PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27412967-0	2016	Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells.	Ditiocarb	40-62	matrix metallopeptidase 1	Homo sapiens	0-26	
8981044-8	1997	In contrast, inhibition of Cu,ZnSOD by diethyldithiocarbamate (DDC), leading to diminished H2O2 production from O2.-, decreased MMP-1 mRNA induction.	Ditiocarb	39-61	matrix metallopeptidase 1	Homo sapiens	128-133	
8981044-8	1997	In contrast, inhibition of Cu,ZnSOD by diethyldithiocarbamate (DDC), leading to diminished H2O2 production from O2.-, decreased MMP-1 mRNA induction.	Ditiocarb	63-66	matrix metallopeptidase 1	Homo sapiens	128-133	
27412967-10	2016	These data indicate that DDC up-regulated MMP-1 in LX-2 cells through the miR-222/ETS-1 pathway.	Ditiocarb	25-28	matrix metallopeptidase 1	Homo sapiens	42-47	
27412967-13	2016	Collectively, these data indicate that DDC up-regulated MMP-1 in LX-2 cells through the Akt and ERK/miR-222/ETS-1 pathways.	Ditiocarb	39-42	matrix metallopeptidase 1	Homo sapiens	56-61	
27412967-2	2016	We previously demonstrated that diethyldithiocarbamate (DDC) up-regulates MMP-1 in hepatic stellate cells via the ERK1/2 and Akt signalling pathways.	Ditiocarb	32-54	matrix metallopeptidase 1	Homo sapiens	74-79	
27412967-2	2016	We previously demonstrated that diethyldithiocarbamate (DDC) up-regulates MMP-1 in hepatic stellate cells via the ERK1/2 and Akt signalling pathways.	Ditiocarb	56-59	matrix metallopeptidase 1	Homo sapiens	74-79	
27412967-5	2016	The data revealed that the transcriptional factor ETS-1, which is an important regulator of MMP-1, was up-regulated in LX-2 cells following DDC treatment.	Ditiocarb	140-143	matrix metallopeptidase 1	Homo sapiens	92-97	
27412967-9	2016	The up-regulation of ETS-1 and MMP-1 in LX-2 cells treated with DDC were inhibited after miR-222 mimic transfection.	Ditiocarb	64-67	matrix metallopeptidase 1	Homo sapiens	31-36	
23577625-0	2013	The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism.	Ditiocarb	21-24	matrix metallopeptidase 1	Homo sapiens	38-43	
23577625-2	2013	However, the effect of DDC on MMP-1 (matrix metalloproteinase-1), which is the main collagen degrading matrix metalloproteinase, has not been reported.	Ditiocarb	23-26	matrix metallopeptidase 1	Homo sapiens	30-35	
23577625-2	2013	However, the effect of DDC on MMP-1 (matrix metalloproteinase-1), which is the main collagen degrading matrix metalloproteinase, has not been reported.	Ditiocarb	23-26	matrix metallopeptidase 1	Homo sapiens	37-63	
23577625-3	2013	In co-culture experiments, we found that DDC significantly enhanced MMP-1 expression in human HSC (LX-2) that were cultured with hepatocyte C3A cells either expressing or not expressing CYP2E1.	Ditiocarb	41-44	matrix metallopeptidase 1	Homo sapiens	68-73	
23577625-5	2013	H2O2 treatment abrogated DDC-induced MMP-1 up-regulation and collagen I decrease, while catalase treatment slightly up-regulated MMP-1 expression.	Ditiocarb	25-28	matrix metallopeptidase 1	Homo sapiens	37-42	
23577625-6	2013	These data suggested that the decrease in ROS by DDC was partially responsible for the MMP-1 up-regulation.	Ditiocarb	49-52	matrix metallopeptidase 1	Homo sapiens	87-92	
23577625-8	2013	The ERK1/2 inhibitor (U0126) and Akt inhibitor (T3830) abrogated the DDC-induced MMP-1 up-regulation.	Ditiocarb	69-72	matrix metallopeptidase 1	Homo sapiens	81-86	
23577625-11	2013	The enhancement of MMP-1 expression by DDC was associated with H2O2 inhibition and coordinated regulation by the ERK1/2 and Akt pathways.	Ditiocarb	39-42	matrix metallopeptidase 1	Homo sapiens	19-24