PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11331248-0 2001 Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells. Tretinoin 84-103 vav guanine nucleotide exchange factor 1 Homo sapiens 39-42 14709332-2 2004 We have previously demonstrated that tyrosine-phosphorylated Vav, also located inside the nucleus of myeloid cells, is up-regulated during maturation of promyelocytic precursors induced by all-trans-retinoic acid (ATRA). Tretinoin 189-212 vav guanine nucleotide exchange factor 1 Homo sapiens 61-64 14709332-2 2004 We have previously demonstrated that tyrosine-phosphorylated Vav, also located inside the nucleus of myeloid cells, is up-regulated during maturation of promyelocytic precursors induced by all-trans-retinoic acid (ATRA). Tretinoin 214-218 vav guanine nucleotide exchange factor 1 Homo sapiens 61-64 14709332-4 2004 These ATRA-induced events are independent on the guanine nucleotide exchange activity of Vav. Tretinoin 6-10 vav guanine nucleotide exchange factor 1 Homo sapiens 89-92 14709332-6 2004 The Vav/p85 interaction is essential for the ATRA-induced PI 3-K activity and for association of PI 3-K with actin, particularly in the nucleus. Tretinoin 45-49 vav guanine nucleotide exchange factor 1 Homo sapiens 4-7 32032659-3 2020 Roscovitine co-treatment enhanced ATRA-induced expression of pS259- pS289/296/301- pS621-c-Raf, pS217/221-Mek, Src Family Kinases (SFKs) Lyn and Fgr and SFK Y416 phosphorylation, adaptor proteins c-Cbl and Slp-76, Vav, and acetylated 14-3-3 in the signalsome. Tretinoin 34-38 vav guanine nucleotide exchange factor 1 Homo sapiens 214-217 33165749-0 2021 Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). Tretinoin 112-135 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 33165749-0 2021 Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). Tretinoin 137-141 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 33165749-5 2021 We demonstrated here that Vav1 sustains the maturation to beta-cells of the normal precursors human Biliary Tree Stem/progenitor Cells (hBTSCs) induced by a differentiation medium containing ATRA and that, in the mature normal pancreas, insulin-producing cells express variable levels of Vav1. Tretinoin 191-195 vav guanine nucleotide exchange factor 1 Homo sapiens 26-30 33165749-6 2021 Using pancreatic ductal adenocarcinoma (PDAC)-derived cells, we also revealed that the ATRA induced up-modulation of Vav1 is essential for the retinoid-induced trans-differentiation of neoplastic cells into insulin producing cells. Tretinoin 87-91 vav guanine nucleotide exchange factor 1 Homo sapiens 117-121 33165749-7 2021 The results of this study identify Vav1 as crucial molecule in ATRA induced maturation of insulin producing cells and suggest this protein as a marker for new strategies ended to restore functional beta-cells. Tretinoin 63-67 vav guanine nucleotide exchange factor 1 Homo sapiens 35-39 32032659-4 2020 Roscovitine enhanced ATRA-induced c-Raf interaction with Lyn, Vav, and c-Cbl. Tretinoin 21-25 vav guanine nucleotide exchange factor 1 Homo sapiens 62-65 32032659-7 2020 Lyn-knockdown enhanced ATRA-induced up-regulation of key signalsome molecules, c-Raf, pS259-c-Raf, pS289/296/301-c-Raf, Vav1, SLP-76, and Fgr, but with essentially total loss of pY416-SFK. Tretinoin 23-27 vav guanine nucleotide exchange factor 1 Homo sapiens 120-124 27480083-0 2016 A network including PU.1, Vav1 and miR-142-3p sustains ATRA-induced differentiation of acute promyelocytic leukemia cells - a short report. Tretinoin 55-59 vav guanine nucleotide exchange factor 1 Homo sapiens 26-30 32256976-8 2020 Roscovitine also enhanced the ATRA-induced nuclear enrichment of other signaling molecules traditionally perceived as cytoplasmic promoters of proliferation, but now known to promote differentiation; in particular: SFKs, Lyn, Fgr; adaptor proteins, c-Cbl, SLP-76; a guanine exchange factor, Vav1; and a transcription factor, IRF-1. Tretinoin 30-34 vav guanine nucleotide exchange factor 1 Homo sapiens 291-295 27480083-4 2016 METHODS: ATRA-induced increases in PU.1 and Vav1 expression in APL-derived NB4 cells were counteracted with specific siRNAs, and the expression of miR-142-3p was measured by quantitative real-time PCR (qRT-PCR). Tretinoin 9-13 vav guanine nucleotide exchange factor 1 Homo sapiens 44-48 27480083-9 2016 CONCLUSIONS: Our results suggest the existence of a Vav1/PU.1/miR-142-3p network that supports ATRA-induced differentiation in APL-derived cells. Tretinoin 95-99 vav guanine nucleotide exchange factor 1 Homo sapiens 52-61 25941627-8 2015 VAF347 augments RA-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47(phox). Tretinoin 16-18 vav guanine nucleotide exchange factor 1 Homo sapiens 51-55 21856460-1 2011 Vav1 is a key molecule in the ATRA-induced acquisition of a mature phenotype by tumoral myeloid precursors. Tretinoin 30-34 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 24922062-5 2014 Two sequentially emergent RA-resistant HL-60 cell lines, R38+ and R38-, distinguishable by RA-inducible CD38 expression, do not arrest in G1/G0 and fail to upregulate CD11b and the myeloid-associated signaling factors Vav1, c-Cbl, Lyn, Fgr, and c-Raf after RA treatment. Tretinoin 26-28 vav guanine nucleotide exchange factor 1 Homo sapiens 218-222 21856460-4 2011 The obtained data demonstrated that, in NB4 cells treated with ATRA, Vav1 is involved in determining the nuclear amount of proteins involved in molecular complexes with DNA and may participate to RNA processing by carrying in the nucleus molecules involved in modulating mRNA production and stability, like hnRNPs and SR proteins. Tretinoin 63-67 vav guanine nucleotide exchange factor 1 Homo sapiens 69-73 