PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26583087-5 2015 We also demonstrate that the presence of IL-2 during the in vitro generation of iTreg cells confers resistance to Th17 conversion but that IL-2 and retinoic acid (RA) cooperate to maintain Foxp3 expression following stimulation under Th17-polarizing conditions. Tretinoin 148-161 forkhead box P3 Mus musculus 189-194 25911751-4 2015 Regulatory functions can be corrected, even in T cells isolated from aged, diabetic mice, by a synergistic activity of retinoic acid, TGF-beta, and IL-2, which enhance connexin 43 and Foxp3 expression in T(regs) and restore the ability of conventional CD4(+) T cells to upregulate Foxp3 and generate peripherally derived T(regs). Tretinoin 119-132 forkhead box P3 Mus musculus 184-189 25911751-4 2015 Regulatory functions can be corrected, even in T cells isolated from aged, diabetic mice, by a synergistic activity of retinoic acid, TGF-beta, and IL-2, which enhance connexin 43 and Foxp3 expression in T(regs) and restore the ability of conventional CD4(+) T cells to upregulate Foxp3 and generate peripherally derived T(regs). Tretinoin 119-132 forkhead box P3 Mus musculus 281-286 25887926-5 2015 Moreover, with the presence of TGF-beta, ATRA upregulated CD4(+)CD25(+)Foxp3(+)Treg cells and suppressed Th17 cells in the blood, spleen and draining lymph nodes of recipient mice, as well as enhanced the Foxp3 expression and inhibited the RORgammat expression in grafts and peripheral blood mononuclear cells (PBMCs). Tretinoin 41-45 forkhead box P3 Mus musculus 71-76 25887926-5 2015 Moreover, with the presence of TGF-beta, ATRA upregulated CD4(+)CD25(+)Foxp3(+)Treg cells and suppressed Th17 cells in the blood, spleen and draining lymph nodes of recipient mice, as well as enhanced the Foxp3 expression and inhibited the RORgammat expression in grafts and peripheral blood mononuclear cells (PBMCs). Tretinoin 41-45 forkhead box P3 Mus musculus 205-210 24659788-3 2014 RA production by CD103(+) dendritic cells and alveolar macrophages functions with TGF-beta to promote conversion of naive T cells into Foxp3(+) regulatory T cells and, thereby, maintain mucosal tolerance. Tretinoin 0-2 forkhead box P3 Mus musculus 135-140 25691937-1 2014 OBJECTIVES: Recent evidence have proposed that Tretinoin produced in the gut preferentially promote differentiation of FoxP3+Treg cells but inhibits Th17 lymphocytes, and this may be the main immunomdulatory mechanism of Tretinoin in vivo. Tretinoin 47-56 forkhead box P3 Mus musculus 119-124 25691937-13 2014 CONCLUSION: The in vivo immunomudlatoty effects of Tretinoin may be partly due to immune deviation from pro-inflammatory cytokine interleukin-17 to anti-inflammatory cytokine interleukin-10, but not absolutely depend on the expansion of FoxP3(+)Treg cells. Tretinoin 51-60 forkhead box P3 Mus musculus 237-242 20679534-2 2010 All-trans retinoic acid (atRA), the active derivative of vitamin A, has been demonstrated to promote Foxp3(+) Treg differentiation and suppress Th17 development. Tretinoin 0-23 forkhead box P3 Mus musculus 101-106 23980207-1 2013 Retinoic acid (RA) enhances TGF-beta-dependent differentiation of Foxp3(+) inducible regulatory T cells (iTregs) and inhibits Th17 differentiation by binding to the RA receptor (RAR)/retinoid X receptor (RXR) heterodimer. Tretinoin 0-13 forkhead box P3 Mus musculus 66-71 23980207-1 2013 Retinoic acid (RA) enhances TGF-beta-dependent differentiation of Foxp3(+) inducible regulatory T cells (iTregs) and inhibits Th17 differentiation by binding to the RA receptor (RAR)/retinoid X receptor (RXR) heterodimer. Tretinoin 