PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22116806-3	2012	The repression of microRNA clusters Mir-17-92 (Mirc1) and Mir-106b-25 (Mirc3) by retinoic acid in turn potentially upregulates the expression of Bim, Kit, Socs3, and Stat3.	Tretinoin	81-94	signal transducer and activator of transcription 3	Mus musculus	166-171	
27089940-10	2016	Our findings demonstrate that the anti-inflammatory properties of RA are mediated in part by suppressing STAT3-mediated activation of cytokine production and cytokine receptor expression in gammadelta T cells, which suppresses their ability to activate Th17 cells.	Tretinoin	66-68	signal transducer and activator of transcription 3	Mus musculus	105-110	
22531980-8	2012	In agreement with these observations, in vitro experiments showed that in the presence of leptin, ATRA directly induced LEPR gene expression through RARalpha, resulting in enhancement of STAT3 and insulin-induced insulin receptor substrate 1 phosphorylation.	Tretinoin	98-102	signal transducer and activator of transcription 3	Mus musculus	187-192	
15978261-5	2005	STAT3 activation was detected in the outermost retina layer in response to CNTF, LIF, FGF1, and IFN-alpha 24 hr after stimulation in postnatal day 1 (PN1) explants, but not FGF2, EGF, IFN-gamma, and retinoic acid (RA).	Tretinoin	199-212	signal transducer and activator of transcription 3	Mus musculus	0-5	
20944006-5	2010	RA promoted bone marrow-derived DC production of bioactive TGF-beta by inhibiting suppressor of cytokine signaling 3 expression and thereby enhancing STAT3 activation.	Tretinoin	0-2	signal transducer and activator of transcription 3	Mus musculus	150-155	
17976305-4	2007	Here we demonstrate that pro-neural effects of LIF and partially also of retinoic acid are abolished by inhibition of the JAK2->STAT3 signalling pathway.	Tretinoin	73-86	signal transducer and activator of transcription 3	Mus musculus	131-136	
17976305-6	2007	These results suggest that in neurogenic regions, cooperative action of LIF and other neuro-differentiation-inducing factors, such as retinoic acid, may be mediated by the STAT3 signalling pathway.	Tretinoin	134-147	signal transducer and activator of transcription 3	Mus musculus	172-177	
19789299-0	2009	All-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis.	Tretinoin	10-23	signal transducer and activator of transcription 3	Mus musculus	35-40	
19789299-2	2009	We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC.	Tretinoin	44-57	signal transducer and activator of transcription 3	Mus musculus	117-167	
19789299-2	2009	We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC.	Tretinoin	44-57	signal transducer and activator of transcription 3	Mus musculus	169-174	
19789299-2	2009	We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC.	Tretinoin	59-63	signal transducer and activator of transcription 3	Mus musculus	117-167	
19789299-2	2009	We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC.	Tretinoin	59-63	signal transducer and activator of transcription 3	Mus musculus	169-174	
19789299-8	2009	Using Western blotting and immunohistochemical staining with phosphospecific antibodies, we show that coadministration of ATRA suppressed the 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation of Stat3 in both models, but was only able to suppress tumor formation in the SENCAR mice.	Tretinoin	122-126	signal transducer and activator of transcription 3	Mus musculus	206-211	
19789299-10	2009	We hypothesize that ATRA blocks tumor formation, at least in part, by targeting events upstream of Stat3, such as the B-Raf/Mek/Erk pathway, and that in the K5.Stat3C mice, in which Stat3 activity is constitutive, it cannot suppress tumor formation.	Tretinoin	20-24	signal transducer and activator of transcription 3	Mus musculus	99-104	
19789299-10	2009	We hypothesize that ATRA blocks tumor formation, at least in part, by targeting events upstream of Stat3, such as the B-Raf/Mek/Erk pathway, and that in the K5.Stat3C mice, in which Stat3 activity is constitutive, it cannot suppress tumor formation.	Tretinoin	20-24	signal transducer and activator of transcription 3	Mus musculus	160-165	
15978261-5	2005	STAT3 activation was detected in the outermost retina layer in response to CNTF, LIF, FGF1, and IFN-alpha 24 hr after stimulation in postnatal day 1 (PN1) explants, but not FGF2, EGF, IFN-gamma, and retinoic acid (RA).	Tretinoin	214-216	signal transducer and activator of transcription 3	Mus musculus	0-5	
14603524-5	2004	We demonstrate that RA-induced differentiation of CCE ES cells is associated with (1) downregulation of the LIF receptor (LIFR); (2) decreased tyrosine phosphorylation of signal transducer and activator of transcription 3 protein (Stat3); and (3) increased activation of extracellular regulated kinase (Erk1/2).	Tretinoin	20-22	signal transducer and activator of transcription 3	Mus musculus	171-221	
14603524-5	2004	We demonstrate that RA-induced differentiation of CCE ES cells is associated with (1) downregulation of the LIF receptor (LIFR); (2) decreased tyrosine phosphorylation of signal transducer and activator of transcription 3 protein (Stat3); and (3) increased activation of extracellular regulated kinase (Erk1/2).	Tretinoin	20-22	signal transducer and activator of transcription 3	Mus musculus	231-236	
9566306-5	1998	Here we report that the level of tyrosine-phosphorylated Stat3 decreases rapidly during differentiation induced by treatment of ES1 cells either with retinoic acid (RA) or by withdrawal of LIF.	Tretinoin	150-163	signal transducer and activator of transcription 3	Mus musculus	57-62