PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28713967-7 2017 It was demonstrated that Notch2 silencing partially reversed the atRA-induced inhibition of ERK phosphorylation in MEPM cells. Tretinoin 65-69 mitogen-activated protein kinase 1 Mus musculus 92-95 31210146-7 2020 In GC-1 cells cultured in vitro, Shp2 knockdown suppressed the retinoic acid (RA)-induced phosphorylation of extracellular-regulated protein kinase (Erk) and protein kinase B (Akt/PKB) and the expression of target genes such as synaptonemal complex protein 3 (Sycp3) and Dmc1. Tretinoin 78-80 mitogen-activated protein kinase 1 Mus musculus 109-147 31210146-7 2020 In GC-1 cells cultured in vitro, Shp2 knockdown suppressed the retinoic acid (RA)-induced phosphorylation of extracellular-regulated protein kinase (Erk) and protein kinase B (Akt/PKB) and the expression of target genes such as synaptonemal complex protein 3 (Sycp3) and Dmc1. Tretinoin 78-80 mitogen-activated protein kinase 1 Mus musculus 149-152 31682623-3 2019 In this study, using a germ cell culture system, we investigated (1) whether RA treatment activates any mitogen-activated protein kinase (MAPK) pathways in fetal germ cells at the time of sex differentiation, and (2) if this is the case, whether the corresponding RA-stimulated signaling pathway regulates Stra8 expression in fetal germ cells and their entry into meiosis. Tretinoin 77-79 mitogen-activated protein kinase 1 Mus musculus 138-142 31035455-2 2019 In F9 embryonic carcinoma cells, RA can induce differentiation towards somatic lineages via the Ras-extracellular signal-regulated kinase (Ras/Erk) pathway, but the mechanism through which it induces the Erk1/2 phosphorylation is unclear. Tretinoin 33-35 mitogen-activated protein kinase 1 Mus musculus 143-146 30864551-3 2019 OBJECTIVE: To investigates the effect of ATRA on the regulation of Th17-Treg balance through ERK and p38 signaling pathway. Tretinoin 41-45 mitogen-activated protein kinase 1 Mus musculus 93-96 30864551-5 2019 The effect of ATRA on the phosphorylation of ERK and P38 was evaluated. Tretinoin 14-18 mitogen-activated protein kinase 1 Mus musculus 45-48 31210146-7 2020 In GC-1 cells cultured in vitro, Shp2 knockdown suppressed the retinoic acid (RA)-induced phosphorylation of extracellular-regulated protein kinase (Erk) and protein kinase B (Akt/PKB) and the expression of target genes such as synaptonemal complex protein 3 (Sycp3) and Dmc1. Tretinoin 63-76 mitogen-activated protein kinase 1 Mus musculus 109-147 31210146-7 2020 In GC-1 cells cultured in vitro, Shp2 knockdown suppressed the retinoic acid (RA)-induced phosphorylation of extracellular-regulated protein kinase (Erk) and protein kinase B (Akt/PKB) and the expression of target genes such as synaptonemal complex protein 3 (Sycp3) and Dmc1. Tretinoin 63-76 mitogen-activated protein kinase 1 Mus musculus 149-152 30864551-0 2019 All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway. Tretinoin 10-23 mitogen-activated protein kinase 1 Mus musculus 73-76 28713967-10 2017 The present findings suggested that during embryonic development, atRA may enhance the expression of Notch2, which may inhibit cellular proliferation, possibly through ERK signaling. Tretinoin 66-70 mitogen-activated protein kinase 1 Mus musculus 168-171 26186635-7 2015 The anti-apoptotic effects of ATRA were associated with partial inhibition of reactive oxygen species (ROS) production and significantly less phosphorylation of mitogen-activated protein kinases (MAPKs) including p38, JNK, and ERK. Tretinoin 30-34 mitogen-activated protein kinase 1 Mus musculus 227-230 26108692-7 2015 In this work, we demonstrate that LiCl, a well-tolerated agent in humans, has antileukemic activity in APL and that it has the potential to restore RA-induced transcriptional activation and differentiation in RA-resistant APL cells in an MEK/ERK-dependent manner. Tretinoin 148-150 mitogen-activated protein kinase 1 Mus musculus 242-245 26186635-11 2015 One possible mechanism underlying these effects is that ATRA could increase ADAM10 expression and thus