PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15046780-6 2004 We demonstrate that retinoic acid already affects in the early stage of germ layer formation, which was demonstrated by a change of Oct-4 and Brachyury gene expression. Tretinoin 20-33 POU class 5 homeobox 1 Homo sapiens 132-137 16195347-9 2005 Retinoic acid triggers Oct4 down-regulation, de novo activation of A-type lamins, and nestin. Tretinoin 0-13 POU class 5 homeobox 1 Homo sapiens 23-27 8289783-14 1994 In accordance with the suggestion that suppression of Oct-3/4 expression is a crucial step during embryogenesis, the Oct-3/4 upstream region contains multiple targets for RA-induced repression, probably to ensure accurate and prompt repression of Oct-3/4 expression. Tretinoin 171-173 POU class 5 homeobox 1 Homo sapiens 117-124 10692469-2 2000 For the first time, we have shown that SF1 and Oct-3/4 are co-expressed in embryonal carcinoma (EC) P19 cells, and their expression is down-regulated with very similar kinetics following retinoic acid (RA) induced differentiation of these cells, suggesting a functional relationship between the two. Tretinoin 187-200 POU class 5 homeobox 1 Homo sapiens 47-54 10692469-2 2000 For the first time, we have shown that SF1 and Oct-3/4 are co-expressed in embryonal carcinoma (EC) P19 cells, and their expression is down-regulated with very similar kinetics following retinoic acid (RA) induced differentiation of these cells, suggesting a functional relationship between the two. Tretinoin 202-204 POU class 5 homeobox 1 Homo sapiens 47-54 10692469-3 2000 Previously, we have shown that the Oct-3/4 promoter harbors an RA-responsive element, RAREoct, which functions in EC cells as a binding site for positive regulators of transcription, such as RAR and RXR. Tretinoin 63-65 POU class 5 homeobox 1 Homo sapiens 35-42 8631309-0 1996 Retinoic acid-mediated down-regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo. Tretinoin 0-13 POU class 5 homeobox 1 Homo sapiens 42-48 7823919-3 1995 Similarly, Oct-3/4 is expressed in embryonal carcinoma (EC) cells and is repressed in retinoic acid (RA)-differentiated EC cells. Tretinoin 86-99 POU class 5 homeobox 1 Homo sapiens 11-18 7823919-3 1995 Similarly, Oct-3/4 is expressed in embryonal carcinoma (EC) cells and is repressed in retinoic acid (RA)-differentiated EC cells. Tretinoin 101-103 POU class 5 homeobox 1 Homo sapiens 11-18 7823919-5 1995 Our present results demonstrate that in P19 and RA-treated P19 cells, the orphan receptors ARP-1/COUP-TFII and EAR-3/COUP-TFI repress Oct-3/4 promoter activity through the RAREoct site in a dose-dependent manner. Tretinoin 48-50 POU class 5 homeobox 1 Homo sapiens 134-141 7823919-14 1995 Most interestingly, in RA-treated EC cells, the kinetics of Oct-3/4 repression inversely correlates with the kinetics of ARP-1/COUP-TFII and EAR-3/COUP-TFI activation. Tretinoin 23-25 POU class 5 homeobox 1 Homo sapiens 60-67 8289783-0 1994 Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region. Tretinoin 0-13 POU class 5 homeobox 1 Homo sapiens 24-31 8289783-3 1994 Retinoic acid (RA)-induced differentiation of embryonal carcinoma (EC) cells is accompanied by decreased expression of the Oct-3/4 gene. Tretinoin 0-13 POU class 5 homeobox 1 Homo sapiens 123-130 8289783-3 1994 Retinoic acid (RA)-induced differentiation of embryonal carcinoma (EC) cells is accompanied by decreased expression of the Oct-3/4 gene. Tretinoin 15-17 POU class 5 homeobox 1 Homo sapiens 123-130 8289783-4 1994 Previous findings show that sequences in the Oct-3/4 enhancer region (designated RARE1) are targets for RA-mediated repression (H. Okazawa, K. Okamoto, F. Ishino, T. Ishino-Kaneko, S. Takeda, Y. Toyoda, M. Muramatsu, and H. Hamada, EMBO J. Tretinoin 81-83 POU class 5 homeobox 1 Homo sapiens 45-52 12841847-8 2003 