PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1551417-3 1992 Substituted isocoumarins are potent inhibitors of proteinase 3 and the best inhibitors are 7-amino-4-chloro-3-(2-bromoethoxy)isocoumarin and 3,4-dichloroisocoumarin (DCI) with kobs/[I] values of 4700 and 2600 M-1.s-1, respectively. 3,4-dichloroisocoumarin 141-164 proteinase 3 Homo sapiens 50-62 9067256-6 1996 Inactivation of myeloblastin by 3,4-dichloroisocoumarin (ki/Ki = 6,389 M(-1)s(-1)) and MeO-Suc-Ala-Ala-Pro-Val-chloromethane (ki/Ki = 579 M(-1) S(-1)) occurred via a two-step, irreversible complexing mechanism with potencies one-half and one-fifth that of leukocyte elastase, respectively. 3,4-dichloroisocoumarin 32-55 proteinase 3 Homo sapiens 16-28 1551417-3 1992 Substituted isocoumarins are potent inhibitors of proteinase 3 and the best inhibitors are 7-amino-4-chloro-3-(2-bromoethoxy)isocoumarin and 3,4-dichloroisocoumarin (DCI) with kobs/[I] values of 4700 and 2600 M-1.s-1, respectively. 3,4-dichloroisocoumarin 166-169 proteinase 3 Homo sapiens 50-62