15-17 forkhead box P3 Mus musculus 66-71 23733880-4 2013 CD103(+) DCs, but not pDCs or lung macrophages, upregulated the expression of retinaldehyde dehydrogenase 2 (aldh1a2), which is key for the production of retinoic acid, a cofactor for TGF-beta for Foxp3 induction. Tretinoin 154-167 forkhead box P3 Mus musculus 197-202 22696440-6 2012 In vitro treatment with ATRA induced the expression of Foxp3 and repressed the IL-17 expression in the CD4(+) T cells in mice. Tretinoin 24-28 forkhead box P3 Mus musculus 55-60 21596042-1 2011 BACKGROUND & AIMS: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting cells. Tretinoin 85-108 forkhead box P3 Mus musculus 233-238 21596042-1 2011 BACKGROUND & AIMS: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting cells. Tretinoin 110-112 forkhead box P3 Mus musculus 233-238 21249211-2 2011 Dendritic cells in gut-related lymphoid organs can produce RA, thereby imprinting gut-homing specificity on T cells and enhancing transforming growth factor (TGF)-beta-dependent induction of Foxp3+ regulatory T cells upon antigen presentation. Tretinoin 59-61 forkhead box P3 Mus musculus 191-196 21068375-6 2010 ITE acts not only on T cells, but also directly on dendritic cells to induce tolerogenic dendritic cells that support FoxP3(+) T(reg) differentiation in a retinoic acid-dependent manner. Tretinoin 155-168 forkhead box P3 Mus musculus 118-123 23657628-6 2013 We found that RA significantly enhanced TGF-beta-induced expression of Foxp3 on naive and committed T cells in vitro and that this was blocked by an antagonist of RARalpha (RARi). Tretinoin 14-16 forkhead box P3 Mus musculus 71-76 22896640-1 2012 Dendritic cells (DC) in the gut promote immune tolerance by expressing retinal dehydrogenase (RALDH), an enzyme that promotes retinoic acid, which aids differentiation of Foxp3+ inducible regulatory T cells (iTreg) in the intestinal mucosa. Tretinoin 126-139 forkhead box P3 Mus musculus 171-176 22696440-5 2012 Interestingly, Foxp3(+) regulatory T cells were markedly increased and IL-17-producing CD4(+) T cells (Th17 cells) were decreased in the spleens of ATRA-treated mice. Tretinoin 148-152 forkhead box P3 Mus musculus 15-20 22472775-4 2012 The tolerogenic features of these subsets are associated with increased production of retinoic acid, which leads to the enhanced induction of Foxp3+ regulatory T cells compared with CD8alpha-beta- pDCs. Tretinoin 86-99 forkhead box P3 Mus musculus 142-147 22222225-1 2012 Dendritic cells (DCs) use all-trans retinoic acid (ATRA) to promote characteristic intestinal responses, including Foxp3(+) Treg conversion, lymphocyte gut homing molecule expression, and IgA production. Tretinoin 26-49 forkhead box P3 Mus musculus 115-120 22222225-1 2012 Dendritic cells (DCs) use all-trans retinoic acid (ATRA) to promote characteristic intestinal responses, including Foxp3(+) Treg conversion, lymphocyte gut homing molecule expression, and IgA production. Tretinoin 51-55 forkhead box P3 Mus musculus 115-120 22134223-9 2012 Also in the MLNs are CD103+ dendritic cells, which drive the differentiation of Foxp3+ T cells in the presence of TGF-beta and retinoic acid produced from dietary vitamin A. Tretinoin 127-140 forkhead box P3 Mus musculus 80-85 22116001-4 2012 We found that in vitro, RA-treated T cells expressed high levels of Foxp3 in the presence of recombinant TGFbeta. Tretinoin 24-26 forkhead box P3 Mus musculus 68-73 22927819-6 2012 Finally, in vivo derived AAMphi have an enhanced capacity to induce Foxp3 expression in CD4+ cells through an RA dependent mechanism, especially in combination with TGF-beta. Tretinoin 