cleave RAGE, which is the main receptor up-stream of MAPKs in myocardial I/R injury, resulting in the down-regulation of MAPK signaling and protective role on myocardial I/R injury. Tretinoin 56-60 mitogen-activated protein kinase 1 Mus musculus 156-160 19432991-0 2009 Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion. Tretinoin 81-94 mitogen-activated protein kinase 1 Mus musculus 32-35 19789299-5 2009 ATRA is a highly efficient suppressor of tumor formation in the two-stage mouse skin carcinogenesis model and we have shown that this effect correlates with the suppression of the B-Raf/Mek/Erk signaling pathway. Tretinoin 0-4 mitogen-activated protein kinase 1 Mus musculus 190-193 19789299-10 2009 We hypothesize that ATRA blocks tumor formation, at least in part, by targeting events upstream of Stat3, such as the B-Raf/Mek/Erk pathway, and that in the K5.Stat3C mice, in which Stat3 activity is constitutive, it cannot suppress tumor formation. Tretinoin 20-24 mitogen-activated protein kinase 1 Mus musculus 128-131 19642999-8 2009 ERK phosphorylation was enhanced in RA-treated cultures at the early stage of differentiation. Tretinoin 36-38 mitogen-activated protein kinase 1 Mus musculus 0-3 19642999-10 2009 This effect depends on RA signaling and its crosstalk with the ERK and Wnt pathways. Tretinoin 23-25 mitogen-activated protein kinase 1 Mus musculus 63-66 23530929-7 2013 Treatment of cells with the specific ERK inhibitor PD98059 completely abolished RA-mediated inhibition of gamma-secretase. Tretinoin 80-82 mitogen-activated protein kinase 1 Mus musculus 37-40 20179094-3 2010 Retinoic acid also induces differentiation in many cellular contexts, but its mechanism of action in relation to Fgf/Erk signalling in ES cells is poorly understood. Tretinoin 0-13 mitogen-activated protein kinase 1 Mus musculus 117-120 19432991-8 2009 The counter-regulated genes have been clustered into functional categories and bioinformatic analysis has identified the B-Raf/Mek/Erk branch of the MAP kinase pathway as one containing several genes whose upregulation by TPA is blocked by ATRA. Tretinoin 240-244 mitogen-activated protein kinase 1 Mus musculus 131-134 18845239-8 2008 Inhibition of MEK1/ERK mitogen-activated protein kinases significantly suppressed atRA-induced NRF2 activation and ARE-regulated gene expression, reducing cell resistance against toxic concentrations of RA. Tretinoin 82-86 mitogen-activated protein kinase 1 Mus musculus 19-22 18845239-8 2008 Inhibition of MEK1/ERK mitogen-activated protein kinases significantly suppressed atRA-induced NRF2 activation and ARE-regulated gene expression, reducing cell resistance against toxic concentrations of RA. Tretinoin 84-86 mitogen-activated protein kinase 1 Mus musculus 19-22 12604597-0 2003 Activation of the Ras-ERK pathway inhibits retinoic acid-induced stimulation of tissue transglutaminase expression in NIH3T3 cells. Tretinoin 43-56 mitogen-activated protein kinase 1 Mus musculus 22-25 16712891-0 2006 atRA-induced apoptosis of mouse embryonic palate mesenchymal cells involves activation of MAPK pathway. Tretinoin 0-4 mitogen-activated protein kinase 1 Mus musculus 90-94 16712891-7 2006 In addition, atRA treatment caused a strong and sustained activation of c-Jun N-terminal kinase (JNK) and p38 kinase (p38), as well as an early but transient activation of extracellular signal-regulated kinase (ERK). Tretinoin 13-17 mitogen-activated protein kinase 1 Mus musculus 172-209 16712891-7 2006 In addition, atRA treatment caused a strong and sustained activation of c-Jun N-terminal kinase (JNK) and p38 kinase (p38), as well as an early but transient activation of extracellular signal-regulated kinase (ERK). Tretinoin 13-17 mitogen-activated protein kinase 1 Mus musculus 211-214 17538947-5 2007 This result has pointed the way toward the detailed study of Raf/Mek/Erk pathway signaling in skin cancer development and its potential as a target pathway for chemoprevention by ATRA and other chemopreventive drugs. Tretinoin 179-183 mitogen-activated protein kinase 1 Mus musculus 69-72 12604597-4 