PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33668324-0	2021	FOXC1 Downregulates Nanog Expression by Recruiting HDAC2 to Its Promoter in F9 Cells Treated by Retinoic Acid.	Tretinoin	96-109	Nanog homeobox	Homo sapiens	20-25	
17272500-5	2007	We used Q(2)ChIP to monitor changes in histone H3 modifications on the 5" regulatory regions of the developmentally regulated genes OCT4, NANOG, LMNA, and PAX6 in the context of retinoic-acid-mediated human embryonal carcinoma cell differentiation.	Tretinoin	178-191	Nanog homeobox	Homo sapiens	138-143	
22339500-0	2012	Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation.	Tretinoin	99-112	Nanog homeobox	Homo sapiens	13-18	
22339500-7	2012	Treatment with RA (retinoic acid) triggers NCCIT cell differentiation, reducing NANOG and OCT4 expression and up-regulating several neural markers [i.e. ASCL1 (achaete-scute complex homologue 1), NEUROD1 (neuronal differentiation 1) and PAX6 (paired box 6)].	Tretinoin	19-32	Nanog homeobox	Homo sapiens	80-85	
19916800-1	2010	Transcription factor FoxA1 plays a critical role during embryonic development and is activated during retinoic acid (RA)-induced neural differentiation of pluripotent P19 embryonal carcinoma cells at the early stage, which is marked by decreased expression of Nanog and increased expression of neural stem cell marker Nestin.	Tretinoin	102-115	Nanog homeobox	Homo sapiens	260-265	
19916800-1	2010	Transcription factor FoxA1 plays a critical role during embryonic development and is activated during retinoic acid (RA)-induced neural differentiation of pluripotent P19 embryonal carcinoma cells at the early stage, which is marked by decreased expression of Nanog and increased expression of neural stem cell marker Nestin.	Tretinoin	117-119	Nanog homeobox	Homo sapiens	260-265	
33668324-2	2021	FOXC1 is up-regulated in retinoic acid-induced differentiation of F9 Embryonal Carcinoma (EC) cells; furthermore, FOXC1 specifically inhibits the core pluripotency factor Nanog by binding to the proximal promoter.	Tretinoin	25-38	Nanog homeobox	Homo sapiens	171-176	
25866159-2	2015	We present a piggyBac transposon gain of function screen in human ES cells that identifies DENND2C, which genetically cooperates with NANOG to maintain self-renewal in the presence of retinoic acid.	Tretinoin	184-197	Nanog homeobox	Homo sapiens	134-139	
28601081-3	2017	We demonstrated decrease in OCT4 and NANOG mRNA and protein levels following exposure to retinoic acid.	Tretinoin	89-102	Nanog homeobox	Homo sapiens	37-42	
25112011-5	2014	In addition, RA induced differentiation of H9 ESC coupled with morphology changes, decreased expression of undifferentiated markers Oct4, Nanog, Sox2 and OCT4 mRNA binding protein Lin28 at mRNA level, and reduced expression of Oct4 at protein level.	Tretinoin	13-15	Nanog homeobox	Homo sapiens	138-143	
24803390-1	2014	Transcription factor Foxa1 plays a critical role during neural differentiation and is induced immediately after retinoic acid (RA)-initiated differentiation of pluripotent P19 embryonal carcinoma cells, correlated with the downregulated expression of pluripotency-related genes such as Nanog.	Tretinoin	112-125	Nanog homeobox	Homo sapiens	286-291	
24803390-1	2014	Transcription factor Foxa1 plays a critical role during neural differentiation and is induced immediately after retinoic acid (RA)-initiated differentiation of pluripotent P19 embryonal carcinoma cells, correlated with the downregulated expression of pluripotency-related genes such as Nanog.	Tretinoin	127-129	Nanog homeobox	Homo sapiens	286-291	
24489122-5	2014	The current study examines RA repression of the Nanog gene and compares the results with RA repression of the Oct4 gene on the chromatin level.	Tretinoin	27-29	Nanog homeobox	Homo sapiens	48-53	
24489122-7	2014	On RA treatment, the Nanog gene locus remodels specifically in the CR1 region of its proximal promoter, with the insertion of a nucleosome and compaction of this region.	Tretinoin	3-5	Nanog homeobox	Homo sapiens	21-26	
24489122-8	2014	Further, RA induces coordinated chromatin-remodeling of both Nanog and Oct4 gene loci, which requires RA receptor-alpha, RIP140 and Brm.	Tretinoin	9-11	Nanog homeobox	Homo sapiens	61-66	
24475288-8	2014	Forced expression of NANOG prevented the induction of resistance to cisplatin by retinoic acid.	Tretinoin	81-94	Nanog homeobox	Homo sapiens	21-26	
24475288-3	2014	Using the human embryonal carcinoma cell line NTera2/D1, we confirmed that exposure to the differentiating agent retinoic acid produced a reduction in pluripotency markers NANOG and POU5F1 (Oct3/4) and an acute concentration-dependent increase in resistance to both cisplatin and paclitaxel that reached as high as 18-fold for cisplatin and 61-fold for paclitaxel within four days.	Tretinoin	113-126	Nanog homeobox	Homo sapiens	172-177