PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26316040-11	2016	CYP polymorphisms may explain why there is wide variation in blood HCQ concentrations.	Hydroxychloroquine	67-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3	
26316040-12	2016	The role of an individual"s CYP polymorphisms should be considered when prescribing oral HCQ.	Hydroxychloroquine	89-92	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	28-31	
35135554-0	2022	Relationship of cytochrome P450 gene polymorphisms with blood concentrations of hydroxychloroquine and its metabolites and adverse drug reactions.	Hydroxychloroquine	80-98	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	16-31	
35135554-2	2022	This study aimed to investigate the relationship of cytochrome P450 (CYP450) gene polymorphisms with blood concentrations of HCQ and its metabolites and adverse drug reactions (ADRs) in patients with SLE and RA.	Hydroxychloroquine	125-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-67	
26316040-1	2016	OBJECTIVE: To evaluate associations of genetic polymorphisms in cytochrome P450 (CYP) isoforms 2D6, 3A5, and 3A4 with blood concentrations of hydroxychloroquine (HCQ) and its metabolite, N-desethyl HCQ (DHCQ), in patients with systemic lupus erythematosus (SLE).	Hydroxychloroquine	142-160	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	64-79	
26316040-1	2016	OBJECTIVE: To evaluate associations of genetic polymorphisms in cytochrome P450 (CYP) isoforms 2D6, 3A5, and 3A4 with blood concentrations of hydroxychloroquine (HCQ) and its metabolite, N-desethyl HCQ (DHCQ), in patients with systemic lupus erythematosus (SLE).	Hydroxychloroquine	142-160	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-84	
26316040-1	2016	OBJECTIVE: To evaluate associations of genetic polymorphisms in cytochrome P450 (CYP) isoforms 2D6, 3A5, and 3A4 with blood concentrations of hydroxychloroquine (HCQ) and its metabolite, N-desethyl HCQ (DHCQ), in patients with systemic lupus erythematosus (SLE).	Hydroxychloroquine	162-165	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	64-79	
26316040-1	2016	OBJECTIVE: To evaluate associations of genetic polymorphisms in cytochrome P450 (CYP) isoforms 2D6, 3A5, and 3A4 with blood concentrations of hydroxychloroquine (HCQ) and its metabolite, N-desethyl HCQ (DHCQ), in patients with systemic lupus erythematosus (SLE).	Hydroxychloroquine	162-165	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-84	
32763298-5	2020	Cytochrome P450 (CYP450) and its isoforms are the main metabolizers of HCQ and CQ.	Hydroxychloroquine	71-74	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15