid cultures from day 3 onwards, by suppressing apoptosis induced by serum and growth factor deprivation. Tretinoin 0-2 CD34 molecule Homo sapiens 165-169 7524761-0 1994 All-trans retinoic acid directly inhibits granulocyte colony-stimulating factor-induced proliferation of CD34+ human hematopoietic progenitor cells. Tretinoin 10-23 CD34 molecule Homo sapiens 105-109 7680579-8 1993 Results on CD34+ BM fractions (substantially reduced in accessory cells) demonstrate that the described effects can probably be attributed to the direct action of RA on these progenitors; single progenitor (CD34+) cell liquid cultures further prove this point. Tretinoin 163-165 CD34 molecule Homo sapiens 11-15 7680579-8 1993 Results on CD34+ BM fractions (substantially reduced in accessory cells) demonstrate that the described effects can probably be attributed to the direct action of RA on these progenitors; single progenitor (CD34+) cell liquid cultures further prove this point. Tretinoin 163-165 CD34 molecule Homo sapiens 207-211