110-112 forkhead box P3 Mus musculus 68-73 20941602-5 2011 We present a detailed protocol demonstrating that polyclonal activation of conventional CD4(+) T cells in the presence of IL-2, TGFbeta, and all trans retinoic acid induces >90% conversion of these T cells to Foxp3-expressing iTregs as well as promotes a three- to fourfold increase in proliferation following a 4-day incubation period in vitro. Tretinoin 151-164 forkhead box P3 Mus musculus 212-217 21931768-1 2011 BACKGROUND: It has been documented all-trans retinoic acid (atRA) promotes the development of TGF-beta-induced CD4(+)Foxp3(+) regulatory T cells (iTreg) that play a vital role in the prevention of autoimmune responses, however, molecular mechanisms involved remain elusive. Tretinoin 45-58 forkhead box P3 Mus musculus 117-122 21931768-1 2011 BACKGROUND: It has been documented all-trans retinoic acid (atRA) promotes the development of TGF-beta-induced CD4(+)Foxp3(+) regulatory T cells (iTreg) that play a vital role in the prevention of autoimmune responses, however, molecular mechanisms involved remain elusive. Tretinoin 60-64 forkhead box P3 Mus musculus 117-122 21931768-3 2011 METHODOLOGY/PRINCIPAL FINDINGS: Addition of atRA to naive CD4(+)CD25(-) cells stimulated with anti-CD3/CD28 antibodies in the presence of TGF-beta not only increased Foxp3(+) iTreg differentiation, but maintained Foxp3 expression through apoptosis inhibition. Tretinoin 44-48 forkhead box P3 Mus musculus 166-171 21931768-3 2011 METHODOLOGY/PRINCIPAL FINDINGS: Addition of atRA to naive CD4(+)CD25(-) cells stimulated with anti-CD3/CD28 antibodies in the presence of TGF-beta not only increased Foxp3(+) iTreg differentiation, but maintained Foxp3 expression through apoptosis inhibition. Tretinoin 44-48 forkhead box P3 Mus musculus 213-218 21931768-7 2011 Conversely, atRA markedly increased ERK1/2 activation, and blockade of ERK1/2 signaling completely abolished the enhanced effects of atRA on Foxp3 expression. Tretinoin 133-137 forkhead box P3 Mus musculus 141-146 20944006-3 2010 RA induced bone marrow-derived DCs to express CCR9 and ALDH1a2 and conferred upon them mucosal DC functions, including induction of Foxp3(+) regulatory T cells, IgA-secreting B cells, and gut-homing molecules. Tretinoin 0-2 forkhead box P3 Mus musculus 132-137 20679534-2 2010 All-trans retinoic acid (atRA), the active derivative of vitamin A, has been demonstrated to promote Foxp3(+) Treg differentiation and suppress Th17 development. Tretinoin 25-29 forkhead box P3 Mus musculus 101-106 20679534-4 2010 We found that nTregs treated with atRA were resistant to Th17 and other Th cell conversion and maintained Foxp3 expression and suppressive activity in the presence of IL-6 in vitro. Tretinoin 34-38 forkhead box P3 Mus musculus 106-111 20432234-1 2010 Intestinal CD103(+) DC promote the differentiation of Foxp3(+) Treg from naive CD4(+) T cells through mechanisms involving TGF-beta and the dietary metabolite, retinoic acid (RA). Tretinoin 160-173 forkhead box P3 Mus musculus 54-59 20432234-1 2010 Intestinal CD103(+) DC promote the differentiation of Foxp3(+) Treg from naive CD4(+) T cells through mechanisms involving TGF-beta and the dietary metabolite, retinoic acid (RA). Tretinoin 175-177 forkhead box P3 Mus musculus 54-59 20483764-2 2010 In the current study, we demonstrate that naive CD4+CD25-Foxp3- T cells specific for the myelin proteolipid protein (PLP)139-151 peptide can be converted into CD25+Foxp3+ induced Treg cells (iTregs) when stimulated in the presence of TGF-beta, retinoic acid, and IL-2. Tretinoin 244-257 forkhead box P3 Mus musculus 57-62 20483764-2 