When breast cancer cell lines were treated with all- trans -retinoic acid, OCT3 expression was repressed, associated with decreased cell proliferation. Tretinoin 48-73 POU class 5 homeobox 1 Homo sapiens 75-79 8993032-2 1997 In P19 EC cells RA treatment stimulates induction of the RAR beta gene, while it represses Oct3/4 gene expression. Tretinoin 16-18 POU class 5 homeobox 1 Homo sapiens 91-97 7945330-7 1994 When F9 EC cells are induced to differentiate by treatment with RA for 48 h, there is a complete loss of the DNA/protein complex containing Oct-3. Tretinoin 64-66 POU class 5 homeobox 1 Homo sapiens 140-145 29620445-6 2018 RA induction led to slender spindles and tadpole-like changes of cell morphology, and the expression of germ cell-specific markers (Oct4, Piwil2, Itgb1, SSEA-1, and Stra8) presented significant upregulation in the RA treatment group according to the polymerase chain reaction and immunofluorescence results. Tretinoin 0-2 POU class 5 homeobox 1 Homo sapiens 132-136 7678695-1 1993 In this study we evaluate, for the first time, the molecular mechanism that underlies the extinction of a tissue-specific transcription factor, Oct-3/4, in somatic cell hybrids and compared it with its down-regulation in retinoic acid (RA)-treated embryonal carcinoma (EC) cells. Tretinoin 221-234 POU class 5 homeobox 1 Homo sapiens 144-151 34817042-9 2021 Expression of OCT4 gene dropped after RA treatment, but it was recovered in NT2-RA-VH cells. Tretinoin 38-40 POU class 5 homeobox 1 Homo sapiens 14-18 32175266-9 2020 It was found that the use of retinoic acid led to the highest expression of C-kit, SSEA4, VASA genes and lower expression of Oct4. Tretinoin 29-42 POU class 5 homeobox 1 Homo sapiens 125-129 30522558-7 2018 At the same time, RA could arrest the cell cycle of CSCs and reduce the expression of Sox-2, Oct-4 in CSCs of melanoma, thereby induced the differentiation of CSCs and increased its sensitivity to paclitaxel. Tretinoin 18-20 POU class 5 homeobox 1 Homo sapiens 93-98 8289783-7 1994 We identified a novel cis element in the Oct-3/4 promoter harbors a putative Sp1 binding site and a RA-responsive element (designated RAREoct), which are juxtaposed to one another. Tretinoin 100-102 POU class 5 homeobox 1 Homo sapiens 41-48 8289783-12 1994 Using site-directed mutagenesis, we show that the RAREoct contributes to the transcriptional activation of Oct-3/4 promoter in P19 cells and, most interestingly, mediates the RA-induced repression in RA-differentiated EC cells. Tretinoin 50-52 POU class 5 homeobox 1 Homo sapiens 107-114 8289783-14 1994 In accordance with the suggestion that suppression of Oct-3/4 expression is a crucial step during embryogenesis, the Oct-3/4 upstream region contains multiple targets for RA-induced repression, probably to ensure accurate and prompt repression of Oct-3/4 expression. Tretinoin 171-173 POU class 5 homeobox 1 Homo sapiens 117-124 1915274-1 1991 Oct3 is an embryonic octamer-binding transcription factor, whose expression is rapidly repressed by retinoic acid (RA). Tretinoin 100-113 POU class 5 homeobox 1 Homo sapiens 0-4 1915274-1 1991 Oct3 is an embryonic octamer-binding transcription factor, whose expression is rapidly repressed by retinoic acid (RA). Tretinoin 115-117 POU class 5 homeobox 1 Homo sapiens 0-4 1915274-2 1991 In this report, we have determined the transcriptional control region of the oct3 gene and studied the mechanism of the RA-mediated repression. Tretinoin 120-122 POU class 5 homeobox 1 Homo sapiens 77-81 1915274-10 1991 We suggest that RARE1 is a critical cis element for oct3 gene expression in embryonic stem cells and for the RA-mediated repression. Tretinoin 16-18 POU class 5 homeobox 1 Homo sapiens 52-56 33241484-9 2021 Compared to OCT4A which is sharply down-regulated in retinoic acid