PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18792915-0	2009	p38-MAPK- and caspase-3-mediated superoxide-induced apoptosis of rat hepatic stellate cells: reversal by retinoic acid.	Tretinoin	105-118	caspase 3	Rattus norvegicus	14-23	
29085977-0	2018	All-trans-retinoic acid ameliorates doxorubicin-induced cardiotoxicity: in vivo potential involvement of oxidative stress, inflammation, and apoptosis via caspase-3 and p53 down-expression.	Tretinoin	0-23	caspase 3	Rattus norvegicus	155-164	
29085977-9	2018	Pretreatment with ATRA maintained cardiac function biomarkers, and reduced proinflammatory cytokines, lipid peroxidation, and immunoexpression of caspase 3 and p53.	Tretinoin	18-22	caspase 3	Rattus norvegicus	146-155	
25532484-13	2015	Amplified activation of caspase 3/7 was in favor of apoptosis in ATRA treated peripheral nerve fibroblasts.	Tretinoin	65-69	caspase 3	Rattus norvegicus	24-33	
20155467-10	2010	After treatment with 10 mumol/L ATRA for 48 h, the Caspase3 and Caspase8 were significantly activated as compared with the control group (P<0.05).	Tretinoin	32-36	caspase 3	Rattus norvegicus	51-59	
28488074-1	2017	OBJECTIVES: To investigate the effect of all-trans retinoic acid (ATRA) on caspase 3 activity, matrix metalloproteinase 2 (MMP-2), and MMP-9 expression and activity as well as in vitro rat bone marrow-derived mesenchymal stem cells (MSCs) migration.	Tretinoin	66-70	caspase 3	Rattus norvegicus	75-84	
24551289-9	2014	Additionally, the caspase-3 activity was also significantly increased in the ATRA-exposed group than control group.	Tretinoin	77-81	caspase 3	Rattus norvegicus	18-27	
11451739-7	2001	tRA-induced apoptosis associated with an increased ratio of bax to bcl-2 by bax overexpression and cleavage of caspase-3.	Tretinoin	0-3	caspase 3	Rattus norvegicus	111-120	
35197751-0	2022	Impact of preconditioning stem cells with all-trans retinoic acid signaling pathway on cisplatin-induced nephrotoxicity by down-regulation of TGFbeta1, IL-6, and caspase-3 and up-regulation of HIF1alpha and VEGF.	Tretinoin	52-65	caspase 3	Rattus norvegicus	162-171	
18156191-7	2008	RA restored the ratio of Bcl-2 to Bax, inhibited cleavage of caspase-3 and -9, and prevented the decreases in the levels of SOD-1 and SOD-2.	Tretinoin	0-2	caspase 3	Rattus norvegicus	61-77	
10733907-4	2000	Cellular caspase 3 activity, another marker of apoptosis, was increased by RA (10 microM) (P < 0.05), but not by 50 microm C2-ceramide.	Tretinoin	75-77	caspase 3	Rattus norvegicus	9-18	
10733907-6	2000	These results suggest that fat cell loss by apoptosis can be regulated, in part, by RA (10 microM) which increases caspase 3 activity and decreases Bcl-2 expression in rat S-V cells.	Tretinoin	84-86	caspase 3	Rattus norvegicus	115-124	
35197751-6	2022	ATRA also supported ADMSCs by a significant down-regulation of caspase-3, il-6 and TGFbeta1, and a significant up-regulation of HIF1, VEGF and CD31 compared to group of cisplatin which reversed the cisplatin effect.	Tretinoin	0-4	caspase 3	Rattus norvegicus	63-72