PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9186002-0	1997	Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons.	Tretinoin	0-13	signal transducer and activator of transcription 2	Homo sapiens	81-86	
22490698-7	2012	RESULTS: The level of phosphorylated-STAT2 was obviously up-regulated in NB4 cells treated with ATRA for 72 hours, as well as the concentration of IFN-alpha in culture supernatants.	Tretinoin	96-100	signal transducer and activator of transcription 2	Homo sapiens	37-42	
22490698-3	2012	The protein levels of tyrosine-phosphorylated STAT2 in ATRA-treated NB4 cells were detected by Western blot.	Tretinoin	55-59	signal transducer and activator of transcription 2	Homo sapiens	46-51	
20137113-2	2010	The results showed that the expression of STAT2, IRF-9 and IRF-1 could be upregulated by ATRA with different kinetics in NB4 cells.	Tretinoin	89-93	signal transducer and activator of transcription 2	Homo sapiens	42-47	
20137113-5	2010	It is concluded that during ATRA-induced APL cell differentiation, IRF-1 is first upregulated by ATRA, and then IRF-1 increases the protein levels of IRF-9 and STAT2 with the downregulation of C/EBPalpha.	Tretinoin	28-32	signal transducer and activator of transcription 2	Homo sapiens	160-165	
16918696-6	2006	We demonstrate that ATRA-induced upregulation of Stat2, ICSBP/IRF8 and C/EBPepsilon, key transcription factors linked to myelomonocytic differentiation, is selectively impaired in cells expressing mutant Stat1.	Tretinoin	20-24	signal transducer and activator of transcription 2	Homo sapiens	49-54	
16918696-8	2006	Taken together, our data suggest that ATRA-induced regulation of Stat2, ICSBP and C/EBPepsilon is dependent on active Stat1, and that a failure to correctly regulate these transcription factors is associated with the inhibition of monocytic differentiation.	Tretinoin	38-42	signal transducer and activator of transcription 2	Homo sapiens	65-70	
9669677-6	1998	In addition, during ATRA-induced myeloid differentiation, gene expression of STAT1, STAT2, and p48 was upregulated.	Tretinoin	20-24	signal transducer and activator of transcription 2	Homo sapiens	84-89	
9186002-4	1997	Here we have studied the activation and induction of IFN-specific transcription factors signal transducer and activator of transcription (STAT) 1, STAT2, and p48 in all-trans-retinoic acid (ATRA)-differentiated myeloid leukemia cells using promyelocytic NB4, myeloblastic HL-60, and monoblastic U937 cells as model systems.	Tretinoin	190-194	signal transducer and activator of transcription 2	Homo sapiens	147-152	
9186002-7	1997	However, during ATRA-induced differentiation, steady-state STAT1, STAT2, and especially p48 mRNA and corresponding protein levels were elevated both in NB4 and U937 cells, apparently correlating to an enhanced responsiveness of these cells to IFNs.	Tretinoin	16-20	signal transducer and activator of transcription 2	Homo sapiens	66-71	
9028332-1	1997	Treatment of freshly isolated acute promyelocytic leukemia (APL) cells and the myelogenous leukemia cell lines, NB4, HL-60, and U937, with all-trans retinoic acid (ATRA) results in a remarkable elevation in the amounts of Stat1 alpha and Stat2 proteins.	Tretinoin	149-162	signal transducer and activator of transcription 2	Homo sapiens	238-243	
9028332-1	1997	Treatment of freshly isolated acute promyelocytic leukemia (APL) cells and the myelogenous leukemia cell lines, NB4, HL-60, and U937, with all-trans retinoic acid (ATRA) results in a remarkable elevation in the amounts of Stat1 alpha and Stat2 proteins.	Tretinoin	164-168	signal transducer and activator of transcription 2	Homo sapiens	238-243