induced differentiation of NT2 cell line, the expression of OCT4B5 remains at low level in differentiated state. Tretinoin 53-66 POU class 5 homeobox 1 Homo sapiens 12-17 28601081-3 2017 We demonstrated decrease in OCT4 and NANOG mRNA and protein levels following exposure to retinoic acid. Tretinoin 89-102 POU class 5 homeobox 1 Homo sapiens 28-32 28911263-9 2017 In the presence of RA, we observed a decrease of OCT4 expression, associated with a loss of clonogenic and proliferation capacities, cell cycle arrest, and upregulation of p21, in HL60, NB4, KASUMI, and Me-1 cell lines. Tretinoin 19-21 POU class 5 homeobox 1 Homo sapiens 49-53 28122350-5 2017 miR-27 asignificantly rescued differentiation and inhibited beta-catenin, LEF1, OCT4 and SOX2 in Wnt/beta-catenin pathway in all-trans-retinoic acid (ATRA)-induced laryngeal cancer cells. Tretinoin 150-154 POU class 5 homeobox 1 Homo sapiens 80-84 27244887-10 2017 In regard to clinical relevance, inhibition of Oct4 by all-trans retinoic acid (ATRA) synergistically increased sensitivity to cisplatin in bladder cancer cells. Tretinoin 55-78 POU class 5 homeobox 1 Homo sapiens 47-51 27244887-10 2017 In regard to clinical relevance, inhibition of Oct4 by all-trans retinoic acid (ATRA) synergistically increased sensitivity to cisplatin in bladder cancer cells. Tretinoin 80-84 POU class 5 homeobox 1 Homo sapiens 47-51 27803451-3 2016 GDF3 and OCT4 was highly expressed in undifferentiated NCCIT cells and then significantly decreased upon retinoic acid-induced differentiation in a time-dependent manner. Tretinoin 105-118 POU class 5 homeobox 1 Homo sapiens 9-13 26840068-6 2016 Remarkably, Zscan4 metastate induced by RA lacks canonical pluripotency genes Oct3/4 and Nanog but retained both self-renewal and pluripotency capabilities. Tretinoin 40-42 POU class 5 homeobox 1 Homo sapiens 78-84 24971534-4 2014 Real-time PCR analysis revealed that OCT4 levels were high in undifferentiated NCCIT cells but significantly decreased upon retinoic acid-mediated differentiation, concomitant with up-regulation of ESE-1 expression. Tretinoin 124-137 POU class 5 homeobox 1 Homo sapiens 37-41 25047539-0 2014 Granulosa cells and retinoic acid co-treatment enrich potential germ cells from manually selected Oct4-EGFP expressing human embryonic stem cells. Tretinoin 20-33 POU class 5 homeobox 1 Homo sapiens 98-102 25880909-9 2015 All-trans retinoic acid treatment reduced MYCN, NCYM, and OCT4 expression, accompanied by the decreased amount of OCT4 recruited onto the intron 1 region of MYCN. Tretinoin 10-23 POU class 5 homeobox 1 Homo sapiens 58-62 25880909-9 2015 All-trans retinoic acid treatment reduced MYCN, NCYM, and OCT4 expression, accompanied by the decreased amount of OCT4 recruited onto the intron 1 region of MYCN. Tretinoin 10-23 POU class 5 homeobox 1 Homo sapiens 114-118 25112011-5 2014 In addition, RA induced differentiation of H9 ESC coupled with morphology changes, decreased expression of undifferentiated markers Oct4, Nanog, Sox2 and OCT4 mRNA binding protein Lin28 at mRNA level, and reduced expression of Oct4 at protein level. Tretinoin 13-15 POU class 5 homeobox 1 Homo sapiens 132-136 25112011-5 2014 In addition, RA induced differentiation of H9 ESC coupled with morphology changes, decreased expression of undifferentiated markers Oct4, Nanog, Sox2 and OCT4 mRNA binding protein Lin28 at mRNA level, and reduced expression of Oct4 at protein level. Tretinoin 13-15 POU class 5 homeobox 1 Homo sapiens 154-158 24475288-3 2014 Using the human embryonal carcinoma cell line NTera2/D1, we confirmed that exposure to the differentiating agent retinoic acid produced a reduction in pluripotency markers NANOG and POU5F1 (Oct3/4) and an acute concentration-dependent increase in resistance to both cisplatin and paclitaxel that reached as