2003 Activation of the Ras-ERK pathway by EGF was sufficient to elicit this effect, since continuous Ras signaling mimicked the actions of EGF and inhibited RA-induced TGase expression, whereas blocking ERK activity in these same cells restored the ability of RA to up-regulate TGase expression. Tretinoin 152-154 mitogen-activated protein kinase 1 Mus musculus 22-25 12604597-4 2003 Activation of the Ras-ERK pathway by EGF was sufficient to elicit this effect, since continuous Ras signaling mimicked the actions of EGF and inhibited RA-induced TGase expression, whereas blocking ERK activity in these same cells restored the ability of RA to up-regulate TGase expression. Tretinoin 255-257 mitogen-activated protein kinase 1 Mus musculus 22-25 12604597-8 2003 These findings demonstrate that TGase may serve as a survival factor and RA-induced TGase expression requires the activation of PI3K but is antagonized by the Ras-ERK pathway. Tretinoin 73-75 mitogen-activated protein kinase 1 Mus musculus 163-166 12494454-10 2003 We tested whether the RA-induced AP-1 activity might be mediated by the ERK1/2 MAPK pathway. Tretinoin 22-24 mitogen-activated protein kinase 1 Mus musculus 79-83 11854287-4 2002 It was found that RA stimulation of NIH3T3 cells activated ERK and phosphoinositide 3-kinase (PI3K); however, only PI3K activation was necessary for RA-induced TGase expression. Tretinoin 18-20 mitogen-activated protein kinase 1 Mus musculus 59-62 12171913-6 2002 Collectively, enhanced binding of Sp1 to promoter I of the KOR gene as a result of inhibiting the ERK pathway contributes to RA induction of this gene in P19. Tretinoin 125-127 mitogen-activated protein kinase 1 Mus musculus 98-101 12165850-5 2002 Differentiation induced by retinoic acid results in the gain of ERK-dependent control of cyclin D1 expression and of S phase progression. Tretinoin 27-40 mitogen-activated protein kinase 1 Mus musculus 64-67 11802792-6 2002 Furthermore, we show that ERK activation is required only during RA treatment. Tretinoin 65-67 mitogen-activated protein kinase 1 Mus musculus 26-29 11802792-0 2002 Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Tretinoin 0-13 mitogen-activated protein kinase 1 Mus musculus 32-35 11802792-4 2002 Treatment of ES cell-derived embryoid bodies with RA resulted in a prolonged activation of the ERK pathway, but not the c-Jun N-terminal kinase, p38 mitogen-activated protein kinase or phosphoinositide 3-kinase pathways. Tretinoin 50-52 mitogen-activated protein kinase 1 Mus musculus 95-98 11802792-5 2002 To investigate the role of ERK activation, co-treatment of RA with PD98059, a specific inhibitor of the ERK signalling pathway, prevented both adipocyte formation and expression of the adipogenic markers, adipocyte lipid-binding protein and peroxisome-proliferator-activated receptor gamma. Tretinoin 59-61 mitogen-activated protein kinase 1 Mus musculus 27-30 11802792-5 2002 To investigate the role of ERK activation, co-treatment of RA with PD98059, a specific inhibitor of the ERK signalling pathway, prevented both adipocyte formation and expression of the adipogenic markers, adipocyte lipid-binding protein and peroxisome-proliferator-activated receptor gamma. Tretinoin 59-61 mitogen-activated protein kinase 1 Mus musculus 104-107 11104676-1 2000 Activation of mitogen-activated protein kinases (MAPKs), their upstream activators MAPK kinases (MAPKKs or MEKs) and induction of MKP-1 (CL100/3CH134) and MKP-3 (Pyst1/rVH6) dual-specificity MAPK phosphatases (MKPs) were studied in the mouse embryonic stem cell line P19 during the 7 day induction of neuronal differentiation triggered by aggregation and retinoic acid. Tretinoin 355-368 mitogen-activated protein kinase 1 Mus musculus 49-53 9261178-11 1997 Furthermore, we demonstrated, using mouse P19 embryonal carcinoma cells, that this 371-base pair sequence is likely to be sufficient to confer the transcriptional activation of the ERK2 promoter during the retinoic acid-induced differentiation of P19 cells. Tretinoin 206-219 mitogen-activated protein kinase 1 Mus musculus 181-185