PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15645120-2 2005 Treatment of SCC25 oral squamous carcinoma cells with sodium butyrate (SB) at 0.5-5 mM or all-trans retinoic acid (ATRA) at 3-300 microM inhibited cell growth and induced apoptosis in a dose-dependent manner with concomittant increases in expression of keratin 13, p21WAF1/Cip1 and p27Kip1 and decreases in expression of COX-2. Tretinoin 115-119 mitochondrially encoded cytochrome c oxidase II Homo sapiens 321-326 12842195-8 2003 Interestingly, the COX-2 protein and COX-2 mRNA were not detected in U937 cells, and their levels remained undetectable during the entire course of RA treatment. Tretinoin 148-150 mitochondrially encoded cytochrome c oxidase II Homo sapiens 19-24 27677346-8 2017 In addition, curcumin and IFN-beta/RA combination inhibited the expression of COX-2 and up-regulated GADD153. Tretinoin 35-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 78-83 22977519-12 2011 In conclusion, the combination of RSG and ATRA reduced the expression of COX-2, MMP-7 and TIMP-1, caused cell cycle arrest at the G1 phase and induced apoptosis, which resulted in the inhibition of cell proliferation in the HCT-15 human colorectal cancer cell line. Tretinoin 42-46 mitochondrially encoded cytochrome c oxidase II Homo sapiens 73-78 22306363-2 2012 Here we investigated the role of COXs (cyclooxygenases) in these effects and we found that, i) ATRA increased the expression of COX-1 and COX-2 mRNA and protein and the intracellular levels (but not the extracellular ones) of PGE(2). Tretinoin 95-99 mitochondrially encoded cytochrome c oxidase II Homo sapiens 138-143 20496179-7 2010 The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines. Tretinoin 68-72 mitochondrially encoded cytochrome c oxidase II Homo sapiens 81-86 20376700-2 2011 We found that in AN(3)CA and F9 cells, this hCOX-2 DR1 mediates responsiveness to all-trans-retinoic acid (tRA) or 9-cis-retinoic acid (9cRA), but this effect was suppressed by PPARdelta. Tretinoin 82-105 mitochondrially encoded cytochrome c oxidase II Homo sapiens 44-50 20376700-2 2011 We found that in AN(3)CA and F9 cells, this hCOX-2 DR1 mediates responsiveness to all-trans-retinoic acid (tRA) or 9-cis-retinoic acid (9cRA), but this effect was suppressed by PPARdelta. Tretinoin 107-110 mitochondrially encoded cytochrome c oxidase II Homo sapiens 44-50 20496179-7 2010 The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines. Tretinoin 68-72 mitochondrially encoded cytochrome c oxidase II Homo sapiens 113-118 20496179-11 2010 In conclusion, celecoxib increased the expression of RARbeta and the level of cellular ATRA sensitivity through COX-2-independent mechanisms. Tretinoin 87-91 mitochondrially encoded cytochrome c oxidase II Homo sapiens 112-117 18926686-6 2009 Retinoic acid also repressed LPS-induced transcription of NF-kappaB target genes such as IL-6, MCP-1 and COX-2. Tretinoin 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 105-110 21351468-7 2009 The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines. Tretinoin 68-72 mitochondrially encoded cytochrome c oxidase II Homo sapiens 81-86 21351468-7 2009 The results showed that celecoxib enhanced the inhibitory effect of ATRA in both COX-2 high-expressing HT-29 and COX-2 low-expressing SW480 cell lines. Tretinoin 68-72 mitochondrially encoded cytochrome c oxidase II Homo sapiens 113-118 18394023-9 2008 RA counteracted the inflammatory regulation of cyclooxygenase (COX)-2 mRNA and protein in astrocytes and thereby reduced the synthesis of PGE(2) by approximately 60%. Tretinoin 0-2 mitochondrially encoded cytochrome c oxidase II Homo sapiens 47-69 17204142-0 2007 All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2. Tretinoin 10-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 32-37 17204142-3 2007 Since ATRA also up-regulated COX-2 expression in SH-SY5Y human neuroblastoma cells, the current study was undertaken to analyze in these cells the mechanism through which ATRA increases COX activity. Tretinoin 6-10 mitochondrially encoded cytochrome c oxidase II Homo sapiens 