high as 18-fold for cisplatin and 61-fold for paclitaxel within four days. Tretinoin 113-126 POU class 5 homeobox 1 Homo sapiens 182-188 25112011-5 2014 In addition, RA induced differentiation of H9 ESC coupled with morphology changes, decreased expression of undifferentiated markers Oct4, Nanog, Sox2 and OCT4 mRNA binding protein Lin28 at mRNA level, and reduced expression of Oct4 at protein level. Tretinoin 13-15 POU class 5 homeobox 1 Homo sapiens 227-231 24489122-3 2014 Our previous studies have addressed chromatin-remodeling of the Oct4 gene locus in retinoic acid (RA)-treated embryonal carcinoma cell line P19, which involves receptor-interacting protein 140 (RIP140) for heterochromatinization on the proximal promoter region of this gene locus. Tretinoin 83-96 POU class 5 homeobox 1 Homo sapiens 64-68 24489122-3 2014 Our previous studies have addressed chromatin-remodeling of the Oct4 gene locus in retinoic acid (RA)-treated embryonal carcinoma cell line P19, which involves receptor-interacting protein 140 (RIP140) for heterochromatinization on the proximal promoter region of this gene locus. Tretinoin 98-100 POU class 5 homeobox 1 Homo sapiens 64-68 24489122-5 2014 The current study examines RA repression of the Nanog gene and compares the results with RA repression of the Oct4 gene on the chromatin level. Tretinoin 89-91 POU class 5 homeobox 1 Homo sapiens 110-114 24489122-8 2014 Further, RA induces coordinated chromatin-remodeling of both Nanog and Oct4 gene loci, which requires RA receptor-alpha, RIP140 and Brm. Tretinoin 9-11 POU class 5 homeobox 1 Homo sapiens 71-75 24475288-3 2014 Using the human embryonal carcinoma cell line NTera2/D1, we confirmed that exposure to the differentiating agent retinoic acid produced a reduction in pluripotency markers NANOG and POU5F1 (Oct3/4) and an acute concentration-dependent increase in resistance to both cisplatin and paclitaxel that reached as high as 18-fold for cisplatin and 61-fold for paclitaxel within four days. Tretinoin 113-126 POU class 5 homeobox 1 Homo sapiens 190-196 23656719-3 2013 We recently reported that AhR promotes retinoic acid (RA)-induced granulocytic differentiation of HL-60 myeloblastic leukemia cells by restricting the nuclear abundance of the stem cell associated transcription factor Oct4. Tretinoin 39-52 POU class 5 homeobox 1 Homo sapiens 218-222 23656719-3 2013 We recently reported that AhR promotes retinoic acid (RA)-induced granulocytic differentiation of HL-60 myeloblastic leukemia cells by restricting the nuclear abundance of the stem cell associated transcription factor Oct4. Tretinoin 54-56 POU class 5 homeobox 1 Homo sapiens 218-222 18719224-0 2008 Spermatogonial stem cell self-renewal requires OCT4, a factor downregulated during retinoic acid-induced differentiation. Tretinoin 83-96 POU class 5 homeobox 1 Homo sapiens 47-51 23533658-9 2013 Finally, we show that impedance profiles of substance-induced NT2 cells and those triggered to differentiate by depletion of the stem cell factor OCT4 are very similar, suggesting that reduction of OCT4 levels has a dominant function for differentiation induced by nucleoside drugs and retinoic acid. Tretinoin 286-299 POU class 5 homeobox 1 Homo sapiens 198-202 22906706-4 2012 The large cell population responds to retinoic acid differentiation with greater than a 50% reduction in cell number and loss of Oct-4 expression, whereas the number of the small cell population does not change and Oct-4 protein expression is maintained. Tretinoin 38-51 POU class 5 homeobox 1 Homo sapiens 129-134 21740303-8 2011 Interestingly, expression of aryl hydrocarbon receptor (AhR), which is RA-induced and known to down-regulate Oct4 and drive RA-induced differentiation, also enhances IRF-1 expression. Tretinoin 71-73 POU class 5 homeobox 1 Homo sapiens 