2010 In the current study, we demonstrate that naive CD4+CD25-Foxp3- T cells specific for the myelin proteolipid protein (PLP)139-151 peptide can be converted into CD25+Foxp3+ induced Treg cells (iTregs) when stimulated in the presence of TGF-beta, retinoic acid, and IL-2. Tretinoin 244-257 forkhead box P3 Mus musculus 164-169 19190084-1 2009 Retinoic acid (RA) produced by intestinal dendritic cells (DCs) imprints gut-homing specificity on lymphocytes and enhances Foxp3(+) regulatory T-cell differentiation. Tretinoin 0-13 forkhead box P3 Mus musculus 124-129 20206130-8 2010 Here we show that exposure to ATRA and TGF-beta induces CD8(+)Foxp3(+) T cells ex vivo, which suppress diabetogenic T cells in vitro and in vivo. Tretinoin 30-34 forkhead box P3 Mus musculus 62-67 19211146-7 2009 However, administration of ATRA to NOD mice in which the proportion and function of CD4(+)Foxp3(+) Treg cells was abrogated by cyclophosphamide (CY), failed to permit progression to T1D. Tretinoin 27-31 forkhead box P3 Mus musculus 90-95 19632226-1 2009 BACKGROUND & AIMS: Retinoic acid plays a positive role in induction of FoxP3(+) regulatory T cells. Tretinoin 23-36 forkhead box P3 Mus musculus 75-80 19715998-3 2009 The aim of this study was to establish if RA synergizing with TGF-beta induced antigen specific CD4(+) CD25(high) Foxp3(+) Treg portraying gut homing receptors. Tretinoin 42-44 forkhead box P3 Mus musculus 114-119 19965837-7 2010 RESULTS: ATRA synergised with TGF-beta to induce Foxp3(+) T regulatory cells (Treg) and reciprocally inhibited development of IL-17-producing T helper cells (Th17) induced by TGF-beta and IL-6. Tretinoin 9-13 forkhead box P3 Mus musculus 49-54 19839007-2 2009 It has been shown recently that intestinal mucosal DC are able to induce Foxp3(+) Treg through production of TGF-beta plus retinoic acid (RA). Tretinoin 123-136 forkhead box P3 Mus musculus 73-78 19839007-2 2009 It has been shown recently that intestinal mucosal DC are able to induce Foxp3(+) Treg through production of TGF-beta plus retinoic acid (RA). Tretinoin 138-140 forkhead box P3 Mus musculus 73-78 19190084-1 2009 Retinoic acid (RA) produced by intestinal dendritic cells (DCs) imprints gut-homing specificity on lymphocytes and enhances Foxp3(+) regulatory T-cell differentiation. Tretinoin 15-17 forkhead box P3 Mus musculus 124-129 18400747-7 2008 Retinoic acid has also been shown to suppress loss of Foxp3 induced by TGF-beta1. Tretinoin 0-13 forkhead box P3 Mus musculus 54-59 19204112-0 2009 Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells. Tretinoin 32-45 forkhead box P3 Mus musculus 80-85 18400747-8 2008 Retinoic acid in the presence of TGF-beta1 reduced STAT6 binding to the Foxp3 promoter and enhanced histone acetylation, thereby reverting the effect of IL-4. Tretinoin 0-13 forkhead box P3 Mus musculus 72-77 26333706-14 2015 The levels of Foxp3, TGF-beta, and IL-10 mRNA, as well as the percentage of CD4+CD25+Foxp3+ T cells, were higher in the ATRA group than in theAR group. Tretinoin 120-124 forkhead box P3 Mus musculus 14-19 34282811-7 2021 LP22A3 induced TGF-beta secretion from the IECs of the small intestine with retinoic acid production probably through TLR2, resulting in an increase in CD103+ DCs and the Foxp3+ Treg population. Tretinoin 76-89 forkhead box P3 Mus musculus 171-176 29876477-3 2018 This data report describes the effect of retinoic acid (RA) and/or anti-interferon-gamma (IFNgamma) antibody supplementation on up-regulation of CD8alpha and Foxp3 in Eed CD4+ T cells, the effect of dose or timing of TGFbeta treatment on CD4+ T cell identity of Eed, adding further