PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24506204-2	2014	In the present study, we investigated the potential role of xanthine dehydrogenase (XDH) in retinoic acid biosynthesis in human thyroid glandular cells (HTGC).	Tretinoin	92-105	xanthine dehydrogenase	Homo sapiens	60-82	
24506204-2	2014	In the present study, we investigated the potential role of xanthine dehydrogenase (XDH) in retinoic acid biosynthesis in human thyroid glandular cells (HTGC).	Tretinoin	92-105	xanthine dehydrogenase	Homo sapiens	84-87	
24506204-4	2014	After partial protein purification, the enzyme responsible for retinoic acid biosynthesis was identified and quantified as XDH by immunoassay, by its ability to oxidize xanthine to uric acid and its sensitivity to the inhibitory effect of oxypurinol.	Tretinoin	63-76	xanthine dehydrogenase	Homo sapiens	123-126	
24506204-5	2014	The evidence of XDH-driven formation of retinoic acid in HTGC cultures further corroborates the potential role of XDH in retinoic acid biosynthesis in the epithelia.	Tretinoin	40-53	xanthine dehydrogenase	Homo sapiens	16-19	
24506204-5	2014	The evidence of XDH-driven formation of retinoic acid in HTGC cultures further corroborates the potential role of XDH in retinoic acid biosynthesis in the epithelia.	Tretinoin	40-53	xanthine dehydrogenase	Homo sapiens	114-117	
24506204-5	2014	The evidence of XDH-driven formation of retinoic acid in HTGC cultures further corroborates the potential role of XDH in retinoic acid biosynthesis in the epithelia.	Tretinoin	121-134	xanthine dehydrogenase	Homo sapiens	16-19	
24506204-5	2014	The evidence of XDH-driven formation of retinoic acid in HTGC cultures further corroborates the potential role of XDH in retinoic acid biosynthesis in the epithelia.	Tretinoin	121-134	xanthine dehydrogenase	Homo sapiens	114-117	
19693777-4	2009	In these latter two cell lines, as opposed to HMEC cells, we observe a residual ability of XDH to produce retinoic acid from retinaldehyde and the inability to use retinol, as a consequence of a deficit in CRBP.	Tretinoin	106-119	xanthine dehydrogenase	Homo sapiens	91-94	
19250215-2	2009	In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC).	Tretinoin	195-218	xanthine dehydrogenase	Homo sapiens	38-60	
19250215-2	2009	In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC).	Tretinoin	195-218	xanthine dehydrogenase	Homo sapiens	62-65	
19250215-2	2009	In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC).	Tretinoin	185-189	xanthine dehydrogenase	Homo sapiens	38-60	
19250215-2	2009	In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC).	Tretinoin	185-189	xanthine dehydrogenase	Homo sapiens	62-65	
19250215-3	2009	Since both XDH and CRBP are required for the biosynthesis of t-RA, we have inspected their bioavailability in both estrogen-responsive and nonresponsive human mammary epithelial cancer cells.	Tretinoin	61-65	xanthine dehydrogenase	Homo sapiens	11-14	
18569334-0	2008	Xanthine dehydrogenase processes retinol to retinoic acid in human mammary epithelial cells.	Tretinoin	44-57	xanthine dehydrogenase	Homo sapiens	0-22	
18569334-7	2008	To get further knowledge regarding this process we have evaluated the biosynthetic pathway of retinoic acid in a human mammary epithelial cell line (HMEC) in which xanthine dehydrogenase (E.C.	Tretinoin	94-107	xanthine dehydrogenase	Homo sapiens	164-186