29-34 17204142-10 2007 RESULTS: ATRA induced a significant increase of COX-2 expression in a dose- and time-dependent manner in SH-SY5Y human neuroblastoma cells, while COX-1 expression remained unchanged. Tretinoin 9-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 48-53 17204142-15 2007 Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect. Tretinoin 167-171 mitochondrially encoded cytochrome c oxidase II Homo sapiens 180-185 17204142-15 2007 Pre-incubation of SH-SY5Y human neuroblastoma cells with either RAR-pan-antagonist LE540 or MAP kinase kinase 1 (MEK-1) inhibitor PD98059 resulted in the abolition of ATRA-induced COX-2 promoter activity, COX-2 protein expression and PGE2 production whereas the retinoid X receptor pan-antagonist HX531, the p38 MAPK inhibitor SB203580 or the c-Jun kinase inhibitor SP600125 did not have any effect. Tretinoin 167-171 mitochondrially encoded cytochrome c oxidase II Homo sapiens 205-210 17204142-17 2007 CONCLUSION: These results highlight the importance of RAR-dependent and kinase-dependent mechanisms for ATRA-induced COX-2 expression and activity. Tretinoin 104-108 mitochondrially encoded cytochrome c oxidase II Homo sapiens 117-122 17159378-1 2007 All-trans retinoic acid (ATRA) increases the expression of COX-1 and COX-2 and the production of PGE2, a prostaglandin with anti-inflammatory effects in human mesangial cells (MC). Tretinoin 0-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 69-74 17159378-1 2007 All-trans retinoic acid (ATRA) increases the expression of COX-1 and COX-2 and the production of PGE2, a prostaglandin with anti-inflammatory effects in human mesangial cells (MC). Tretinoin 25-29 mitochondrially encoded cytochrome c oxidase II Homo sapiens 69-74 16894348-1 2006 BACKGROUND AND PURPOSE: Preliminary results in human mesangial cells (MC) suggested that all-trans retinoic acid (ATRA) increased the expression of COX-2 and the production of prostaglandin E2 (PGE2), a PG with anti-inflammatory effects in MC. Tretinoin 89-112 mitochondrially encoded cytochrome c oxidase II Homo sapiens 148-153 16894348-1 2006 BACKGROUND AND PURPOSE: Preliminary results in human mesangial cells (MC) suggested that all-trans retinoic acid (ATRA) increased the expression of COX-2 and the production of prostaglandin E2 (PGE2), a PG with anti-inflammatory effects in MC. Tretinoin 114-118 mitochondrially encoded cytochrome c oxidase II Homo sapiens 148-153 16894348-2 2006 The aim of this work is to confirm that ATRA increases the expression of COX-2 in MC and to examine the mechanisms involved. Tretinoin 40-44 mitochondrially encoded cytochrome c oxidase II Homo sapiens 73-78 16894348-8 2006 COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found. Tretinoin 23-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5 16894348-8 2006 COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found. Tretinoin 23-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 153-158 16894348-8 2006 COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found. Tretinoin 23-27 mitochondrially encoded cytochrome c oxidase II Homo sapiens 153-158 16894348-8 2006 COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found. Tretinoin 120-124 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5 16894348-8 2006 COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found. Tretinoin 120-124 mitochondrially encoded cytochrome c oxidase II Homo sapiens 153-158 16894348-8 2006 COX-2 up-regulation by ATRA was due to transcriptional mechanisms as pre-incubation with actinomycin D abolished it and ATRA increased the expression of COX-2 mRNA and the activity of a human COX-2 promoter construct, whereas post-transcriptional mechanisms were not found. Tretinoin 120-124 mitochondrially encoded cytochrome c oxidase II Homo sapiens 153-158 16894348-10 2006 Instead ATRA might act through a sustained activation of extracellular signal-regulated kinase 1/2 (ERK1/2) since up-regulation of COX-2 was prevented by inhibition of the activation of ERK1/2 with PD098059. Tretinoin 8-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 131-136