information regarding the conditions that induces CD8alpha, and mRNA expression changes of genes encoding polycomb repressive complex 2 (PRC2) subunits by TGFbeta treatment. Tretinoin 56-58 forkhead box P3 Mus musculus 158-163 17785809-2 2007 We found that the major vitamin A metabolite all-trans-retinoic acid induces histone acetylation at the FoxP3 gene promoter and expression of the FoxP3 protein in CD4+ T cells. Tretinoin 45-68 forkhead box P3 Mus musculus 104-109 17785809-2 2007 We found that the major vitamin A metabolite all-trans-retinoic acid induces histone acetylation at the FoxP3 gene promoter and expression of the FoxP3 protein in CD4+ T cells. Tretinoin 45-68 forkhead box P3 Mus musculus 146-151 17785809-4 2007 Retinoic acid can promote TGF-beta1-dependent generation of FoxP3+ regulatory T cells but decrease the TGF-beta1- and IL-6-dependent generation of inflammatory Th17 cells in mouse T cells. Tretinoin 0-13 forkhead box P3 Mus musculus 60-65 34447371-0 2021 Retinoic Acid Induces Functionally Suppressive Foxp3+RORgammat+ T Cells In Vitro. Tretinoin 0-13 forkhead box P3 Mus musculus 47-52 34447371-2 2021 This study aimed to discern the role played by IL-6 and retinoic acid (RA) in the in vitro generation of Foxp3+RORgammat+ T cells and to investigate whether such cells have suppressive properties. Tretinoin 56-69 forkhead box P3 Mus musculus 105-110 31235250-0 2019 The isoflavone puerarin induces Foxp3+ regulatory T cells by augmenting retinoic acid production, thereby inducing mucosal immune tolerance in a murine food allergy model. Tretinoin 72-85 forkhead box P3 Mus musculus 32-37 31053627-3 2019 We showed that dendritic cells (DCs), engineered to de novo produce high concentrations of both 1,25-dihydroxyvitamin D, the active vitamin D metabolite, and retinoic acid, an active vitamin A metabolite, augmented the induction of T cells that express both the regulatory molecule Foxp3 and the gut-homing receptor CCR9 in vitro and in vivo. Tretinoin 158-171 forkhead box P3 Mus musculus 282-287 30894405-2 2019 Retinoic acid (RA) can promote peripheral conversion of naive T cells into Foxp3+ Treg cells. Tretinoin 0-13 forkhead box P3 Mus musculus 75-80 29876477-3 2018 This data report describes the effect of retinoic acid (RA) and/or anti-interferon-gamma (IFNgamma) antibody supplementation on up-regulation of CD8alpha and Foxp3 in Eed CD4+ T cells, the effect of dose or timing of TGFbeta treatment on CD4+ T cell identity of Eed, adding further information regarding the conditions that induces CD8alpha, and mRNA expression changes of genes encoding polycomb repressive complex 2 (PRC2) subunits by TGFbeta treatment. Tretinoin 41-54 forkhead box P3 Mus musculus 158-163 27089940-1 2016 Retinoic acid (RA) in the steady state enhances induction of Foxp3(+) regulatory T (Treg) cells and inhibits differentiation of Th1 and Th17 cells, thereby maintaining tolerance, but can in inflammatory conditions promote effector Th1 and Th17 cells that mediate inflammation. Tretinoin 0-13 forkhead box P3 Mus musculus 61-66 27089940-1 2016 Retinoic acid (RA) in the steady state enhances induction of Foxp3(+) regulatory T (Treg) cells and inhibits differentiation of Th1 and Th17 cells, thereby maintaining tolerance, but can in inflammatory conditions promote effector Th1 and Th17 cells that mediate inflammation. Tretinoin 15-17 forkhead box P3 Mus musculus 61-66 26333706-14 2015 The levels of Foxp3, TGF-beta, and IL-10 mRNA, as well as the percentage of CD4+CD25+Foxp3+ T cells, were higher in the ATRA group than in theAR group. Tretinoin 120-124 forkhead box P3 Mus musculus 85-90