21156171-9 2011 Another is Vav1, which also showed only basal expression after ATRA treatment in CD38 Delta11-20 expressing cells. Tretinoin 63-67 vav guanine nucleotide exchange factor 1 Homo sapiens 11-15 18642942-0 2008 Vav1 modulates protein expression during ATRA-induced maturation of APL-derived promyelocytes: a proteomic-based analysis. Tretinoin 41-45 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 20028078-1 2010 Vav1, whose physiological expression is restricted to hematopoietic system, is one of the signaling proteins up-regulated by all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL)-derived precursors, in which it promotes the overcoming of the differentiation blockade. Tretinoin 135-148 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 20028078-1 2010 Vav1, whose physiological expression is restricted to hematopoietic system, is one of the signaling proteins up-regulated by all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL)-derived precursors, in which it promotes the overcoming of the differentiation blockade. Tretinoin 150-154 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 20028078-3 2010 Here, we have found that phosphorylation of Vav1 Y174, that is known to regulate Vav1 activity in mature neutrophils, is up-regulated by ATRA in NB4 cells. Tretinoin 137-141 vav guanine nucleotide exchange factor 1 Homo sapiens 44-48 20028078-3 2010 Here, we have found that phosphorylation of Vav1 Y174, that is known to regulate Vav1 activity in mature neutrophils, is up-regulated by ATRA in NB4 cells. Tretinoin 137-141 vav guanine nucleotide exchange factor 1 Homo sapiens 81-85 20028078-6 2010 In fact, the overexpression of a mutated form of Vav1, in which Y745 was replaced with a phenylalanine, significantly reduced the ATRA-induced CD11b expression and essentially abrogated the differentiation-related acquisition of the migratory capability. Tretinoin 130-134 vav guanine nucleotide exchange factor 1 Homo sapiens 49-53 19747912-0 2010 Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation. Tretinoin 140-144 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 19747912-1 2010 Vav1 plays an important role in the all-trans retinoic acid (ATRA)-induced completion of the differentiation program of acute promyelocytic leukemia (APL)-derived cells, in which it strengthens the drug effects and is involved in the regulation of maturation-related proteins, such as the CD11b surface antigen. Tretinoin 46-59 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 19747912-1 2010 Vav1 plays an important role in the all-trans retinoic acid (ATRA)-induced completion of the differentiation program of acute promyelocytic leukemia (APL)-derived cells, in which it strengthens the drug effects and is involved in the regulation of maturation-related proteins, such as the CD11b surface antigen. Tretinoin 61-65 vav guanine nucleotide exchange factor 1 Homo sapiens 0-4 19747912-6 2010 The reported data suggest that the ATRA-induced increase of Vav1 expression and tyrosine phosphorylation may be involved in recruiting PU.1 to its consensus sequence on the CD11b promoter and, ultimately, in regulating CD11b expression during the late stages of neutrophil differentiation of APL-derived promyelocytes. Tretinoin 35-39 vav guanine nucleotide exchange factor 1 Homo sapiens 60-64 18642942-2 2008 At variance, down-modulation of Vav1 prevents ATRA-induced maturation, and in particular, the inhibition of its tyrosine phosphorylation prevents the neutrophil differentiation-related changes of cell morphology. Tretinoin 46-50 vav guanine nucleotide exchange factor 1 Homo sapiens 32-36 18642942-4 2008 By means of a proteomic approach, here we have investigated a possible role for Vav1 in modulating protein expression during ATRA treatment of tumoral promyelocytes. Tretinoin 125-129 vav guanine nucleotide exchange factor 1 Homo sapiens 80-84 15878332-3 2005 We have previously demonstrated that the amount and the tyrosine phosphorylation of Vav are up-regulated in both whole cells and nuclei of tumoral promyelocytes induced to granulocytic maturation by ATRA and that tyrosine-phosphorylated Vav does not display any ATRA-induced GEF activity but contributes to the regulation of PI 3-K activity. Tretinoin 199-203 vav guanine nucleotide exchange factor 1 Homo sapiens 84-87 15878332-3 2005 We have previously demonstrated that the amount and the tyrosine phosphorylation of Vav are up-regulated in both whole cells and nuclei of tumoral promyelocytes induced to granulocytic maturation by ATRA and that tyrosine-phosphorylated Vav does not display any ATRA-induced GEF activity but contributes to the regulation of PI 3-K activity. Tretinoin 262-266 vav guanine nucleotide exchange factor 1 Homo sapiens 84-87 15878332-4 2005 In this study, we report that Vav accumulates in nuclei of ATRA-treated APL-derived cells and that the down-modulation of Vav prevents differentiation of tumoral promyelocytes, indicating that it is a key molecule in ATRA-dependent myeloid maturation. Tretinoin 59-63 vav guanine nucleotide exchange factor 1 Homo sapiens 30-33 15878332-6 2005 Consistent with an effect of Vav on the transcriptional machinery, array profiling shows that the inhibition of the Syk-dependent tyrosine phosphorylation of Vav reduces the number of ATRA-induced genes. Tretinoin 184-188 vav guanine nucleotide exchange factor 1 Homo sapiens 29-32 15878332-6 2005 Consistent with an effect of Vav on the transcriptional machinery, array profiling shows that the inhibition of the Syk-dependent tyrosine phosphorylation of Vav reduces the number of ATRA-induced genes. Tretinoin 184-188 vav guanine nucleotide exchange factor 1 Homo sapiens 158-161