109-113 21262915-0 2011 Activation of the aryl hydrocarbon receptor AhR Promotes retinoic acid-induced differentiation of myeloblastic leukemia cells by restricting expression of the stem cell transcription factor Oct4. Tretinoin 57-70 POU class 5 homeobox 1 Homo sapiens 190-194 21262915-7 2011 RA upregulated AhR and downregulated Oct4 during differentiation of HL-60 promyelocytic leukemia cells. Tretinoin 0-2 POU class 5 homeobox 1 Homo sapiens 37-41 21262915-11 2011 Consistent with the hypothesized importance of Oct4 downregulation for differentiation, parental cells rendered resistant to RA by biweekly high RA exposure displayed elevated Oct4 levels that failed to be downregulated. Tretinoin 145-147 POU class 5 homeobox 1 Homo sapiens 47-51 21111795-9 2011 Non significant Oct-4 modulation in co-exposure with ATRA was observed at compounds, which potentiated ATRA-mediated effects in the reporter gene assay. Tretinoin 53-57 POU class 5 homeobox 1 Homo sapiens 16-21 21111795-9 2011 Non significant Oct-4 modulation in co-exposure with ATRA was observed at compounds, which potentiated ATRA-mediated effects in the reporter gene assay. Tretinoin 103-107 POU class 5 homeobox 1 Homo sapiens 16-21 20477760-7 2010 We demonstrate that WRNp localizes to the Oct4 promoter during retinoic acid-induced differentiation of human pluripotent cells and associates with the de novo methyltransferase Dnmt3b in the chromatin of differentiating pluripotent cells. Tretinoin 63-76 POU class 5 homeobox 1 Homo sapiens 42-46 20477760-9 2010 The lack of DNA methylation was associated with continued, albeit greatly reduced, Oct4 expression in WRN-deficient, retinoic acid-treated cells, which resulted in attenuated differentiation. Tretinoin 117-130 POU class 5 homeobox 1 Homo sapiens 83-87 18930031-6 2008 During retinoic acid-induced neuronal differentiation, Cyclin D2 protein but not mRNA expression is strongly increased, concurrent with the down-regulation of miR-302b and Oct4. Tretinoin 7-20 POU class 5 homeobox 1 Homo sapiens 172-176 22640830-7 2012 ATRA suppressed the expression of the stem cell markers Oct4, Sox2, Nestin and CD44 in HNSC CSCs and inhibited the proliferation of HNSC CSCs in vitro and in vivo. Tretinoin 0-4 POU class 5 homeobox 1 Homo sapiens 56-60 23000165-2 2012 LRH-1 and OCT4 are co-expressed in undifferentiated NCCIT cells and decreased during retinoic acid-induced differentiation. Tretinoin 85-98 POU class 5 homeobox 1 Homo sapiens 10-14 22339500-7 2012 Treatment with RA (retinoic acid) triggers NCCIT cell differentiation, reducing NANOG and OCT4 expression and up-regulating several neural markers [i.e. ASCL1 (achaete-scute complex homologue 1), NEUROD1 (neuronal differentiation 1) and PAX6 (paired box 6)]. Tretinoin 19-32 POU class 5 homeobox 1 Homo sapiens 90-94 21608077-4 2011 When compared with wild-type ESCs and gastrulating embryos, Oct4 repression is lost and its proximal promoter is significantly hypomethylated in retinoic acid (RA)-differentiated GCNF(-/-) ESCs and GCNF(-/-) embryos. Tretinoin 145-158 POU class 5 homeobox 1 Homo sapiens 60-64 21608077-4 2011 When compared with wild-type ESCs and gastrulating embryos, Oct4 repression is lost and its proximal promoter is significantly hypomethylated in retinoic acid (RA)-differentiated GCNF(-/-) ESCs and GCNF(-/-) embryos. Tretinoin 160-162 POU class 5 homeobox 1 Homo sapiens 60-64 21360626-0 2011 Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter. Tretinoin 34-47 POU class 5 homeobox 1 Homo sapiens 80-84 21262915-11 2011 Consistent with the hypothesized importance of Oct4 downregulation for differentiation, parental cells rendered resistant to RA by biweekly high RA exposure displayed elevated Oct4 levels that failed to be downregulated. Tretinoin 145-147 POU class 5 homeobox 1 Homo sapiens 