PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15389522-6 2005 Retinoic acid treatment markedly increased expression of osteopontin up to 48 h after stimulation. Tretinoin 0-13 secreted phosphoprotein 1 Rattus norvegicus 57-68 10687528-0 1999 Effect of retinoic acid on osteopontin expression in rat clonal dental pulp cells. Tretinoin 10-23 secreted phosphoprotein 1 Rattus norvegicus 27-38 10687528-2 1999 An immunoprecipitation assay clarified that retinoic acid caused an increase in phosphorylated osteopontin synthesis that was dose-dependent, and marked increases were observed at retinoic acid concentrations of 10(-6) to 10(-5) M (1.7-fold). Tretinoin 44-57 secreted phosphoprotein 1 Rattus norvegicus 95-106 10687528-2 1999 An immunoprecipitation assay clarified that retinoic acid caused an increase in phosphorylated osteopontin synthesis that was dose-dependent, and marked increases were observed at retinoic acid concentrations of 10(-6) to 10(-5) M (1.7-fold). Tretinoin 180-193 secreted phosphoprotein 1 Rattus norvegicus 95-106 10687528-4 1999 Because osteopontin has an important role in the mineralization process, these results suggest that retinoic acid regulates mineralization, which takes place in the pulp cavity, including reparative dentin formation. Tretinoin 100-113 secreted phosphoprotein 1 Rattus norvegicus 8-19 8835849-3 1996 Retinoic acid (RA) acted synergistically with type I collagen at each concentration to induce a much greater increase in OP mRNA than in cells on plastic. Tretinoin 0-13 secreted phosphoprotein 1 Rattus norvegicus 121-123 9846167-5 1998 Retinoic acid (RA), which has also been shown to promote osteoblastic differentiation, synergized with type I collagen to cause super-induction of OP mRNA. Tretinoin 0-13 secreted phosphoprotein 1 Rattus norvegicus 147-149 9846167-5 1998 Retinoic acid (RA), which has also been shown to promote osteoblastic differentiation, synergized with type I collagen to cause super-induction of OP mRNA. Tretinoin 15-17 secreted phosphoprotein 1 Rattus norvegicus 147-149 9618139-0 1998 Transcriptional and posttranscriptional regulation of osteopontin gene expression in preosteoblasts by retinoic acid. Tretinoin 103-116 secreted phosphoprotein 1 Rattus norvegicus 54-65 9618139-1 1998 This study examines the relative importance of transcriptional and posttranscriptional actions of retinoic acid (RA) in the regulation of osteopontin gene expression in a rat clonal preosteoblastic cell line, UMR 201. Tretinoin 98-111 secreted phosphoprotein 1 Rattus norvegicus 138-149 9618139-1 1998 This study examines the relative importance of transcriptional and posttranscriptional actions of retinoic acid (RA) in the regulation of osteopontin gene expression in a rat clonal preosteoblastic cell line, UMR 201. Tretinoin 113-115 secreted phosphoprotein 1 Rattus norvegicus 138-149 9618139-2 1998 Nuclear run-on analysis demonstrated constitutive expression of the osteopontin gene which was increased by threefold after 4 hr treatment with 1 microM RA, returning to a basal level by 24 hr. Tretinoin 153-155 secreted phosphoprotein 1 Rattus norvegicus 68-79 9618139-3 1998 However, Northern blot analysis, performed concurrently, showed that RA progressively increased the steady-state osteopontin mRNA level beginning 2 hr before any increase in gene transcription and peaking at 24 hr. Tretinoin 69-71 secreted phosphoprotein 1 Rattus norvegicus 113-124 9618139-7 1998 However, RA resulted in a time-dependent accumulation of mature osteopontin mRNA in all cellular subfractions, suggesting that the proficiency of nuclear processing of primary mRNA transcripts was greatly enhanced by RA. Tretinoin 9-11 secreted phosphoprotein 1 Rattus norvegicus 64-75 8835849-3 1996 Retinoic acid (RA) acted synergistically with type I collagen at each concentration to induce a much greater increase in OP mRNA than in cells on plastic. Tretinoin 15-17 secreted phosphoprotein 1 Rattus norvegicus 121-123 8835849-4 1996 In addition, RA increased the phosphorylation of secreted OP. Tretinoin 13-15 secreted phosphoprotein 1 Rattus norvegicus 58-60 7588278-11 1995 RA also induced osteopontin gene expression in concert with vitamin D in normal rats. Tretinoin 0-2 secreted phosphoprotein 1 Rattus norvegicus 16-27 7581951-5 1995 Short-term (24 h) exposure to RA at 10(-8) mol/l, which is a physiological concentration, decreased and increased the levels of ALP and osteopontin mRNA on day 6, respectively. Tretinoin 30-32 secreted phosphoprotein 1 Rattus norvegicus 136-147 7581951-8 1995 At a high concentration (10(-6) mol/l), RA increased the level of osteopontin mRNA on day 6 and decreased the levels of ALP and osteocalcin mRNA irrespective of culture period. Tretinoin 40-42 secreted phosphoprotein 1 Rattus norvegicus 66-77 8410463-6 1993 Individually, RA and calcitriol induced mRNA expression for ALP, matrix-gla protein (MGP), and osteopontin (OP). Tretinoin 14-16 secreted phosphoprotein 1 Rattus norvegicus 95-106 7785896-6 1995 Expression of OPN mRNA is upregulated by growth and differentiation factors (PDGF, EGF, TGF-beta and BMP-7/OP-1) and by mechanical stress, which promote bone formation, as well as by osteotropic hormones (retinoic acid and vitamin D3), which can promote bone resorption and remodelling. Tretinoin 205-218 secreted phosphoprotein 1 Rattus norvegicus 14-17 8227157-9 1993 In contrast, RA treatment induced osteopontin (OP) mRNA expression more strongly in cells plated on collagen compared with plastic within 24 hr and this was maintained for 72 hr. Tretinoin 13-15 secreted phosphoprotein 1 Rattus norvegicus 34-45 8227157-9 1993 In contrast, RA treatment induced osteopontin (OP) mRNA expression more strongly in cells plated on collagen compared with plastic within 24 hr and this was maintained for 72 hr. Tretinoin 13-15 secreted phosphoprotein 1 Rattus norvegicus 47-49 8410463-6 1993 Individually, RA and calcitriol induced mRNA expression for ALP, matrix-gla protein (MGP), and osteopontin (OP). Tretinoin 14-16 secreted phosphoprotein 1 Rattus norvegicus 108-110 8410463-8 1993 The combination of RA and calcitriol had a synergistic effect on ALP, OP, and especially MGP mRNA expression but significantly reduced the expression of pro-alpha 1(I) collagen mRNA. Tretinoin 19-21 secreted phosphoprotein 1 Rattus norvegicus 70-72 8410463-10 1993 The addition of AA to RA resulted in a decrease in the steady state level of OP, whereas its cotreatment with calcitriol caused a decrease in pro-alpha 1(I) collagen and ALP mRNA. Tretinoin 22-24 secreted phosphoprotein 1 Rattus norvegicus 77-79