PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27412967-13	2016	Collectively, these data indicate that DDC up-regulated MMP-1 in LX-2 cells through the Akt and ERK/miR-222/ETS-1 pathways.	Ditiocarb	39-42	AKT serine/threonine kinase 1	Homo sapiens	88-91	
27412967-0	2016	Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells.	Ditiocarb	40-62	AKT serine/threonine kinase 1	Homo sapiens	80-83	
27412967-2	2016	We previously demonstrated that diethyldithiocarbamate (DDC) up-regulates MMP-1 in hepatic stellate cells via the ERK1/2 and Akt signalling pathways.	Ditiocarb	32-54	AKT serine/threonine kinase 1	Homo sapiens	125-128	
27412967-2	2016	We previously demonstrated that diethyldithiocarbamate (DDC) up-regulates MMP-1 in hepatic stellate cells via the ERK1/2 and Akt signalling pathways.	Ditiocarb	56-59	AKT serine/threonine kinase 1	Homo sapiens	125-128	
26994002-2	2016	Prior research has implicated signaling through the MAPK and AKT/PI3K pathways in the progression of DTC.	Ditiocarb	101-104	AKT serine/threonine kinase 1	Homo sapiens	61-64	
23577625-0	2013	The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism.	Ditiocarb	21-24	AKT serine/threonine kinase 1	Homo sapiens	100-103	
30780891-4	2012	Molecular studies have demonstrated that the development and progression of DTC are associated with a series of consistent abnormalities in pathways such as MAPK/ERK and PI3/Akt, which govern cellular growth, proliferation, apoptosis and angiogenesis.	Ditiocarb	76-79	AKT serine/threonine kinase 1	Homo sapiens	174-177	
23577625-7	2013	ERK1/2 (extracellular signal-regulated kinase 1/2), Akt (protein kinase B) and p38 were significantly activated by DDC.	Ditiocarb	115-118	AKT serine/threonine kinase 1	Homo sapiens	52-55	
23577625-8	2013	The ERK1/2 inhibitor (U0126) and Akt inhibitor (T3830) abrogated the DDC-induced MMP-1 up-regulation.	Ditiocarb	69-72	AKT serine/threonine kinase 1	Homo sapiens	33-36	
23577625-11	2013	The enhancement of MMP-1 expression by DDC was associated with H2O2 inhibition and coordinated regulation by the ERK1/2 and Akt pathways.	Ditiocarb	39-42	AKT serine/threonine kinase 1	Homo sapiens	124-127