PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21626648-9 2013 The process of EB formation (mimicking the early postimplantation embryo development) is regulated by RA-induced apoptosis through the activation of caspase and P38 MAPK/JNK pathway. Tretinoin 102-104 mitogen-activated protein kinase 8 Mus musculus 170-173 28718066-9 2017 In the NTD model, the expression levels of Dvl, RhoA, and p-Jnk were significantly higher in the RA group than in the control group, whereas they were significantly reduced in the RA + taurine group. Tretinoin 97-99 mitogen-activated protein kinase 8 Mus musculus 60-63 28718066-9 2017 In the NTD model, the expression levels of Dvl, RhoA, and p-Jnk were significantly higher in the RA group than in the control group, whereas they were significantly reduced in the RA + taurine group. Tretinoin 180-182 mitogen-activated protein kinase 8 Mus musculus 60-63 26186635-7 2015 The anti-apoptotic effects of ATRA were associated with partial inhibition of reactive oxygen species (ROS) production and significantly less phosphorylation of mitogen-activated protein kinases (MAPKs) including p38, JNK, and ERK. Tretinoin 30-34 mitogen-activated protein kinase 8 Mus musculus 218-221 21626648-0 2013 Retinoic acid influences the embryoid body formation in mouse embryonic stem cells by induction of caspase and p38 MAPK/JNK-mediated apoptosis. Tretinoin 0-13 mitogen-activated protein kinase 8 Mus musculus 120-123 18720064-3 2009 ATRA is a potent inhibitor of activator protein 1, a transcription factor of the JNK pathway. Tretinoin 0-4 mitogen-activated protein kinase 8 Mus musculus 81-84 21626648-6 2013 JNK, P-38 and caspase activation were shown in the nature of RA-triggered apoptotic signaling in ES cells. Tretinoin 61-63 mitogen-activated protein kinase 8 Mus musculus 0-3 16712891-8 2006 Importantly, atRA-induced DNA fragmentation and capase-3 activation were prevented by pretreatment with the JNK inhibitor (SP600125) and the p38 MAPK inhibitor (SB202190), but not by pretreatment with MEK inhibitor (U0126). Tretinoin 13-17 mitogen-activated protein kinase 8 Mus musculus 108-111 18383274-5 2008 Moreover, RA increased the expression of active CREB by enhancing the activity of JNK. Tretinoin 10-12 mitogen-activated protein kinase 8 Mus musculus 82-85 18383274-6 2008 Our research suggests that CREB plays a role in RA-induced NPC differentiation by increasing the expression of active JNK. Tretinoin 48-50 mitogen-activated protein kinase 8 Mus musculus 118-121 16712891-7 2006 In addition, atRA treatment caused a strong and sustained activation of c-Jun N-terminal kinase (JNK) and p38 kinase (p38), as well as an early but transient activation of extracellular signal-regulated kinase (ERK). Tretinoin 13-17 mitogen-activated protein kinase 8 Mus musculus 72-95 16712891-7 2006 In addition, atRA treatment caused a strong and sustained activation of c-Jun N-terminal kinase (JNK) and p38 kinase (p38), as well as an early but transient activation of extracellular signal-regulated kinase (ERK). Tretinoin 13-17 mitogen-activated protein kinase 8 Mus musculus 97-100 16084493-9 2005 Phospho-JNK immunohistochemistry showed that ATRA inhibited the activation of JNK. Tretinoin 45-49 mitogen-activated protein kinase 8 Mus musculus 8-11 16084493-9 2005 Phospho-JNK immunohistochemistry showed that ATRA inhibited the activation of JNK. Tretinoin 45-49 mitogen-activated protein kinase 8 Mus musculus 78-81 15492006-7 2004 Expression of the dominant negative p115RhoGEF was able to inhibit activation of both RhoA and JNK1 in response to either retinoic acid or the expression of a constitutively activated mutant of G alpha(13). Tretinoin 122-135 mitogen-activated protein kinase 8 Mus musculus 95-99 16619266-0 2006 Endodermal differentiation of murine embryonic carcinoma cells by retinoic acid requires JLP, a JNK-scaffolding protein. Tretinoin 66-79 mitogen-activated protein kinase 8 Mus musculus 96-99 16619266-5 2006 Here, we report that RA stimulates the expression of JNK-interacting leucine zipper protein (JLP), a newly identified JNK-scaffolding protein and its critical role in RA-mediated endodermal differentiation. Tretinoin 21-23 mitogen-activated protein kinase 8 Mus musculus 53-56 16619266-5 2006 Here, we report that RA stimulates the expression of JNK-interacting leucine zipper protein (JLP), a newly identified JNK-scaffolding protein and its critical role in RA-mediated endodermal differentiation. Tretinoin 167-169 mitogen-activated protein kinase 8 Mus musculus 53-56 11401397-0 2001 Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation. Tretinoin 0-13 mitogen-activated protein kinase 8 Mus musculus 66-89 11401397-3 2001 The present study examines the relationship between RA and mitogen-activated protein kinase signaling in neural crest cells and demonstrates that c-Jun N-terminal kinase (JNK) activation is severely repressed by RA. Tretinoin 52-54 mitogen-activated protein kinase 8 Mus musculus 146-169 11401397-3 2001 The present study examines the relationship between RA and mitogen-activated protein kinase signaling in neural crest cells and demonstrates that c-Jun N-terminal kinase (JNK) activation is severely repressed by RA. Tretinoin 52-54 mitogen-activated protein kinase 8 Mus musculus 171-174 11401397-3 2001 The present study examines the relationship between RA and mitogen-activated protein kinase signaling in neural crest cells and demonstrates that c-Jun N-terminal kinase (JNK) activation is severely repressed by RA. Tretinoin 212-214 mitogen-activated protein kinase 8 Mus musculus 146-169 11401397-3 2001 The present study examines the relationship between RA and mitogen-activated protein kinase signaling in neural crest cells and demonstrates that c-Jun N-terminal kinase (JNK) activation is severely repressed by RA. Tretinoin 212-214 mitogen-activated protein kinase 8 Mus musculus 171-174 11401397-9 2001 These data demonstrate that the JNK signaling pathway and c-Jun activation are critical for cardiac neural crest outgrowth and are potential targets for the action of RA. Tretinoin 167-169 mitogen-activated protein kinase 8 Mus musculus 32-35