PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12494454-10	2003	We tested whether the RA-induced AP-1 activity might be mediated by the ERK1/2 MAPK pathway.	Tretinoin	22-24	mitogen-activated protein kinase 3	Mus musculus	72-78	
14603524-5	2004	We demonstrate that RA-induced differentiation of CCE ES cells is associated with (1) downregulation of the LIF receptor (LIFR); (2) decreased tyrosine phosphorylation of signal transducer and activator of transcription 3 protein (Stat3); and (3) increased activation of extracellular regulated kinase (Erk1/2).	Tretinoin	20-22	mitogen-activated protein kinase 3	Mus musculus	303-309	
26108692-1	2015	We recently identified that the MEK/ERK1/2 pathway synergized with retinoic acid (RA) to restore both transcriptional activity and RA-induced differentiation in RA-resistant acute promyelocytic leukemia (APL) cells.	Tretinoin	67-80	mitogen-activated protein kinase 3	Mus musculus	36-42	
31682623-0	2019	Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells.	Tretinoin	0-13	mitogen-activated protein kinase 3	Mus musculus	25-31	
31682623-4	2019	When XX germ cells at embryonic day (E) 12.5 were cultured with RA, the extracellular-signal-regulated kinase (ERK) 1/2 pathway was predominantly activated.	Tretinoin	64-66	mitogen-activated protein kinase 3	Mus musculus	72-119	
31682623-7	2019	Taken together, our results suggest the novel concept that the RA functions by stimulating the ERK1/2 pathway and that this activity is critical for Stra8 expression and meiotic progression in fetal germ cells.	Tretinoin	63-65	mitogen-activated protein kinase 3	Mus musculus	95-101	
31035455-2	2019	In F9 embryonic carcinoma cells, RA can induce differentiation towards somatic lineages via the Ras-extracellular signal-regulated kinase (Ras/Erk) pathway, but the mechanism through which it induces the Erk1/2 phosphorylation is unclear.	Tretinoin	33-35	mitogen-activated protein kinase 3	Mus musculus	204-210	
31035455-6	2019	In summary, RA can mediate cell differentiation by phosphorylating Erk1/2 via miR-485 and Abhd2.	Tretinoin	12-14	mitogen-activated protein kinase 3	Mus musculus	67-73	
26108692-1	2015	We recently identified that the MEK/ERK1/2 pathway synergized with retinoic acid (RA) to restore both transcriptional activity and RA-induced differentiation in RA-resistant acute promyelocytic leukemia (APL) cells.	Tretinoin	82-84	mitogen-activated protein kinase 3	Mus musculus	36-42	
26108692-1	2015	We recently identified that the MEK/ERK1/2 pathway synergized with retinoic acid (RA) to restore both transcriptional activity and RA-induced differentiation in RA-resistant acute promyelocytic leukemia (APL) cells.	Tretinoin	131-133	mitogen-activated protein kinase 3	Mus musculus	36-42	
23530929-6	2013	In addition, RA-induced inhibition of gamma-secretase activity was found to be mediated through significant activation of extracellular signal-regulated kinases (ERK1/2).	Tretinoin	13-15	mitogen-activated protein kinase 3	Mus musculus	162-168	
26208884-5	2015	Most interestingly, TLR ligation in the presence of recombinant IL-10 (rIL-10) or retinoic acid (RA) led to ERK1/2 activation independent of MEK1 in BMDMs derived from Mek1(d/d)Sox2(Cre) mice and led to inhibition of STAT4 and decreased IL-12 levels.	Tretinoin	82-95	mitogen-activated protein kinase 3	Mus musculus	108-114	
24440820-6	2014	We demonstrate that during neuronal differentiation of Neuro-2a cells, RA induces Chka expression by a mechanism that involves ERK1/2 activation which triggers C/EBPbeta expression.	Tretinoin	71-73	mitogen-activated protein kinase 3	Mus musculus	127-133	
21931768-7	2011	Conversely, atRA markedly increased ERK1/2 activation, and blockade of ERK1/2 signaling completely abolished the enhanced effects of atRA on Foxp3 expression.	Tretinoin	12-16	mitogen-activated protein kinase 3	Mus musculus	36-42	
21931768-7	2011	Conversely, atRA markedly increased ERK1/2 activation, and blockade of ERK1/2 signaling completely abolished the enhanced effects of atRA on Foxp3 expression.	Tretinoin	133-137	mitogen-activated protein kinase 3	Mus musculus	71-77	
17712061-4	2008	atRA (10 nM) increased ERK1/2 phosphorylation within 10 min.	Tretinoin	0-4	mitogen-activated protein kinase 3	Mus musculus	23-29	
17026715-5	2006	Western blot analysis showed a dramatic increase in ERK 1/2 phosphorylation (p-ERK 1/2) 1-5 days after RA induction, which was attenuated in the presence of the p-ERK 1/2-specific inhibitor UO126.	Tretinoin	103-105	mitogen-activated protein kinase 3	Mus musculus	52-59	
17026715-5	2006	Western blot analysis showed a dramatic increase in ERK 1/2 phosphorylation (p-ERK 1/2) 1-5 days after RA induction, which was attenuated in the presence of the p-ERK 1/2-specific inhibitor UO126.	Tretinoin	103-105	mitogen-activated protein kinase 3	Mus musculus	79-86	
17026715-5	2006	Western blot analysis showed a dramatic increase in ERK 1/2 phosphorylation (p-ERK 1/2) 1-5 days after RA induction, which was attenuated in the presence of the p-ERK 1/2-specific inhibitor UO126.	Tretinoin	103-105	mitogen-activated protein kinase 3	Mus musculus	52-57