176-180 21262915-12 2011 Together, our results suggested that therapeutic effects of RA-induced leukemia differentiation depend on AhR and its ability to downregulate the stem cell factor Oct4. Tretinoin 60-62 POU class 5 homeobox 1 Homo sapiens 163-167 20123703-7 2010 Furthermore, stimulation with retinoic acid resulted in down-regulation of OCT4 expression, however, without multilineage differentiation. Tretinoin 30-43 POU class 5 homeobox 1 Homo sapiens 75-79 20727175-0 2010 Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient. Tretinoin 0-13 POU class 5 homeobox 1 Homo sapiens 64-68 20727175-11 2010 We attribute the effect of RA on Xist to RA"s repressive influence on Oct4, a pluripotency factor recently shown to regulate Tsix and Xist. Tretinoin 27-29 POU class 5 homeobox 1 Homo sapiens 70-74 20727175-11 2010 We attribute the effect of RA on Xist to RA"s repressive influence on Oct4, a pluripotency factor recently shown to regulate Tsix and Xist. Tretinoin 41-43 POU class 5 homeobox 1 Homo sapiens 70-74 20727175-15 2010 CONCLUSIONS: We conclude that RA treatment leads to premature downregulation of Oct4 and partial derepression of Xist irrespective of X-chromosome counting. Tretinoin 30-32 POU class 5 homeobox 1 Homo sapiens 80-84 19131575-7 2009 Mechanism dissection suggests that TR2 and TR4 may affect the Oct-3/4 gene by binding to a direct repeat-1 element located in its promoter region, which is influenced by retinoic acid. Tretinoin 170-183 POU class 5 homeobox 1 Homo sapiens 62-69 18719224-6 2008 In addition to developing a method to test specific gene function in GS cells, we demonstrate that retinoic acid (RA) triggers GS cells to shift to a differentiated, premeiotic state lacking OCT4 and PLZF expression and colonization activity. Tretinoin 99-112 POU class 5 homeobox 1 Homo sapiens 191-195 18719224-6 2008 In addition to developing a method to test specific gene function in GS cells, we demonstrate that retinoic acid (RA) triggers GS cells to shift to a differentiated, premeiotic state lacking OCT4 and PLZF expression and colonization activity. Tretinoin 114-116 POU class 5 homeobox 1 Homo sapiens 191-195 18719224-7 2008 Our data support a model in which OCT4 and PLZF maintain SSCs in an undifferentiated state and RA triggers spermatogonial differentiation through the direct or indirect downregulation of OCT4 and PLZF. Tretinoin 95-97 POU class 5 homeobox 1 Homo sapiens 187-191 18682553-0 2008 Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression. Tretinoin 0-13 POU class 5 homeobox 1 Homo sapiens 122-126 18810488-2 2008 The hOct4 promoter is unmethylated in mESCs and it undergoes methylation during retinoic acid-induced differentiation. Tretinoin 80-93 POU class 5 homeobox 1 Homo sapiens 4-9 18682553-6 2008 To normally proliferating P19 stem cell culture, exposure to a physiological concentration of atRA triggers a rapid nongenomic signaling cascade to suppress Oct4 gene and regulate cell proliferation. Tretinoin 94-98 POU class 5 homeobox 1 Homo sapiens 157-161 17226773-4 2007 We found that Oct4 and SF-1 were co-expressed in undifferentiated human embryonal carcinoma NCCIT cells and downregulated during retinoic acid-mediated differentiation. Tretinoin 129-142 POU class 5 homeobox 1 Homo sapiens 14-18 17314394-7 2007 Retinoic acid-mediated differentiation of reprogrammed cells elicits OCT4 promoter remethylation and transcriptional repression. Tretinoin 0-13 POU class 5 homeobox 1 Homo sapiens 69-73 17272500-5 2007 We used Q(2)ChIP to monitor changes in histone H3 modifications on the 5" regulatory regions of the developmentally regulated genes OCT4, NANOG, LMNA, and PAX6 in the context of retinoic-acid-mediated human embryonal carcinoma cell differentiation. Tretinoin 178-191 POU class 5 homeobox 1 Homo sapiens 132-136